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Jérôme Frenette

Professeur titulaire

Jérôme Frenette
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire
Perte d’autonomie et réadaptation
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Maladies musculaires
  • Lésions musculosquelettiques et réparations
  • Ostéoporose
  • Maladies du tissu osseux
  • Fibroses
  • Trauma/blessures
Vieillissement
  • Dégénérescence cellulaire
  • Génétique du vieillissement

Projets de recherche

  • Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Development of a monosaccharide therapy using N-acetylglucosamine to mitigate Duchenne muscular dystrophy - The Foundation for gene and cell therapy Jesse's Journey, co-chercheur - 2021-05-31 au 2024-05-30
  • Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-10-01 au 2023-03-31
  • Development of a glycobiology therapy to mitigate the progression of Duchenne muscular dystrophy - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), co-chercheur - 2021-07-01 au 2022-06-30
  • Deciphering the role of RANK/RANKL/OPG in skeletal muscle. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31
  • Does anti-RANKL therapy prevent glucocorticoid induced bone loss and promote muscle function in a mouse model of Duchenne muscular dystrophy - lifeArc, University of Edinburgh, co-chercheur - 2021-04-01 au 2022-03-31
  • La protéine S100B est-elle un outil de dépistage valide pour réduire le nombre de tomodensitométries inutiles suite à un traumatisme cranio-cérébral léger? - Fonds de recherche du Québec - Santé - Consortium pour le développement de la recherche en traumatologie, co-chercheur - 2017-04-01 au 2022-01-31
  • Does anti-RANKL therapy prevent glucocorticoid induced bone loss in a mouse model of Duchenne muscular dystrophy? - Duchenne Parent Project, University of Edinburgh, co-chercheur - 2020-10-01 au 2021-07-31
  • Development of a therapy for Duchenne muscular dystrophy using N-acetylglucosamine - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Wellesley Therapeutics Inc, Fondation du CHU de Québec - Réseau de centres d'excellence (RCE), co-chercheur - 2019-06-15 au 2021-03-31
  • Therapeutic impact of OPG on muscle structure and function in a preclinical mouse model of Duchenne Muscular Distrophy - Ryan's Quest, chercheur principal - 2016-02-17 au 2021-02-16

