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Jean-Philippe Lambert

Professeur agrégé

Jean-Philippe Lambert
jean-philippe.lambert.2@ulaval.ca
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Signalisation cellulaire et cancer
Génomique et protéomique
  • Mécanismes biologiques et biochimiques
  • Protéomique fonctionnelle et structurale
Organisation et fonctions biologiques

Projets de recherche

  • Chromatin structure and function as a readout of physical interactions - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2024-04-01 au 2029-03-31
  • Étude des interactions bromodomain-dépendantes et de leurs impacts sur le cycle de transcription - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2022-07-01 au 2026-06-30
  • Mitochondria bound to lipid droplets as new regulators of insulin resistance - Diabète Canada - Subvention de fonctionnement : Mettre fin au diabète prix 2022, co-chercheur - 2022-12-01 au 2025-11-30
  • Elucidation of bromodomain functions within SWI/SNF complexes - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Tetrahymena thermophila - un model évolutionnaire divergent pour découvrir de nouveau modes de régulation transcriptionnelle - Conseil de recherches en sciences naturelles et génie Canada, Fonds de recherche du Québec - Nature et technologies - Programme NOVA- FRQNT-CRSNG pour chercheurs et chercheuses en début de carrière (PILOTE), chercheur principal - 2022-03-15 au 2025-03-14
  • Structural characterization of full-length BET proteins and their functional implications to cancer - Société de recherche sur le cancer - Subvention de fonctionnement, chercheur principal - 2022-09-01 au 2024-08-31
  • TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
  • Caractérisation du protéome mitochondrial de la prostate - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, co-chercheur - 2022-09-21 au 2023-03-31
  • Investigating TBC1D9 therapeutic potential for triple negative breast cancer - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, chercheur principal - 2022-09-21 au 2023-03-31
  • Predict to prevent: Advanced proteomics profiling for precision medicine - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), co-chercheur - 2021-03-23 au 2022-09-30
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma - Société de recherche sur le cancer, Génome Québec - Subvention de fonctionnement, chercheur principal - 2020-09-01 au 2022-08-31
  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2018-07-01 au 2022-06-30
  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2018-07-01 au 2022-06-30
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-06-01 au 2022-05-31
  • COVID19 persistent symptomatology: an investigation of the metabolomic and proteomic underpinning - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-06-01 au 2022-05-31
  • Salaire d'un professeur sous octroi - CHU de Québec – Université Laval – CHUL, chercheur principal - 2017-05-01 au 2022-04-30
  • Characterization of the scaffolding roles of bromodomain containing proteins at the level of chromatin - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31

Publications

  • Mapping physical interactions within chromatin by proteomic approaches, Gingras, A.-C., Pawson, T., Lambert, J.-P., Proteomics, 2012, 10.1002/pmic.201100547
  • Proteomics investigation of bromodomains functional roles in SWI/SNF complexes, , 11th annual symposium of the Canadian National Proteomics Network, 2019
