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Centre de recherche du CHU de Québec - Université Laval
Partager la fiche :
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de
médecine :
Bioinformatique / données massives (big data)
Pédagogie des sciences de la santé
Reproduction, génétique, périnatalité et développement
Santé cardiovasculaire, respiratoire et métabolisme
Domaines et intérêts de recherche du (de la)
professeur(e) :
Nutrition et métabolisme
Maladies lipidiques
Désordres métaboliques
Diabète
Métabolisme
Obésité
Santé circulatoire et respiratoire
Hypertension artérielle
Maladies cardiovasculaires
Athérosclérose
Système cardiovasculaire
Santé de la mère, des enfants et des adolescents
Prééclampsie
Dépistage prénatal et néonatal
Périnatalité
Prématurité
Projets de recherche
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval- Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia- Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2017-04-01 au 2022-03-31
Salaire d'un professeur sous octroi- CHU de Québec – Université Laval – Hôpital Hôtel-Dieu-de-Québec, CHU de Québec – Université Laval – CHUL, chercheur principal - 2004-04-01 au 2020-06-30
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Publications
Marginal Impact of Brown Seaweed Ascophyllum nodosum and Fucus vesiculosus Extract on Metabolic and Inflammatory Response in Overweight and Obese Prediabetic Subjects, Marlène Vodouhè, Julie Marois, Valérie Guay, Nadine Leblanc, Stanley John Weisnagel, Jean-François Bilodeau, Hélène Jacques, Marine Drugs, 2022, 10.3390/md20030174
Impact of dairy intake on plasma f2-isoprostane profiles in overweight subjects with hyperinsulinemia: A randomized crossover trial, Khorraminezhad, L., Bilodeau, J.-F., Greffard, K., Larose, J., Rudkowska, I., Nutrients, 2021, 10.3390/nu13062088
Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growth, Bilodeau, J.-F., Gevariya, N., Larose, J., Robitaille, K., Roy, J., Oger, C., Galano, J.-M., Bergeron, A., Durand, T., Fradet, Y., Julien, P., Fradet, V., Prostaglandins Leukotrienes and Essential Fatty Acids, 2021, 10.1016/j.plefa.2020.102215
Maternal vitamin D, oxidative stress, and pre-eclampsia, Wei, S.Q., Bilodeau, J.-F., Julien, P., Luo, Z.-C., Abenhaim, H.A., Bi, W.G., Nuyt, A.M., Leduc, L., Audibert, F., Fraser, W.D., International Journal of Gynecology and Obstetrics, 2021, 10.1002/ijgo.13559
The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsia, Bilodeau, J.-F., Gagné, A., Greffard, K., Audibert, F., Fraser, W.D., Julien, P., Pregnancy Hypertension, 2021, 10.1016/j.preghy.2021.06.009
Statistical and machine-learning analyses in nutritional genomics studies, Khorraminezhad, L., Leclercq, M., Droit, A., Bilodeau, J.-F., Rudkowska, I., Nutrients, 2020, 10.3390/nu12103140
Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes, O'Connor, S., Greffard, K., Leclercq, M., Julien, P., Weisnagel, S.J., Gagnon, C., Droit, A., Bilodeau, J.-F., Rudkowska, I., Molecular Nutrition and Food Research, 2019, 10.1002/mnfr.201900126
Physical fitness is associated with prostaglandin F2α isomers during pregnancy, Bilodeau, J.-F., Bisson, M., Larose, J., Pronovost, E., Brien, M., Greffard, K., Marc, I., Prostaglandins Leukotrienes and Essential Fatty Acids, 2019, 10.1016/j.plefa.2019.05.001
F 2 -isoprostanes and fatty acids profile in early pregnancy complicated by pre-existing diabetes, Taschereau-Charron, A., Bilodeau, J.-F., Larose, J., Greffard, K., Berthiaume, L., Audibert, F., Fraser, W.D., Julien, P., Rudkowska, I., Prostaglandins Leukotrienes and Essential Fatty Acids, 2018, 10.1016/j.plefa.2018.07.008
Alterations of fatty acid profiles in gestational diabetes and influence of the diet, Taschereau-Charron, A., Da Silva, M.S., Bilodeau, J.-F., Morisset, A.-S., Julien, P., Rudkowska, I., Maturitas, 2017, 10.1016/j.maturitas.2017.01.014
Dietary fats and F2-isoprostanes: A review of the clinical evidence, Da Silva, M.S., Bilodeau, J.-F., Julien, P., Rudkowska, I., Critical Reviews in Food Science and Nutrition, 2017, 10.1080/10408398.2016.1196646
Increased placental phospholipase A2 gene expression and free F2-isoprostane levels in response to oxidative stress in preeclampsia, Brien, M., Larose, J., Greffard, K., Julien, P., Bilodeau, J.F., Placenta, 2017, 10.1016/j.placenta.2017.05.004
Modulation of the biomarkers of inflammation and oxidative stress by ruminant trans fatty acids and dairy proteins in vascular endothelial cells (HUVEC), Da Silva, M.S., Bilodeau, J.-F., Larose, J., Greffard, K., Julien, P., Barbier, O., Rudkowska, I., Prostaglandins Leukotrienes and Essential Fatty Acids, 2017, 10.1016/j.plefa.2017.09.016
Placental dimethyl acetal fatty acid derivatives are elevated in preeclampsia, Brien, M., Berthiaume, L., Rudkowska, I., Julien, P., Bilodeau, J.F., Placenta, 2017, 10.1016/j.placenta.2017.01.129
Trans Fatty Acids Suppress TNF-α-Induced Inflammatory Gene Expression in Endothelial (HUVEC) and Hepatocellular Carcinoma (HepG2) Cells, Da Silva, M.S., Julien, P., Bilodeau, J.-F., Barbier, O., Rudkowska, I., Lipids, 2017, 10.1007/s11745-017-4243-4
Perinatal oxidative stress may affect fetal ghrelin levels in humans, Luo, Z.-C., Bilodeau, J.-F., Monique Nuyt, A., Fraser, W.D., Julien, P., Audibert, F., Xiao, L., Garofalo, C., Levy, E., Scientific Reports, 2015, 10.1038/srep17881
Plasma F2-isoprostane class VI isomers at 12-18 weeks of pregnancy are associated with later occurrence of preeclampsia, Bilodeau, J.-F., Qin Wei, S., Larose, J., Greffard, K., Moisan, V., Audibert, F., Fraser, W.D., Julien, P., Free Radical Biology and Medicine, 2015, 10.1016/j.freeradbiomed.2015.05.012
F2-isoprostanes are correlated with trans fatty acids in the plasma of pregnant women, Larose, J., Julien, P., Greffard, K., Fraser, W.D., Audibert, F., Wei, S.Q., Bilodeau, J.-F., Prostaglandins Leukotrienes and Essential Fatty Acids, 2014, 10.1016/j.plefa.2014.09.010
Review: Maternal and placental antioxidant response to preeclampsia - Impact on vasoactive eicosanoids, Bilodeau, J.-F., Placenta, 2014, 10.1016/j.placenta.2013.11.013
Analysis of F2 -isoprostanes in plasma of pregnant women by HPLC-MS/MS using a column packed with core-shell particles, Larose, J., Julien, P., Bilodeau, J.-F., Journal of Lipid Research, 2013, 10.1194/jlr.D034553
The use of antioxidants in pre-eclampsia, Bilodeau, J.-F., Studies on Women's Health, 2013, 10.1007/978-1-62703-041-0_6
Effect of dietary organic and inorganic selenium on antioxidant status, embryo development, and reproductive performance in hyperovulatory first-parity gilts, Fortier, M.-E., Audet, I., Giguère, A., Laforest, J.-P., Bilodeau, J.-F., Quesnel, H., Matte, J.J., Journal of Animal Science, 2012, 10.2527/jas.2010-3340
Sex-specific perinatal expression of glutathione peroxidases during mouse lung development, Tondreau, M.Y., Boucher, E., Simard, M., Tremblay, Y., Bilodeau, J.-F., Molecular and Cellular Endocrinology, 2012, 10.1016/j.mce.2012.01.022
The polyol pathway in the bovine oviduct, Larose, J., Laflamme, J., Côté, I., Lapointe, J., Frenette, G., Sullivan, R., Bilodeau, J.-F., Molecular Reproduction and Development, 2012, 10.1002/mrd.22067
Altered placental glutathione peroxidase mRNA expression in preeclampsia according to the presence or absence of labor, Roland-Zejly, L., Moisan, V., St-Pierre, I., Bilodeau, J.-F., Placenta, 2011, 10.1016/j.placenta.2010.11.005
Effects of Labor on Placental Expression of Superoxide Dismutases in Preeclampsia, Roland, L., Beauchemin, D., Acteau, G., Fradette, C., St-Pierre, I., Bilodeau, J.-F., Placenta, 2010, 10.1016/j.placenta.2010.02.007
Existence of compensatory defense mechanisms against oxidative stress and hypertension in preeclampsia., Roland, L., Gagné, A., Bélanger, M.C., Boutet, M., Berthiaume, L., Fraser, W.D., Julien, P., Bilodeau, J.F., Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy, 2010, 10.3109/10641950902777689
Expression of prostaglandin E synthases in the bovine oviduct, Gauvreau, D., Moisan, V., Roy, M., Fortier, M.A., Bilodeau, J.-F., Theriogenology, 2010, 10.1016/j.theriogenology.2009.08.006
Plasma interleukin-18 (IL-18) levels are correlated with antioxidant vitamin coenzyme Q10 in preeclampsia, Roland, L., Gagné, A., Bélanger, M.-C., Boutet, M., Julien, P., Bilodeau, J.-F., Acta Obstetricia et Gynecologica Scandinavica, 2010, 10.3109/00016340903576020
Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood, Boutet, M., Roland, L., Thomas, N., Bilodeau, J.-F., American Journal of Obstetrics and Gynecology, 2009, 10.1016/j.ajog.2008.12.031
Expression of superoxide dismutases in the bovine oviduct during the estrous cycle, Roy, M., Gauvreau, D., Bilodeau, J.-F., Theriogenology, 2008, 10.1016/j.theriogenology.2008.05.042
Impact of cryopreservation and reactive oxygen species on DNA integrity, lipid peroxidation, and functional parameters in ram sperm, Peris, S.I., Bilodeau, J.-F., Dufour, M., Bailey, J.L., Molecular Reproduction and Development, 2007, 10.1002/mrd.20686
Hormonal and spatial regulation of nitric oxide synthases (NOS) (Neuronal NOS, Inducible NOS, and Endothelial NOS) in the oviducts, Lapointe, J., Roy, M., St-Pierre, I., Kimmins, S., Gauvreau, D., MacLaren, L.A., Bilodeau, J.-F., Endocrinology, 2006, 10.1210/en.2005-1548
Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts, Lapointe, J., Kimmins, S., MacLaren, L.A., Bilodeau, J.-F., Endocrinology, 2005, 10.1210/en.2004-1373
Antioxidant defenses are modulated in the cow oviduct during the estrous cycle, Lapointe, J., Bilodeau, J.-F., Biology of Reproduction, 2003, 10.1095/biolreprod.102.007476
Antioxidant requirements for bovine oocytes varies during in vitro maturation, fertilization and development, Ali, A.A., Bilodeau, J.F., Sirard, M.A., Theriogenology, 2003, 10.1016/S0093-691X(02)01125-1
Current concepts in the use of antioxidants for the treatment of preeclampsia., Bilodeau, J.F., Hubel, C.A., Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC, 2003, 10.1016/S1701-2163(16)31003-9
Semen characteristics of genetically identical quadruplet bulls, Lessard, C., Masseau, I., Bilodeau, J.-F., Kroetsch, T., Twagiramungu, H., Bailey, J.L., Leclerc, P., Sullivan, R., Theriogenology, 2003, 10.1016/S0093-691X(02)01256-6
Glutathione peroxidase-1 expression enhances recovery of human breast carcinoma cells from hyperoxic cell cycle arrest, Bilodeau, J.-F., Patenaude, A., Piedboeuf, B., Carrier, C., Petrov, P., Faure, R., Mirault, M.-E., Free Radical Biology and Medicine, 2002, 10.1016/S0891-5849(02)01013-4
Reactive oxygen species-mediated loss of bovine sperm motility in egg yolk Tris extender: Protection by pyruvate, metal chelators and bovine liver or oviductal fluid catalase, Bilodeau, J.-F., Blanchette, S., Cormier, N., Sirard, M.-A., Theriogenology, 2002, 10.1016/S0093-691X(01)00702-6
Thiols prevent H2O2-mediated loss of sperm motility in cryopreserved bull semen, Bilodeau, J.-F., Blanchette, S., Gagnon, C., Sirard, M.-A., Theriogenology, 2001, 10.1016/S0093-691X(01)00562-3
Epithelial and stromal uterine cells cultured in vitro protect bovine sperm from hydrogen peroxide, Lapointe, S., Bilodeau, J.-F., Lemieux, D., Asselin, E., Fortier, M., Sirard, M.-A., Theriogenology, 2000, 10.1016/S0093-691X(00)00354-X
Hyperoxia induces S-phase cell-cycle arrest and p21(Cip1/Waf1)- independent Cdk2 inhibition in human carcinoma T47D-H3 cells, Bilodeau, J.-F., Faure, R., Piedboeuf, B., Mirault, M.-E., Experimental Cell Research, 2000, 10.1006/excr.2000.4844
Levels of antioxidant defenses are decreased in bovine spermatozoa after a cycle of freezing and thawing, Bilodeau, J.-F., Chatterjee, S., Sirard, M.-A., Gagnon, C., Molecular Reproduction and Development, 2000, 10.1002/(SICI)1098-2795(200003)55:3<282::AID-MRD6>3.0.CO;2-7
Minireview: Semen cryopreservation in domestic animals: A damaging and capacitating phenomenon, Bailey, J.L., Bilodeau, J.-F., Cormier, N., Journal of Andrology, 2000
Increased resistance of GPx-1 transgenic mice to tumor promoter-induced loss of glutathione peroxidase activity in skin, Bilodeau, J.-F., Mirault, M.-E., International Journal of Cancer, 1999, 10.1002/(SICI)1097-0215(19990315)80:6<863::AID-IJC11>3.0.CO;2-9
Effects of nonsteroidal antiinflammatory drugs on oxidative pathways in A/J mice, Bilodeau, J.-F., Wang, M., Chung, F.-L., Castonguay, A., Free Radical Biology and Medicine, 1995, 10.1016/0891-5849(94)00099-6
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Hélène Suzanne Fougere - Post-doctorat - En cours
Maxime Tondreau - Maitrîse avec mémoire - 2011/05
Jessica Larose - Maitrîse avec mémoire - 2013/05
Catherine Routhier - Maitrîse avec mémoire - 2014/01
Mélanie Brien - Maitrîse avec mémoire - 2017/01
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec, Québec G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail