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Jean-François Bilodeau

Professeur titulaire

Jean-François Bilodeau
jean-francois.bilodeau@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Bioinformatique / données massives (big data)
  • Pédagogie des sciences de la santé
  • Reproduction, génétique, périnatalité et développement
  • Santé cardiovasculaire, respiratoire et métabolisme

Domaines de recherche

  • Biologie des lipides (y compris la lipidomique)
  • Spectrométrie analytique
  • Fécondité et santé maternelle

Financements des 2 dernières années

  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2017-04-01 au 2022-03-31

Publications

  • Effect of dietary organic and inorganic selenium on antioxidant status, embryo development, and reproductive performance in hyperovulatory first-parity gilts, Matte, J.J., Quesnel, H., Bilodeau, J.-F., Laforest, J.-P., Giguère, A., Audet, I., Fortier, M.-E., Journal of Animal Science, 2012, 10.2527/jas.2010-3340
  • Alterations of fatty acid profiles in gestational diabetes and influence of the diet, Rudkowska, I., Julien, P., Morisset, A.-S., Bilodeau, J.-F., Da Silva, M.S., Taschereau-Charron, A., Maturitas, 2017, 10.1016/j.maturitas.2017.01.014
  • Existence of compensatory defense mechanisms against oxidative stress and hypertension in preeclampsia., Bilodeau, J.F., Julien, P., Fraser, W.D., Berthiaume, L., Boutet, M., Bélanger, M.C., Gagné, A., Roland, L., Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy, 2010, 10.3109/10641950902777689
  • Placental dimethyl acetal fatty acid derivatives are elevated in preeclampsia, Bilodeau, J.F., Julien, P., Rudkowska, I., Berthiaume, L., Brien, M., Placenta, 2017, 10.1016/j.placenta.2017.01.129
  • Hyperoxia induces S-phase cell-cycle arrest and p21(Cip1/Waf1)- independent Cdk2 inhibition in human carcinoma T47D-H3 cells, Mirault, M.-E., Piedboeuf, B., Faure, R., Bilodeau, J.-F., Experimental Cell Research, 2000, 10.1006/excr.2000.4844
  • Thiols prevent H2O2-mediated loss of sperm motility in cryopreserved bull semen, Sirard, M.-A., Gagnon, C., Blanchette, S., Bilodeau, J.-F., Theriogenology, 2001, 10.1016/S0093-691X(01)00562-3
  • Glutathione peroxidase-1 expression enhances recovery of human breast carcinoma cells from hyperoxic cell cycle arrest, Mirault, M.-E., Faure, R., Petrov, P., Carrier, C., Piedboeuf, B., Patenaude, A., Bilodeau, J.-F., Free Radical Biology and Medicine, 2002, 10.1016/S0891-5849(02)01013-4
  • F 2 -isoprostanes and fatty acids profile in early pregnancy complicated by pre-existing diabetes, Rudkowska, I., Julien, P., Audibert, F., Fraser, W.D., Berthiaume, L., Greffard, K., Larose, J., Bilodeau, J.-F., Taschereau-Charron, A., Prostaglandins Leukotrienes and Essential Fatty Acids, 2018, 10.1016/j.plefa.2018.07.008
  • Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes, Rudkowska, I., Bilodeau, J.-F., Droit, A., Gagnon, C., Weisnagel, S.J., Julien, P., Leclercq, M., Greffard, K., O'Connor, S., Molecular Nutrition and Food Research, 2019, 10.1002/mnfr.201900126
  • Effects of Labor on Placental Expression of Superoxide Dismutases in Preeclampsia, Bilodeau, J.-F., St-Pierre, I., Fradette, C., Acteau, G., Beauchemin, D., Roland, L., Placenta, 2010, 10.1016/j.placenta.2010.02.007
