Luca Pellegrini

Professeur titulaire

luca.pellegrini@fmed.ulaval.ca

Dép. biologie moléculaire, biochimie médicale et pathologie

Centre thématique de recherche en neurosciences

Centre de recherche CERVO

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Contribution à la recherche

Projets de recherche

The Mitochondrial-ER (mt-ER), a new type of endoplasmic reticulum: from structure to function - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31
Mitochondria-endoplasmic reticulum contacts and cristae dynamics in health and disease - Instituts de recherche en santé du Canada - Volet Projet: Concours pilotes, chercheur principal - 2016-07-01 au 2021-06-30

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Publications

A three-organelle complex made by wrappER contacts with peroxisomes and mitochondria responds to liver lipid flux changes, Nicolò Ilacqua, Irene Anastasia, Andrea Raimondi, Philippe Lemieux, Thomas Q. de Aguiar Vallim, Katalin Toth, Eugene V. Koonin, Luca Pellegrini, Journal of Cell Science, 2022, 10.1242/jcs.259091
Isolation and analysis of fractions enriched in WrappER-associated mitochondria from mouse liver, Nicolò Ilacqua, Irene Anastasia, Luca Pellegrini, STAR Protocols, 2021, 10.1016/j.xpro.2021.100752
Coming together to define membrane contact sites, Scorrano, L., De Matteis, M.A., Emr, S., Giordano, F., Hajnóczky, G., Kornmann, B., Lackner, L.L., Levine, T.P., Pellegrini, L., Reinisch, K., Rizzuto, R., Simmen, T., Stenmark, H., Ungermann, C., Schuldiner, M., Nature Communications, 2019, 10.1038/s41467-019-09253-3
An ode to mitochondria biologists, new and old, Pellegrini, L., Scorrano, L., Biochemical and Biophysical Research Communications, 2018, 10.1016/j.bbrc.2018.02.207
Corrigendum: Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway, Pozzobon, T., Facchinello, N., Bossi, F., Capitani, N., Benagiano, M., Di Benedetto, G., Zennaro, C., West, N., Codolo, G., Bernardini, M., Baldari, C.T., D'Elios, M.M., Pellegrini, L., Argenton, F., de Bernard, M., Scientific reports, 2018, 10.1038/srep46945
Erratum: Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane (Proc Natl Acad Sci USA (2018) 115 (E6497–E6506) DOI: 10.1073/pnas.1806318115), Burdyga, A., Surdo, N.C., Monterisi, S., Benedetto, G.D., Grisan, F., Penna, E., Pellegrini, L., Zaccolo, M., Bortolozzi, M., Swietach, P., Pozzan, T., Lefkimmiatis, K., Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1812383115
Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane, Burdyga, A., Surdo, N.C., Monterisi, S., Benedetto, G.D., Grisan, F., Penna, E., Pellegrini, L., Bortolozzi, M., Swietach, P., Pozzan, T., Lefkimmiatis, K., Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1806318115
The making of a mammalian peroxisome, version 2.0: Mitochondria get into the mix, Schrader, M., Pellegrini, L., Cell Death and Differentiation, 2017, 10.1038/cdd.2017.23
Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control, Glytsou, C., Calvo, E., Cogliati, S., Mehrotra, A., Anastasia, I., Rigoni, G., Raimondi, A., Shintani, N., Loureiro, M., Vazquez, J., Pellegrini, L., Enriquez, J.A., Scorrano, L., Soriano, M.E., Cell Reports, 2016, 10.1016/j.celrep.2016.11.049
The coming of age of the mitochondria-ER contact: A matter of thickness, Giacomello, M., Pellegrini, L., Cell Death and Differentiation, 2016, 10.1038/cdd.2016.52
Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway, Pozzobon, T., Facchinello, N., Bossi, F., Capitani, N., Benagiano, M., Di Benedetto, G., Zennaro, C., West, N., Codolo, G., Bernardini, M., Baldari, C.T., D'Elios, M.M., Pellegrini, L., Argenton, F., De Bernard, M., Scientific Reports, 2016, 10.1038/srep18785
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver, Sood, A., Jeyaraju, D.V., Prudent, J., Caron, A., Lemieux, P., McBride, H.M., Laplante, M., Tóth, K., Pellegrini, L., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1408061111
Rhomboid proteases in mitochondria and plastids: Keeping organelles in shape, Jeyaraju, D.V., Sood, A., Laforce-Lavoie, A., Pellegrini, L., Biochimica et Biophysica Acta - Molecular Cell Research, 2013, 10.1016/j.bbamcr.2012.05.019
The dynamin GTPase OPA1: More than mitochondria?, Belenguer, P., Pellegrini, L., Biochimica et Biophysica Acta - Molecular Cell Research, 2013, 10.1016/j.bbamcr.2012.08.004
Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site, Warr, M.R., Mills, J.R., Nguyen, M., Lemaire-Ewing, S., Baardsnes, J., Sun, K.L.W., Malina, A., Young, J.C., Jeyaraju, D.V., O'Connor-McCourt, M., Pellegrini, L., Pelletier, J., Shore, G.C., Journal of Biological Chemistry, 2011, 10.1074/jbc.M111.218321
Structural and mechanistic basis of Parl activity and regulation, Jeyaraju, D.V., McBride, H.M., Hill, R.B., Pellegrini, L., Cell Death and Differentiation, 2011, 10.1038/cdd.2011.22