  • Data Independent Acquisition analysis in ProHits 4.0, Gingras, A.-C., Choi, H., Nesvizhskii, A.I., Bandeira, N., Raught, B., Tyers, M., Larsen, B., Lambert, J.-P., Wang, J., Tsou, C.-C., Zhang, J.P., Knight, J.D.R., Liu, G., Journal of Proteomics, 2016, 10.1016/j.jprot.2016.04.042
  • Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition, Gingras, A.-C., Tate, S., Bonner, R., Pawson, T., Aebersold, R., Vidal, M., Lindquist, S., Zhong, Q., Lin, Z.-Y., Taipale, M., Larsen, B., Couzens, A.L., Ivosev, G., Lambert, J.-P., Nature Methods, 2013, 10.1038/nmeth.2702
  • Proteomics: From gel based to gel free, Figeys, D., Smith, J.C., Ethier, M., Lambert, J.-P., Analytical Chemistry, 2005, 10.1021/ac050586d
  • A New Look at Protein Complexes; A Modified Chromatin Immunopurifcation Approach Applied to the Study of Histone Htz1 and Yta7, , 50th Canadian Society of Biochemistry, Molecular and Cellular Biology conference, 2007
  • The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila, Fillingham, J., Pearlman, R.E., Gingras, A.-C., Thuppu Mudalige, C., Burtch, A., Ponce, M., Nabeel-Shah, S., Lambert, J.-P., Garg, J., Saettone, A., Epigenetics and Chromatin, 2018, 10.1186/s13072-018-0180-6
  • Molecular dissection of the mode of resistance to BET bromodomain inhibitors in melanoma, , 5th Canadian Cancer Research Conference, 2019
  • Functional proteomics characterization of the human acetyl lysine machinery, , The 3rd Canadian Conference on Epigenetics. Epigenomics in Development and Disease, 2016
  • Measurement and analysis of lysine acetylation by KAT complexes in vitro and in vivo, Côté, J., Lambert, J.-P., Lashgari, A., Methods in Molecular Biology, 2019, 10.1007/978-1-4939-9434-2_5
  • The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation, Fillingham, J., Pearlman, R.E., Lambert, J.-P., Greenblatt, J., Pu, S., Marquez, S., Ponce, M., Cadorin, M., Nabeel-Shah, S., Saettone, A., Garg, J., Current Biology, 2019, 10.1016/j.cub.2019.06.052
  • The tale of two domains: Proteomics and genomics analysis of SMYD2, a new histone methyltransferase, Figeys, D., Skerjanc, I.S., Elisma, F., Al-Madhoun, A.S., Lambert, J.-P., Abu-Farha, M., Molecular and Cellular Proteomics, 2008, 10.1074/mcp.M700271-MCP200
  • Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains, Gingras, A.-C., Filippakopoulos, P., Wilson, M.D., Bandeira, N., Pelletier, L., Stucki, M., Newman, J.A., St-Denis, N., Gonzalez-Badillo, B., Knight, J.D.R., Tucholska, M., Lin, Z.-Y., Abdouni, H., Gupta, G.D., Uusküla-Reimand, L., Savitsky, P., Hou, H., Fujisawa, T., Picaud, S., Lambert, J.-P., Molecular Cell, 2019, 10.1016/j.molcel.2018.11.006
  • Two-Color Cell Array Screen Reveals Interdependent Roles for Histone Chaperones and a Chromatin Boundary Regulator in Histone Gene Repression, Andrews, B.J., Greenblatt, J., Hughes, T.R., Figeys, D., Nislow, C., Peña-Castillo, L., Tsui, K., van Bakel, H., Lambert, J.-P., Kainth, P., Fillingham, J., Molecular Cell, 2009, 10.1016/j.molcel.2009.06.023
  • Systematic proteomic study of the human acetylome components, , 13th International conference on Systems Biology, 2012
  • AIRE is a critical spindle-associated protein in embryonic stem cells, Rossant, J., Gingras, A.-C., Cockburn, K., Lambert, J.-P., Gu, B., eLife, 2017, 10.7554/eLife.28131
  • Losing a BET in the nucleolus – unexpected consequences of bromodomain inhibition, , 6th annual Canadian National Proteomics Network, 2014
  • Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein, Andrews, B.J., Fillingham, J., Figeys, D., Nislow, C., Kainth, P., Friesen, H., Kaluarachchi, S., van Bakel, H., Tsui, K., van Dyk, D., Lambert, J.-P., Kurat, C.F., Genes and Development, 2011, 10.1101/gad.173427.111
  • Revisiting the budding yeast protein interactome: histones, their chaperones and beyond, , 2009 Progress in Systems Biology Symposium, 2009
  • A Targeted Proteomic Approach for the Study of the Human Acetylome, , 4th annual Canadian National Proteomics Network. , 2012
  • Déployer des nouveaux outils de biotinylation de proximité pour disséquer les modes de résistance aux inhibiteurs de bromodomaines de la famille BET chez les mélanomes, , 23è journée scientifique des étudiants du CRC, 2019
  • Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling, Pawson, T., Iscove, N.N., Gingras, A.-C., Dick, J.E., Minden, M.D., Herrington, R., Milyavsky, M., Adissu, H.A., Lambert, J.-P., Kofler, M.M., Jin, J., Gish, G., Ruston, J., Frelin, C., Louria-Hayon, I., Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1319665110
  • Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2, Leach, M.D., Cowen, L.E., Khalimonchuk, O., Gingras, A.-C., Lambert, J.-P., Wong, E.O.Y., Bohovych, I., Xie, J.L., Microbial Cell, 2017, 10.15698/mic2017.10.594
  • Defining the budding yeast chromatin-associated interactome, Figeys, D., Baetz, K., Greenblatt, J., Siahbazi, M., Fillingham, J., Lambert, J.-P., Molecular Systems Biology, 2010, 10.1038/msb.2010.104
  • Proteomics investigation of bromodomain functions within SWI/SNF complexes, , 23è journée scientifique des étudiants du CRC, 2019
  • Proteomics contribution to the elucidation of the steroid hormone receptors functions, Lambert, J.-P., Agbo, L., Journal of Steroid Biochemistry and Molecular Biology, 2019, 10.1016/j.jsbmb.2019.105387
  • Use of data dependent and independent mass spectrometry acquisition for the systematic study of the human acetylome components, , 9th annual US HUPO meeting, 2013
  • BETting on the therapeutic modulation of the epigenome – a systematic proteomic study of the acetylome components, , 2013 Chromatin Structure & Function conference, 2013
  • Histone recognition and large-scale structural analysis of the human bromodomain family, Knapp, S., Arrowsmith, C.H., Gingras, A.-C., Pawson, T., Müller, S., Volkmer, R., Felletar, I., Barsyte-Lovejoy, D., Lambert, J.-P., Keates, T., Mangos, M., Picaud, S., Filippakopoulos, P., Cell, 2012, 10.1016/j.cell.2012.02.013
  • Systematic study of human bromodomain specificity, , 55th annual meeting of the Canadian Society for Molecular BioSciences, 2012
  • A Novel Approach for the Analysis of Histone H2A and Htz1 Interaction Partners by Modified Chromatin Immunoprecipitation and Mass Spectrometry, , 5th Annual World Congress Human Proteome Organization (HUPO), 2006
  • Proximity biotinylation and CRISPR-Cas9, two approaches working together for defining the chromatin environment at specific genomic locus, , 23è journée scientifique des étudiants du CRC, 2019
  • Large-scale mapping of human protein-protein interactions by mass spectrometry, Figeys, D., Topaloglou, T., Morin, G.B., Moran, M.F., Adams, S.-L., Kinach, R., Muskat, B., Gladwish, K., Colwill, K., Hogue, K., Kuehl, B., Stewart, I.I., Duewel, H.S., Lambert, J.-P., Abu-Farha, M., Vasilescu, J., Sheng, Y., Ethier, M., Bukhman, Y.V., Ornatsky, O., Zhang, S., Moore, L., Heilbut, A., Ho, Y., Dharsee, M., Taylor, R., Li, M., O'Connor, L., Robinson, M.D., McBroom-Cerajewski, L., Climie, S., Taylor, P., Li, H., Elisma, F., Chu, P., Ewing, R.M., Molecular Systems Biology, 2007, 10.1038/msb4100134