Publications

  • The Association Between Self-Reported Cigarette Smoking and Spinal Pain is Not Explained by Serum Cotinine Levels, , Annals of epidemiology, 2022, 10.1016/j.annepidem.2021.12.006
  • Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice, , Biochimica et biophysica acta. Molecular cell research, 2021, 10.1016/j.bbamcr.2020.118917
  • Post-concussion symptoms in sports-related mild traumatic brain injury compared to non-sports-related mild traumatic brain injury, , Cjem, 2021, 10.1007/s43678-020-00060-0
  • S100B protein level for the detection of clinically significant intracranial haemorrhage in patients with mild traumatic brain injury: a subanalysis of a prospective cohort study, , Emergency medicine journal : EMJ, 2021, 10.1136/emermed-2020-209583
  • Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice, , Human molecular genetics, 2020, 10.1093/hmg/ddz312
  • An anti-RANKL treatment reduces muscle inflammation and dysfunction and strengthens bone in dystrophic mice, , Human molecular genetics, 2019, 10.1093/hmg/ddz124
  • Detection of S-100β Protein in Plasma and Urine After a Mild Traumatic Brain Injury, , The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2019, 10.1017/cjn.2019.61
  • Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture, , Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018, 10.1002/jbmr.3546
  • Galectin-3 and N-acetylglucosamine promote myogenesis and improve skeletal muscle function in the mdx model of Duchenne muscular dystrophy, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018, 10.1096/fj.201701151RRR
  • Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy, , Acta neuropathologica communications, 2018, 10.1186/s40478-018-0533-1
  • Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review, , Brain injury, 2018, 10.1080/02699052.2017.1385097
  • Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis, , Journal of neurotrauma, 2018, 10.1089/neu.2017.5013
  • Targeting the Muscle-Bone Unit: Filling Two Needs with One Deed in the Treatment of Duchenne Muscular Dystrophy, , Current osteoporosis reports, 2018, 10.1007/s11914-018-0468-2
  • Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice, , PloS one, 2018, 10.1371/journal.pone.0198408
  • Vitamin C is not the Missing Link Between Cigarette Smoking and Spinal Pain, , Spine, 2018, 10.1097/BRS.0000000000002466
  • Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness, , Skeletal muscle, 2017, 10.1186/s13395-016-0119-1
  • Osteoprotegerin and β-Agonists Mitigate Muscular Dystrophy in Slow- and Fast-Twitch Skeletal Muscles, , The American journal of pathology, 2017, 10.1016/j.ajpath.2016.11.006
  • A short-term statin treatment changes the contractile properties of fast-twitch skeletal muscles, , BMC musculoskeletal disorders, 2016, 10.1186/s12891-016-1306-2
  • Inflammation and muscle regeneration, a double-edged sword, , Medecine sciences : M/S, 2016, 10.1051/medsci/20163206022
  • Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM, , Journal of neurophysiology, 2016, 10.1152/jn.00556.2015
  • Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles, , American journal of physiology. Cell physiology, 2016, 10.1152/ajpcell.00285.2015
  • Physiological role of receptor activator nuclear factor-kB (RANK) in denervation-induced muscle atrophy and dysfunction, , Receptors & clinical investigation, 2016, 10.14800/rci.1323
  • Serum vitamin C and spinal pain: a nationwide study, , Pain, 2016, 10.1097/j.pain.0000000000000671
  • A 12-Week Exercise Program for Pregnant Women with Obesity to Improve Physical Activity Levels: An Open Randomised Preliminary Study, , PloS one, 2015, 10.1371/journal.pone.0137742
  • Corrigendum: Inhibition of JAK-STAT signaling stimulates adult satellite cell function, , Nature medicine, 2015, 10.1038/nm0415-414a
  • New method for determining total calcium content in tissue applied to skeletal muscle with and without calsequestrin, , The Journal of general physiology, 2015, 10.1085/jgp.201411250
  • Osteoprotegerin protects against muscular dystrophy, , The American journal of pathology, 2015, 10.1016/j.ajpath.2015.01.006
  • Statin intolerance and associated muscular dysfunctions, , Medecine sciences : M/S, 2015, 10.1051/medsci/20153112014
  • Inhibition of JAK-STAT signaling stimulates adult satellite cell function, , Nature medicine, 2014, 10.1038/nm.3655
  • Macrophage depletion reduces cell proliferation and extracellular matrix accumulation but increases the ultimate tensile strength of injured Achilles tendons, , Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014, 10.1002/jor.22504
  • Measurement of skeletal muscle radiation attenuation and basis of its biological variation, , Acta physiologica (Oxford, England), 2014, 10.1111/apha.12224
  • Nucleoside triphosphate diphosphohydrolase-1 ectonucleotidase is required for normal vas deferens contraction and male fertility through maintaining P2X1 receptor function, , The Journal of biological chemistry, 2014, 10.1074/jbc.M114.604082
  • Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength, , The Journal of cell biology, 2014, 10.1083/jcb.201310035
  • Investigation of wild-type and mycolactone-negative mutant Mycobacterium ulcerans on skeletal muscle: IGF-1 protects against mycolactone-induced muscle catabolism, , American journal of physiology. Regulatory, integrative and comparative physiology, 2013, 10.1152/ajpregu.00587.2012
  • Macrophage colony-stimulating factor-induced macrophage differentiation promotes regrowth in atrophied skeletal muscles and C2C12 myotubes, , The American journal of pathology, 2013, 10.1016/j.ajpath.2012.10.010
  • Buruli ulcer - beyond the skin, impact on skeletal muscle, , Medecine sciences : M/S, 2011, 10.1051/medsci/2011272187
  • Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation, , American journal of physiology. Regulatory, integrative and comparative physiology, 2011, 10.1152/ajpregu.00393.2010
  • Dystrophin expression following the transplantation of normal muscle precursor cells protects mdx muscle from contraction-induced damage, , Cell transplantation, 2010, 10.3727/096368910X4863235
  • Laminin-111: a potential therapeutic agent for Duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.165
