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Lucie Germain

Professeure titulaire

Directeur(trice), Centre de recherche en organogenèse expérimentale

Lucie Germain
Lucie.Germain@fmed.ulaval.ca
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Peau
  • Affections cutanées
  • Fibroses
  • Tissu conjonctif
Cellulaire
Organismes vivants (êtres humains - Psychologie/aspects biologiques)

Projets de recherche

  • Chaire de recherche du Canada en Cellules Souches et Génie Tissulaire - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2022-01-01 au 2028-12-31
  • Régénération de la peau humaine : Une peau reconstruite par génie tissulaire pigmentée produite plus rapidement pour traiter les patients grands brûlés - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-07-01 au 2027-06-30
  • Real World Clinical and Economic Burden of Severe Burn Injuries - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-10-01 au 2026-09-30
  • Tissue-engineered solutions for uro-genital reconstruction, and replacing banned synthetic meshes - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2026-09-30
  • Tissue engineering to treat Canadian burn patients: the Self-Assembled Skin Substitutes (SASS) - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), co-chercheur - 2022-04-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • PSO du Gvt du Québec:Salles GMP pour la consolidation de tissus en médecine régénératrice. Qui va avec FCI: A cGMP facilily for Personalized Tissus Engineering - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), co-chercheur - 2022-03-30 au 2025-03-30
  • Clinical trial of cultured epithelial corneal autografts for the treatment of Canadians with limbal stem cell deficiency - Secrétariat des programmes interorganismes à l’intention des établissements - Réseau de centres d'excellence (RCE), chercheur principal - 2023-04-01 au 2025-01-31
  • Allogeneic dermis to accelerate the production of a tissue-engineered skin substitute to treat Canadian burn patients - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), co-chercheur - 2023-04-01 au 2025-01-31
  • Combining tissue-engineered skin with ex vivo gene therapy correction to develop a treatment for epidermolysis bullosa - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), chercheur principal - 2022-04-01 au 2024-03-31
  • Cellules souches stromales de cornées humaines pour développer de nouvelles thérapies tissulaires dans le traitement des plaies cornéens - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2023-03-01 au 2024-03-31
  • Projets structurants ThéCell 2023-2024_Greffons d’épiderme autologue en combinant thérapie génique et génie tissulaire pour traiter l’épidermolyse bulleuse jonctionnelle - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2023-04-01 au 2024-03-31
  • Cellules souches stromales de cornées humaines pour développer de nouvelles thérapies tissulaires dans le traitement des plaies cornéens - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2023-03-01 au 2024-03-31
  • A multicenter skin research group focusing on novel treatment for epidermolysis - Instituts de recherche en santé du Canada - Subventions Catalyseur de réseaux, University of Toronto, co-chercheur - 2022-12-01 au 2023-11-30
  • Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques - Fondation de l'Université Laval - Chaires de recherche sans organismes subventionnaires, chercheur principal - 2013-05-01 au 2023-08-12
  • Banque de fibroblastes humains - Soeurs de la Charité de Québec, chercheur principal - 2022-06-28 au 2023-06-27
  • La réponse immunitaire aux peaux reconstruites avec des cellules allogéniques. - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, chercheur principal - 2022-04-01 au 2023-03-31
  • Effet de la lumière sur les peaux reconstruites - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-03-30 au 2023-03-29
  • Cultured epithelial corneal autografts for the treatment of canadians with limbal stem cell deficiency - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), chercheur principal - 2020-01-01 au 2023-01-31
  • Skin Investigation Network of Canada (SkIN Canada) - Instituts de recherche en santé du Canada - Subventions Catalyseur de réseaux, University of Toronto, co-chercheur - 2020-01-01 au 2022-12-31
  • Recherche en vue de développer un traitement pour les patients atteints d'épidermolyse bulleuse dystrophique - Fondation du CHU de Québec, chercheur principal - 2021-09-14 au 2022-09-13
  • Les cellules souches épithéliales et le génie tissulaire : de la recherche fondamentale à la recherche clinique. - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2015-07-01 au 2022-06-30
  • Soutien à la recherche dans le domaine des maladies auto-immunes et de la cicatrisation - Fondation de l'Université Laval, chercheur principal - 2016-04-01 au 2022-03-31
  • The Canadian National Transplant Research Program : Increasing Donation and Improving Transplantation Outcomes - Instituts de recherche en santé du Canada - Autre : Recherche sur la transplantation, University of Alberta, co-chercheur - 2013-04-01 au 2022-03-31
  • Monitoring expression of the transcription factors Sp1 and NFI as markers of cell quality in human corneal epithelial cells cultured on different cell carriers - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, co-chercheur - 2021-02-01 au 2022-03-31
  • Towards an epidermolysis bullosa clinical trial with tissue-engineered skin after ex vivo gene therapy correction - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Fondation du CHU de Québec, Fonds de recherche du Québec - Santé - Réseau de centres d'excellence (RCE), chercheur principal - 2020-08-01 au 2022-02-28
  • Self-Assembly Skin Substitutes (SASS) for the treatment of acute wounds of Canadian burn patients - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), co-chercheur - 2020-01-01 au 2022-01-31
  • Chaire de recherche du Canada EN CELLULES SOUCHES ET GÉNIE TISSULAIRE - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2015-01-01 au 2021-12-31

Publications

  • Selective culture of epithelial cells from primary breast carcinomas using irradiated 3T3 cells as feeder layer, Têtu, B., Auger, F., Germain, L., Tremblay, N., Goulet, F., Wang, C.S., Pathology Research and Practice, 2001, 10.1078/0344-0338-00030
  • Multistep production of bioengineered skin substitutes: Sequential modulation of culture conditions, Goulet, F., Germain, L., Juhasz, J., Noël, P., Guignard, R., Tremblay, N., Pouliot, R., Auger, F.A., In Vitro Cellular and Developmental Biology - Animal, 2000, 10.1290/1071-2690(2000)036<0096:MPOBSS>2.3.CO;2
  • Role of wound healing myofibroblasts on re-epithelialization of human skin, Germain, L., Garrel, D., Auger, F.A., Moulin, V., Burns, 2000, 10.1016/S0305-4179(99)00091-1
  • Tissue engineering of the vascular system: From capillaries to larger blood vessels, Auger, F., Rémy-Zolghadri, M., Germain, L., Medical and Biological Engineering and Computing, 2000, 10.1007/BF02344782
  • Tissue engineering of the vascular system: full spectrum of tissue engineered blood vessels (TEBV), Germain, Lucie, Grenier, Guillaume, Black, Annie, Remy-Zolghadri, Murielle, Auger, Francois, Annals of Biomedical Engineering, 2000
  • Antiangiogenic effects of the oral administration of liquid cartilage extract in humans, Garrel, D.R., Dupont, E., El-Khouri, S., Gaudreau, P., Saint-Cyr, M., Germain, L., Thibodeau, A., Berbari, P., Journal of Surgical Research, 1999, 10.1006/jsre.1999.5698