  • Functional proteomics characterization of the human acetyl lysine machinery, , 3rd Canadian Conference on Epigenetics. Epigenomics in Development and Disease, 2016
  • Exploring the rewiring of BET protein interactome following bromodomain inhibition, , 10th annual symposium of the Canadian National Proteomics Network, 2018
  • S-nitrosation of disulfide-reduced oxytocin studied by mass spectrometry, , 87th Canadian Society for Chemistry Conference and Exhibition, 2004
  • Molecular dissection of the mode of resistance to BET bromomdomain inhibitors in melanoma, , 11th annual symposium of the Canadian National Proteomics Network, 2019
  • Using ProHits to store, annotate, and analyze Affinity purification-mass spectrometry (AP-MS) Data, Gingras, A.-C., Tyers, M., Raught, B., Nesvizhskii, A.I., Larsen, B., Lambert, J.-P., Srikumar, T., Zhang, J., Choi, H., Liu, G., Current Protocols in Bioinformatics, 2012, 10.1002/0471250953.bi0816s39
  • Targeted proteomics analyses of phosphorylation-dependent signalling networks, Bisson, N., Lambert, J.-P., Dionne, U., Banerjee, S.L., Journal of Proteomics, 2018, 10.1016/j.jprot.2018.02.004
  • Myosin phosphatase modulates the cardiac cell fate by regulating the subcellular localization of Nkx2.5 in a Wnt/rho-associated protein kinase-dependent pathway, Skerjanc, I.S., Puri, P.L., Figeys, D., Ruel, M., Boisvenue, S., Malecova, B., Lambert, J.-P., Shelton, M., Ryan, T., Circulation Research, 2013, 10.1161/CIRCRESAHA.112.275818
  • Dual action antifungal small molecule modulates multidrug efflux and TOR signaling, ECowen, L., Gunatilaka, A., Heitman, J., Gingras, A.-C., Coccetti, P., Nislow, C., Andes, D., Sanglard, D., PRoth, F., Loewith, R.J., Schmitt, L., Niewola-Staszkowska, K., Döhl, K., Ammar, R., Tripodi, F., Bahn, Y.-S., Kim, T., Lee, S.C., Averette, A.F., Lambert, J.-P., Wijeratne, E.M.K., Gunaherath, G.M.K.B., Shekhar-Guturja, T., Nature Chemical Biology, 2016, 10.1038/nchembio.2165
  • A Novel Approach for the Analysis of Histone H2A and Htz1 Interaction Partners by Modified Chromatin Immunoprecipitation and Mass Spectrometry, , 2nd Annual Progress in Systems Biology at Ottawa, 2006
  • Revisiting the budding yeast protein interactome: histones, their chaperones and beyond, , 2009 Progress in Systems Biology Symposium, 2009
  • Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity, Baetz, K., Figeys, D., Skerjanc, I.S., Al-Madhoun, A.S., Gerdes, M., Lambert, J.-P., Mitchell, L., Molecular and Cellular Biology, 2008, 10.1128/MCB.01653-07
  • MSPLIT-DIA: Sensitive peptide identification for data-independent acquisition, Bandeira, N., Gingras, A.-C., Larsen, B., Tate, S., Lambert, J.-P., Knight, J.D.R., Tucholska, M., Wang, J., Nature Methods, 2015, 10.1038/nmeth.3655
  • Exploring the rewiring of BET protein interactome following bromodomain inhibition, , 10th annual symposium of the Canadian National Proteomics Network, 2018
  • Functional interplay within the BET protein family impacts cell growth, , 8th Annual CNPN Symposium on proteomic advances in health and diseases, 2016
  • Using proximity biotinylation at defined genomic locus to investigate the scaffolding roles of bromodomain containing proteins, , Journée de la recherche du CHU de Québec – Université Laval 2019, 2019