Vesicular zinc regulates the Ca ²⁺ sensitivity of a subpopulation of presynaptic vesicles at hippocampal mossy fiber terminals, Lavoie, N., Jeyaraju, D.V., Peralta III, M.R., Seress, L., Pellegrini, L., Tóth, K., Journal of Neuroscience, 2011, 10.1523/JNEUROSCI.4164-11.2011
The PARL family of mitochondrial rhomboid proteases, Hill, R.B., Pellegrini, L., Seminars in Cell and Developmental Biology, 2010, 10.1016/j.semcdb.2009.12.011
Calcium regulation of mitochondria motility and morphology, Jeyaraju, D.V., Cisbani, G., Pellegrini, L., Biochimica et Biophysica Acta - Bioenergetics, 2009, 10.1016/j.bbabio.2008.12.005
Hax1 lacks BH modules and is peripherally associated to heavy membranes: Implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis, Jeyaraju, D.V., Cisbani, G., De Brito, O.M., Koonin, E.V., Pellegrini, L., Cell Death and Differentiation, 2009, 10.1038/cdd.2009.110
A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis, Pellegrini, L., Scorrano, L., Cell Death and Differentiation, 2007, 10.1038/sj.cdd.4402145
Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats, Lavoie, N., Peralta III, M.R., Chiasson, M., Lafortune, K., Pellegrini, L., Seress, L., Tóth, K., Journal of Physiology, 2007, 10.1113/jphysiol.2006.121848
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling, Cipolat, S., Rudka, T., Hartmann, D., Costa, V., Serneels, L., Craessaerts, K., Metzger, K., Frezza, C., Annaert, W., D'Adamio, L., Derks, C., Dejaegere, T., Pellegrini, L., D'Hooge, R., Scorrano, L., De Strooper, B., Cell, 2006, 10.1016/j.cell.2006.06.021
Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology, Jeyaraju, D.V., Xu, L., Letellier, M.-C., Bandaru, S., Zunino, R., Berg, E.A., McBride, H.M., Pellegrini, L., Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0604983103
Cell type-specific action of seizure-induced intracellular zinc accumulation in the rat hippocampus, Côté, A., Chiasson, M., Peralta III, M.R., Lafortune, K., Pellegrini, L., Tóth, K., Journal of Physiology, 2005, 10.1113/jphysiol.2005.089458
Self-regulated Cleavage of the Mitochondrial Intramembrane-cleaving Protease PARL Yields Pβ, a Nuclear-targeted Peptide, Sík, A., Passer, B.J., Koonin, E.V., Pellegrini, L., Journal of Biological Chemistry, 2004, 10.1074/jbc.M313756200
The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers., Koonin, E.V., Makarova, K.S., Rogozin, I.B., Davidovic, L., Letellier, M.C., Pellegrini, L., Genome biology, 2003
PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2, Pellegrini, L., Passer, B.J., Canelles, M., Lefterov, I., Kelly Ganjei, J., Fowlkes, B.J., Koonin, E.V., D'Adamio, L., Journal of Alzheimer's Disease, 2001, 10.3233/JAD-2001-3203
Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid β protein precursor, Passer, B., Pellegrini, L., Russo, C., Siegel, R.M., Lenardo, M.J., Schettini, G., Bachmann, M., Tabaton, M., D'Adamio, L., Journal of Alzheimer's Disease, 2000, 10.3233/JAD-2000-23-408
Alternative, non-secretase processing of Alzheimer's β-amyloid precursor protein during apoptosis by caspase-6 and -8, Pellegrini, L., Passer, B.J., Tabaton, M., Ganjei, J.K., D'Adamio, L., Journal of Biological Chemistry, 1999, 10.1074/jbc.274.30.21011
Cloning of AIP1, a novel protein that associates with the apoptosis- linked gene ALG-2 in a Ca²⁺-dependent reaction, Vito, P., Pellegrini, L., Guiet, C., D'Adamio, L., Journal of Biological Chemistry, 1999, 10.1074/jbc.274.3.1533
Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death, Passer, B.J., Pellegrini, L., Vito, P., Ganjei, J.K., D'Adamio, L., Journal of Biological Chemistry, 1999, 10.1074/jbc.274.34.24007
Analysis of the methylation pattern of the maize opaque-2 (o2) promoter and in Vitro binding studies indicate that the o2 B-zip protein and other endosperm factors can bind to methylated target sequences, Rossi, V., Motto, M., Pellegrini, L., Journal of Biological Chemistry, 1997, 10.1074/jbc.272.21.13758
Phenylalanine ammonia-lyase in tobacco. Molecular cloning and gene expression during the hypersensitive reaction to tobacco mosaic virus and the response to a fungal elicitor, Pellegrini, L., Rohfritsch, O., Fritig, B., Legrand, M., Plant Physiology, 1994, 10.1104/pp.106.3.877
Molecular cloning and expression of a new class of ortho-diphenol-O-methyltransferases induced in tobacco (Nicotiana tabacum L.) leaves by infection or elicitor treatment, Pellegrini, L., Geoffroy, P., Fritig, B., Legrand, M., Plant Physiology, 1993, 10.1104/pp.103.2.509

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009

Vishal Bharmauria - Doctorat - En cours
Nicolo' Ilacqua - Doctorat - En cours
Rana Ghandehari Alavijeh - Doctorat - En cours
Aditi Sood - Doctorat - 2015/01
Yanina Mircheva - Doctorat - 2021/01
Irene Anastasia - Doctorat - 2021/05

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Mettre à jour mon profil de professeur(e)

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4645
Québec, Québec G1V 0A6
Canada

Renseignements - Secrétariat :
vdres@fmed.ulaval.ca
Téléphone 418 656-2690

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca