Découvrez nos professeurs et professeures!

Jean-Philippe Lambert

Professeur sous octroi agrégé

Jean-Philippe Lambert
Centre de recherche sur le cancer
Centre de recherche en données massives
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Signalisation cellulaire et cancer
Génomique et protéomique
  • Mécanismes biologiques et biochimiques
  • Protéomique fonctionnelle et structurale
Organisation et fonctions biologiques

Projets de recherche

  • Étude des interactions bromodomain-dépendantes et de leurs impacts sur le cycle de transcription - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2022-07-01 au 2026-06-30
  • Elucidation of bromodomain functions within SWI/SNF complexes - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Tetrahymena thermophila - un model évolutionnaire divergent pour découvrir de nouveau modes de régulation transcriptionnelle - Conseil de recherches en sciences naturelles et génie Canada, Fonds de recherche du Québec - Nature et technologies - Programme NOVA- FRQNT-CRSNG pour chercheurs et chercheuses en début de carrière (PILOTE), chercheur principal - 2022-03-15 au 2025-03-14
  • Predict to prevent: Advanced proteomics profiling for precision medicine - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), co-chercheur - 2021-03-23 au 2022-09-30
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma - Société de recherche sur le cancer, Génome Québec - Subvention de fonctionnement, chercheur principal - 2020-09-01 au 2022-08-31
  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2018-07-01 au 2022-06-30
  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2018-07-01 au 2022-06-30
  • COVID19 persistent symptomatology: an investigation of the metabolomic and proteomic underpinning - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-06-01 au 2022-05-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-06-01 au 2022-05-31
  • Salaire d'un professeur sous octroi - CHU de Québec – Université Laval – CHUL, chercheur principal - 2017-05-01 au 2022-04-30
  • Characterization of the scaffolding roles of bromodomain containing proteins at the level of chromatin - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31
  • Establishment of an infrastructure for functional proteomics studies of cancer - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2018-09-01 au 2021-06-30
  • Elucidation of bromodomain functions within SWI/SNF complexes (Prix) - Instituts de recherche en santé du Canada - Subvention Projet - Annonce de priorités : Prix : Chercheur en début de carrière dans le domaine du cancer, chercheur principal - 2020-03-01 au 2021-02-28

Publications

  • Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging, Maltais, R., Ngueta Djiemeny, A., Roy, J., Barbeau, X., Lambert, J.-P., Poirier, D., Bioorganic and Medicinal Chemistry, 2020, 10.1016/j.bmc.2020.115368
  • Emerging tools to investigate bromodomain functions, Kougnassoukou Tchara, P.-E., Filippakopoulos, P., Lambert, J.-P., Methods, 2020, 10.1016/j.ymeth.2019.11.003
  • Invesitgation fonctionnelle des sous-unités à bromodomaines des complexes SWI/SNF chez l’humain, , 24è journée scientifique des étudiants du CRC, 2020
  • IRX3/5 regulate mitotic chromatid segregation and limb bud shape, Tao, H., Lambert, J.-P., Yung, T.M., Zhu, M., Hahn, N.A., Li, D., Lau, K., Sturgeon, K., Puviindran, V., Zhang, X., Gong, W., Chen, X.X., Anderson, G., Garry, D.J., Henkelman, R.M., Sun, Y., Iulianella, A., Kawakami, Y., Gingras, A.-C., Hui, C.-C., Hopyan, S., Development (Cambridge, England), 2020, 10.1242/dev.180042
  • JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage, Fages, J., Chailleux, C., Humbert, J., Jang, S.-M., Loehr, J., Lambert, J.-P., Cote, J., Trouche, D., Canitrot, Y., PLoS Genetics, 2020, 10.1371/journal.pgen.1008511
  • Machine learning analysis identifies genes differentiating triple negative breast cancers, Kothari, C., Osseni, M.A., Agbo, L., Ouellette, G., Déraspe, M., Laviolette, F., Corbeil, J., Lambert, J.-P., Diorio, C., Durocher, F., Scientific Reports, 2020, 10.1038/s41598-020-67525-1
  • Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila, Nabeel-Shah, S., Ashraf, K., Saettone, A., Garg, J., Derynck, J., Lambert, J.-P., Pearlman, R.E., Fillingham, J., Scientific Reports, 2020, 10.1038/s41598-019-56867-0
  • Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution, Louphrasitthiphol, P., Siddaway, R., Loffreda, A., Pogenberg, V., Friedrichsen, H., Schepsky, A., Zeng, Z., Lu, M., Strub, T., Freter, R., Lisle, R., Suer, E., Thomas, B., Schuster-Böckler, B., Filippakopoulos, P., Middleton, M., Lu, X., Patton, E.E., Davidson, I., Lambert, J.-P., Wilmanns, M., Steingrímsson, E., Mazza, D., Goding, C.R., Molecular Cell, 2020, 10.1016/j.molcel.2020.05.025
  • Molecular dissection of the mode of resistance to BET bromodomain inhibitors in melanoma, , 5th Canadian Cancer Research Conference, 2019
  • Déployer des nouveaux outils de biotinylation de proximité pour disséquer les modes de résistance aux inhibiteurs de bromodomaines de la famille BET chez les mélanomes, , 23è journée scientifique des étudiants du CRC, 2019
  • Proximity biotinylation and CRISPR-Cas9, two approaches working together for defining the chromatin environment at specific genomic locus, , 23è journée scientifique des étudiants du CRC, 2019
  • Étude fonctionnelle des protéines à bromodomonaines des complexes SWI/SNF, , Journée de la recherche du CHU de Québec – Université Laval, 2019
  • Molecular dissection of the mode of resistance to BET bromomdomain inhibitors in melanoma, , 11th annual symposium of the Canadian National Proteomics Network, 2019
  • Proteomics investigation of bromodomains functional roles in SWI/SNF complexes, , 11th annual symposium of the Canadian National Proteomics Network, 2019
  • Using proximity biotinylation at defined genomic locus to investigate the scaffolding roles of bromodomain containing proteins, , Journée de la recherche du CHU de Québec – Université Laval 2019, 2019
  • Using proximity biotinylation at defined genomic locus to investigate the scaffolding roles of bromodomain containing proteins, , 11th annual symposium of the Canadian National Proteomics Network, 2019
  • BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma, Herbert, K., Binet, R., Lambert, J.-P., Louphrasitthiphol, P., Kalkavan, H., Sesma-Sanz, L., Robles-Espinoza, C.D., Sarkar, S., Suer, E., Andrews, S., Chauhan, J., Roberts, N.D., Middleton, M.R., Gingras, A.-C., Masson, J.-Y., Larue, L., Falletta, P., Goding, C.R., Genes and Development, 2019, 10.1101/gad.314633.118
  • CRISPR-based tools to interrogate a locus-specific proteome, , Séminaires Étudiants de l’axe endocrinologie et néphrologie, 2019
  • Étude fonctionnelle des protéines à bromodomonaines des complexes SWI/SNF, , Séminaires Étudiants de l’axe endocrinologie et néphrologie, 2019
  • Functional proteomics of nuclear proteins in Tetrahymena thermophila: A review, Saettone, A., Nabeel-Shah, S., Garg, J., Lambert, J.-P., Pearlman, R.E., Fillingham, J., Genes, 2019, 10.3390/genes10050333
  • Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains, Lambert, J.-P., Picaud, S., Fujisawa, T., Hou, H., Savitsky, P., Uusküla-Reimand, L., Gupta, G.D., Abdouni, H., Lin, Z.-Y., Tucholska, M., Knight, J.D.R., Gonzalez-Badillo, B., St-Denis, N., Newman, J.A., Stucki, M., Pelletier, L., Bandeira, N., Wilson, M.D., Filippakopoulos, P., Gingras, A.-C., Molecular Cell, 2019, 10.1016/j.molcel.2018.11.006
  • Measurement and analysis of lysine acetylation by KAT complexes in vitro and in vivo, Lashgari, A., Lambert, J.-P., Côté, J., Methods in Molecular Biology, 2019, 10.1007/978-1-4939-9434-2_5
  • Proteomic Analysis of Histones H2A/H2B and Variant Hv1 in Tetrahymena thermophila Reveals an Ancient Network of Chaperones, Ashraf, K., Nabeel-Shah, S., Garg, J., Saettone, A., Derynck, J., Gingras, A.-C., Lambert, J.-P., Pearlman, R.E., Fillingham, J., Molecular Biology and Evolution, 2019, 10.1093/molbev/msz039
  • Proteomics contribution to the elucidation of the steroid hormone receptors functions, Agbo, L., Lambert, J.-P., Journal of Steroid Biochemistry and Molecular Biology, 2019, 10.1016/j.jsbmb.2019.105387
  • Proteomics investigation of bromodomain functions within SWI/SNF complexes, , 23è journée scientifique des étudiants du CRC, 2019
  • The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation, Garg, J., Saettone, A., Nabeel-Shah, S., Cadorin, M., Ponce, M., Marquez, S., Pu, S., Greenblatt, J., Lambert, J.-P., Pearlman, R.E., Fillingham, J., Current Biology, 2019, 10.1016/j.cub.2019.06.052
  • Exploring the rewiring of BET protein interactome following bromodomain inhibition, , 10th annual symposium of the Canadian National Proteomics Network, 2018
  • Exploring the rewiring of BET protein interactome following bromodomain inhibition, , 10th annual symposium of the Canadian National Proteomics Network, 2018
  • Targeted proteomics analyses of phosphorylation-dependent signalling networks, Banerjee, S.L., Dionne, U., Lambert, J.-P., Bisson, N., Journal of Proteomics, 2018, 10.1016/j.jprot.2018.02.004
  • The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila, Saettone, A., Garg, J., Lambert, J.-P., Nabeel-Shah, S., Ponce, M., Burtch, A., Thuppu Mudalige, C., Gingras, A.-C., Pearlman, R.E., Fillingham, J., Epigenetics and Chromatin, 2018, 10.1186/s13072-018-0180-6
  • Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination, Billon, P., Li, J., Lambert, J.-P., Chen, Y., Tremblay, V., Brunzelle, J.S., Gingras, A.-C., Verreault, A., Sugiyama, T., Couture, J.-F., Côté, J., Molecular Cell, 2017, 10.1016/j.molcel.2016.10.033
  • AIRE is a critical spindle-associated protein in embryonic stem cells, Gu, B., Lambert, J.-P., Cockburn, K., Gingras, A.-C., Rossant, J., eLife, 2017, 10.7554/eLife.28131
  • Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7, Wan, L.C.K., Maisonneuve, P., Szilard, R.K., Lambert, J.-P., Ng, T.F., Manczyk, N., Huang, H., Laister, R., Caudy, A.A., Gingras, A.-C., Durocher, D., Sicheri, F., Nucleic Acids Research, 2017, 10.1093/nar/gkw1181
  • Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation, Meier, J.C., Tallant, C., Fedorov, O., Witwicka, H., Hwang, S.-Y., Van Stiphout, R.G., Lambert, J.-P., Rogers, C., Yapp, C., Gerstenberger, B.S., Fedele, V., Savitsky, P., Heidenreich, D., Daniels, D.L., Owen, D.R., Fish, P.V., Igoe, N.M., Bayle, E.D., Haendler, B., Oppermann, U.C.T., Buffa, F., Brennan, P.E., Müller, S., Gingras, A.C., Odgren, P.R., Birnbaum, M.J., Knapp, S., ACS Chemical Biology, 2017, 10.1021/acschembio.7b00481
  • Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2, Xie, J.L., Bohovych, I., Wong, E.O.Y., Lambert, J.-P., Gingras, A.-C., Khalimonchuk, O., Cowen, L.E., Leach, M.D., Microbial Cell, 2017, 10.15698/mic2017.10.594
  • Functional proteomics characterization of the human acetyl lysine machinery, , The 3rd Canadian Conference on Epigenetics. Epigenomics in Development and Disease, 2016
  • Functional proteomics characterization of the human acetyl lysine machinery, , 3rd Canadian Conference on Epigenetics. Epigenomics in Development and Disease, 2016
  • Functional interplay within the BET protein family impacts cell growth, , 8th Annual CNPN Symposium on proteomic advances in health and diseases, 2016
  • BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation, Feng, Y., Vlassis, A., Roques, C., Lalonde, M.-E., González-Aguilera, C., Lambert, J.-P., Lee, S.-B., Zhao, X., Alabert, C., Johansen, J.V., Paquet, E., Yang, X.-J., Gingras, A.-C., Côté, J., Groth, A., EMBO Journal, 2016, 10.15252/embj.201591293
  • Data Independent Acquisition analysis in ProHits 4.0, Liu, G., Knight, J.D.R., Zhang, J.P., Tsou, C.-C., Wang, J., Lambert, J.-P., Larsen, B., Tyers, M., Raught, B., Bandeira, N., Nesvizhskii, A.I., Choi, H., Gingras, A.-C., Journal of Proteomics, 2016, 10.1016/j.jprot.2016.04.042
  • Dual action antifungal small molecule modulates multidrug efflux and TOR signaling, Shekhar-Guturja, T., Gunaherath, G.M.K.B., Wijeratne, E.M.K., Lambert, J.-P., Averette, A.F., Lee, S.C., Kim, T., Bahn, Y.-S., Tripodi, F., Ammar, R., Döhl, K., Niewola-Staszkowska, K., Schmitt, L., Loewith, R.J., PRoth, F., Sanglard, D., Andes, D., Nislow, C., Coccetti, P., Gingras, A.-C., Heitman, J., Gunatilaka, A., ECowen, L., Nature Chemical Biology, 2016, 10.1038/nchembio.2165
  • Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin, Savitsky, P., Krojer, T., Fujisawa, T., Lambert, J.-P., Picaud, S., Wang, C.-Y., Shanle, E.K., Krajewski, K., Friedrichsen, H., Kanapin, A., Goding, C., Schapira, M., Samsonova, A., Strahl, B.D., Gingras, A.-C., Filippakopoulos, P., Cell Reports, 2016, 10.1016/j.celrep.2016.11.014
  • Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia, Picaud, S., Leonards, K., Lambert, J.-P., Dovey, O., Wells, C., Fedorov, O., Monteiro, O., Fujisawa, T., Wang, C.-Y., Lingard, H., Tallant, C., Nikbin, N., Guetzoyan, L., Ingham, R., Ley, S.V., Brennan, P., Muller, S., Samsonova, A., Gingras, A.-C., Schwaller, J., Vassiliou, G., Knapp, S., Filippakopoulos, P., Science Advances, 2016, 10.1126/sciadv.1600760
  • SAINTq: Scoring protein-protein interactions in affinity purification – mass spectrometry experiments with fragment or peptide intensity data, Teo, G., Koh, H., Fermin, D., Lambert, J.-P., Knight, J.D.R., Gingras, A.-C., Choi, H., Proteomics, 2016, 10.1002/pmic.201500499
  • The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation, Jacquet, K., Fradet-Turcotte, A., Avvakumov, N., Lambert, J.-P., Roques, C., Pandita, R.K., Paquet, E., Herst, P., Gingras, A.-C., Pandita, T.K., Legube, G., Doyon, Y., Durocher, D., Côté, J., Molecular Cell, 2016, 10.1016/j.molcel.2016.03.031