  • Macrophages protect against muscle atrophy and promote muscle recovery in vivo and in vitro: a mechanism partly dependent on the insulin-like growth factor-1 signaling molecule, , The American journal of pathology, 2010, 10.2353/ajpath.2010.090884
  • Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon, , Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2010, 10.1002/jor.21092
  • Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone, , Microbes and infection, 2009, 10.1016/j.micinf.2008.11.016
  • Thrombocytopenia alters early but not late repair in a mouse model of Achilles tendon injury, , Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2009, 10.1111/j.1524-475X.2009.00467.x
  • Neutrophil-induced skeletal muscle damage: a calculated and controlled response following hindlimb unloading and reloading, , American journal of physiology. Regulatory, integrative and comparative physiology, 2008, 10.1152/ajpregu.90318.2008
  • Subcutaneous injection of Mycobacterium ulcerans causes necrosis, chronic inflammatory response and fibrosis in skeletal muscle, , Microbes and infection, 2008, 10.1016/j.micinf.2008.07.041
  • Inflammatory cells do not decrease the ultimate tensile strength of intact tendons in vivo and in vitro: protective role of mechanical loading, , Journal of applied physiology (Bethesda, Md. : 1985), 2007, 10.1152/japplphysiol.00162.2006
  • Mast cells can modulate leukocyte accumulation and skeletal muscle function following hindlimb unloading, , Journal of applied physiology (Bethesda, Md. : 1985), 2007, 10.1152/japplphysiol.01132.2006
  • Pifithrin-alpha, an inhibitor of p53 transactivation, alters the inflammatory process and delays tendon healing following acute injury, , American journal of physiology. Regulatory, integrative and comparative physiology, 2007, 10.1152/ajpregu.00411.2005
  • Early voluntary exercise does not promote healing in a rat model of Achilles tendon injury, , Journal of applied physiology (Bethesda, Md. : 1985), 2006, 10.1152/japplphysiol.00301.2006
  • Periodic direct current does not promote wound closure in an in vitro dynamic model of cell migration, , Physical therapy, 2006, 10.1093/ptj/86.1.50
  • Inflammation and tendon healing, , Medecine sciences : M/S, 2005, 10.1051/medsci/2005212181
  • Body weight, limb size, and muscular properties of early paraplegic mice, , Journal of neurotrauma, 2004, 10.1089/0897715041651060
  • Insulin-dependent diabetes impairs the inflammatory response and delays angiogenesis following Achilles tendon injury, , American journal of physiology. Regulatory, integrative and comparative physiology, 2004, 10.1152/ajpregu.00536.2003
  • Macrophages, not neutrophils, infiltrate skeletal muscle in mice deficient in P/E selectins after mechanical reloading, , American journal of physiology. Regulatory, integrative and comparative physiology, 2003, 10.1152/ajpregu.00175.2003
  • Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration, , Laboratory investigation; a journal of technical methods and pathology, 2003, 10.1097/01.lab.0000078688.07696.ac
  • Lengthening contraction-induced inflammation is linked to secondary damage but devoid of neutrophil invasion, , Journal of applied physiology (Bethesda, Md. : 1985), 2002, 10.1152/japplphysiol.00803.2001
  • Muscle impairment occurs rapidly and precedes inflammatory cell accumulation after mechanical loading, , American journal of physiology. Regulatory, integrative and comparative physiology, 2002, 10.1152/ajpregu.00189.2001
  • Neutrophils and macrophages accumulate sequentially following Achilles tendon injury, , Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2001, 10.1016/S0736-0266(01)00031-6
  • Accumulation of PDGF+ cells and internalisation of the PDGF receptor at myotendinous junction following modified hindlimb muscle use in the rat, , Journal of anatomy, 2000, 10.1046/j.1469-7580.2000.19620211.x
  • Complement activation promotes muscle inflammation during modified muscle use, , The American journal of pathology, 2000, 10.1016/S0002-9440(10)65081-X
  • Modulation of structural protein content of the myotendinous junction following eccentric contractions, , International journal of sports medicine, 2000, 10.1055/s-2000-3774
  • Macrophage invasion does not contribute to muscle membrane injury during inflammation, , Journal of leukocyte biology, 1999
  • Increased endothelial cell expression of platelet-endothelial cell adhesion molecule-1 during hyperoxic lung injury, , American journal of respiratory cell and molecular biology, 1998, 10.1165/ajrcmb.19.4.2349
  • Mechanical loading regulates expression of talin and its mRNA, which are concentrated at myotendinous junctions, , The American journal of physiology, 1998, 10.1152/ajpcell.1998.275.3.C818
  • Carbohydrate utilization in rat soleus muscle is influenced by carbonic anhydrase III activity, , The American journal of physiology, 1997, 10.1152/ajpregu.1997.273.4.R1211
  • In vivo expression of intercellular adhesion molecule 1 in type II pneumocytes during hyperoxia, , American journal of respiratory cell and molecular biology, 1996, 10.1165/ajrcmb.15.1.8679224
  • Effect of carbonic anhydrase III inhibition on substrate utilization and fatigue in rat soleus, , Canadian journal of physiology and pharmacology, 1993, 10.1139/y93-043
  • Fatigue and recovery of rat soleus muscle are influenced by inhibition of an intracellular carbonic anhydrase isoform, , The American journal of physiology, 1991, 10.1152/ajpregu.1991.260.3.R615

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Zineb Bouredji - Doctorat - En cours
  • Laetitia Marcadet - Doctorat - En cours
  • Mélissa De la Durantaye - Maitrîse avec mémoire - 2013/05
  • Rachelle Gosselin - Maitrîse avec mémoire - 2015/01
  • Antoine Boulanger Piette - Maitrîse avec mémoire - 2015/01
  • Sébastien Dufresne - Maitrîse avec mémoire - 2016/01
  • Dounia Hamoudi - Doctorat - 2021/05

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4645
Québec (Québec) G1V 0A6
Canada

Renseignements - Secrétariat
418 656-2690
vdres@fmed.ulaval.ca

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

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