  • Tissue engineering [3], Auger, F.A., Germain, L., L'Heureux, N., Science, 1999
  • A completely biological tissue-engineered human blood vessel, Auger, F.A., Germain, L., Labbé, R., Pâquet, S., L'Heureux, N., FASEB Journal, 1998, 10.1096/fasebj.12.1.47
  • Expression of heat shock proteins in mouse skin during wound healing, Germain, L., Tanguay, R.M., Morrow, G., Li, H., Landry, J., Auger, F.A., Moulin, V., Laplante, A.F., Journal of Histochemistry and Cytochemistry, 1998, 10.1177/002215549804601109
  • In vitro reconstruction of a human capillary-like network in a tissue- engineered skin equivalent, Auger, F.A., Germain, L., L'Heureux, N., Berthod, F., Black, A.F., FASEB Journal, 1998, 10.1096/fasebj.12.13.1331
  • Production of bioengineered cancer tissue constructs in vitro: Epithelium-mesenchyme heterotypic interactions, Têtu, B., Germain, L., Tremblay, N., Auger, F., Goulet, F., Wang, C.S., In Vitro Cellular and Developmental Biology - Animal, 2001, 10.1290/1071-2690(2001)037<0434:POBCTC>2.0.CO;2
  • Mechanisms of wound reepithelialization: Hints from a tissue-engineered reconstructed skin to long-standing questions, Moulin, V., Auger, F.A., Germain, L., Laplante, A.F., FASEB Journal, 2001, 10.1096/fj.01-0250com
  • Characterization of a 150 kDa accessory receptor for TGF-β1 on keratinocytes: Direct evidence for a GPI anchor and ligand binding of the released form, Philip, A., Hooper, N.M., Germain, L., Larouche, D., Tam, B.Y.Y., Journal of Cellular Biochemistry, 2001, 10.1002/jcb.1074
  • Storage and translational issues in reparative medicine: Breakout session summary, Kocsis, J.D., Ratner, B.D., Lee, R.C., Germain, L., Brockbank, K., Anderson, D.K., Toner, M., Kocsis, J.D., Annals of the New York Academy of Sciences, 2002, 10.1111/j.1749-6632.2002.tb03101.x
  • The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation, Germain, L., Blouin, R., Robitaille, K., Proulx, R., Robitaille, H., Journal of Biological Chemistry, 2005, 10.1074/jbc.M411619200
  • Recent optimization of a tissue engineered blood vessel: The LOEX experience, Germain, L., Rémy-Zolghadri, M., Grenier, G., Laflamme, K., Auger, F.A., International Congress Series, 2004, 10.1016/S0531-5131(03)01768-0
  • The graft of a human endothelializated reconstructed skin accelerates the time of revascularization, Auger, F.A., Germain, L., Berthod, F., Hudon, V., Tremblay, P.-L., Transactions - 7th World Biomaterials Congress, 2004
  • Normal human Merkel cells are present in epidermal cell populations isolated and cultured from glabrous and hairy skin sites, Germain, L., Roy, A., Caouette-Laberge, L., Couture, V., Beauparlant, A., Guignard, R., Fugère, C., Larouche, D., Fradette, J., Journal of Investigative Dermatology, 2003, 10.1046/j.1523-1747.2003.12024.x
  • Tissue engineering: A tool to understand the physiological mechanisms,Le génie tissulaire au service de la compréhension du vivant, Auger, F.A., Germain, L., Berthod, F., Goulet, F., Moulin, V., Medecine/Sciences, 2003, 10.1051/medsci/200319101003
  • A truly new approach for tissue engineering: the LOEX self-assembly technique., Germain, L., Grenier, G., Rémy-Zolghadri, M., Auger, F.A., Ernst Schering Research Foundation workshop, 2002, 10.1007/978-3-662-04816-0_6
  • Engineering human tissues for in vivo applications: Storage and translational issues for tissue repair and regeneration, Germain, L., Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2002
  • The feeder layer-mediated extended lifetime of cultured human skin keratinocytes is associated with altered levels of the transcription factors Sp1 and Sp3, Guérin, S.L., Germain, L., Lefort, N.R., Leclerc, S., Paquet, C., Fugère, C., Masson-Gadais, B., Journal of Cellular Physiology, 2006, 10.1002/jcp.20529
  • Inosculation of tissue-engineered capillaries with the host's vasculature in a reconstructed skin transplanted on mice, Auger, F.A., Germain, L., Berthod, F., Hudon, V., Tremblay, P.-L., American Journal of Transplantation, 2005, 10.1111/j.1600-6143.2005.00790.x
  • Mechanical loading modulates the differentiation state of vascular smooth muscle cells, Germain, L., Auger, F.A., Labbé, R., Baker, K., Guignard, R., Bergeron, F., Rémy-Zolghadri, M., Grenier, G., Tissue Engineering, 2006, 10.1089/ten.2006.12.3159
  • Canadian haematopoietic stem cell scientists received the Lasker Award,Des Canadiens «précurseurs de la recherche sur les cellules souches hématopoïétiques» lauréats du prix Lasker, Paquet, C., Larouche, D., Germain, L., Medecine/Sciences, 2006, 10.1051/medsci/2006222212
  • Tissue engineering of human cornea, Guérin, S.L., Gaudreault, M., Giasson, C.J., Germain, L., Auger, F.A., Carrier, P., Guillemette, M., Proulx, S., Biomaterials and Regenerative Medicine in Ophthalmology, 2009, 10.1533/9781845697433.1.150
  • Transplantation of a tissue-engineered corneal endothelium reconstructed on a devitalized carrier in the feline model, Brunette, I., Germain, L., Brunette, I., Devaux, A., Uwamaliya, J.D., Audet, C., Nada, O., Bensaoula, T., Proulx, S., Investigative Ophthalmology and Visual Science, 2009, 10.1167/iovs.08-2793
  • Adventitia contribution to vascular contraction: Hints provided by tissue-engineered substitutes, Germain, L., D'Orléans-Juste, P., Auger, F.A., Cardiovascular Research, 2007, 10.1016/j.cardiores.2007.06.001
  • Tendons and ligaments, Auger, F.A., Poole, A.R., Germain, L., Goulet, F., Principles of Tissue Engineering, 2007, 10.1016/B978-012370615-7/50064-0
  • Adventitia contribution in vascular tone: Insights from adventitia-derived cells in a tissue-engineered human blood vessel, Germain, L., Auger, F.A., D'Orléans-Juste, P., Labbé, R., Baker, K., Pouliot, S., Rémy-Zolghadri, M., Roberge, C.J., Grenier, G., Laflamme, K., FASEB Journal, 2006, 10.1096/fj.05-4702fje
  • Evolution of three dimensional skin equivalent models reconstructed in vitro by tissue engineering, Damour, O., Auger, F.A., Braye, F., Bechetoille, N., Kinikoglu, B., Germain, L., Lequeux, C., Fradette, J., Auxenfans, C., European Journal of Dermatology, 2009, 10.1684/ejd.2008.0573
  • Regeneration of skin and cornea by tissue engineering, Germain, L., Auger, F.A., Carrier, P., Fradette, J., Paquet, C., Larouche, D., Methods in Molecular Biology, 2009, 10.1007/978-1-59745-060-7_15
  • Regenerative medicine: Stem cells, cellular and matricial interactions in the reconstruction of skin and cornea by tissue engineering,La médecine régénératrice : les cellules souches, les interactions cellulaires et matricielles dans la reconstruction cutanée et cornéenne par génie tissulaire, Germain, L., Auger, F.A., Beauparlant, A., Carrier, P., Paquet, C., Proulx, S., Lavoie, A., Larouche, D., Pathologie Biologie, 2009, 10.1016/j.patbio.2008.04.015
  • Human fibroblast-derived ECM as a scaffold for vascular tissue engineering, Germain, L., Auger, F.A., Labbé, R., Lavoie, A., Larouche, D., Gauvin, R., Bourget, J.-M., Biomaterials, 2012, 10.1016/j.biomaterials.2012.09.015
  • A Computer-Controlled Apparatus for the Characterization of Mechanical and Viscoelastic Properties of Tissue-Engineered Vascular Constructs, Germain, L., Auger, F.A., Larouche, D., Gauvin, R., Levesque, P., Cardiovascular Engineering and Technology, 2011, 10.1007/s13239-011-0033-y
  • Biaxial biomechanical properties of self-assembly tissue-engineered blood vessels, Gleason, R.L., Germain, L., Auger, F.A., Gauvin, R., Zaucha, M.T., Journal of the Royal Society Interface, 2011, 10.1098/rsif.2010.0228