  • Expression of prostaglandin E synthases in the bovine oviduct, Bilodeau, J.-F., Fortier, M.A., Roy, M., Moisan, V., Gauvreau, D., Theriogenology, 2010, 10.1016/j.theriogenology.2009.08.006
  • Perinatal oxidative stress may affect fetal ghrelin levels in humans, Levy, E., Garofalo, C., Xiao, L., Audibert, F., Julien, P., Fraser, W.D., Monique Nuyt, A., Bilodeau, J.-F., Luo, Z.-C., Scientific Reports, 2015, 10.1038/srep17881
  • Physical fitness is associated with prostaglandin F2α isomers during pregnancy, Marc, I., Greffard, K., Brien, M., Pronovost, E., Larose, J., Bisson, M., Bilodeau, J.-F., Prostaglandins Leukotrienes and Essential Fatty Acids, 2019, 10.1016/j.plefa.2019.05.001
  • Trans Fatty Acids Suppress TNF-α-Induced Inflammatory Gene Expression in Endothelial (HUVEC) and Hepatocellular Carcinoma (HepG2) Cells, Rudkowska, I., Barbier, O., Bilodeau, J.-F., Julien, P., Da Silva, M.S., Lipids, 2017, 10.1007/s11745-017-4243-4
  • Impact of dairy intake on plasma f2-isoprostane profiles in overweight subjects with hyperinsulinemia: A randomized crossover trial, Rudkowska, I., Larose, J., Greffard, K., Bilodeau, J.-F., Khorraminezhad, L., Nutrients, 2021, 10.3390/nu13062088
  • Plasma interleukin-18 (IL-18) levels are correlated with antioxidant vitamin coenzyme Q10 in preeclampsia, Bilodeau, J.-F., Julien, P., Boutet, M., Bélanger, M.-C., Gagné, A., Roland, L., Acta Obstetricia et Gynecologica Scandinavica, 2010, 10.3109/00016340903576020
  • Dietary fats and F2-isoprostanes: A review of the clinical evidence, Rudkowska, I., Julien, P., Bilodeau, J.-F., Da Silva, M.S., Critical Reviews in Food Science and Nutrition, 2017, 10.1080/10408398.2016.1196646
  • Reactive oxygen species-mediated loss of bovine sperm motility in egg yolk Tris extender: Protection by pyruvate, metal chelators and bovine liver or oviductal fluid catalase, Sirard, M.-A., Cormier, N., Blanchette, S., Bilodeau, J.-F., Theriogenology, 2002, 10.1016/S0093-691X(01)00702-6
  • The polyol pathway in the bovine oviduct, Bilodeau, J.-F., Sullivan, R., Frenette, G., Lapointe, J., Côté, I., Laflamme, J., Larose, J., Molecular Reproduction and Development, 2012, 10.1002/mrd.22067
  • Levels of antioxidant defenses are decreased in bovine spermatozoa after a cycle of freezing and thawing, Gagnon, C., Sirard, M.-A., Chatterjee, S., Bilodeau, J.-F., Molecular Reproduction and Development, 2000, 10.1002/(SICI)1098-2795(200003)55:3<282::AID-MRD6>3.0.CO;2-7
  • Industrial and Ruminant Trans-Fatty Acids-Enriched Diets Differentially Modulate the Microbiome and Fecal Metabolites in C57BL/6 Mice, Iwona Rudkowska, Nicolas Bertrand, Jane A. Foster, Arnaud Droit, Jean-François Bilodeau, Mickael Leclercq, Karine Greffard, Emma Tolsdorf, Miranda Green, Farzad Mohammadi, Nutrients, 2023, 10.3390/nu15061433
  • Marginal Impact of Brown Seaweed Ascophyllum nodosum and Fucus vesiculosus Extract on Metabolic and Inflammatory Response in Overweight and Obese Prediabetic Subjects, Hélène Jacques, Jean-François Bilodeau, Stanley John Weisnagel, Nadine Leblanc, Valérie Guay, Julie Marois, Marlène Vodouhè, Marine Drugs, 2022, 10.3390/md20030174
  • Analysis of F2 -isoprostanes in plasma of pregnant women by HPLC-MS/MS using a column packed with core-shell particles, Bilodeau, J.-F., Julien, P., Larose, J., Journal of Lipid Research, 2013, 10.1194/jlr.D034553
