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Luca Pellegrini

Professeur titulaire

luca.pellegrini@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
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Contribution à la recherche

Projets de recherche

  • Mechanisms and function of wrappER contacts with mitochondria and peroxisomes in health and disease - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
  • The Mitochondrial-ER (mt-ER), a new type of endoplasmic reticulum: from structure to function - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31

Publications

  • The dynamin GTPase OPA1: More than mitochondria?, Pellegrini, L., Belenguer, P., Biochimica et Biophysica Acta - Molecular Cell Research, 2013, 10.1016/j.bbamcr.2012.08.004
  • The PARL family of mitochondrial rhomboid proteases, Pellegrini, L., Hill, R.B., Seminars in Cell and Developmental Biology, 2010, 10.1016/j.semcdb.2009.12.011
  • Self-regulated Cleavage of the Mitochondrial Intramembrane-cleaving Protease PARL Yields Pβ, a Nuclear-targeted Peptide, Pellegrini, L., Koonin, E.V., Passer, B.J., Sík, A., Journal of Biological Chemistry, 2004, 10.1074/jbc.M313756200
  • Mitochondrion-dependent N-terminal processing of outer membrane Mcl-1 protein removes an essential Mule/Lasu1 protein-binding site, Shore, G.C., Pelletier, J., Pellegrini, L., O'Connor-McCourt, M., Jeyaraju, D.V., Young, J.C., Malina, A., Sun, K.L.W., Baardsnes, J., Lemaire-Ewing, S., Nguyen, M., Mills, J.R., Warr, M.R., Journal of Biological Chemistry, 2011, 10.1074/jbc.M111.218321
  • The coming of age of the mitochondria-ER contact: A matter of thickness, Pellegrini, L., Giacomello, M., Cell Death and Differentiation, 2016, 10.1038/cdd.2016.52
  • The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers., Pellegrini, L., Letellier, M.C., Davidovic, L., Rogozin, I.B., Makarova, K.S., Koonin, E.V., Genome biology, 2003
  • Rhomboid proteases in mitochondria and plastids: Keeping organelles in shape, Pellegrini, L., Laforce-Lavoie, A., Sood, A., Jeyaraju, D.V., Biochimica et Biophysica Acta - Molecular Cell Research, 2013, 10.1016/j.bbamcr.2012.05.019
  • Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control, Soriano, M.E., Scorrano, L., Enriquez, J.A., Pellegrini, L., Vazquez, J., Loureiro, M., Shintani, N., Raimondi, A., Rigoni, G., Anastasia, I., Mehrotra, A., Cogliati, S., Calvo, E., Glytsou, C., Cell Reports, 2016, 10.1016/j.celrep.2016.11.049
  • Phenylalanine ammonia-lyase in tobacco. Molecular cloning and gene expression during the hypersensitive reaction to tobacco mosaic virus and the response to a fungal elicitor, Legrand, M., Fritig, B., Rohfritsch, O., Pellegrini, L., Plant Physiology, 1994, 10.1104/pp.106.3.877
  • Molecular cloning and expression of a new class of ortho-diphenol-O-methyltransferases induced in tobacco (Nicotiana tabacum L.) leaves by infection or elicitor treatment, Legrand, M., Fritig, B., Geoffroy, P., Pellegrini, L., Plant Physiology, 1993, 10.1104/pp.103.2.509
  • Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway, De Bernard, M., Argenton, F., Pellegrini, L., D'Elios, M.M., Baldari, C.T., Bernardini, M., Codolo, G., West, N., Zennaro, C., Di Benedetto, G., Benagiano, M., Capitani, N., Bossi, F., Facchinello, N., Pozzobon, T., Scientific Reports, 2016, 10.1038/srep18785
  • Isolation and analysis of fractions enriched in WrappER-associated mitochondria from mouse liver, Luca Pellegrini, Irene Anastasia, Nicolò Ilacqua, STAR Protocols, 2021, 10.1016/j.xpro.2021.100752
  • An ode to mitochondria biologists, new and old, Scorrano, L., Pellegrini, L., Biochemical and Biophysical Research Communications, 2018, 10.1016/j.bbrc.2018.02.207
  • A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver, Pellegrini, L., Tóth, K., Laplante, M., McBride, H.M., Lemieux, P., Caron, A., Prudent, J., Jeyaraju, D.V., Sood, A., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1408061111
  • Calcium regulation of mitochondria motility and morphology, Pellegrini, L., Cisbani, G., Jeyaraju, D.V., Biochimica et Biophysica Acta - Bioenergetics, 2009, 10.1016/j.bbabio.2008.12.005
  • A three-organelle complex made by wrappER contacts with peroxisomes and mitochondria responds to liver lipid flux changes, Luca Pellegrini, Eugene V. Koonin, Katalin Toth, Thomas Q. de Aguiar Vallim, Philippe Lemieux, Andrea Raimondi, Irene Anastasia, Nicolò Ilacqua, Journal of Cell Science, 2022, 10.1242/jcs.259091
  • Erratum: Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane (Proc Natl Acad Sci USA (2018) 115 (E6497–E6506) DOI: 10.1073/pnas.1806318115), Lefkimmiatis, K., Pozzan, T., Swietach, P., Bortolozzi, M., Zaccolo, M., Pellegrini, L., Penna, E., Grisan, F., Benedetto, G.D., Monterisi, S., Surdo, N.C., Burdyga, A., Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1812383115