  • Comparative study of bovine, porcine and avian collagens for the production of a tissue engineered dermis, Berthod, F., Germain, L., Gariépy, C., Cliche, S., Gauvin, R., Parenteau-Bareil, R., Acta Biomaterialia, 2011, 10.1016/j.actbio.2011.06.020
  • Corneal endothelial toxicity of air and SF6, Brunette, I., Germain, L., Carrier, P., Proulx, S., Bensaoula, T., Nada, O., Hoffart, L., Aminian, A., Landry, H., Investigative Ophthalmology and Visual Science, 2011, 10.1167/iovs.10-6187
  • Normal human epithelial cells regulate the size and morphology of tissue-engineered capillaries, Germain, L., Auger, F.A., Berthod, F., Baker, K., Roberge, C.J., Tomasetig, F., Fortin, V., Fradette, J., Rochon, M.-H., Tissue Engineering - Part A, 2010, 10.1089/ten.tea.2009.0090
  • Restoration of the transepithelial potential within tissue-engineered human skin in vitro and during the wound healing process in vivo, Moulin, V.J., Germain, L., Plante, M., Bourdages, M., Goulet, D., Auger, F.A., Roberge, C.J., Gauvin, R., Lévesque, P., Rochette-Drouin, O., Dubé, J., Tissue Engineering - Part A, 2010, 10.1089/ten.tea.2010.0030
  • Tissue-engineered vascular substitutes: New models toward successful small diameter grafts, Auger, F.A., Germain, L., Lacroix, D., D'Orléans-Juste, P., Advances in Vascular Medicine, 2010, 10.1007/978-1-84882-637-3_9
  • Differential binding of the transcription factors Sp1, AP-1, and NFI to the promoter of the human α5 integrin gene dictates its transcriptional activity, Guérin, S.L., Germain, L., Drouin, R., Leclerc, S., Zaniolo, K., Masson-Gadais, B., Gingras, M.-È., Investigative Ophthalmology and Visual Science, 2009, 10.1167/iovs.08-2059
  • Prospective study on the treatment of lower-extremity chronic venous and mixed ulcers using tissue-engineered skin substitute made by the self-assembly approach, Auger, F.A., Germain, L., Moulin, V.J., Larouche, D., Rochon, M.-H., Dubé, N., Ospina, C.E., Arsenault, F., Roy, M., Soucy, J., Rodrigue, B., Labbé, R., Genest, H., Cloutier, C.B., Boa, O., Advances in Skin and Wound Care, 2013, 10.1097/01.ASW.0000433102.48268.2a
  • Human epithelial stem cells persist within tissue-engineered skin produced by the self-assembly approach, Germain, L., Fradette, J., Pouliot, R., Kim, D.H., Dunnwald, M., Robitaille, H., Sauvé, S., Desgagné, M., Paquet, C., Larouche, D., Goyer, B., Beauparlant, A., Fugère, C., Lavoie, A., Tissue Engineering - Part A, 2013, 10.1089/ten.tea.2012.0117
  • Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media, Andriantsitohaina, R., Germain, L., Asfar, P., Mercat, A., Leonetti, D., Martinez, M.C., Meziani, F., Bourget, J.-M., Mostefai, H.A., Clinical Science, 2013, 10.1042/CS20120441
  • Progress in developing a living human tissue-engineered tri-leaflet heart valve assembled from tissue produced by the self-assembly approach, Germain, L., Auger, F.A., Roberge, C.J., Lafrance, H., Gauvin, R., Bourget, J.-M., Dubé, J., Acta Biomaterialia, 2014, 10.1016/j.actbio.2014.04.033
  • A comparative study of bovine and porcine pericardium to highlight their potential advantages to manufacture percutaneous cardiovascular implants, Guidoin, R., Germain, L., Zhang, Z., Guzman, R., Larouche, D., Li, B., Klein, J., Mehri, Y., Marinov, G., Gauvin, R., Journal of Biomaterials Applications, 2013, 10.1177/0885328212465482
  • Minimal contraction for tissue-engineered skin substitutes when matured at the air-liquid interface, Germain, L., Auger, F.A., Guignard, R., Marcoux, H., Larouche, D., Gauvin, R., Journal of Tissue Engineering and Regenerative Medicine, 2013, 10.1002/term.543
  • Adherens junction proteins are expressed in collagen corneal equivalents produced in vitro with human cells, Germain, L., Carrier, P., Deschambeault, A., Giasson, C.J., Molecular Vision, 2014
  • Mechanical properties of endothelialized fibroblast-derived vascular scaffolds stimulated in a bioreactor, Auger, F.A., Ruel, J., Germain, L., Tremblay, C., Lacroix, D., Bourget, J.-M., Vallières, K., Gauvin, R., Laterreur, V., Tondreau, M.Y., Acta Biomaterialia, 2015, 10.1016/j.actbio.2015.02.026
  • A Floating Thrombus Anchored at the Proximal Anastomosis of a Woven Thoracic Graft Mimicking a Genuine Aortic Dissection, Guidoin, R., Jing, Z., Germain, L., Douville, Y., Zhang, Z., Wang, L., Guzman, R., Bourget, J.-M., Lin, J., Rochette-Drouin, O., Verdant, A., Bondarenko, O., Fu, Y., Liu, B., Li, B., Journal of long-term effects of medical implants, 2015, 10.1615/jlongtermeffmedimplants.2015012263
  • The tissue-engineered human cornea as a model to study expression of matrix metalloproteinases during corneal wound healing, Guérin, S.L., Germain, L., Patenaude, J., Lake, J., Carrier, P., Zaniolo, K., Couture, C., Biomaterials, 2016, 10.1016/j.biomaterials.2015.11.006
  • The ROVT Elan Valved Biplex conduits for the reconstruction of the right ventricular outflow tract, Zhang, Z., Germain, L., Dionne, G., Desaulniers, D., Guzman, R., Qin, B., Wang, L., Lin, J., Li, X., Paynter, R., Bourget, J.-M., Weerasena, N., Li, B., Fu, Y., Guidoin, R., Journal of Long-Term Effects of Medical Implants, 2016, 10.1615/JLongTermEffMedImplants.2016013857
  • Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries, Germain, L., Moulin, V.J., Auger, F.A., Gauvin, R., Lavoie, A., Ayoub, A., Martel, I., Guignard, R., Desgagné, M., Cantin-Warren, L., Larouche, D., BioResearch Open Access, 2016, 10.1089/biores.2016.0036
  • Isolation and culture of human keratinocytes, Germain, L., Larouche, D., Lavoie, A., Le-Bel, G., Cortez Ghio, S., Methods in Molecular Biology, 2019, 10.1007/978-1-4939-9473-1_1
  • The Red Kangaroo pericardium as a material source for the manufacture of percutaneous heart valves,Le péricarde du kangourou roux comme source d'approvisionnement de matériel pour la fabrication de valves cardiaques percutanées, Guidoin, R., Germain, L., Zhang, Z., How, D., Philippe, E., Reed, R.R., Bourget, J.M., Le-Bel, G., Rouse, E.N., Mao, J., Meng, S., Morphologie, 2019, 10.1016/j.morpho.2018.12.004
  • Enhanced wound healing of tissue-engineered human corneas through altered phosphorylation of the CREB and AKT signal transduction pathways, Guérin, S.L., Germain, L., Zaniolo, K., Desjardins, P., Couture, C., Acta Biomaterialia, 2018, 10.1016/j.actbio.2018.04.021
  • Expression of C4.4A in an in Vitro Human Tissue-Engineered Skin Model, Germain, L., Ploug, M., Rochette-Drouin, O., Jacobsen, B., Larouche, D., BioMed Research International, 2017, 10.1155/2017/2403072
  • Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves, Guidoin, R., Reed, R.R., Zhang, Z., Fatouraee, N., Germain, L., How, D., Le-Bel, G., Rouse, E.N., Tong, Y., Rassoli, A., Mao, J., Artificial Organs, 2019, 10.1111/aor.13503
  • Immune tolerance of tissue-engineered skin produced with allogeneic or xenogeneic fibroblasts and syngeneic keratinocytes grafted on mice, Germain, L., Auger, F.A., Bernier, V., Pruneau, V., Veillette, N., Kim, D.H., Larouche, D., Goyer, B., Acta Biomaterialia, 2019, 10.1016/j.actbio.2019.04.010
  • Grafting of an autologous tissue-engineered human corneal epithelium to a patient with limbal stem cell deficiency (LSCD), Bazin, R., Guérin, S.L., Germain, L., Mouriaux, F., Carrier, P., Guérin, L.-P., Le-Bel, G., American Journal of Ophthalmology Case Reports, 2019, 10.1016/j.ajoc.2019.100532
  • CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma, Simard, M.J., Gebauer, F., Germain, L., Goyer, B., Harvey, L.-M., Houle, F., Guitart, T., Kakumani, P.K., Oncogene, 2021, 10.1038/s41388-021-01767-9
  • Biofabrication and preclinical evaluation of a large-sized human self-assembled skin substitute, Moulin, V.J., Auger, F.A., Germain, L., Attiogbe, É., Ayoub, A., Mayrand, D., Kawecki, F., Biomedical Materials (Bristol), 2021, 10.1088/1748-605X/abbdbe
  • Contribution of the Transcription Factors Sp1/Sp3 and AP-1 to Clusterin Gene Expression during Corneal Wound Healing of Tissue-Engineered Human Corneas, Sylvain L. Guérin, Lucie Germain, Manel Benhassine, Pascale Desjardins, Gaëtan Le-Bel, Christelle Gross, International Journal of Molecular Sciences, 2021, 10.3390/ijms222212426
  • Structural and Functional Validation of a Full-Thickness Self-Assembled Skin Equivalent for Disease Modeling, Jung U Shin, Dong Hyun Kim, Lucie Germain, Israël Martel, Carolyne Simard-Bisson, Aram Kim, Su-Ji Shon, Bo Ram Mok, Pharmaceutics, 2022, 10.3390/pharmaceutics14061211
  • The Ins and Outs of Clusterin: Its Role in Cancer, Eye Diseases and Wound Healing, Sylvain L. Guérin, Lucie Germain, Bianca G. Socol, Louis-Philippe Guérin, Christelle Gross, International Journal of Molecular Sciences, 2023, 10.3390/ijms241713182
  • In vitro reconstruction of a human capillary-like network in a tissue- engineered skin equivalent, Auger, F.A., Germain, L., L'Heureux, N., Berthod, F., Black, A.F., FASEB Journal, 1998, 10.1096/fasebj.12.13.1331
  • Expression of heat shock proteins in mouse skin during wound healing, Germain, L., Tanguay, R.M., Morrow, G., Li, H., Landry, J., Auger, F.A., Moulin, V., Laplante, A.F., Journal of Histochemistry and Cytochemistry, 1998, 10.1177/002215549804601109
  • A completely biological tissue-engineered human blood vessel, Auger, F.A., Germain, L., Labbé, R., Pâquet, S., L'Heureux, N., FASEB Journal, 1998, 10.1096/fasebj.12.1.47
  • Tissue engineering [3], Auger, F.A., Germain, L., L'Heureux, N., Science, 1999
  • Antiangiogenic effects of the oral administration of liquid cartilage extract in humans, Garrel, D.R., Dupont, E., El-Khouri, S., Gaudreau, P., Saint-Cyr, M., Germain, L., Berbari, P., Thibodeau, A., Journal of Surgical Research, 1999, 10.1006/jsre.1999.5698
  • Tissue engineering of the vascular system: full spectrum of tissue engineered blood vessels (TEBV), Germain, Lucie, Grenier, Guillaume, Black, Annie, Remy-Zolghadri, Murielle, Auger, Francois, Annals of Biomedical Engineering, 2000
  • Tissue engineering of the vascular system: From capillaries to larger blood vessels, Auger, F., Rémy-Zolghadri, M., Germain, L., Medical and Biological Engineering and Computing, 2000, 10.1007/BF02344782
  • Role of wound healing myofibroblasts on re-epithelialization of human skin, Germain, L., Garrel, D., Auger, F.A., Moulin, V., Burns, 2000, 10.1016/S0305-4179(99)00091-1
  • Multistep production of bioengineered skin substitutes: Sequential modulation of culture conditions, Goulet, F., Germain, L., Juhasz, J., Noël, P., Guignard, R., Tremblay, N., Pouliot, R., Auger, F.A., In Vitro Cellular and Developmental Biology - Animal, 2000, 10.1290/1071-2690(2000)036<0096:MPOBSS>2.3.CO;2
  • Selective culture of epithelial cells from primary breast carcinomas using irradiated 3T3 cells as feeder layer, Têtu, B., Auger, F., Germain, L., Tremblay, N., Goulet, F., Wang, C.S., Pathology Research and Practice, 2001, 10.1078/0344-0338-00030
  • Characterization of a 150 kDa accessory receptor for TGF-β1 on keratinocytes: Direct evidence for a GPI anchor and ligand binding of the released form, Philip, A., Hooper, N.M., Germain, L., Larouche, D., Tam, B.Y.Y., Journal of Cellular Biochemistry, 2001, 10.1002/jcb.1074
  • Mechanisms of wound reepithelialization: Hints from a tissue-engineered reconstructed skin to long-standing questions, Moulin, V., Auger, F.A., Germain, L., Laplante, A.F., FASEB Journal, 2001, 10.1096/fj.01-0250com
  • Production of bioengineered cancer tissue constructs in vitro: Epithelium-mesenchyme heterotypic interactions, Têtu, B., Germain, L., Tremblay, N., Auger, F., Goulet, F., Wang, C.S., In Vitro Cellular and Developmental Biology - Animal, 2001, 10.1290/1071-2690(2001)037<0434:POBCTC>2.0.CO;2
  • Storage and translational issues in reparative medicine: Breakout session summary, Kocsis, J.D., Ratner, B.D., Lee, R.C., Germain, L., Brockbank, K., Anderson, D.K., Toner, M., Kocsis, J.D., Annals of the New York Academy of Sciences, 2002, 10.1111/j.1749-6632.2002.tb03101.x
  • Engineering human tissues for in vivo applications: Storage and translational issues for tissue repair and regeneration, Germain, L., Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2002
  • A truly new approach for tissue engineering: the LOEX self-assembly technique., Germain, L., Grenier, G., Rémy-Zolghadri, M., Auger, F.A., Ernst Schering Research Foundation workshop, 2002, 10.1007/978-3-662-04816-0_6
  • Tissue engineering: A tool to understand the physiological mechanisms,Le génie tissulaire au service de la compréhension du vivant, Auger, F.A., Germain, L., Berthod, F., Goulet, F., Moulin, V., Medecine/Sciences, 2003, 10.1051/medsci/200319101003
  • Differential binding of the transcription factors Sp1, AP-1, and NFI to the promoter of the human α5 integrin gene dictates its transcriptional activity, Guérin, S.L., Germain, L., Drouin, R., Leclerc, S., Zaniolo, K., Masson-Gadais, B., Gingras, M.-È., Investigative Ophthalmology and Visual Science, 2009, 10.1167/iovs.08-2059
  • Evolution of three dimensional skin equivalent models reconstructed in vitro by tissue engineering, Damour, O., Auger, F.A., Braye, F., Bechetoille, N., Kinikoglu, B., Germain, L., Lequeux, C., Fradette, J., Auxenfans, C., European Journal of Dermatology, 2009, 10.1684/ejd.2008.0573
  • Regeneration of skin and cornea by tissue engineering, Germain, L., Auger, F.A., Carrier, P., Fradette, J., Paquet, C., Larouche, D., Methods in Molecular Biology, 2009, 10.1007/978-1-59745-060-7_15
  • Regenerative medicine: Stem cells, cellular and matricial interactions in the reconstruction of skin and cornea by tissue engineering,La médecine régénératrice : les cellules souches, les interactions cellulaires et matricielles dans la reconstruction cutanée et cornéenne par génie tissulaire, Germain, L., Auger, F.A., Beauparlant, A., Carrier, P., Paquet, C., Proulx, S., Lavoie, A., Larouche, D., Pathologie Biologie, 2009, 10.1016/j.patbio.2008.04.015
  • Normal human Merkel cells are present in epidermal cell populations isolated and cultured from glabrous and hairy skin sites, Germain, L., Roy, A., Caouette-Laberge, L., Couture, V., Beauparlant, A., Guignard, R., Fugère, C., Larouche, D., Fradette, J., Journal of Investigative Dermatology, 2003, 10.1046/j.1523-1747.2003.12024.x
  • The graft of a human endothelializated reconstructed skin accelerates the time of revascularization, Auger, F.A., Germain, L., Berthod, F., Hudon, V., Tremblay, P.-L., Transactions - 7th World Biomaterials Congress, 2004
  • Recent optimization of a tissue engineered blood vessel: The LOEX experience, Germain, L., Rémy-Zolghadri, M., Grenier, G., Laflamme, K., Auger, F.A., International Congress Series, 2004, 10.1016/S0531-5131(03)01768-0
  • The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation, Germain, L., Blouin, R., Robitaille, K., Proulx, R., Robitaille, H., Journal of Biological Chemistry, 2005, 10.1074/jbc.M411619200
  • Inosculation of tissue-engineered capillaries with the host's vasculature in a reconstructed skin transplanted on mice, Auger, F.A., Germain, L., Berthod, F., Hudon, V., Tremblay, P.-L., American Journal of Transplantation, 2005, 10.1111/j.1600-6143.2005.00790.x