  • Functional proteomics characterization of epigenetics regulators involved in melanoma, , Melanoma: From Basic Science to Clinical Applications, 2015
  • MSPLIT-DIA: Sensitive peptide identification for data-independent acquisition, Wang, J., Tucholska, M., Knight, J.D.R., Lambert, J.-P., Tate, S., Larsen, B., Gingras, A.-C., Bandeira, N., Nature Methods, 2015, 10.1038/nmeth.3655
  • Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes, Lambert, J.-P., Tucholska, M., Go, C., Knight, J.D.R., Gingras, A.-C., Journal of Proteomics, 2015, 10.1016/j.jprot.2014.09.011
  • Losing a BET in the nucleolus – unexpected consequences of bromodomain inhibition, , 6th annual Canadian National Proteomics Network, 2014
  • (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells, Barsyte-Lovejoy, D., Li, F., Oudhoff, M.J., Tatlock, J.H., Dong, A., Zeng, H., Wu, H., Freeman, S.A., Schapira, M., Senisterra, G.A., Kuznetsova, E., Marcellus, R., Allali-Hassani, A., Kennedy, S., Lambert, J.-P., Couzens, A.L., Aman, A., Gingras, A.-C., Al-Awar, R., Fish, P.V., Gerstenberger, B.S., Roberts, L., Benn, C.L., Grimley, R.L., Braam, M.J.S., Rossi, F.M.V., Sudol, M., Brown, P.J., Bunnage, M.E., Owen, D.R., Zaph, C., Vedadi, M., Arrowsmith, C.H., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1407358111
  • Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching, Philpott, M., Rogers, C.M., Yapp, C., Wells, C., Lambert, J.-P., Strain-Damerell, C., Burgess-Brown, N.A., Gingras, A.-C., Knapp, S., Müller, S., Epigenetics and Chromatin, 2014, 10.1186/1756-8935-7-14
  • Betting on the therapeutic modulation of the epigenome – a systematic proteomic study of the acetylome components, , 2nd Canadian Conference on Epigenetics: Epigenetics, Eh!, 2014
  • Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation, Kurat, C.F., Lambert, J.-P., Petschnigg, J., Friesen, H., Pawson, T., Rosebrock, A., Gingras, A.-C., Fillingham, J., Andrews, B., Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1414024111
  • Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners, Lambert, J.-P., Tucholska, M., Pawson, T., Gingras, A.-C., Journal of Proteomics, 2014, 10.1016/j.jprot.2013.12.022
  • BETting on the therapeutic modulation of the epigenome – a systematic proteomic study of the acetylome components, , 2013 Chromatin Structure & Function conference, 2013
  • Conserved Asf1-importin β physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila, Garg, J., Lambert, J.-P., Karsou, A., Marquez, S., Nabeel-Shah, S., Bertucci, V., Retnasothie, D.V., Radovani, E., Pawson, T., Gingras, A.-C., Pearlman, R.E., Fillingham, J.S., Journal of Proteomics, 2013, 10.1016/j.jprot.2013.09.018
  • Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling, Louria-Hayon, I., Frelin, C., Ruston, J., Gish, G., Jin, J., Kofler, M.M., Lambert, J.-P., Adissu, H.A., Milyavsky, M., Herrington, R., Minden, M.D., Dick, J.E., Gingras, A.-C., Iscove, N.N., Pawson, T., Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1319665110
  • Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition, Lambert, J.-P., Ivosev, G., Couzens, A.L., Larsen, B., Taipale, M., Lin, Z.-Y., Zhong, Q., Lindquist, S., Vidal, M., Aebersold, R., Pawson, T., Bonner, R., Tate, S., Gingras, A.-C., Nature Methods, 2013, 10.1038/nmeth.2702
  • MChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases, Mitchell, L., Huard, S., Cotrut, M., Pourhanifeh-Lemeri, R., Steunou, A.-L., Hamza, A., Lambert, J.-P., Zhou, H., Ning, Z., Basu, A., Côté, J., Figeys, D.A., Baetz, K., Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1218515110
  • Myosin phosphatase modulates the cardiac cell fate by regulating the subcellular localization of Nkx2.5 in a Wnt/rho-associated protein kinase-dependent pathway, Ryan, T., Shelton, M., Lambert, J.-P., Malecova, B., Boisvenue, S., Ruel, M., Figeys, D., Puri, P.L., Skerjanc, I.S., Circulation Research, 2013, 10.1161/CIRCRESAHA.112.275818
  • Progress toward the therapeutic modulation of the human acetylome, , 2013 Scientific Retreat of the Lunenfeld-Tanenbaum Research Institute, 2013
  • The CRAPome: A contaminant repository for affinity purification-mass spectrometry data, Mellacheruvu, D., Wright, Z., Couzens, A.L., Lambert, J.-P., St-Denis, N.A., Li, T., Miteva, Y.V., Hauri, S., Sardiu, M.E., Low, T.Y., Halim, V.A., Bagshaw, R.D., Hubner, N.C., Al-Hakim, A., Bouchard, A., Faubert, D., Fermin, D., Dunham, W.H., Goudreault, M., Lin, Z.-Y., Badillo, B.G., Pawson, T., Durocher, D., Coulombe, B., Aebersold, R., Superti-Furga, G., Colinge, J., Heck, A.J.R., Choi, H., Gstaiger, M., Mohammed, S., Cristea, I.M., Bennett, K.L., Washburn, M.P., Raught, B., Ewing, R.M., Gingras, A.-C., Nesvizhskii, A.I., Nature Methods, 2013, 10.1038/nmeth.2557
  • Use of data dependent and independent mass spectrometry acquisition for the systematic study of the human acetylome components, , 9th annual US HUPO meeting, 2013
  • Systematic proteomic study of the human acetylome components, , 13th International conference on Systems Biology, 2012
  • A Targeted Proteomic Approach for the Study of the Human Acetylome, , 4th annual Canadian National Proteomics Network. , 2012
  • Exploring the yeast acetylome using functional genomics, Kaluarachchi Duffy, S., Friesen, H., Baryshnikova, A., Lambert, J.-P., Chong, Y.T., Figeys, D., Andrews, B., Cell, 2012, 10.1016/j.cell.2012.02.064
  • Histone recognition and large-scale structural analysis of the human bromodomain family, Filippakopoulos, P., Picaud, S., Mangos, M., Keates, T., Lambert, J.-P., Barsyte-Lovejoy, D., Felletar, I., Volkmer, R., Müller, S., Pawson, T., Gingras, A.-C., Arrowsmith, C.H., Knapp, S., Cell, 2012, 10.1016/j.cell.2012.02.013
  • Mapping physical interactions within chromatin by proteomic approaches, Lambert, J.-P., Pawson, T., Gingras, A.-C., Proteomics, 2012, 10.1002/pmic.201100547
  • Systematic study of human bromodomain specificity, , 55th annual meeting of the Canadian Society for Molecular BioSciences, 2012
  • Using ProHits to store, annotate, and analyze Affinity purification-mass spectrometry (AP-MS) Data, Liu, G., Zhang, J., Choi, H., Lambert, J.-P., Srikumar, T., Larsen, B., Nesvizhskii, A.I., Raught, B., Tyers, M., Gingras, A.-C., Current Protocols in Bioinformatics, 2012, 10.1002/0471250953.bi0816s39
  • Development of a multiplexed microfluidic proteomic reactor and its application for studying protein-protein interactions, Tian, R., Hoa, X.D., Lambert, J.-P., Pezacki, J.P., Veres, T., Figeys, D., Analytical Chemistry, 2011, 10.1021/ac200194d
  • Regulation of septin dynamics by the saccharomyces cerevisiae lysine acetyltransferase NuA4, Mitchell, L., Lau, A., Lambert, J.-P., Zhou, H., Fong, Y., Couture, J.-F., Figeys, D., Baetz, K., PLoS ONE, 2011, 10.1371/journal.pone.0025336
  • Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein, Kurat, C.F., Lambert, J.-P., van Dyk, D., Tsui, K., van Bakel, H., Kaluarachchi, S., Friesen, H., Kainth, P., Nislow, C., Figeys, D., Fillingham, J., Andrews, B.J., Genes and Development, 2011, 10.1101/gad.173427.111
  • Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor, Kennedy, M.A., Kabbani, N., Lambert, J.-P., Swayne, L.A., Ahmed, F., Figeys, D., Bennett, S.A.L., Bryan, J., Baetz, K., PLoS Genetics, 2011, 10.1371/journal.pgen.1001299
  • Toward a System View of Acetyl Lysine Signaling, , 2011 Scientific Retreat of the Lunenfeld-Tanenbaum Research Institute, 2011
  • Analysis of low-abundance proteins using the proteomic reactor with pH fractionation, Zhou, H., Hou, W., Lambert, J.-P., Tian, R., Figeys, D., Talanta, 2010, 10.1016/j.talanta.2009.07.018
  • Defining the budding yeast chromatin-associated interactome, Lambert, J.-P., Fillingham, J., Siahbazi, M., Greenblatt, J., Baetz, K., Figeys, D., Molecular Systems Biology, 2010, 10.1038/msb.2010.104
  • New ammunition for the proteomic reactor: Strong anion exchange beads and multiple enzymes enhance protein identification and sequence coverage, Zhou, H., Hou, W., Lambert, J.-P., Figeys, D., Analytical and Bioanalytical Chemistry, 2010, 10.1007/s00216-010-3791-8
  • A novel proteomics approach for the discovery of chromatinassociated protein networks, Lambert, J.-P., Mitchell, L., Rudner, A., Baetz, K., Figeys, D., Molecular and Cellular Proteomics, 2009, 10.1074/mcp.M800447-MCP200
  • Large-Scale Proteomics Characterization of the Budding Yeast Chromatin by mChIP, , 8th annual world congress of the human proteome organization (HUPO), 2009
  • Large-Scale Proteomics Characterization of the Budding Yeast Chromatin by mChIP, , 8th annual world congress of the human proteome organization (HUPO), 2009
  • Of proteins and DNA - Proteomic role in the field of chromatin research, Lambert, J.-P., Baetz, K., Figeys, D., Molecular BioSystems, 2009, 10.1039/b907925b
  • Physical Interplay Between Histone H3/H4 Chaperones Revealed Through mChIP Characterization of Chromatin in Budding Yeast, , Chromatin Structure & Function, 2009
  • Revisiting the budding yeast protein interactome: histones, their chaperones and beyond, , 2009 Progress in Systems Biology Symposium, 2009
  • Revisiting the budding yeast protein interactome: histones, their chaperones and beyond, , 2009 Progress in Systems Biology Symposium, 2009
  • Two-Color Cell Array Screen Reveals Interdependent Roles for Histone Chaperones and a Chromatin Boundary Regulator in Histone Gene Repression, Fillingham, J., Kainth, P., Lambert, J.-P., van Bakel, H., Tsui, K., Peña-Castillo, L., Nislow, C., Figeys, D., Hughes, T.R., Greenblatt, J., Andrews, B.J., Molecular Cell, 2009, 10.1016/j.molcel.2009.06.023
  • Yta7, a New Player in Saccharomyces Cerevisiae DNA Damage Response, , 51st Annual Meeting of the Canadian Society of Biochemistry and Molecular & Cellular Biology, 2008
  • Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity, Mitchell, L., Lambert, J.-P., Gerdes, M., Al-Madhoun, A.S., Skerjanc, I.S., Figeys, D., Baetz, K., Molecular and Cellular Biology, 2008, 10.1128/MCB.01653-07