  • Machine learning analysis identifies genes differentiating triple negative breast cancers, Durocher, F., Diorio, C., Lambert, J.-P., Corbeil, J., Laviolette, F., Déraspe, M., Ouellette, G., Agbo, L., Osseni, M.A., Kothari, C., Scientific Reports, 2020, 10.1038/s41598-020-67525-1
  • Analysis of low-abundance proteins using the proteomic reactor with pH fractionation, Figeys, D., Tian, R., Lambert, J.-P., Hou, W., Zhou, H., Talanta, 2010, 10.1016/j.talanta.2009.07.018
  • Étude fonctionnelle des protéines à bromodomonaines des complexes SWI/SNF, , Journée de la recherche du CHU de Québec – Université Laval, 2019
  • New ammunition for the proteomic reactor: Strong anion exchange beads and multiple enzymes enhance protein identification and sequence coverage, Figeys, D., Lambert, J.-P., Hou, W., Zhou, H., Analytical and Bioanalytical Chemistry, 2010, 10.1007/s00216-010-3791-8
  • Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination, Côté, J., Couture, J.-F., Sugiyama, T., Verreault, A., Gingras, A.-C., Brunzelle, J.S., Tremblay, V., Chen, Y., Lambert, J.-P., Li, J., Billon, P., Molecular Cell, 2017, 10.1016/j.molcel.2016.10.033
  • JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage, Canitrot, Y., Trouche, D., Cote, J., Lambert, J.-P., Loehr, J., Jang, S.-M., Humbert, J., Chailleux, C., Fages, J., PLoS Genetics, 2020, 10.1371/journal.pgen.1008511
  • Regulation of septin dynamics by the saccharomyces cerevisiae lysine acetyltransferase NuA4, Baetz, K., Figeys, D., Couture, J.-F., Fong, Y., Zhou, H., Lambert, J.-P., Lau, A., Mitchell, L., PLoS ONE, 2011, 10.1371/journal.pone.0025336
  • Progress toward the therapeutic modulation of the human acetylome, , 2013 Scientific Retreat of the Lunenfeld-Tanenbaum Research Institute, 2013
  • SAINTq: Scoring protein-protein interactions in affinity purification – mass spectrometry experiments with fragment or peptide intensity data, Choi, H., Gingras, A.-C., Knight, J.D.R., Lambert, J.-P., Fermin, D., Koh, H., Teo, G., Proteomics, 2016, 10.1002/pmic.201500499
  • A novel proteomics approach for the discovery of chromatinassociated protein networks, Figeys, D., Baetz, K., Rudner, A., Mitchell, L., Lambert, J.-P., Molecular and Cellular Proteomics, 2009, 10.1074/mcp.M800447-MCP200
  • Functional proteomics characterization of epigenetics regulators involved in melanoma, , Melanoma: From Basic Science to Clinical Applications, 2015
  • Large-Scale Proteomics Characterization of the Budding Yeast Chromatin by mChIP, , 8th annual world congress of the human proteome organization (HUPO), 2009
  • The Identification of Nuclear FMRP Isoform Iso6 Partners, Rachid Mazroui, Jean-Philippe Lambert, Pauline Adjibade, Samer Hussein, Alexandre Simard, Emeline I. J. Lelong, Nassim Ledoux, Cells, 2023, 10.3390/cells12242807
  • Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry, Figeys, D., Smith, J.C., Lambert, J.-P., Vasilescu, J., Denis, N.J., Proteomics, 2007, 10.1002/pmic.200600410
  • Physical Interplay Between Histone H3/H4 Chaperones Revealed Through mChIP Characterization of Chromatin in Budding Yeast, , Chromatin Structure & Function, 2009
  • Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor, Baetz, K., Bryan, J., Bennett, S.A.L., Figeys, D., Ahmed, F., Swayne, L.A., Lambert, J.-P., Kabbani, N., Kennedy, M.A., PLoS Genetics, 2011, 10.1371/journal.pgen.1001299
  • A Novel Approach for the Analysis of Chromatin Bound Protein Complex Applied to the Study of Htz1p and Yta7p, , 50th Canadian Society of Biochemistry, Molecular and Cellular Biology conference, 2007
  • Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia, Filippakopoulos, P., Knapp, S., Vassiliou, G., Schwaller, J., Gingras, A.-C., Samsonova, A., Muller, S., Brennan, P., Ley, S.V., Ingham, R., Guetzoyan, L., Nikbin, N., Tallant, C., Lingard, H., Wang, C.-Y., Fujisawa, T., Monteiro, O., Fedorov, O., Wells, C., Dovey, O., Lambert, J.-P., Leonards, K., Picaud, S., Science Advances, 2016, 10.1126/sciadv.1600760
  • Betting on the therapeutic modulation of the epigenome – a systematic proteomic study of the acetylome components, , 2nd Canadian Conference on Epigenetics: Epigenetics, Eh!, 2014
  • (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells, Arrowsmith, C.H., Vedadi, M., Zaph, C., Owen, D.R., Bunnage, M.E., Brown, P.J., Sudol, M., Rossi, F.M.V., Braam, M.J.S., Grimley, R.L., Benn, C.L., Roberts, L., Gerstenberger, B.S., Fish, P.V., Al-Awar, R., Gingras, A.-C., Aman, A., Couzens, A.L., Lambert, J.-P., Kennedy, S., Allali-Hassani, A., Marcellus, R., Kuznetsova, E., Senisterra, G.A., Schapira, M., Freeman, S.A., Wu, H., Zeng, H., Dong, A., Tatlock, J.H., Oudhoff, M.J., Li, F., Barsyte-Lovejoy, D., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1407358111
  • The CRAPome: A contaminant repository for affinity purification-mass spectrometry data, Nesvizhskii, A.I., Gingras, A.-C., Ewing, R.M., Raught, B., Washburn, M.P., Bennett, K.L., Cristea, I.M., Mohammed, S., Gstaiger, M., Choi, H., Heck, A.J.R., Colinge, J., Superti-Furga, G., Aebersold, R., Coulombe, B., Durocher, D., Pawson, T., Badillo, B.G., Lin, Z.-Y., Goudreault, M., Dunham, W.H., Fermin, D., Faubert, D., Bouchard, A., Al-Hakim, A., Hubner, N.C., Bagshaw, R.D., Halim, V.A., Low, T.Y., Sardiu, M.E., Hauri, S., Miteva, Y.V., Li, T., St-Denis, N.A., Lambert, J.-P., Couzens, A.L., Wright, Z., Mellacheruvu, D., Nature Methods, 2013, 10.1038/nmeth.2557
  • Invesitgation fonctionnelle des sous-unités à bromodomaines des complexes SWI/SNF chez l’humain, , 24è journée scientifique des étudiants du CRC, 2020
  • Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging, Poirier, D., Lambert, J.-P., Barbeau, X., Roy, J., Ngueta Djiemeny, A., Maltais, R., Bioorganic and Medicinal Chemistry, 2020, 10.1016/j.bmc.2020.115368
  • Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila, Fillingham, J., Pearlman, R.E., Lambert, J.-P., Derynck, J., Garg, J., Saettone, A., Ashraf, K., Nabeel-Shah, S., Scientific Reports, 2020, 10.1038/s41598-019-56867-0
  • Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes, Gingras, A.-C., Knight, J.D.R., Go, C., Tucholska, M., Lambert, J.-P., Journal of Proteomics, 2015, 10.1016/j.jprot.2014.09.011
  • Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching, Müller, S., Knapp, S., Gingras, A.-C., Burgess-Brown, N.A., Strain-Damerell, C., Lambert, J.-P., Wells, C., Yapp, C., Rogers, C.M., Philpott, M., Epigenetics and Chromatin, 2014, 10.1186/1756-8935-7-14
  • Stir bar sorptive extraction based on restricted access material for the direct extraction of caffeine and metabolites in biological fluids, Dieter Lubda, Elizabeth Kwong, Wayne M. Mullett, Jean-Philippe Lambert, Journal of Chromatography A, 2005, 10.1016/j.chroma.2005.03.119
  • Proteomics in 2005/2006: Developments, applications and challenges, Figeys, D., Elisma, F., Lambert, J.-P., Smith, J.C., Analytical Chemistry, 2007, 10.1021/ac070741j
  • Of proteins and DNA - Proteomic role in the field of chromatin research, Figeys, D., Baetz, K., Lambert, J.-P., Molecular BioSystems, 2009, 10.1039/b907925b
  • Emerging tools to investigate bromodomain functions, Lambert, J.-P., Filippakopoulos, P., Kougnassoukou Tchara, P.-E., Methods, 2020, 10.1016/j.ymeth.2019.11.003
  • Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7, Sicheri, F., Durocher, D., Gingras, A.-C., Caudy, A.A., Laister, R., Huang, H., Manczyk, N., Ng, T.F., Lambert, J.-P., Szilard, R.K., Maisonneuve, P., Wan, L.C.K., Nucleic Acids Research, 2017, 10.1093/nar/gkw1181
  • Functional proteomics of nuclear proteins in Tetrahymena thermophila: A review, Fillingham, J., Pearlman, R.E., Lambert, J.-P., Garg, J., Nabeel-Shah, S., Saettone, A., Genes, 2019, 10.3390/genes10050333
  • Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution, Goding, C.R., Mazza, D., Steingrímsson, E., Wilmanns, M., Lambert, J.-P., Davidson, I., Patton, E.E., Lu, X., Middleton, M., Filippakopoulos, P., Schuster-Böckler, B., Thomas, B., Suer, E., Lisle, R., Freter, R., Strub, T., Lu, M., Zeng, Z., Schepsky, A., Friedrichsen, H., Pogenberg, V., Loffreda, A., Siddaway, R., Louphrasitthiphol, P., Molecular Cell, 2020, 10.1016/j.molcel.2020.05.025
  • Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners, Gingras, A.-C., Pawson, T., Tucholska, M., Lambert, J.-P., Journal of Proteomics, 2014, 10.1016/j.jprot.2013.12.022
  • Étude fonctionnelle des protéines à bromodomonaines des complexes SWI/SNF, , Séminaires Étudiants de l’axe endocrinologie et néphrologie, 2019
  • Conserved Asf1-importin β physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila, Fillingham, J.S., Pearlman, R.E., Gingras, A.-C., Pawson, T., Radovani, E., Retnasothie, D.V., Bertucci, V., Nabeel-Shah, S., Marquez, S., Karsou, A., Lambert, J.-P., Garg, J., Journal of Proteomics, 2013, 10.1016/j.jprot.2013.09.018
  • Analysis of protein interaction networks using mass spectrometry compatible techniques, Figeys, D., Vasilescu, J., Lambert, J.-P., Ethier, M., Analytica Chimica Acta, 2006, 10.1016/j.aca.2005.12.046
  • Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin, Filippakopoulos, P., Gingras, A.-C., Strahl, B.D., Samsonova, A., Schapira, M., Goding, C., Kanapin, A., Friedrichsen, H., Krajewski, K., Shanle, E.K., Wang, C.-Y., Picaud, S., Lambert, J.-P., Fujisawa, T., Krojer, T., Savitsky, P., Cell Reports, 2016, 10.1016/j.celrep.2016.11.014
  • Toward a System View of Acetyl Lysine Signaling, , 2011 Scientific Retreat of the Lunenfeld-Tanenbaum Research Institute, 2011
  • Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation, Knapp, S., Birnbaum, M.J., Odgren, P.R., Gingras, A.C., Müller, S., Brennan, P.E., Buffa, F., Oppermann, U.C.T., Haendler, B., Bayle, E.D., Igoe, N.M., Fish, P.V., Owen, D.R., Daniels, D.L., Heidenreich, D., Savitsky, P., Fedele, V., Gerstenberger, B.S., Yapp, C., Rogers, C., Lambert, J.-P., Van Stiphout, R.G., Hwang, S.-Y., Witwicka, H., Fedorov, O., Tallant, C., Meier, J.C., ACS Chemical Biology, 2017, 10.1021/acschembio.7b00481
  • The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation, Côté, J., Durocher, D., Doyon, Y., Legube, G., Pandita, T.K., Gingras, A.-C., Herst, P., Paquet, E., Pandita, R.K., Roques, C., Lambert, J.-P., Avvakumov, N., Fradet-Turcotte, A., Jacquet, K., Molecular Cell, 2016, 10.1016/j.molcel.2016.03.031
  • A Novel Proteomic Approach to Chromatin Immunopurification Uncovers a Role for Yta7 in DNA Damage Response, , Chromatin Structure & Function 2007, 2007
  • BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation, Groth, A., Côté, J., Gingras, A.-C., Yang, X.-J., Paquet, E., Johansen, J.V., Alabert, C., Zhao, X., Lee, S.-B., Lambert, J.-P., González-Aguilera, C., Lalonde, M.-E., Roques, C., Vlassis, A., Feng, Y., EMBO Journal, 2016, 10.15252/embj.201591293
  • CRISPR-based tools to interrogate a locus-specific proteome, , Séminaires Étudiants de l’axe endocrinologie et néphrologie, 2019
  • Exploring the yeast acetylome using functional genomics, Andrews, B., Figeys, D., Chong, Y.T., Lambert, J.-P., Baryshnikova, A., Friesen, H., Kaluarachchi Duffy, S., Cell, 2012, 10.1016/j.cell.2012.02.064
  • Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation, Andrews, B., Fillingham, J., Gingras, A.-C., Rosebrock, A., Pawson, T., Friesen, H., Petschnigg, J., Lambert, J.-P., Kurat, C.F., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1414024111
  • Yta7, a New Player in Saccharomyces Cerevisiae DNA Damage Response, , 51st Annual Meeting of the Canadian Society of Biochemistry and Molecular & Cellular Biology, 2008
  • Using proximity biotinylation at defined genomic locus to investigate the scaffolding roles of bromodomain containing proteins, , 11th annual symposium of the Canadian National Proteomics Network, 2019
  • Development of a multiplexed microfluidic proteomic reactor and its application for studying protein-protein interactions, Figeys, D., Veres, T., Pezacki, J.P., Lambert, J.-P., Hoa, X.D., Tian, R., Analytical Chemistry, 2011, 10.1021/ac200194d
  • Proteomic Analysis of Histones H2A/H2B and Variant Hv1 in Tetrahymena thermophila Reveals an Ancient Network of Chaperones, Fillingham, J., Pearlman, R.E., Lambert, J.-P., Gingras, A.-C., Derynck, J., Saettone, A., Garg, J., Nabeel-Shah, S., Ashraf, K., Molecular Biology and Evolution, 2019, 10.1093/molbev/msz039
  • MChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases, Baetz, K., Figeys, D.A., Côté, J., Basu, A., Ning, Z., Zhou, H., Lambert, J.-P., Hamza, A., Steunou, A.-L., Pourhanifeh-Lemeri, R., Cotrut, M., Huard, S., Mitchell, L., Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1218515110
  • BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma, Goding, C.R., Falletta, P., Larue, L., Masson, J.-Y., Gingras, A.-C., Middleton, M.R., Roberts, N.D., Chauhan, J., Andrews, S., Suer, E., Sarkar, S., Robles-Espinoza, C.D., Sesma-Sanz, L., Kalkavan, H., Louphrasitthiphol, P., Lambert, J.-P., Binet, R., Herbert, K., Genes and Development, 2019, 10.1101/gad.314633.118
  • Large-Scale Proteomics Characterization of the Budding Yeast Chromatin by mChIP, , 8th annual world congress of the human proteome organization (HUPO), 2009
  • IRX3/5 regulate mitotic chromatid segregation and limb bud shape, Hopyan, S., Hui, C.-C., Gingras, A.-C., Kawakami, Y., Iulianella, A., Sun, Y., Henkelman, R.M., Garry, D.J., Anderson, G., Chen, X.X., Gong, W., Zhang, X., Puviindran, V., Sturgeon, K., Lau, K., Li, D., Hahn, N.A., Zhu, M., Yung, T.M., Lambert, J.-P., Tao, H., Development (Cambridge, England), 2020, 10.1242/dev.180042

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Naomie Linteau - Doctorat - En cours
  • Sophie Anne Blanchet - Doctorat - En cours
  • Ismaël Saïdi - Maîtrise avec mémoire - En cours
  • Jenifer Espinoza Romero - Maîtrise avec mémoire - En cours
  • Pata-Eting Kougnassoukou Tchara - Doctorat - En cours
  • Lynda Marie Clemence Agbo - Doctorat - 2022/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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