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Jorge Soliz

Professeur titulaire

jorge.soliz@criucpq.ulaval.ca

Département de pédiatrie

Centre thématique de recherche en neurosciences

Groupe de recherche en santé respiratoire

Centre de recherche de l'Institut universitaire de cardiologie et de pneumonie de Québec (Affilié à l’Université Laval)

Centre de recherche de l'Institut universitaire de cardiologie et de pneumonie de Québec (Reconnu FRQ - secteur santé)

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Neurosciences et santé mentale
Santé cardiovasculaire, respiratoire et métabolisme

Projets de recherche en cours

Hyperactive mitochondria: a novel mechanism to explain early life stress-related sleep apneas in adult mice - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2022-10-01 au 2027-09-30
FGR-Cardiorespiratory Hypoxia Resilience: Molecular and Physiological Insights from High-Altitude Adapted Populations - Université Laval - Fonds internes - Fonds général de recherche du CRSNG, chercheur principal - 2025-07-22 au 2026-07-21

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Financements des 2 dernières années

Collaboration avec l’Institut bolivien de biologie de haute altitude - Affaires mondiales Canada - Programme de mobilité enseignante pour la création de partenariats, chercheur principal - 2024-04-11 au 2025-05-31
Estradiol receptor alpha mediates sex-specific responses in an animal model of sleep apnea - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-04-01 au 2024-03-31