  • The feeder layer-mediated extended lifetime of cultured human skin keratinocytes is associated with altered levels of the transcription factors Sp1 and Sp3, Guérin, S.L., Germain, L., Lefort, N.R., Leclerc, S., Paquet, C., Fugère, C., Masson-Gadais, B., Journal of Cellular Physiology, 2006, 10.1002/jcp.20529
  • Mechanical loading modulates the differentiation state of vascular smooth muscle cells, Germain, L., Auger, F.A., Labbé, R., Baker, K., Guignard, R., Bergeron, F., Rémy-Zolghadri, M., Grenier, G., Tissue Engineering, 2006, 10.1089/ten.2006.12.3159
  • Canadian haematopoietic stem cell scientists received the Lasker Award,Des Canadiens «précurseurs de la recherche sur les cellules souches hématopoïétiques» lauréats du prix Lasker, Paquet, C., Larouche, D., Germain, L., Medecine/Sciences, 2006, 10.1051/medsci/2006222212
  • Tendons and ligaments, Auger, F.A., Poole, A.R., Germain, L., Goulet, F., Principles of Tissue Engineering, 2007, 10.1016/B978-012370615-7/50064-0
  • Adventitia contribution in vascular tone: Insights from adventitia-derived cells in a tissue-engineered human blood vessel, Germain, L., Auger, F.A., D'Orléans-Juste, P., Labbé, R., Baker, K., Pouliot, S., Rémy-Zolghadri, M., Grenier, G., Roberge, C.J., Laflamme, K., FASEB Journal, 2006, 10.1096/fj.05-4702fje
  • Adventitia contribution to vascular contraction: Hints provided by tissue-engineered substitutes, Germain, L., D'Orléans-Juste, P., Auger, F.A., Cardiovascular Research, 2007, 10.1016/j.cardiores.2007.06.001
  • Tissue engineering of human cornea, Guérin, S.L., Gaudreault, M., Giasson, C.J., Germain, L., Auger, F.A., Carrier, P., Guillemette, M., Proulx, S., Biomaterials and Regenerative Medicine in Ophthalmology, 2009, 10.1533/9781845697433.1.150
  • Transplantation of a tissue-engineered corneal endothelium reconstructed on a devitalized carrier in the feline model, Brunette, I., Germain, L., Brunette, I., Devaux, A., Uwamaliya, J.D., Audet, C., Nada, O., Bensaoula, T., Proulx, S., Investigative Ophthalmology and Visual Science, 2009, 10.1167/iovs.08-2793
  • Restoration of the transepithelial potential within tissue-engineered human skin in vitro and during the wound healing process in vivo, Moulin, V.J., Germain, L., Plante, M., Bourdages, M., Goulet, D., Auger, F.A., Roberge, C.J., Gauvin, R., Lévesque, P., Rochette-Drouin, O., Dubé, J., Tissue Engineering - Part A, 2010, 10.1089/ten.tea.2010.0030
  • Tissue-engineered vascular substitutes: New models toward successful small diameter grafts, Auger, F.A., Germain, L., Lacroix, D., D'Orléans-Juste, P., Advances in Vascular Medicine, 2010, 10.1007/978-1-84882-637-3_9
  • Corneal endothelial toxicity of air and SF6, Brunette, I., Germain, L., Carrier, P., Proulx, S., Bensaoula, T., Nada, O., Hoffart, L., Aminian, A., Landry, H., Investigative Ophthalmology and Visual Science, 2011, 10.1167/iovs.10-6187
  • Normal human epithelial cells regulate the size and morphology of tissue-engineered capillaries, Germain, L., Auger, F.A., Berthod, F., Baker, K., Roberge, C.J., Tomasetig, F., Fortin, V., Fradette, J., Rochon, M.-H., Tissue Engineering - Part A, 2010, 10.1089/ten.tea.2009.0090
  • Comparative study of bovine, porcine and avian collagens for the production of a tissue engineered dermis, Berthod, F., Germain, L., Gariépy, C., Cliche, S., Gauvin, R., Parenteau-Bareil, R., Acta Biomaterialia, 2011, 10.1016/j.actbio.2011.06.020
  • Biaxial biomechanical properties of self-assembly tissue-engineered blood vessels, Gleason, R.L., Germain, L., Auger, F.A., Gauvin, R., Zaucha, M.T., Journal of the Royal Society Interface, 2011, 10.1098/rsif.2010.0228
  • Prospective study on the treatment of lower-extremity chronic venous and mixed ulcers using tissue-engineered skin substitute made by the self-assembly approach, Auger, F.A., Germain, L., Moulin, V.J., Larouche, D., Rochon, M.-H., Dubé, N., Ospina, C.E., Arsenault, F., Roy, M., Soucy, J., Rodrigue, B., Labbé, R., Genest, H., Cloutier, C.B., Boa, O., Advances in Skin and Wound Care, 2013, 10.1097/01.ASW.0000433102.48268.2a
  • Human fibroblast-derived ECM as a scaffold for vascular tissue engineering, Germain, L., Auger, F.A., Labbé, R., Lavoie, A., Larouche, D., Gauvin, R., Bourget, J.-M., Biomaterials, 2012, 10.1016/j.biomaterials.2012.09.015
  • A Computer-Controlled Apparatus for the Characterization of Mechanical and Viscoelastic Properties of Tissue-Engineered Vascular Constructs, Germain, L., Auger, F.A., Larouche, D., Gauvin, R., Levesque, P., Cardiovascular Engineering and Technology, 2011, 10.1007/s13239-011-0033-y
  • Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media, Andriantsitohaina, R., Germain, L., Asfar, P., Mercat, A., Leonetti, D., Martinez, M.C., Meziani, F., Bourget, J.-M., Mostefai, H.A., Clinical Science, 2013, 10.1042/CS20120441
  • Minimal contraction for tissue-engineered skin substitutes when matured at the air-liquid interface, Germain, L., Auger, F.A., Guignard, R., Marcoux, H., Larouche, D., Gauvin, R., Journal of Tissue Engineering and Regenerative Medicine, 2013, 10.1002/term.543
  • Human epithelial stem cells persist within tissue-engineered skin produced by the self-assembly approach, Germain, L., Fradette, J., Pouliot, R., Kim, D.H., Dunnwald, M., Robitaille, H., Sauvé, S., Desgagné, M., Paquet, C., Larouche, D., Goyer, B., Beauparlant, A., Fugère, C., Lavoie, A., Tissue Engineering - Part A, 2013, 10.1089/ten.tea.2012.0117
  • Progress in developing a living human tissue-engineered tri-leaflet heart valve assembled from tissue produced by the self-assembly approach, Germain, L., Auger, F.A., Roberge, C.J., Lafrance, H., Gauvin, R., Bourget, J.-M., Dubé, J., Acta Biomaterialia, 2014, 10.1016/j.actbio.2014.04.033
  • A comparative study of bovine and porcine pericardium to highlight their potential advantages to manufacture percutaneous cardiovascular implants, Guidoin, R., Germain, L., Zhang, Z., Guzman, R., Larouche, D., Li, B., Klein, J., Mehri, Y., Marinov, G., Gauvin, R., Journal of Biomaterials Applications, 2013, 10.1177/0885328212465482
  • A Floating Thrombus Anchored at the Proximal Anastomosis of a Woven Thoracic Graft Mimicking a Genuine Aortic Dissection, Guidoin, R., Jing, Z., Germain, L., Douville, Y., Zhang, Z., Wang, L., Guzman, R., Bourget, J.-M., Lin, J., Rochette-Drouin, O., Bondarenko, O., Verdant, A., Fu, Y., Liu, B., Li, B., Journal of long-term effects of medical implants, 2015, 10.1615/jlongtermeffmedimplants.2015012263
  • Mechanical properties of endothelialized fibroblast-derived vascular scaffolds stimulated in a bioreactor, Auger, F.A., Ruel, J., Germain, L., Tremblay, C., Lacroix, D., Bourget, J.-M., Vallières, K., Gauvin, R., Laterreur, V., Tondreau, M.Y., Acta Biomaterialia, 2015, 10.1016/j.actbio.2015.02.026
  • Adherens junction proteins are expressed in collagen corneal equivalents produced in vitro with human cells, Germain, L., Carrier, P., Deschambeault, A., Giasson, C.J., Molecular Vision, 2014
  • The ROVT Elan Valved Biplex conduits for the reconstruction of the right ventricular outflow tract, Zhang, Z., Germain, L., Dionne, G., Desaulniers, D., Guzman, R., Wang, L., Qin, B., Lin, J., Li, X., Paynter, R., Bourget, J.-M., Weerasena, N., Li, B., Fu, Y., Guidoin, R., Journal of Long-Term Effects of Medical Implants, 2016, 10.1615/JLongTermEffMedImplants.2016013857
