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Jorge Soliz

Professeur titulaire

jorge.soliz@criucpq.ulaval.ca
Centre thématique de recherche en neurosciences
Groupe de recherche en santé respiratoire
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Santé circulatoire et respiratoire
  • Appareil respiratoire
  • Environnement et maladies respiratoires
Santé différentielle des sexes
  • Stéroïdes
Maladies infectieuses et immunitaires
Subcellulaire

Projets de recherche

  • Hyperactive mitochondria: a novel mechanism to explain early life stress-related sleep apneas in adult mice - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Estradiol receptor alpha mediates sex-specific responses in an animal model of sleep apnea - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-04-01 au 2024-03-31
  • Hyperactive mitochondria: a novel mechanism to explain early life stress leading to sleep-disordered breathing (SDB) in adult mice - Fondation de l'Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2022-01-01 au 2022-12-31
  • Salaire d'un professeur - Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2016-10-01 au 2022-06-30
  • L'estradiol prévient la dysfonction pancréatique dans un modèle animal d'apnée du sommeil - Fondation de l'Université Laval, co-chercheur - 2019-12-01 au 2021-11-30
  • Dysfonctionnements respiratoires néonatals: un problème lié au sexe et à la mitochondrie - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2019-07-01 au 2021-06-30
  • Mitochondria are structurally and functionally sex specific: neonatal brain and intermittent hypoxia - Fondation de l'Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2020-01-01 au 2020-12-31

Publications

  • Malat1 deficiency prevents hypoxia-induced lung dysfunction by protecting the access to alveoli., Jorge Soliz, Sallé-Lefort S, Miard S, Henry C, Arias-Reyes C, Marcouiller F, Beaulieu MJ, Aubin S, Lechasseur A, Jubinville É, Marsolais D, Morissette MC, Joseph V, Soliz J, Bossé Y, Picard F, Frontiers in physiology, 2022, 10.3389/fphys.2022.949378
  • Corrigendum: Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies., Jorge Soliz, Janes TA, Ambrozio-Marques D, Fournier S, Joseph V, Soliz J, Kinkead R, Frontiers in physiology, 2022, 10.3389/fphys.2022.964673
  • Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill COVID-19 patients at high altitudes., Jorge Soliz, Viruez-Soto A, Arias S, Casas-Mamani R, Rada-Barrera G, Alfredo Merino-Luna, Molano-Franco D, JUAN AMILCAR TINOCO SOLORZANO, Danuzia Marques, Zubieta-DeUrioste N, Zubieta-Calleja G, Arias-Reyes C, Soliz J, Respiratory physiology & neurobiology, 2022, 10.1016/j.resp.2022.103868
  • Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies., Jorge Soliz, Janes TA, Ambrozio-Marques D, Fournier S, Joseph V, Soliz J, Kinkead R, Frontiers in physiology, 2021, 10.3389/fphys.2021.781662
  • Cerebral Erythropoietin Prevents Sex-Dependent Disruption of Respiratory Control Induced by Early Life Stress., Jorge Soliz, Elliot-Portal E, Arias-Reyes C, Laouafa S, Tam R, Kinkead R, Soliz J, Frontiers in physiology, 2021, 10.3389/fphys.2021.701344
  • Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice., Jorge Soliz, Robert Jacobs, Mostafa A. Aboouf, Koester-Hegmann C, Muttathukunnel P, Laouafa S, Christian Arias Reyes, Markus Thiersch, Soliz J, Max Gassmann, Edith Marianne Schneider Gasser, Communications biology, 2021, 10.1038/s42003-021-02465-8
  • Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients., Jorge Soliz, Juan Alonso Leon-Abarca, Arianna Portmann, Mayte Bryce-Alberti, Ruiz-Sánchez C, Roberto Accinelli, Soliz J, Gonzales GF, PloS one, 2021, 10.1371/journal.pone.0255144
  • Low serum erythropoietin levels are associated with fatal COVID-19 cases at 4,150 meters above sea level., Viruez-Soto A, López-Dávalos MM, Rada-Barrera G, Alfredo Merino-Luna, Molano-Franco D, JUAN AMILCAR TINOCO SOLORZANO, Zubieta-DeUrioste N, Zubieta-Calleja G, Arias-Reyes C, Jorge Soliz, Respiratory physiology & neurobiology, 2021, 10.1016/j.resp.2021.103709
  • Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent., Christian Arias Reyes, Carvajal-Rodriguez F, Poma-Machicao L, Aliaga-Raduán F, Danuzia Marques, Natalia Zubieta-DeUrioste, Accinelli RA, Edith Marianne Schneider Gasser, Gustavo Zubieta-Calleja, Mathias Dutschmann, Jorge Soliz, PloS one, 2021, 10.1371/journal.pone.0237294
  • Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia., Jorge Soliz, Arias-Reyes C, Soliz J, Joseph V, Frontiers in physiology, 2021, 10.3389/fphys.2021.647822
  • Re: "Mortality Attributed to COVID-19 in High-Altitude Populations" by Woolcott and Bergman., Jorge Soliz, Gustavo Zubieta-Calleja, Alfredo Merino-Luna, Zubieta-DeUrioste N, Armijo-Subieta NF, Soliz J, Arias-Reyes C, Escalante-Kanashiro R, Carmona-Suazo JA, López-Bascope A, Calle-Aracena JM, Epstein M, Maravi E, High altitude medicine & biology, 2021, 10.1089/ham.2020.0195
  • Clinical evolution of COVID-19 during pregnancy at different altitudes: a population-based study, Juan Alonso Leon-Abarca, Maria Teresa Peña-Gallardo, Jorge Soliz, Roberto Accinelli, 2020, 10.1101/2020.09.14.20193177
  • Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?, , Respiratory physiology & neurobiology, 2020, 10.1016/j.resp.2020.103476
  • Does the pathogenesis of SARS-CoV-2 virus decrease at high-altitude?, , Respiratory physiology & neurobiology, 2020, 10.1016/j.resp.2020.103443
  • COVID-19 and Pneumolysis Simulating Extreme High-altitude Exposure with Altered Oxygen Transport Physiology; Multiple Diseases, and Scarce Need of Ventilators: Andean Condor's-eye-view., Jorge Soliz, Gustavo Zubieta-Calleja, Zubieta-DeUrioste N, Venkatesh T, Kusal Das, Soliz J, Reviews on recent clinical trials, 2020, 10.2174/1574887115666200925141108
  • Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis., Jorge Soliz, Blais-Lecours P, Laouafa S, Arias-Reyes C, Santos WL, Joseph V, Janette Burgess, Halayko AJ, Soliz J, David Marsolais, American journal of respiratory cell and molecular biology, 2020, 10.1165/rcmb.2018-0397oc
  • Erythropoietin and caffeine exert similar protective impact against neonatal intermittent hypoxia: Apnea of prematurity and sex dimorphism., Jorge Soliz, Laouafa S, Iturri P, Arias-Reyes C, Marcouiller F, Gonzales M, Joseph V, Aida Bairam, Soliz J, Experimental neurology, 2019, 10.1016/j.expneurol.2019.112985
  • Developmental expression patterns of erythropoietin and its receptor in mouse brainstem respiratory regions., Jorge Soliz, Edith Marianne Schneider Gasser, Elliot-Portal E, Arias-Reyes C, Karen Marlene Losantos-Ramos, Khalid K, Omolara Ogunshola, Soliz J, Respiratory physiology & neurobiology, 2019, 10.1016/j.resp.2019.05.012
  • NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent., Jorge Soliz, Arias-Reyes C, Karen Marlene Losantos-Ramos, Gonzales M, Furrer D, Soliz J, Respiratory physiology & neurobiology, 2019, 10.1016/j.resp.2019.05.011
  • Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats., Jorge Soliz, Laouafa S, Damien Roussel, Marcouiller F, Soliz J, Gozal D, Aida Bairam, Vincent Joseph, Acta physiologica (Oxford, England), 2019, 10.1111/apha.13255
  • Brain-derived erythropoietin protects from intermittent hypoxia-induced cardiorespiratory dysfunction and oxidative stress in mice. , Jorge Soliz, Elliot-Portal E, Laouafa S, Arias-Reyes C, Janes TA, Joseph V, Soliz J, Sleep, 2018, 10.1093/sleep/zsy072