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Publications

PI3K and MEK1/2 molecular pathways are involved in the erythropoietin-mediated regulation of the central respiratory command., Soliz J, Caravagna C, Jorge Soliz, Respiratory physiology & neurobiology, 2014, 10.1016/j.resp.2014.11.012
Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients., Gonzales GF, Soliz J, Accinelli RA, Ruiz-Sánchez C, Bryce-Alberti M, Portmann-Baracco A, Leon-Abarca JA, Jorge Soliz, PloS one, 2021, 10.1371/journal.pone.0255144
Neonatal Maternal Separation Augments Carotid Body Response to Hypoxia in Adult Males but Not Female Rats., Kinkead R, Tam R, Soliz J, Jorge Soliz, Frontiers in physiology, 2016, 10.3389/fphys.2016.00432
Brain-derived erythropoietin protects from intermittent hypoxia-induced cardiorespiratory dysfunction and oxidative stress in mice. , Soliz J, Joseph V, Janes TA, Arias-Reyes C, Laouafa S, Elliot-Portal E, Jorge Soliz, Sleep, 2018, 10.1093/sleep/zsy072
Long-term effects of neonatal cryoanesthesia on hypoxic ventilatory response in weanling rats depend on neonatal testosterone., Pequignot JM, Soliz J, Joseph V, Jorge Soliz, Advances in experimental medicine and biology, 2003, 10.1007/978-1-4419-9280-2_70
Cerebral Erythropoietin Prevents Sex-Dependent Disruption of Respiratory Control Induced by Early Life Stress., Soliz J, Kinkead R, Tam R, Laouafa S, Arias-Reyes C, Elliot-Portal E, Jorge Soliz, Frontiers in physiology, 2021, 10.3389/fphys.2021.701344
Oxygen therapy limiting peripheral oxygen saturation to 89-93% is associated with a better survival prognosis for critically ill COVID-19 patients at high altitudes., Soliz J, Arias-Reyes C, Zubieta-Calleja G, Zubieta-DeUrioste N, Marques DA, Tinoco-Solorzano A, Molano-Franco D, Merino-Luna A, Rada-Barrera G, Casas-Mamani R, Arias S, Viruez-Soto A, Jorge Soliz, Respiratory physiology & neurobiology, 2022, 10.1016/j.resp.2022.103868
Role of Estradiol Receptor Beta (ERβ) on Arterial Pressure, Respiratory Chemoreflex and Mitochondrial Function in Young and Aged Female Mice., Joseph V, Bairam A, Soliz J, Marcouiller F, Roussel D, Laouafa S, Jorge Soliz, Advances in experimental medicine and biology, 2018, 10.1007/978-3-319-91137-3_15
Gestational stress promotes pathological apneas and sex-specific disruption of respiratory control development in newborn rat., Kinkead R, Bairam A, Soliz J, Caravagna C, Gulemetova R, Fournier S, Julien C, Steele S, Fournier S, Jorge Soliz, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 10.1523/jneurosci.1214-12.2013
Respiratory plasticity in response to changes in oxygen supply and demand., Wilkinson KA, Tikkanen HO, Rusko HK, Reid SG, Paul RJ, O'Halloran KD, Miller BM, McGuire M, Maurer J, Kim CB, Gassmann M, Fu Z, Fergusson EK, Zeis B, Soliz J, Peltonen JE, Hsia CC, Bradford A, Powell FL, Bavis RW, Jorge Soliz, Integrative and comparative biology, 2007, 10.1093/icb/icm070
Low serum erythropoietin levels are associated with fatal COVID-19 cases at 4,150 meters above sea level., Soliz J, Arias-Reyes C, Zubieta-Calleja G, Zubieta-DeUrioste N, Tinoco-Solorozano A, Molano-Franco D, Merino-Luna A, Rada-Barrera G, López-Dávalos MM, Viruez-Soto A, Respiratory physiology & neurobiology, 2021, 10.1016/j.resp.2021.103709
Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis., Marsolais D, Soliz J, Halayko AJ, Burgess JK, Joseph V, Santos WL, Arias-Reyes C, Laouafa S, Blais-Lecours P, Jorge Soliz, American journal of respiratory cell and molecular biology, 2020, 10.1165/rcmb.2018-0397oc
Post-natal hypoxic activity of the central respiratory command is improved in transgenic mice overexpressing Epo in the brain., Soliz J, Kinkead R, Caravagna C, Jorge Soliz, Respiratory physiology & neurobiology, 2014, 10.1016/j.resp.2014.06.003
Hypoxia tolerance in animals: biology and application., Gassmann M, Soliz J, Deten A, Nilsson GE, Morris S, Viney M, Wren JF, Terwilliger N, Welker AF, Hermes-Lima M, Hu J, Wichmann D, Gorr TA, Jorge Soliz, Physiological and biochemical zoology : PBZ, 2010, 10.1086/648581