  • The tissue-engineered human cornea as a model to study expression of matrix metalloproteinases during corneal wound healing, Guérin, S.L., Germain, L., Patenaude, J., Lake, J., Carrier, P., Zaniolo, K., Couture, C., Biomaterials, 2016, 10.1016/j.biomaterials.2015.11.006
  • Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries, Germain, L., Moulin, V.J., Auger, F.A., Gauvin, R., Lavoie, A., Ayoub, A., Martel, I., Guignard, R., Desgagné, M., Cantin-Warren, L., Larouche, D., BioResearch Open Access, 2016, 10.1089/biores.2016.0036
  • Enhanced wound healing of tissue-engineered human corneas through altered phosphorylation of the CREB and AKT signal transduction pathways, Guérin, S.L., Germain, L., Zaniolo, K., Desjardins, P., Couture, C., Acta Biomaterialia, 2018, 10.1016/j.actbio.2018.04.021
  • Expression of C4.4A in an in Vitro Human Tissue-Engineered Skin Model, Germain, L., Ploug, M., Rochette-Drouin, O., Larouche, D., Jacobsen, B., BioMed Research International, 2017, 10.1155/2017/2403072
  • Isolation and culture of human keratinocytes, Germain, L., Larouche, D., Lavoie, A., Le-Bel, G., Cortez Ghio, S., Methods in Molecular Biology, 2019, 10.1007/978-1-4939-9473-1_1
  • The Red Kangaroo pericardium as a material source for the manufacture of percutaneous heart valves,Le péricarde du kangourou roux comme source d'approvisionnement de matériel pour la fabrication de valves cardiaques percutanées, Guidoin, R., Germain, L., Zhang, Z., How, D., Philippe, E., Reed, R.R., Bourget, J.M., Le-Bel, G., Rouse, E.N., Mao, J., Meng, S., Morphologie, 2019, 10.1016/j.morpho.2018.12.004
  • Immune tolerance of tissue-engineered skin produced with allogeneic or xenogeneic fibroblasts and syngeneic keratinocytes grafted on mice, Germain, L., Auger, F.A., Bernier, V., Pruneau, V., Veillette, N., Kim, D.H., Larouche, D., Goyer, B., Acta Biomaterialia, 2019, 10.1016/j.actbio.2019.04.010
  • Grafting of an autologous tissue-engineered human corneal epithelium to a patient with limbal stem cell deficiency (LSCD), Bazin, R., Guérin, S.L., Germain, L., Mouriaux, F., Carrier, P., Guérin, L.-P., Le-Bel, G., American Journal of Ophthalmology Case Reports, 2019, 10.1016/j.ajoc.2019.100532
  • Morphologic and Functional Properties of Bronchial Cells Isolated from Normal and Asthmatic Subjects, Auger, F.A., Germain, L., Xu, W., Beutet, M., Laviolette, M., Dubé, J., Tremblay, N., Chakir, J., Boulet, L.-P., Goulet, F., American Journal of Respiratory Cell and Molecular Biology, 1996, 10.1165/ajrcmb.15.3.8810634
  • The Ins and Outs of Clusterin: Its Role in Cancer, Eye Diseases and Wound Healing, Sylvain L. Guérin, Lucie Germain, Bianca G. Socol, Louis-Philippe Guérin, Christelle Gross, International Journal of Molecular Sciences, 2023, 10.3390/ijms241713182
  • Structural and Functional Validation of a Full-Thickness Self-Assembled Skin Equivalent for Disease Modeling, Jung U Shin, Dong Hyun Kim, Lucie Germain, Israël Martel, Carolyne Simard-Bisson, Aram Kim, Su-Ji Shon, Bo Ram Mok, Pharmaceutics, 2022, 10.3390/pharmaceutics14061211
  • Contribution of the Transcription Factors Sp1/Sp3 and AP-1 to Clusterin Gene Expression during Corneal Wound Healing of Tissue-Engineered Human Corneas, Sylvain L. Guérin, Lucie Germain, Manel Benhassine, Pascale Desjardins, Gaëtan Le-Bel, Christelle Gross, International Journal of Molecular Sciences, 2021, 10.3390/ijms222212426
  • Biofabrication and preclinical evaluation of a large-sized human self-assembled skin substitute, Moulin, V.J., Auger, F.A., Germain, L., Attiogbe, É., Ayoub, A., Mayrand, D., Kawecki, F., Biomedical Materials (Bristol), 2021, 10.1088/1748-605X/abbdbe
  • CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma, Simard, M.J., Gebauer, F., Germain, L., Goyer, B., Harvey, L.-M., Houle, F., Guitart, T., Kakumani, P.K., Oncogene, 2021, 10.1038/s41388-021-01767-9
  • Donkey pericardium compares favorably with commercial xenopericardia used in the manufacture of transcatheter heart valves, Guidoin, R., Reed, R.R., Zhang, Z., Fatouraee, N., Germain, L., How, D., Le-Bel, G., Rouse, E.N., Tong, Y., Rassoli, A., Mao, J., Artificial Organs, 2019, 10.1111/aor.13503
  • From newborn to adult: Phenotypic and functional properties of skin equivalent and human skin as a function of donor age, Germain, L., Auger, F.A., L'Heureux, N., Michel, M., Journal of Cellular Physiology, 1997, 10.1002/(SICI)1097-4652(199705)171:2<179::AID-JCP8>3.0.CO;2-L
  • Tissue-engineered human skin substitutes developed from collagen-populated hydrated gels: Clinical and fundamental applications, Germain, L., Moulin, V., Berthod, F., Goulet, F., Rouabhia, M., Auger, F.A., Medical and Biological Engineering and Computing, 1998, 10.1007/BF02518887
  • Modulated response to cytokines of human wound healing myofibroblasts compared to dermal fibroblasts, Germain, L., O'Connor-McCourt, M.D., Garrel, D., Auger, F.A., Castilloux, G., Moulin, V., Experimental Cell Research, 1998, 10.1006/excr.1997.3827
  • TGF-β receptor expression on human keratinocytes: A 150 kDa GPI- anchored TGF-β1 binding protein forms a heteromeric complex with type I and type II receptors, Philip, A., Germain, L., Tam, B.Y.Y., Journal of Cellular Biochemistry, 1998, 10.1002/(SICI)1097-4644(19980915)70:4<573::AID-JCB13>3.0.CO;2-I
  • Applications of the tissue-engineered human blood vessel reconstructed by the self-assembly approach, Guillaume, G., Karina, L., Murielle, R.-Z., François, A., Lucie, G., Third Smith and Nephew International Symposium - Translating Tissue Engineering into Products, 2002
  • Engineering human tissues for in vivo applications, Auger, F.A., Berthod, F., Moulin, V., Goulet, F., Germain, L., Annals of the New York Academy of Sciences, 2002, 10.1111/j.1749-6632.2002.tb03099.x
  • Reconstructed human skin produced in vitro and grafted on athymic mice, Germain, L., Li, H., Xu, W., Juhasz, J., Auger, F.A., Larouche, D., Pouliot, R., Transplantation, 2002, 10.1097/00007890-200206150-00010
  • Collagen fibril network and elastic system remodeling in a reconstructed skin transplanted on nude mice, Auger, F.A., Damour, O., Xu, W., Li, H., Germain, L., Berthod, F., Matrix Biology, 2001, 10.1016/S0945-053X(01)00162-7
  • Can we produce a human corneal equivalent by tissue engineering?, Guérin, S.L., Salesse, C., Auger, F.A., Carrier, P., Germain, L., Progress in Retinal and Eye Research, 2000, 10.1016/S1350-9462(00)00005-7
  • Establishment and characterization of a new cell line derived from a human primary breast carcinoma, Têtu, B., Germain, L., Champetier, S., Auger, F., Drouin, R.E., Lavoie, J., Goulet, F., Wang, C.S., Cancer Genetics and Cytogenetics, 2000, 10.1016/S0165-4608(99)00253-8
  • What's new in human wound-healing myofibroblasts?, Germain, L., Castilloux, G., O'Connor-McCourt, M., Auger, F.A., Garrel, D., Moulin, V., Current topics in pathology. Ergebnisse der Pathologie, 1999, 10.1007/978-3-642-58456-5_13
  • Production of tissue-engineered three-dimensional human bronchial models, Goulet, F., Boulet, L.P., Boutet, M., Germain, L., Laviolette, M., Auger, F.A., Bernier, V., Tremblay, P., Paquette, J.S., In Vitro Cellular and Developmental Biology - Animal, 2003, 10.1290/1543-706x(2003)039<0213:potthb>2.0.co;2
  • Shear stress induced MAPKinases activation in endothelial cells cultured on vascular prostheses, Germain, L., Auger, F.A., Bordenave, L., Bareille, R., Oligny, J.F., Daculsi, R., Fernandez, Ph., Rémy-Zolghadri, M., Archives of Physiology and Biochemistry, 2004
  • Tissue-engineered skin substitutes: From in vitro constructs to in vivo applications, Germain, L., Pouliot, R., Moulin, V., Berthod, F., Auger, F.A., Biotechnology and Applied Biochemistry, 2004, 10.1042/ba20030229