  • Divergent Mitochondrial Antioxidant Activities and Lung Alveolar Architecture in the Lungs of Rats and Mice at High Altitude., Jorge Soliz, Jochmans-Lemoine A, Revollo S, Villalpando G, Valverde I, Gonzales M, Laouafa S, Soliz J, Joseph V, Frontiers in physiology, 2018, 10.3389/fphys.2018.00311
  • Role of Estradiol Receptor Beta (ERβ) on Arterial Pressure, Respiratory Chemoreflex and Mitochondrial Function in Young and Aged Female Mice., Jorge Soliz, Laouafa S, Damien Roussel, Marcouiller F, Soliz J, Aida Bairam, Joseph V, Advances in experimental medicine and biology, 2018, 10.1007/978-3-319-91137-3_15
  • Increased ventilation in female erythropoietin-deficient mouse line is not progesterone and estrous stage-dependent., Jorge Soliz, Jeton F, Soliz J, Dominique Marchant, Joseph V, Jean-Paul Richalet, Pichon A, nicolas voituron, Respiratory physiology & neurobiology, 2017, 10.1016/j.resp.2017.07.002
  • Pharmacological, but not genetic, alteration of neural Epo modifies the CO2/H+ central chemosensitivity in postnatal mice., Jorge Soliz, Laouafa S, Perrin-Terrin AS, Jeton F, Elliot-Portal E, Tam R, Laurence BODINEAU, nicolas voituron, Soliz J, Respiratory physiology & neurobiology, 2017, 10.1016/j.resp.2017.04.003
  • Efficient breathing at neonatal ages: A sex and Epo-dependent issue., Jorge Soliz, Iturri P, Aida Bairam, Soliz J, Respiratory physiology & neurobiology, 2016, 10.1016/j.resp.2016.12.004
  • Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO2 in rats., Jorge Soliz, Silva CA, Vicente MC, Tenorio-Lopes L, Soliz J, Luciane Gargaglioni, Respiratory physiology & neurobiology, 2016, 10.1016/j.resp.2016.10.011
  • HIF1α and physiological responses to hypoxia are correlated in mice but not in rats., Jorge Soliz, Jochmans-Lemoine A, Shahare M, Soliz J, Vincent Joseph, The Journal of experimental biology, 2016, 10.1242/jeb.142869
  • Neonatal Maternal Separation Augments Carotid Body Response to Hypoxia in Adult Males but Not Female Rats., Jorge Soliz, Soliz J, Tam R, Richard Kinkead, Frontiers in physiology, 2016, 10.3389/fphys.2016.00432
  • Hypercapnic ventilatory response is decreased in a mouse model of excessive erythrocytosis., Jorge Soliz, Laouafa S, Elliot-Portal E, Revollo S, Edith Marianne Schneider Gasser, Joseph V, nicolas voituron, Max Gassmann, Soliz J, American journal of physiology. Regulatory, integrative and comparative physiology, 2016, 10.1152/ajpregu.00226.2016
  • The central chemosensitivity is not altered by cerebral erythropoietin., Jorge Soliz, Ballot O, Laouafa S, Elliot-Portal E, Tam R, nicolas voituron, Joseph V, Soliz J, Neuroscience letters, 2015, 10.1016/j.neulet.2015.10.026
  • PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons., Jorge Soliz, Natasha Kumar, Velic A, Soliz J, Shi Y, Li K, Sheng Wang, Janelle Weaver, Sen J, Stephen BG Abbott, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Max Gassmann, Suply T, Seuwen K, Guyenet PG, Wagner CA, Bayliss DA, Science (New York, N.Y.), 2015, 10.1126/science.aaa0922
  • Chronic overexpression of cerebral Epo improves the ventilatory response to acute hypoxia during the postnatal development., Jorge Soliz, Céline Caravagna, Edith Marianne Schneider Gasser, Ballot O, Joseph V, Soliz J, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2015, 10.1016/j.ijdevneu.2015.06.001
  • Endogenous brain erythropoietin is a potent sex-specific respiratory stimulant in adult and newborn mice., Jorge Soliz, Ballot O, Joseph V, Soliz J, Journal of applied physiology (Bethesda, Md. : 1985), 2015, 10.1152/japplphysiol.00143.2015
  • Inhibition of Protein Kinases AKT and ERK1/2 Reduce the Carotid Body Chemoreceptor Response to Hypoxia in Adult Rats., Jorge Soliz, Iturri P, Joseph V, Rodrigo G, Aida Bairam, Soliz J, Advances in experimental medicine and biology, 2015, 10.1007/978-3-319-18440-1_31