  • The tale of two domains: Proteomics and genomics analysis of SMYD2, a new histone methyltransferase, Abu-Farha, M., Lambert, J.-P., Al-Madhoun, A.S., Elisma, F., Skerjanc, I.S., Figeys, D., Molecular and Cellular Proteomics, 2008, 10.1074/mcp.M700271-MCP200
  • A New Look at Protein Complexes; A Modified Chromatin Immunopurifcation Approach Applied to the Study of Histone Htz1 and Yta7, , 50th Canadian Society of Biochemistry, Molecular and Cellular Biology conference, 2007
  • A Novel Approach for the Analysis of Chromatin Bound Protein Complex Applied to the Study of Htz1p and Yta7p, , 50th Canadian Society of Biochemistry, Molecular and Cellular Biology conference, 2007
  • A Novel Proteomic Approach to Chromatin Immunopurification Uncovers a Role for Yta7 in DNA Damage Response, , Chromatin Structure & Function 2007, 2007
  • Large-scale mapping of human protein-protein interactions by mass spectrometry, Ewing, R.M., Chu, P., Elisma, F., Li, H., Taylor, P., Climie, S., McBroom-Cerajewski, L., Robinson, M.D., O'Connor, L., Li, M., Taylor, R., Dharsee, M., Ho, Y., Heilbut, A., Moore, L., Zhang, S., Ornatsky, O., Bukhman, Y.V., Ethier, M., Sheng, Y., Vasilescu, J., Abu-Farha, M., Lambert, J.-P., Duewel, H.S., Stewart, I.I., Kuehl, B., Hogue, K., Colwill, K., Gladwish, K., Muskat, B., Kinach, R., Adams, S.-L., Moran, M.F., Morin, G.B., Topaloglou, T., Figeys, D., Molecular Systems Biology, 2007, 10.1038/msb4100134
  • Proteomics in 2005/2006: Developments, applications and challenges, Smith, J.C., Lambert, J.-P., Elisma, F., Figeys, D., Analytical Chemistry, 2007, 10.1021/ac070741j
  • Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry, Denis, N.J., Vasilescu, J., Lambert, J.-P., Smith, J.C., Figeys, D., Proteomics, 2007, 10.1002/pmic.200600410
  • A Novel Approach for the Analysis of Histone H2A and Htz1 Interaction Partners by Modified Chromatin Immunoprecipitation and Mass Spectrometry, , 2nd Annual Progress in Systems Biology at Ottawa, 2006
  • A Novel Approach for the Analysis of Histone H2A and Htz1 Interaction Partners by Modified Chromatin Immunoprecipitation and Mass Spectrometry, , 5th Annual World Congress Human Proteome Organization (HUPO), 2006
  • Analysis of protein interaction networks using mass spectrometry compatible techniques, Ethier, M., Lambert, J.-P., Vasilescu, J., Figeys, D., Analytica Chimica Acta, 2006, 10.1016/j.aca.2005.12.046
  • Stir bar sorptive extraction based on restricted access material for the direct extraction of caffeine and metabolites in biological fluids, Jean-Philippe Lambert, Wayne M. Mullett, Elizabeth Kwong, Dieter Lubda, Journal of Chromatography A, 2005, 10.1016/j.chroma.2005.03.119
  • Proteomics: From gel based to gel free, Lambert, J.-P., Ethier, M., Smith, J.C., Figeys, D., Analytical Chemistry, 2005, 10.1021/ac050586d
  • S-nitrosation of disulfide-reduced oxytocin studied by mass spectrometry, , 87th Canadian Society for Chemistry Conference and Exhibition, 2004

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Pata-Eting Kougnassoukou Tchara - Doctorat - En cours
  • Lynda Agbo - Doctorat - En cours
  • Anahita Lashgari - Post-doctorat - En cours
  • Sophie Anne Blanchet - Doctorat - En cours
  • Chahinez Noufi - Maitrîse avec mémoire - En cours

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4645
Québec (Québec) G1V 0A6
Canada

Renseignements - Secrétariat
418 656-2690
vdres@fmed.ulaval.ca

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

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