  • A tissue-engineered endothelialized dermis to study the modulation of angiogenic and angiostatic molecules on capillary-like tube formation in vitro, Auger, F.A., Germain, L., Damour, O., Black, A.F., Berthod, F., Hudon, V., British Journal of Dermatology, 2003, 10.1046/j.1365-2133.2003.05298.x
  • Tissue-engineered vascular adventitia with vasa vasorum improves graft integration and vascularization through inosculation, Auger, F.A., Germain, L., Labbé, R., Perron, C., Gauvin, R., Guillemette, M.D., Tissue Engineering - Part A, 2010, 10.1089/ten.tea.2009.0612
  • A novel cylindrical biaxial computer-controlled bioreactor and biomechanical testing device for vascular tissue engineering, Gleason Jr., R.L., Michaels, T.E., Germain, L., Auger, F.A., Gauvin, R., Wan, W., Raykin, J., Zaucha, M.T., Tissue Engineering - Part A, 2009, 10.1089/ten.tea.2008.0369
  • Identification of functional markers in a self-assembled skin substitute in vitro, Germain, L., Goulet, F., Islam, N., Cvetkovska, B., In Vitro Cellular and Developmental Biology - Animal, 2009, 10.1007/s11626-008-9140-y
  • Tissue engineering of feline corneal endothelium using a devitalized human cornea as carrier, Germain, L., Brunette, I., Giasson, C.J., Carrier, P., Deschambeault, A., D'Arc Uwamaliya, J., Audet, C., Proulx, S., Tissue Engineering - Part A, 2009, 10.1089/ten.tea.2008.0208
  • Characterization of wound reepithelialization using a new human tissue-engineered corneal wound healing model, Germain, L., Guérin, S.L., Auger, F.A., Giasson, C.J., Talbot, M., Deschambeault, A., Carrier, P., Investigative Ophthalmology and Visual Science, 2008, 10.1167/iovs.07-0904
  • IFATS collection: Using human adipose-derived stem/stromal cells for the production of new skin substitutes, Fradette, J., Vincent, C., Germain, L., Marceau-Fortier, G., Trottier, V., Stem Cells, 2008, 10.1634/stemcells.2008-0031
  • Transcriptional regulation of the human α6 integrin gene by the transcription factor NFI during corneal wound healing, Guérin, S.L., Germain, L., Carrier, P., Leclerc, S., Gingras, M.-E., Vigneault, F., Gaudreault, M., Investigative Ophthalmology and Visual Science, 2008, 10.1167/iovs.08-1913
  • Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile, Germain, L., Coulombe, P.A., Fradette, J., Tong, X., Larouche, D., FASEB Journal, 2008, 10.1096/fj.07-8109com
  • Optimization of culture conditions for porcine corneal endothelial cells, Germain, L., Brunette, I., Auger, F.A., Giasson, C.J., Carrier, P., Deschambeault, A., Martel, S., Gagnon, N., Bourget, J.-M., Proulx, S., Molecular Vision, 2007
  • The antiwrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology, Marceau, F., Germain, L., Morissette, G., British Journal of Dermatology, 2007, 10.1111/j.1365-2133.2007.07681.x
  • Autologous transplantation of rabbit limbal epithelia cultured on fibrin gels for ocular surface reconstruction, Germain, L., Bazin, R., Auger, F.A., Guérin, S.L., Deschambeault, A., Giasson, C.J., Carrier, P., Talbot, M., Molecular Vision, 2006
  • Role of the extracellular matrix proteins in the resistance of SP6.5 uveal melanoma cells toward cisplatin., Petitclerc, E., Guérin, S.L., Germain, L., Paquet-Bouchard, C., Collin, C., Talbot, M., Bérubé, M., International journal of oncology, 2005, 10.3892/ijo.26.2.405
  • Endothelium properties of a tissue-engineered blood vessel for small-diameter vascular reconstruction, Auger, F.A., Germain, L., Oligny, J.-F., Laganière, J., Rémy-Zolghadri, M., Journal of Vascular Surgery, 2004, 10.1016/j.jvs.2003.08.007
  • Investigation of ultrashort pulse laser ablation of the cornea and hydrogels for eye microsurgery, Kieffer, J.-C., Vidal, F., Parent, M., Ozaki, T., Lavertu, P.-L., Olivié, G., Martin, F., Germain, L., Chaker, M., Brunette, I., Bigaouette, N., Zhou, S., Girard, G., Proceedings of SPIE - The International Society for Optical Engineering, 2004, 10.1117/12.567111
  • Tendons and Ligament Tissue Engineering, Hart, D.A., Germain, L., Chabaud, S., Simon, F., Lamontagne, J., Cloutier, R., Auger, F.A., Goulet, F., Principles of Tissue Engineering: Fourth Edition, 2013, 10.1016/B978-0-12-398358-9.00059-8
  • Erratum: Skin substitutes and wound healing (Skin Pharmacol Physiol (2009) 22: 2 (94-102) DOI: 10.1159/000178868), Germain, L., Lacroix, D., Auger, F.A., Skin Pharmacology and Physiology, 2012
  • Rescue of the transcription factors Sp1 and NFI in human skin keratinocytes through a feeder-layer-dependent suppression of the proteasome activity, Guérin, S.L., Germain, L., Masson-Gadais, B., Rochette, P.J., Touzel-Deschênes, L., Vigneault, F., Gaudreault, M., Duval, C., Journal of Molecular Biology, 2012, 10.1016/j.jmb.2012.01.021
  • Identification of epithelial stem cells in vivo and in vitro using keratin 19 and BrdU., Germain, L., Simard-Bisson, C., Paquet, C., Lavoie, A., Larouche, D., Methods in molecular biology (Clifton, N.J.), 2010, 10.1007/978-1-60761-380-0_27
  • Qualitatively monitoring binding and expression of the transcription factor sp1 as a useful tool to evaluate the reliability of primary cultured epithelial stem cells in tissue reconstruction, Guérin, S.L., Germain, L., Larouche, D., Gaudreault, M., Methods in Molecular Biology, 2013, 10.1007/978-1-62703-330-5_11
  • Tissue engineering of skin and cornea: Development of new models for in vitro studies, Germain, L., Guérin, S.L., Fradette, J., Auger, F.A., Duranceau, L., Martel, I., Carrier, P., Robitaille, H., Gaudreault, M., Simard-Bisson, C., Proulx, S., Bisson, F., Larouche, D., Paquet, C., Annals of the New York Academy of Sciences, 2010, 10.1111/j.1749-6632.2009.05373.x
  • Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types, Germain, L., Auger, F.A., Guérin, S.L., Giasson, C.J., Audet, C., Deschambeault, A., Carrier, P., Uwamaliya, J.D., Proulx, S., Molecular Vision, 2010
  • Tissue-Engineered Tubular Heart Valves Combining a Novel Precontraction Phase with the Self-Assembly Method, Auger, F.A., Germain, L., Kawecki, F., Tremblay, C., Galbraith, T., Ruel, J., Picard-Deland, M., Annals of Biomedical Engineering, 2017, 10.1007/s10439-016-1708-1
  • 27.12 MHz Radiofrequency Ablation for Benign Cutaneous Lesions, Larouche, D., Germain, L., Beaumont, C., Piquette, R., Hyun, D.J., Kim, D.H., BioMed Research International, 2016, 10.1155/2016/6016943
  • In Vivo Remodeling of Fibroblast-Derived Vascular Scaffolds Implanted for 6 Months in Rats, Auger, F.A., Ruel, J., Germain, L., Lacroix, D., Tremblay, C., Bourget, J.-M., Gauvin, R., Vallières, K., Laterreur, V., Tondreau, M.Y., BioMed Research International, 2016, 10.1155/2016/3762484
  • Transcatheter heart valve crimping and the protecting effects of a polyester cuff,Sertissage des valves cardiaques percutanées et la protection possible d'une collerette de tissu, Zhang, Z., Germain, L., Wang, L., Bruneval, P., Guan, X., How, D., Rochette-Drouin, O., Mao, J., Lin, J., Zegdi, R., Guidoin, R., Morphologie, 2016, 10.1016/j.morpho.2016.06.005
  • Contribution of Sp1 to telomerase expression and activity in skin keratinocytes cultured with a feeder layer, Germain, L., Guérin, S.L., Auger, F.A., Boudreau, F., Damour, O., Landreville, S., Rochette, P.J., Zaniolo, K., Bourget, J.-M., Paquet, C., Bisson, F., Journal of Cellular Physiology, 2015, 10.1002/jcp.24706
  • Effect of 27-MHz radiofrequency on hair follicles: Histological evaluation of skin treated Ex Vivo, Larouche, D., Germain, L., Beaumont, C., Ratté, G., Lavoie, A., Kim, D.H., Dermatologic Surgery, 2015, 10.1097/DSS.0000000000000324
  • Human adipose-derived stromal cells for the production of completely autologous self-assembled tissue-engineered vascular substitutes, Auger, F.A., Fradette, J., Germain, L., Ruel, J., Tondreau, M.Y., Laterreur, V., Vallières, K., Acta Biomaterialia, 2015, 10.1016/j.actbio.2015.06.011
  • A new construction technique for tissue-engineered heart valves using the self-Assembly method, Auger, F.A., Germain, L., Lacroix, D., Tondreau, M.Y., Vallières, K., Laterreur, V., Bourget, J.-M., Ruel, J., Tremblay, C., Tissue Engineering - Part C: Methods, 2014, 10.1089/ten.tec.2013.0698
  • Using human umbilical cord cells for tissue engineering: A comparison with skin cells, Auger, F.A., Germain, L., Guignard, R., Morissette Martin, P., Fradette, J., Hayward, C.J., Differentiation, 2014, 10.1016/j.diff.2014.05.001
  • A tissue-engineered corneal wound healing model for the characterization of reepithelialization, Germain, L., Auger, F.A., Guérin, S.L., Carrier, P., Zaniolo, K., Methods in Molecular Biology, 2013, 10.1007/978-1-62703-505-7_4
  • Effect of intense pulsed light treatment on human skin in vitro: Analysis of immediate effects on dermal papillae and hair follicle stem cells, Germain, L., Beaumont, C., Ratté, G., Kim, D.H., Larouche, D., British Journal of Dermatology, 2013, 10.1111/bjd.12477
  • Irradiated human dermal fibroblasts are as efficient as mouse fibroblasts as a feeder layer to improve human epidermal cell culture lifespan, Germain, L., Guérin, S.L., Auger, F.A., Damour, O., Simard-Bisson, C., Zaniolo, K., Larouche, D., Lavoie, A., Rochefort, É., Bisson, F., International Journal of Molecular Sciences, 2013, 10.3390/ijms14034684
  • Translating the combination of gene therapy and tissue engineering for treating recessive dystrophic epidermolysis bullosa, Germain, L., Caruso, M., Moulin, V.J., Larochelle, S., Ghio, S.C., Bisson, F., Ghani, K., Larouche, D., Piaceski, A.D., European Cells and Materials, 2018, 10.22203/eCM.v035a06
  • In Vivo Evaluation and Imaging of a Bilayered Self-Assembled Skin Substitute Using a Decellularized Dermal Matrix Grafted on Mice, Auger, F.A., Gauvin, R., Germain, L., Moulin, V.J., Larouche, D., Guignard, R., Perron, C., Goyer, B., Beaudoin Cloutier, C., Tissue Engineering - Part A, 2017, 10.1089/ten.tea.2016.0296
  • Correlation between structural changes and acute thrombogenicity in transcatheter pericardium valves after crimping and balloon deployment,Corrélation entre les altérations structurales et la thrombogénicité aiguë des valves percutanées en péricarde après sertissage et expansion, Guidoin, R., Zhang, Z., Germain, L., Wang, L., Merkel, N.O., Xu, T., Fu, Y., Mao, J., Convelbo, C., Merhi, Y., Wawryko, P., Lin, J., Zegdi, R., Bourget, J.-M., Morphologie, 2017, 10.1016/j.morpho.2016.06.003
  • A Role for DLK in Microtubule Reorganization to the Cell Periphery and in the Maintenance of Desmosomal and Tight Junction Integrity, Germain, L., Hirai, S.-I., Blouin, R., Guérin, S.L., Larouche, D., Bidoggia, J., Simard-Bisson, C., Journal of Investigative Dermatology, 2017, 10.1016/j.jid.2016.07.035
  • Qualitatively monitoring binding and expression of the transcription factors Sp1 and NFI as a useful tool to evaluate the quality of primary cultured epithelial stem cells in tissue reconstruction, Guérin, S.L., Germain, L., Larouche, D., Cortez Ghio, S., Le-Bel, G., Methods in Molecular Biology, 2019, 10.1007/7651_2018_153
  • Specialized Living Wound Dressing Based on the Self-Assembly Approach of Tissue Engineering, Lucie Germain, François A. Auger, Danielle Larouche, Sergio Cortez Ghio, Rina Guignard, Laurence Cantin-Warren, Journal of Functional Biomaterials, 2018, 10.3390/jfb9030053
  • Contribution of the WNK1 kinase to corneal wound healing using the tissue-engineered human cornea as an in vitro model, Guérin, S.L., Germain, L., Couture, C., Desjardins, P., Journal of Tissue Engineering and Regenerative Medicine, 2019, 10.1002/term.2912
  • Production of Tissue-Engineered Skin Substitutes for Clinical Applications: Elimination of Serum, Lucie Germain, Julie Fradette, Danielle Larouche, Meryem Safoine, Brice Magne, Étienne Savard, Martin A. Barbier, Sergio Cortez Ghio, Emilie J. Doucet, International Journal of Molecular Sciences, 2023, 10.3390/ijms241612537
  • A Newly Developed Chemically Defined Serum-Free Medium Suitable for Human Primary Keratinocyte Culture and Tissue Engineering Applications, Lucie Germain, Alain Garnier, Sylvain Guérin, Julie Fradette, Danielle Larouche, Amélie Morissette, Emilie Jolibois, Andréanne Cartier, Gaëtan Le-Bel, Meryem Safoine, Imad Debbah, Emilie J. Doucet, Martin A. Barbier, Sergio Cortez Ghio, International Journal of Molecular Sciences, 2023, 10.3390/ijms24031821
  • Influence of the Postmortem/Storage Time of Human Corneas on the Properties of Cultured Limbal Epithelial Cells, Sylvain L. Guérin, Lucie Germain, Camille Couture, Sergio Cortez Ghio, Christelle Gross, Pascale Desjardins, Gaëtan Le-Bel, Cells, 2022, 10.3390/cells11172716
  • Cultured Autologous Corneal Epithelia for the Treatment of Unilateral Limbal Stem Cell Deficiency: A Case Series of 15 Patients, Lucie Germain, Richard Bazin, Ralph Kyrillos, Bartha M. Knoppers, François A. Auger, Anne Faucher, Mohib W. Morcos, Danielle Larouche, Louis-Philippe Guérin, Biomedicines, 2022, 10.3390/biomedicines10081958
  • The Human Tissue-Engineered Cornea (hTEC): Recent Progress, Sylvain L. Guérin, Lucie Germain, Richard Bazin, Elodie Boisselier, Elodie Gillard, Camille Couture, Pascale Desjardins, Gaëtan Le-Bel, Louis-Philippe Guérin, International Journal of Molecular Sciences, 2021, 10.3390/ijms22031291
  • Limb salvage after aneurysmal degeneration of a cryopreserved vein allograft: Searching the autologous veins of the arm is worth the effort,Sauvetage de membre après dégénération anévrysmale d'une homogreffe veineuse : l'effort de recherche des veines autologues du bras est justifié, Guidoin, R., Germain, L., Wang, L., Zhang, Z., Zhou, T., Philippe, E., How, D., Le-Bel, G., Mao, Y., Wawryko, P., Mao, J., Febrer, G., Tong, Y., Morphologie, 2020, 10.1016/j.morpho.2020.05.001

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Bettina Cattier - Doctorat - En cours
  • Ludivine Dubourget - Maîtrise avec mémoire - En cours
  • Martin Alexandre Barbier - Doctorat - En cours
  • Karel Ferland - Doctorat - En cours
  • Henri De Koninck - Maîtrise avec mémoire - En cours
  • Brice Valentin Magne - Post-doctorat - En cours
  • Augustin C. Barolet - Doctorat - En cours
  • Etienne Savard - Maîtrise avec mémoire - En cours
  • Francis Bisson - Maîtrise avec mémoire - 2012/05
  • Jean-Michel Bourget - Doctorat - 2014/05
  • Benjamin Goyer - Maîtrise avec mémoire - 2015/01
  • Carolyne Simard-Bisson - Doctorat - 2015/09
  • Camille Couture - Maîtrise avec mémoire - 2016/05
  • Chanel Beaudoin-Cloutier - Doctorat - 2016/05
  • Angela Dakiw Piaceski - Maîtrise avec mémoire - 2016/09
  • Pascale Desjardins - Maîtrise avec mémoire - 2018/09
  • Michael Boivin-Welch - Maîtrise avec mémoire - 2019/01
  • Gaëtan Le Bel - Doctorat - 2020/05
  • Alex Larose - Maîtrise avec mémoire - 2021/05
  • Sergio Cortez Ghio - Doctorat - 2021/09
  • Emilie Doucet - Maîtrise avec mémoire - 2022/05
  • Anabelle Demers - Maîtrise avec mémoire - 2022/05

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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