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Jérôme Frenette

Professeur titulaire

Jérôme Frenette
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire
Perte d’autonomie et réadaptation
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Maladies musculaires
  • Lésions musculosquelettiques et réparations
  • Ostéoporose
  • Maladies du tissu osseux
  • Fibroses
  • Trauma/blessures
  • Dégénérescence cellulaire
  • Génétique du vieillissement

Projets de recherche

  • Decipher the physiological functions of osteoprotegerin in skeletal and cardiac muscles - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
  • Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Development of a monosaccharide therapy using N-acetylglucosamine to mitigate Duchenne muscular dystrophy - The Foundation for gene and cell therapy Jesse's Journey, co-chercheur - 2021-05-31 au 2024-05-30
  • Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-10-01 au 2023-03-31
  • Development of a glycobiology therapy to mitigate the progression of Duchenne muscular dystrophy - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Réseau de centres d'excellence (RCE), co-chercheur - 2021-07-01 au 2022-06-30
  • Does anti-RANKL therapy prevent glucocorticoid induced bone loss and promote muscle function in a mouse model of Duchenne muscular dystrophy - lifeArc, University of Edinburgh, co-chercheur - 2021-04-01 au 2022-03-31
  • Deciphering the role of RANK/RANKL/OPG in skeletal muscle. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31