Chronic overexpression of cerebral Epo improves the ventilatory response to acute hypoxia during the postnatal development., Soliz J, Joseph V, Ballot O, Schneider Gasser EM, Caravagna C, Jorge Soliz, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2015, 10.1016/j.ijdevneu.2015.06.001
Does the pathogenesis of SARS-CoV-2 virus decrease at high-altitude?, , Respiratory physiology & neurobiology, 2020, 10.1016/j.resp.2020.103443
Perinatal steroid exposure and respiratory control during early postnatal life., Joseph V, Soliz J, Jorge Soliz, Respiratory physiology & neurobiology, 2005, 10.1016/j.resp.2005.01.013
Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?, , Respiratory physiology & neurobiology, 2020, 10.1016/j.resp.2020.103476
Enhanced erythropoietin expression in the brainstem of newborn rats at high altitude., Soliz J, Soria R, Grenacher B, Villalpando G, Gonzales M, Seaborn T, Jorge Soliz, Neuroscience letters, 2011, 10.1016/j.neulet.2011.07.019
Erythropoietin and the sex-dimorphic chemoreflex pathway., , Advances in experimental medicine and biology, 2012, 10.1007/978-94-007-4584-1_8
Re: "Mortality Attributed to COVID-19 in High-Altitude Populations" by Woolcott and Bergman., Maravi E, Epstein M, Calle-Aracena JM, López-Bascope A, Carmona-Suazo JA, Escalante-Kanashiro R, Arias-Reyes C, Soliz J, Armijo-Subieta NF, Zubieta-DeUrioste N, Merino-Luna A, Zubieta-Calleja G, Jorge Soliz, High altitude medicine & biology, 2021, 10.1089/ham.2020.0195
PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons., Bayliss DA, Wagner CA, Guyenet PG, Seuwen K, Suply T, Gassmann M, Bettoni C, Mohebbi N, Perez-Reyes E, Ludwig MG, Lazarenko RM, Abbott SB, Sen J, Weaver JL, Wang S, Shi Y, Li K, Soliz J, Velic A, Kumar NN, Jorge Soliz, Science (New York, N.Y.), 2015, 10.1126/science.aaa0922
Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways., Hermann DM, Gassmann M, Bassetti CL, Soliz J, Kilic U, Kilic E, Jorge Soliz, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, 10.1096/fj.05-3941fje
Efficient breathing at neonatal ages: A sex and Epo-dependent issue., Soliz J, Bairam A, Iturri P, Jorge Soliz, Respiratory physiology & neurobiology, 2016, 10.1016/j.resp.2016.12.004
Corrigendum: Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies., Kinkead R, Soliz J, Joseph V, Fournier S, Ambrozio-Marques D, Janes TA, Jorge Soliz, Frontiers in physiology, 2022, 10.3389/fphys.2022.964673
Using plethysmography to determine erythropoietin's impact on neural control of ventilation., Soliz J, Gassmann M, Seaborn T, Jorge Soliz, Methods in molecular biology (Clifton, N.J.), 2013, 10.1007/978-1-62703-308-4_18
NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent., Soliz J, Furrer D, Gonzales M, Losantos-Ramos K, Arias-Reyes C, Jorge Soliz, Respiratory physiology & neurobiology, 2019, 10.1016/j.resp.2019.05.011
The central chemosensitivity is not altered by cerebral erythropoietin., Soliz J, Joseph V, Voituron N, Tam R, Elliot-Portal E, Laouafa S, Ballot O, Jorge Soliz, Neuroscience letters, 2015, 10.1016/j.neulet.2015.10.026
Mice and Rats Display Different Ventilatory, Hematological, and Metabolic Features of Acclimatization to Hypoxia., Joseph V, Soliz J, Arias-Reyes C, Jorge Soliz, Frontiers in physiology, 2021, 10.3389/fphys.2021.647822
Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin., Gassmann M, Hermann DM, Soulage C, Soliz J, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2007, 10.1152/ajpregu.00350.2007
Developmental expression patterns of erythropoietin and its receptor in mouse brainstem respiratory regions., Soliz J, Ogunshola O, Khalid K, Losantos-Ramos K, Arias-Reyes C, Elliot-Portal E, Schneider Gasser EM, Jorge Soliz, Respiratory physiology & neurobiology, 2019, 10.1016/j.resp.2019.05.012
Inhibition of Protein Kinases AKT and ERK1/2 Reduce the Carotid Body Chemoreceptor Response to Hypoxia in Adult Rats., Soliz J, Bairam A, Rodrigo G, Joseph V, Iturri P, Jorge Soliz, Advances in experimental medicine and biology, 2015, 10.1007/978-3-319-18440-1_31
Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice., Gassmann M, van Patot MT, Borter E, Soulage C, Soliz J, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2008, 10.1152/ajpregu.00876.2007
Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2., Hermann DM, Gassmann M, Bassetti CI, Soliz J, Kilic E, Kilic U, Jorge Soliz, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, 10.1096/fj.04-2493fje
Endogenous brain erythropoietin is a potent sex-specific respiratory stimulant in adult and newborn mice., Soliz J, Joseph V, Ballot O, Jorge Soliz, Journal of applied physiology (Bethesda, Md. : 1985), 2015, 10.1152/japplphysiol.00143.2015
Impaired ventilatory acclimatization to hypoxia in female mice overexpressing erythropoietin: unexpected deleterious effect of estradiol in carotid bodies., Soliz J, Vogel J, Doan VD, Pfistner C, Gassmann M, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2010, 10.1152/ajpregu.00205.2010
Erythropoietin and caffeine exert similar protective impact against neonatal intermittent hypoxia: Apnea of prematurity and sex dimorphism., Soliz J, Bairam A, Joseph V, Gonzales M, Marcouiller F, Arias-Reyes C, Iturri P, Laouafa S, Jorge Soliz, Experimental neurology, 2019, 10.1016/j.expneurol.2019.112985
Hypercapnic ventilatory response is decreased in a mouse model of excessive erythrocytosis., Soliz J, Gassmann M, Voituron N, Joseph V, Schneider Gasser EM, Revollo S, Elliot-Portal E, Laouafa S, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2016, 10.1152/ajpregu.00226.2016
Gender differentiation of the chemoreflex during growth at high altitude: functional and neurochemical studies., Pequignot JM, Spielvogel H, Favier R, Dalmaz Y, Cottet-Emard JM, Semporé B, Pequignot J, Soliz J, Joseph V, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2000, 10.1152/ajpregu.2000.278.4.r806
Brain-derived neurotrophic factor interacts with astrocytes and neurons to control respiration., Seaborn T, Soliz J, Caravagna C, Jorge Soliz, The European journal of neuroscience, 2013, 10.1111/ejn.12320
Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats., Pequignot JM, Favier R, Spielvogel H, Soria R, Pequignot J, Soliz J, Joseph V, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2002, 10.1152/ajpregu.00398.2001
The neuronal control of hypoxic ventilation: erythropoietin and sexual dimorphism., Soliz J, Tissot van Patot M, Gassmann M, Jorge Soliz, Annals of the New York Academy of Sciences, 2009, 10.1111/j.1749-6632.2009.05028.x
Malat1 deficiency prevents hypoxia-induced lung dysfunction by protecting the access to alveoli., Picard F, Bossé Y, Soliz J, Joseph V, Morissette MC, Marsolais D, Jubinville É, Lechasseur A, Aubin S, Beaulieu MJ, Marcouiller F, Arias-Reyes C, Henry C, Miard S, Sallé-Lefort S, Jorge Soliz, Frontiers in physiology, 2022, 10.3389/fphys.2022.949378
Non-erythroid functions of erythropoietin., , Advances in experimental medicine and biology, 2003, 10.1007/978-1-4419-8997-0_22
Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia., Joseph V, Gassmann M, Soliz J, Jorge Soliz, The Journal of physiology, 2007, 10.1113/jphysiol.2007.133454
Erythropoietin and its antagonist regulate hypoxic fictive breathing in newborn mice., Soliz J, Gestreau C, Seaborn T, Khemiri H, Jorge Soliz, Respiratory physiology & neurobiology, 2012, 10.1016/j.resp.2012.05.027
Clinical evolution of COVID-19 during pregnancy at different altitudes: a population-based study, Roberto Accinelli, Jorge Soliz, Maria Teresa Peña-Gallardo, Juan Alonso Leon-Abarca, 2020, 10.1101/2020.09.14.20193177
Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin., Gassmann M, Lundby C, Soulage C, Thomsen JJ, Soliz J, Jorge Soliz, American journal of physiology. Regulatory, integrative and comparative physiology, 2009, 10.1152/ajpregu.90967.2008
Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins., Tanner FC, Lüscher TF, Watanabe T, Steffel J, Johansen P, Borén J, Mocharla P, Soliz J, Akhmedov A, Becher B, Hofmann J, Rohrer L, Sluka SH, Rozenberg I, Jorge Soliz, Arteriosclerosis, thrombosis, and vascular biology, 2010, 10.1161/atvbaha.109.201079
Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice., Schneider Gasser EM, Gassmann M, Soliz J, Thiersch M, Arias-Reyes C, Laouafa S, Muttathukunnel P, Koester-Hegmann C, Aboouf MA, Jacobs RA, Jorge Soliz, Communications biology, 2021, 10.1038/s42003-021-02465-8
HIF1α and physiological responses to hypoxia are correlated in mice but not in rats., Joseph V, Soliz J, Shahare M, Jochmans-Lemoine A, Jorge Soliz, The Journal of experimental biology, 2016, 10.1242/jeb.142869
Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies., Gassmann M, Ogunshola O, Pequignot JM, Vogel J, Becskei C, Soulage C, Joseph V, Soliz J, Jorge Soliz, The Journal of physiology, 2005, 10.1113/jphysiol.2005.093328
Testosterone Supplementation Induces Age-Dependent Augmentation of the Hypoxic Ventilatory Response in Male Rats With Contributions From the Carotid Bodies., Kinkead R, Soliz J, Joseph V, Fournier S, Ambrozio-Marques D, Janes TA, Jorge Soliz, Frontiers in physiology, 2021, 10.3389/fphys.2021.781662
Erythropoietin in the Locus coeruleus attenuates the ventilatory response to CO₂ in rats., Gargaglioni LH, Soliz J, Tenorio-Lopes L, Vicente MC, Silva CA, Jorge Soliz, Respiratory physiology & neurobiology, 2016, 10.1016/j.resp.2016.10.011
Pharmacological, but not genetic, alteration of neural Epo modifies the CO₂/H⁺ central chemosensitivity in postnatal mice., Soliz J, Voituron N, Bodineau L, Tam R, Elliot-Portal E, Jeton F, Perrin-Terrin AS, Laouafa S, Jorge Soliz, Respiratory physiology & neurobiology, 2017, 10.1016/j.resp.2017.04.003
Divergent Mitochondrial Antioxidant Activities and Lung Alveolar Architecture in the Lungs of Rats and Mice at High Altitude., Joseph V, Soliz J, Laouafa S, Gonzales M, Valverde I, Villalpando G, Revollo S, Jochmans-Lemoine A, Jorge Soliz, Frontiers in physiology, 2018, 10.3389/fphys.2018.00311
Increased ventilation in female erythropoietin-deficient mouse line is not progesterone and estrous stage-dependent., Voituron N, Pichon A, Richalet JP, Joseph V, Marchant D, Soliz J, Jeton F, Jorge Soliz, Respiratory physiology & neurobiology, 2017, 10.1016/j.resp.2017.07.002
Erythropoietin and respiratory control at adulthood and during early postnatal life., Soliz J, Jorge Soliz, Respiratory physiology & neurobiology, 2012, 10.1016/j.resp.2012.07.018
Decreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent., Soliz J, Dutschmann M, Zubieta-Calleja G, Schneider-Gasser EM, Accinelli RA, Zubieta-DeUrioste N, Marques DA, Aliaga-Raduán F, Poma-Machicao L, Carvajal-Rodriguez F, Arias-Reyes C, PloS one, 2021, 10.1371/journal.pone.0237294
Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats., Joseph V, Bairam A, Gozal D, Soliz J, Marcouiller F, Roussel D, Laouafa S, Jorge Soliz, Acta physiologica (Oxford, England), 2019, 10.1111/apha.13255
Erythropoietin modulates the neural control of hypoxic ventilation., Soliz J, Gassmann M, Jorge Soliz, Cellular and molecular life sciences : CMLS, 2009, 10.1007/s00018-009-0142-z
COVID-19 and Pneumolysis Simulating Extreme High-altitude Exposure with Altered Oxygen Transport Physiology; Multiple Diseases, and Scarce Need of Ventilators: Andean Condor's-eye-view., Soliz J, Das KK, Venkatesh T, Zubieta-DeUrioste N, Zubieta-Calleja G, Jorge Soliz, Reviews on recent clinical trials, 2020, 10.2174/1574887115666200925141108

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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/08

Fernanda Aliaga Raduan - Doctorat - En cours
Andres Bruno Rojas Ruiz - Doctorat - En cours
Jaime Pablo Iturri Soliz - Doctorat - En cours
Lida Sanchez Sanchez - Post-doctorat - En cours
Christian Luis Carlos Arias Reyes - Doctorat - 2023/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

Biologie cellulaire et moléculaire
Neurobiologie — Neurosciences

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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