  • Coming together to define membrane contact sites, Schuldiner, M., Ungermann, C., Stenmark, H., Simmen, T., Rizzuto, R., Reinisch, K., Pellegrini, L., Levine, T.P., Lackner, L.L., Kornmann, B., Hajnóczky, G., Giordano, F., Emr, S., De Matteis, M.A., Scorrano, L., Nature Communications, 2019, 10.1038/s41467-019-09253-3
  • Corrigendum: Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway, de Bernard, M., Argenton, F., Pellegrini, L., D'Elios, M.M., Baldari, C.T., Bernardini, M., Codolo, G., West, N., Zennaro, C., Di Benedetto, G., Benagiano, M., Capitani, N., Bossi, F., Facchinello, N., Pozzobon, T., Scientific reports, 2018, 10.1038/srep46945
  • Cloning of AIP1, a novel protein that associates with the apoptosis- linked gene ALG-2 in a Ca2+-dependent reaction, D'Adamio, L., Guiet, C., Pellegrini, L., Vito, P., Journal of Biological Chemistry, 1999, 10.1074/jbc.274.3.1533
  • Structural and mechanistic basis of Parl activity and regulation, Pellegrini, L., Hill, R.B., McBride, H.M., Jeyaraju, D.V., Cell Death and Differentiation, 2011, 10.1038/cdd.2011.22
  • Hax1 lacks BH modules and is peripherally associated to heavy membranes: Implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis, Pellegrini, L., Koonin, E.V., De Brito, O.M., Cisbani, G., Jeyaraju, D.V., Cell Death and Differentiation, 2009, 10.1038/cdd.2009.110
  • Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane, Lefkimmiatis, K., Pozzan, T., Swietach, P., Bortolozzi, M., Pellegrini, L., Penna, E., Grisan, F., Benedetto, G.D., Monterisi, S., Surdo, N.C., Burdyga, A., Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1806318115
  • Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology, Pellegrini, L., McBride, H.M., Berg, E.A., Zunino, R., Bandaru, S., Letellier, M.-C., Xu, L., Jeyaraju, D.V., Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0604983103
  • Cell type-specific action of seizure-induced intracellular zinc accumulation in the rat hippocampus, Tóth, K., Pellegrini, L., Lafortune, K., Peralta III, M.R., Chiasson, M., Côté, A., Journal of Physiology, 2005, 10.1113/jphysiol.2005.089458
  • PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2, D'Adamio, L., Koonin, E.V., Fowlkes, B.J., Kelly Ganjei, J., Lefterov, I., Canelles, M., Passer, B.J., Pellegrini, L., Journal of Alzheimer's Disease, 2001, 10.3233/JAD-2001-3203
  • The making of a mammalian peroxisome, version 2.0: Mitochondria get into the mix, Pellegrini, L., Schrader, M., Cell Death and Differentiation, 2017, 10.1038/cdd.2017.23
  • Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death, D'Adamio, L., Ganjei, J.K., Vito, P., Pellegrini, L., Passer, B.J., Journal of Biological Chemistry, 1999, 10.1074/jbc.274.34.24007
  • A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis, Scorrano, L., Pellegrini, L., Cell Death and Differentiation, 2007, 10.1038/sj.cdd.4402145
  • Vesicular zinc regulates the Ca 2+ sensitivity of a subpopulation of presynaptic vesicles at hippocampal mossy fiber terminals, Tóth, K., Pellegrini, L., Seress, L., Peralta III, M.R., Jeyaraju, D.V., Lavoie, N., Journal of Neuroscience, 2011, 10.1523/JNEUROSCI.4164-11.2011
  • Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid β protein precursor, D'Adamio, L., Tabaton, M., Bachmann, M., Schettini, G., Lenardo, M.J., Siegel, R.M., Russo, C., Pellegrini, L., Passer, B., Journal of Alzheimer's Disease, 2000, 10.3233/JAD-2000-23-408
  • Alternative, non-secretase processing of Alzheimer's β-amyloid precursor protein during apoptosis by caspase-6 and -8, D'Adamio, L., Ganjei, J.K., Tabaton, M., Passer, B.J., Pellegrini, L., Journal of Biological Chemistry, 1999, 10.1074/jbc.274.30.21011
  • Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats, Tóth, K., Seress, L., Pellegrini, L., Lafortune, K., Chiasson, M., Peralta III, M.R., Lavoie, N., Journal of Physiology, 2007, 10.1113/jphysiol.2006.121848
  • Analysis of the methylation pattern of the maize opaque-2 (o2) promoter and in Vitro binding studies indicate that the o2 B-zip protein and other endosperm factors can bind to methylated target sequences, Pellegrini, L., Motto, M., Rossi, V., Journal of Biological Chemistry, 1997, 10.1074/jbc.272.21.13758
  • Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling, De Strooper, B., Scorrano, L., D'Hooge, R., Pellegrini, L., Dejaegere, T., Derks, C., D'Adamio, L., Annaert, W., Frezza, C., Metzger, K., Craessaerts, K., Serneels, L., Costa, V., Hartmann, D., Rudka, T., Cipolat, S., Cell, 2006, 10.1016/j.cell.2006.06.021

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Aditi Sood - Doctorat - 2015/01
  • Rana Ghandehari Alavijeh - Maîtrise avec mémoire - 2020/09
  • Yanina Mircheva - Doctorat - 2021/01
  • Irene Anastasia - Doctorat - 2021/05
  • Nicolo' Ilacqua - Doctorat - 2023/05
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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