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Josée Lavoie

Professeure titulaire

Josée Lavoie
josee.lavoie@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Projets de recherche

  • Regulation of nuclear dynamics by tyrosine kinase signaling - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2022-04-01 au 2027-03-31
  • TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
  • Deciphering mechanical stress-induced nuclear envelope remodeling in tumor cells - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2020-09-01 au 2022-08-31

Publications

  • Activation of adenovirus type 2 early region 4 ORF4 cytoplasmic death function by direct binding to Src kinase domain., , The Journal of biological chemistry, 2004, 10.1074/jbc.m400933200
  • [Alternative cell death pathways: lessons learned from a viral protein]., , Bulletin du cancer, 2006
  • Proteomic Analysis of Src Family Kinases Signaling Complexes in Golgi/Endosomal Fractions Using a Site-Selective Anti-Phosphotyrosine Antibody: Identification of LRP1-Insulin Receptor Complexes, , Journal of Proteome Research, 2010, 10.1021/pr900481b
  • Inhibition of Daxx-mediated apoptosis by heat shock protein 27., , Molecular and cellular biology, 2000, 10.1128/mcb.20.20.7602-7612.2000
  • Src-family kinase signaling, actin-mediated membrane trafficking and organellar dynamics in the control of cell fate: Lessons to be learned from the adenovirus E4orf4 death factor, , Cellular Signalling, 2010, 10.1016/j.cellsig.2010.04.007
  • HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency, , The FASEB Journal, 2018, 10.1096/fj.201700558rr
  • Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27., , Molecular and cellular biology, 1995, 10.1128/mcb.15.1.505
  • The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis., , Journal of virology, 1998, 10.1128/jvi.72.9.7144-7153.1998
  • Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization., , The Journal of biological chemistry, 1993
  • Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src., , The FEBS journal, 2006, 10.1111/j.1742-4658.2006.05125.x
  • A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis, , PLOS Genetics, 2015, 10.1371/journal.pgen.1005582
  • Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts., , Oncogene, 1997, 10.1038/sj.onc.1201038
  • A Functional Interplay between the Small GTPase Rab11a and Mitochondria-shaping Proteins Regulates Mitochondrial Positioning and Polarization of the Actin Cytoskeleton Downstream of Src Family Kinases, , Journal of Biological Chemistry, 2014, 10.1074/jbc.m113.516351
  • Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein., , The Journal of cell biology, 2002, 10.1083/jcb.200201106
  • JNK-mediated Phosphorylation of Paxillin in Adhesion Assembly and Tension-induced Cell Death by the Adenovirus Death Factor E4orf4, , Journal of Biological Chemistry, 2008, 10.1074/jbc.m803364200
  • Regulation of Cell Death by Recycling Endosomes and Golgi Membrane Dynamics via a Pathway Involving Src-family kinases, Cdc42 and Rab11a, , Molecular Biology of the Cell, 2009, 10.1091/mbc.e09-01-0057
  • Expression of Drosophila's 27 kDa heat shock protein into rodent cells confers thermal resistance., , Biochemical and biophysical research communications, 1992, 10.1016/s0006-291x(05)80963-5
  • Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases., , The Journal of cell biology, 2000, 10.1083/jcb.150.5.1037
  • Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments, , Journal of Visualized Experiments, 2016, 10.3791/54557
  • Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27., , The Journal of biological chemistry, 1993
  • Adenovirus E4orf4 hijacks rho GTPase-dependent actin dynamics to kill cells: a role for endosome-associated actin assembly., , Molecular biology of the cell, 2006, 10.1091/mbc.e05-12-1146
  • The adenovirus E4orf4 protein induces growth arrest and mitotic catastrophe in H1299 human lung carcinoma cells, , Oncogene, 2009, 10.1038/onc.2008.393
  • Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II., , The Journal of biological chemistry, 1992
  • Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death., , Oncogene, 2004, 10.1038/sj.onc.1207919
  • Cytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein., , Molecular and cellular biology, 2002, 10.1128/mcb.22.1.41-56.2002
  • Cytoskeleton keratin regulation of FasR signaling through modulation of actin/ezrin interplay at lipid rafts in hepatocytes, , Apoptosis, 2012, 10.1007/s10495-012-0733-2
  • A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry., , Progress in cell cycle research, 1996, 10.1007/978-1-4615-5873-6_5
  • BAG3P215L/KO Mice as a Model of BAG3P209L Myofibrillar Myopathy, , The American Journal of Pathology, 2020, 10.1016/j.ajpath.2019.11.005
  • Regulated targeting of BAX to mitochondria., , The Journal of cell biology, 1998, 10.1083/jcb.143.1.207
  • Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27., , Journal of cell science, 1997
  • Characterization of 45-kDa/54-kDa HSP27 kinase, a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27-kDa heat-shock protein HSP27., , European journal of biochemistry, 1995, 10.1111/j.1432-1033.1995.tb20404.x
  • Keratin 8/18 regulation of insulin receptor signaling and trafficking in hepatocytes through a concerted phosphoinositide‐dependent Akt and Rab5 modulation, , The FASEB Journal, 2017, 10.1096/fj.201700036r
  • E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk., , The Journal of cell biology, 1998, 10.1083/jcb.140.3.637
  • Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death, , Journal of Cell Biology, 2020, 10.1083/jcb.201805122
  • Metformin rescues muscle function in BAG3 myofibrillar myopathy models, , Autophagy, 2020, 10.1080/15548627.2020.1833500

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Arianne Gervais - Maîtrise avec mémoire - En cours
  • Dominic Poirier - Doctorat - 2010/05
  • Anas Damlaj - Maîtrise avec mémoire - 2012/05
  • Claire Dziengelewski - Maîtrise avec mémoire - 2015/01
  • Alexandra Jetté - Maîtrise avec mémoire - 2015/09
  • Solenn Guilbert - Doctorat - 2017/09
  • Marc-Antoine Rodrigue - Maîtrise avec mémoire - 2017/09
  • Alice Anaïs Varlet - Doctorat - 2018/01
  • Carole Luthold - Doctorat - 2019/01
  • Hadrien Benk-Fortin - Maîtrise avec mémoire - 2022/05
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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