  • PI3K and MEK1/2 molecular pathways are involved in the erythropoietin-mediated regulation of the central respiratory command., Jorge Soliz, Céline Caravagna, Soliz J, Respiratory physiology & neurobiology, 2014, 10.1016/j.resp.2014.11.012
  • Post-natal hypoxic activity of the central respiratory command is improved in transgenic mice overexpressing Epo in the brain., Jorge Soliz, Céline Caravagna, Richard Kinkead, Soliz J, Respiratory physiology & neurobiology, 2014, 10.1016/j.resp.2014.06.003
  • Brain-derived neurotrophic factor interacts with astrocytes and neurons to control respiration., Jorge Soliz, Céline Caravagna, Soliz J, Seaborn T, The European journal of neuroscience, 2013, 10.1111/ejn.12320
  • Gestational stress promotes pathological apneas and sex-specific disruption of respiratory control development in newborn rat., Jorge Soliz, Fournier S, Steele S, Julien C, Fournier S, Gulemetova R, Céline Caravagna, Soliz J, Aida Bairam, Richard Kinkead, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/jneurosci.1214-12.2013
  • Using plethysmography to determine erythropoietin's impact on neural control of ventilation., Jorge Soliz, Seaborn T, Max Gassmann, Soliz J, Methods in molecular biology (Clifton, N.J.), 2013, 10.1007/978-1-62703-308-4_18
  • Erythropoietin and respiratory control at adulthood and during early postnatal life., Jorge Soliz, Soliz J, Respiratory physiology & neurobiology, 2012, 10.1016/j.resp.2012.07.018
  • Erythropoietin and its antagonist regulate hypoxic fictive breathing in newborn mice., Jorge Soliz, Khemiri H, Seaborn T, Christian Gestreau, Soliz J, Respiratory physiology & neurobiology, 2012, 10.1016/j.resp.2012.05.027
  • Erythropoietin and the sex-dimorphic chemoreflex pathway., , Advances in experimental medicine and biology, 2012, 10.1007/978-94-007-4584-1_8
  • Enhanced erythropoietin expression in the brainstem of newborn rats at high altitude., Jorge Soliz, Seaborn T, Gonzales M, Villalpando G, Grenacher B, Soria R, Soliz J, Neuroscience letters, 2011, 10.1016/j.neulet.2011.07.019
  • Impaired ventilatory acclimatization to hypoxia in female mice overexpressing erythropoietin: unexpected deleterious effect of estradiol in carotid bodies., Jorge Soliz, Max Gassmann, Pfistner C, Doan VD, Johannes Vogel, Soliz J, American journal of physiology. Regulatory, integrative and comparative physiology, 2010, 10.1152/ajpregu.00205.2010
  • Hypoxia tolerance in animals: biology and application., Jorge Soliz, Thomas Gorr, Wichmann D, Hu J, Marcelo Hermes-Lima, Welker, A.F., Terwilliger N, Wren JF, Viney M, Morris S, Nilsson GE, Deten A, Soliz J, Gassmann M, Physiological and biochemical zoology : PBZ, 2010, 10.1086/648581
  • Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins., Jorge Soliz, Rozenberg I, Susanna Sluka, Rohrer L, Hofmann J, Burkhard Becher, Akhmedov A, Soliz J, Mocharla P, Borén J, Pål Johansen, Steffel J, Watanabe T, Lüscher TF, Tanner FC, Arteriosclerosis, thrombosis, and vascular biology, 2010, 10.1161/atvbaha.109.201079
  • The neuronal control of hypoxic ventilation: erythropoietin and sexual dimorphism., Jorge Soliz, Max Gassmann, Martha C. Tissot van Patot, Soliz J, Annals of the New York Academy of Sciences, 2009, 10.1111/j.1749-6632.2009.05028.x
  • Erythropoietin modulates the neural control of hypoxic ventilation., Jorge Soliz, Max Gassmann, Soliz J, Cellular and molecular life sciences : CMLS, 2009, 10.1007/s00018-009-0142-z
  • Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin., Jorge Soliz, Soliz J, Thomsen JJ, Christophe Soulage, Lundby C, Max Gassmann, American journal of physiology. Regulatory, integrative and comparative physiology, 2009, 10.1152/ajpregu.90967.2008
  • Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice., Jorge Soliz, Soliz J, Christophe Soulage, Borter E, van Patot MT, Max Gassmann, American journal of physiology. Regulatory, integrative and comparative physiology, 2008, 10.1152/ajpregu.00876.2007
  • Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin., Jorge Soliz, Soliz J, Christophe Soulage, Hermann DM, Max Gassmann, American journal of physiology. Regulatory, integrative and comparative physiology, 2007, 10.1152/ajpregu.00350.2007
  • Respiratory plasticity in response to changes in oxygen supply and demand., Jorge Soliz, Bavis RW, Powell FL, Bradford A, Hsia CC, Peltonen JE, Soliz J, Zeis B, Fergusson EK, Fu Z, Max Gassmann, Kim CB, Maurer J, McGuire M, Miller BM, Ken O'Halloran, Paul RJ, Reid SG, Rusko HK, Tikkanen HO, Katherine A. Wilkinson, Integrative and comparative biology, 2007, 10.1093/icb/icm070
  • Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia., Jorge Soliz, Soliz J, Max Gassmann, Joseph V, The Journal of physiology, 2007, 10.1113/jphysiol.2007.133454
  • Perinatal steroid exposure and respiratory control during early postnatal life., Jorge Soliz, Soliz J, Joseph V, Respiratory physiology & neurobiology, 2005, 10.1016/j.resp.2005.01.013
  • Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways., Jorge Soliz, Kilic E, Kilic U, Soliz J, Claudio L.A. Bassetti, Max Gassmann, Hermann DM, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, 10.1096/fj.05-3941fje
  • Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies., Jorge Soliz, Soliz J, Joseph V, Christophe Soulage, Becskei C, Johannes Vogel, Pequignot JM, Omolara Ogunshola, Max Gassmann, The Journal of physiology, 2005, 10.1113/jphysiol.2005.093328
  • Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2., Jorge Soliz, Kilic U, Kilic E, Soliz J, Claudio L.A. Bassetti, Max Gassmann, Hermann DM, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.04-2493fje
  • Long-term effects of neonatal cryoanesthesia on hypoxic ventilatory response in weanling rats depend on neonatal testosterone., Jorge Soliz, Joseph V, Soliz J, Pequignot JM, Advances in experimental medicine and biology, 2003, 10.1007/978-1-4419-9280-2_70
  • Non-erythroid functions of erythropoietin., , Advances in experimental medicine and biology, 2003, 10.1007/978-1-4419-8997-0_22
  • Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats., Jorge Soliz, Joseph V, Soliz J, Soria R, Pequignot J, Favier R, Spielvogel H, Pequignot JM, American journal of physiology. Regulatory, integrative and comparative physiology, 2002, 10.1152/ajpregu.00398.2001
  • Gender differentiation of the chemoreflex during growth at high altitude: functional and neurochemical studies., Jorge Soliz, Joseph V, Soliz J, Pequignot J, Semporé B, Cottet-Emard JM, Dalmaz Y, Favier R, Spielvogel H, Pequignot JM, American journal of physiology. Regulatory, integrative and comparative physiology, 2000, 10.1152/ajpregu.2000.278.4.r806

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Elizabeth Elliot Portal - Doctorat - En cours
  • Sofien Laouafa - Post-doctorat - En cours
  • Lida Sanchez Sanchez - Post-doctorat - En cours
  • Andres Bruno Rojas Ruiz - Doctorat - En cours
  • Christian Luis Carlos Arias Reyes - Doctorat - En cours
  • Saúl Kevin Chávez Alvarez - Doctorat - En cours
  • Céline Michelle Caravagna - Doctorat - 2015/01
  • Hanan Khemiri - Doctorat - 2015/05
  • Orlane Ballot - Maîtrise avec mémoire - 2016/01
  • Manju Shahare - Maîtrise avec mémoire - 2016/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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