  • Mechanical loading regulates expression of talin and its mRNA, which are concentrated at myotendinous junctions, , The American journal of physiology, 1998, 10.1152/ajpcell.1998.275.3.C818
  • Carbohydrate utilization in rat soleus muscle is influenced by carbonic anhydrase III activity, , The American journal of physiology, 1997, 10.1152/ajpregu.1997.273.4.R1211
  • Effect of carbonic anhydrase III inhibition on substrate utilization and fatigue in rat soleus, , Canadian journal of physiology and pharmacology, 1993, 10.1139/y93-043
  • Complement activation promotes muscle inflammation during modified muscle use, , The American journal of pathology, 2000, 10.1016/S0002-9440(10)65081-X
  • Inflammation and tendon healing, , Medecine sciences : M/S, 2005, 10.1051/medsci/2005212181
  • Body weight, limb size, and muscular properties of early paraplegic mice, , Journal of neurotrauma, 2004, 10.1089/0897715041651060
  • Insulin-dependent diabetes impairs the inflammatory response and delays angiogenesis following Achilles tendon injury, , American journal of physiology. Regulatory, integrative and comparative physiology, 2004, 10.1152/ajpregu.00536.2003
  • Macrophages, not neutrophils, infiltrate skeletal muscle in mice deficient in P/E selectins after mechanical reloading, , American journal of physiology. Regulatory, integrative and comparative physiology, 2003, 10.1152/ajpregu.00175.2003
  • Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon, , Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2010, 10.1002/jor.21092
  • Neutrophils and macrophages accumulate sequentially following Achilles tendon injury, , Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2001, 10.1016/S0736-0266(01)00031-6
  • Lengthening contraction-induced inflammation is linked to secondary damage but devoid of neutrophil invasion, , Journal of applied physiology (Bethesda, Md. : 1985), 2002, 10.1152/japplphysiol.00803.2001
  • Early voluntary exercise does not promote healing in a rat model of Achilles tendon injury, , Journal of applied physiology (Bethesda, Md. : 1985), 2006, 10.1152/japplphysiol.00301.2006
  • Dystrophin expression following the transplantation of normal muscle precursor cells protects mdx muscle from contraction-induced damage, , Cell transplantation, 2010, 10.3727/096368910X4863235
  • Osteoprotegerin protects against muscular dystrophy, , The American journal of pathology, 2015, 10.1016/j.ajpath.2015.01.006
  • Measurement of skeletal muscle radiation attenuation and basis of its biological variation, , Acta physiologica (Oxford, England), 2014, 10.1111/apha.12224
  • Investigation of wild-type and mycolactone-negative mutant Mycobacterium ulcerans on skeletal muscle: IGF-1 protects against mycolactone-induced muscle catabolism, , American journal of physiology. Regulatory, integrative and comparative physiology, 2013, 10.1152/ajpregu.00587.2012
  • Mycobacterium ulcerans infections cause progressive muscle atrophy and dysfunction, and mycolactone impairs satellite cell proliferation, , American journal of physiology. Regulatory, integrative and comparative physiology, 2011, 10.1152/ajpregu.00393.2010
  • New method for determining total calcium content in tissue applied to skeletal muscle with and without calsequestrin, , The Journal of general physiology, 2015, 10.1085/jgp.201411250
  • Macrophages protect against muscle atrophy and promote muscle recovery in vivo and in vitro: a mechanism partly dependent on the insulin-like growth factor-1 signaling molecule, , The American journal of pathology, 2010, 10.2353/ajpath.2010.090884
  • Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone, , Microbes and infection, 2009, 10.1016/j.micinf.2008.11.016
  • Corrigendum: Inhibition of JAK-STAT signaling stimulates adult satellite cell function, , Nature medicine, 2015, 10.1038/nm0415-414a
  • Osteoprotegerin and β-Agonists Mitigate Muscular Dystrophy in Slow- and Fast-Twitch Skeletal Muscles, , The American journal of pathology, 2017, 10.1016/j.ajpath.2016.11.006
  • Targeting the Muscle-Bone Unit: Filling Two Needs with One Deed in the Treatment of Duchenne Muscular Dystrophy, , Current osteoporosis reports, 2018, 10.1007/s11914-018-0468-2
  • Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy, , Acta neuropathologica communications, 2018, 10.1186/s40478-018-0533-1
  • Galectin-3 and N-acetylglucosamine promote myogenesis and improve skeletal muscle function in the mdx model of Duchenne muscular dystrophy, , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018, 10.1096/fj.201701151RRR
  • Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture, , Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018, 10.1002/jbmr.3546
  • Post-concussion symptoms in sports-related mild traumatic brain injury compared to non-sports-related mild traumatic brain injury, , Cjem, 2021, 10.1007/s43678-020-00060-0
  • An anti-RANKL treatment reduces muscle inflammation and dysfunction and strengthens bone in dystrophic mice, , Human molecular genetics, 2019, 10.1093/hmg/ddz124
  • Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice, , Biochimica et biophysica acta. Molecular cell research, 2021, 10.1016/j.bbamcr.2020.118917
  • RANKL Inhibition Reduces Cardiac Hypertrophy in mdx Mice and Possibly in Children with Duchenne Muscular Dystrophy, Jerome Frenette, Anteneh Argaw, A. Russell Tupling, Leanne M. Ward, Hideo Yagita, Zineb Bouredji, Nasrin Khan, Emma Sara Juracic, Laetitia Marcadet, Cells, 2023, 10.3390/cells12111538
  • In vivo expression of intercellular adhesion molecule 1 in type II pneumocytes during hyperoxia, , American journal of respiratory cell and molecular biology, 1996, 10.1165/ajrcmb.15.1.8679224
  • Fatigue and recovery of rat soleus muscle are influenced by inhibition of an intracellular carbonic anhydrase isoform, , The American journal of physiology, 1991, 10.1152/ajpregu.1991.260.3.R615
  • Macrophage invasion does not contribute to muscle membrane injury during inflammation, , Journal of leukocyte biology, 1999
  • Muscle impairment occurs rapidly and precedes inflammatory cell accumulation after mechanical loading, , American journal of physiology. Regulatory, integrative and comparative physiology, 2002, 10.1152/ajpregu.00189.2001
  • Nonsteroidal anti-inflammatory drug reduces neutrophil and macrophage accumulation but does not improve tendon regeneration, , Laboratory investigation; a journal of technical methods and pathology, 2003, 10.1097/01.lab.0000078688.07696.ac
  • Mast cells can modulate leukocyte accumulation and skeletal muscle function following hindlimb unloading, , Journal of applied physiology (Bethesda, Md. : 1985), 2007, 10.1152/japplphysiol.01132.2006
  • Neutrophil-induced skeletal muscle damage: a calculated and controlled response following hindlimb unloading and reloading, , American journal of physiology. Regulatory, integrative and comparative physiology, 2008, 10.1152/ajpregu.90318.2008
  • Inflammatory cells do not decrease the ultimate tensile strength of intact tendons in vivo and in vitro: protective role of mechanical loading, , Journal of applied physiology (Bethesda, Md. : 1985), 2007, 10.1152/japplphysiol.00162.2006
  • Thrombocytopenia alters early but not late repair in a mouse model of Achilles tendon injury, , Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2009, 10.1111/j.1524-475X.2009.00467.x
  • Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength, , The Journal of cell biology, 2014, 10.1083/jcb.201310035
  • Macrophage colony-stimulating factor-induced macrophage differentiation promotes regrowth in atrophied skeletal muscles and C2C12 myotubes, , The American journal of pathology, 2013, 10.1016/j.ajpath.2012.10.010
  • Buruli ulcer - beyond the skin, impact on skeletal muscle, , Medecine sciences : M/S, 2011, 10.1051/medsci/2011272187
  • Statin intolerance and associated muscular dysfunctions, , Medecine sciences : M/S, 2015, 10.1051/medsci/20153112014
  • Nucleoside triphosphate diphosphohydrolase-1 ectonucleotidase is required for normal vas deferens contraction and male fertility through maintaining P2X1 receptor function, , The Journal of biological chemistry, 2014, 10.1074/jbc.M114.604082
  • Serum vitamin C and spinal pain: a nationwide study, , Pain, 2016, 10.1097/j.pain.0000000000000671
  • A 12-Week Exercise Program for Pregnant Women with Obesity to Improve Physical Activity Levels: An Open Randomised Preliminary Study, , PloS one, 2015, 10.1371/journal.pone.0137742
  • Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles, , American journal of physiology. Cell physiology, 2016, 10.1152/ajpcell.00285.2015
  • Inflammation and muscle regeneration, a double-edged sword, , Medecine sciences : M/S, 2016, 10.1051/medsci/20163206022
  • Vitamin C is not the Missing Link Between Cigarette Smoking and Spinal Pain, , Spine, 2018, 10.1097/BRS.0000000000002466
  • A short-term statin treatment changes the contractile properties of fast-twitch skeletal muscles, , BMC musculoskeletal disorders, 2016, 10.1186/s12891-016-1306-2
  • Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis, , Journal of neurotrauma, 2018, 10.1089/neu.2017.5013
  • The Association Between Self-Reported Cigarette Smoking and Spinal Pain is Not Explained by Serum Cotinine Levels, , Annals of epidemiology, 2022, 10.1016/j.annepidem.2021.12.006
  • Detection of S-100β Protein in Plasma and Urine After a Mild Traumatic Brain Injury, , The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2019, 10.1017/cjn.2019.61
  • Increased endothelial cell expression of platelet-endothelial cell adhesion molecule-1 during hyperoxic lung injury, , American journal of respiratory cell and molecular biology, 1998, 10.1165/ajrcmb.19.4.2349
  • Accumulation of PDGF+ cells and internalisation of the PDGF receptor at myotendinous junction following modified hindlimb muscle use in the rat, , Journal of anatomy, 2000, 10.1046/j.1469-7580.2000.19620211.x
  • Modulation of structural protein content of the myotendinous junction following eccentric contractions, , International journal of sports medicine, 2000, 10.1055/s-2000-3774
  • Subcutaneous injection of Mycobacterium ulcerans causes necrosis, chronic inflammatory response and fibrosis in skeletal muscle, , Microbes and infection, 2008, 10.1016/j.micinf.2008.07.041
  • Pifithrin-alpha, an inhibitor of p53 transactivation, alters the inflammatory process and delays tendon healing following acute injury, , American journal of physiology. Regulatory, integrative and comparative physiology, 2007, 10.1152/ajpregu.00411.2005
  • Periodic direct current does not promote wound closure in an in vitro dynamic model of cell migration, , Physical therapy, 2006, 10.1093/ptj/86.1.50
  • Inhibition of JAK-STAT signaling stimulates adult satellite cell function, , Nature medicine, 2014, 10.1038/nm.3655
  • Macrophage depletion reduces cell proliferation and extracellular matrix accumulation but increases the ultimate tensile strength of injured Achilles tendons, , Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014, 10.1002/jor.22504
  • Laminin-111: a potential therapeutic agent for Duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.165
  • Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness, , Skeletal muscle, 2017, 10.1186/s13395-016-0119-1
  • Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM, , Journal of neurophysiology, 2016, 10.1152/jn.00556.2015
  • Physiological role of receptor activator nuclear factor-kB (RANK) in denervation-induced muscle atrophy and dysfunction, , Receptors & clinical investigation, 2016, 10.14800/rci.1323
  • Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice, , PloS one, 2018, 10.1371/journal.pone.0198408
  • Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice, , Human molecular genetics, 2020, 10.1093/hmg/ddz312
  • Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review, , Brain injury, 2018, 10.1080/02699052.2017.1385097
  • S100B protein level for the detection of clinically significant intracranial haemorrhage in patients with mild traumatic brain injury: a subanalysis of a prospective cohort study, , Emergency medicine journal : EMJ, 2021, 10.1136/emermed-2020-209583

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Zineb Bouredji - Doctorat - En cours
  • Anthony Facchin - Doctorat - En cours
  • Mélissa De la Durantaye - Maîtrise avec mémoire - 2013/05
  • Rachelle Gosselin - Maîtrise avec mémoire - 2015/01
  • Antoine Boulanger Piette - Maîtrise avec mémoire - 2015/01
  • Sébastien Dufresne - Maîtrise avec mémoire - 2016/01
  • Dounia Hamoudi - Doctorat - 2021/05
  • Laetitia Marcadet - Doctorat - 2023/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.