  • Plasma F2-isoprostane class VI isomers at 12-18 weeks of pregnancy are associated with later occurrence of preeclampsia, Julien, P., Fraser, W.D., Audibert, F., Moisan, V., Greffard, K., Larose, J., Qin Wei, S., Bilodeau, J.-F., Free Radical Biology and Medicine, 2015, 10.1016/j.freeradbiomed.2015.05.012
  • Modulation of the biomarkers of inflammation and oxidative stress by ruminant trans fatty acids and dairy proteins in vascular endothelial cells (HUVEC), Rudkowska, I., Barbier, O., Julien, P., Greffard, K., Larose, J., Bilodeau, J.-F., Da Silva, M.S., Prostaglandins Leukotrienes and Essential Fatty Acids, 2017, 10.1016/j.plefa.2017.09.016
  • Sex-specific perinatal expression of glutathione peroxidases during mouse lung development, Bilodeau, J.-F., Tremblay, Y., Simard, M., Boucher, E., Tondreau, M.Y., Molecular and Cellular Endocrinology, 2012, 10.1016/j.mce.2012.01.022
  • Altered placental glutathione peroxidase mRNA expression in preeclampsia according to the presence or absence of labor, Bilodeau, J.-F., St-Pierre, I., Moisan, V., Roland-Zejly, L., Placenta, 2011, 10.1016/j.placenta.2010.11.005
  • The use of antioxidants in pre-eclampsia, Bilodeau, J.-F., Studies on Women's Health, 2013, 10.1007/978-1-62703-041-0_6
  • Expression of superoxide dismutases in the bovine oviduct during the estrous cycle, Bilodeau, J.-F., Gauvreau, D., Roy, M., Theriogenology, 2008, 10.1016/j.theriogenology.2008.05.042
  • Semen characteristics of genetically identical quadruplet bulls, Sullivan, R., Leclerc, P., Bailey, J.L., Twagiramungu, H., Kroetsch, T., Bilodeau, J.-F., Masseau, I., Lessard, C., Theriogenology, 2003, 10.1016/S0093-691X(02)01256-6
  • Increased resistance of GPx-1 transgenic mice to tumor promoter-induced loss of glutathione peroxidase activity in skin, Mirault, M.-E., Bilodeau, J.-F., International Journal of Cancer, 1999, 10.1002/(SICI)1097-0215(19990315)80:6<863::AID-IJC11>3.0.CO;2-9
  • Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood, Bilodeau, J.-F., Thomas, N., Roland, L., Boutet, M., American Journal of Obstetrics and Gynecology, 2009, 10.1016/j.ajog.2008.12.031
  • Hormonal and spatial regulation of nitric oxide synthases (NOS) (Neuronal NOS, Inducible NOS, and Endothelial NOS) in the oviducts, Bilodeau, J.-F., MacLaren, L.A., Gauvreau, D., Kimmins, S., St-Pierre, I., Roy, M., Lapointe, J., Endocrinology, 2006, 10.1210/en.2005-1548
  • Antioxidant requirements for bovine oocytes varies during in vitro maturation, fertilization and development, Sirard, M.A., Bilodeau, J.F., Ali, A.A., Theriogenology, 2003, 10.1016/S0093-691X(02)01125-1
  • Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts, Bilodeau, J.-F., MacLaren, L.A., Kimmins, S., Lapointe, J., Endocrinology, 2005, 10.1210/en.2004-1373
  • Current concepts in the use of antioxidants for the treatment of preeclampsia., Hubel, C.A., Bilodeau, J.F., Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC, 2003, 10.1016/S1701-2163(16)31003-9
  • Impact of cryopreservation and reactive oxygen species on DNA integrity, lipid peroxidation, and functional parameters in ram sperm, Bailey, J.L., Dufour, M., Bilodeau, J.-F., Peris, S.I., Molecular Reproduction and Development, 2007, 10.1002/mrd.20686
  • The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsia, Julien, P., Fraser, W.D., Audibert, F., Greffard, K., Gagné, A., Bilodeau, J.-F., Pregnancy Hypertension, 2021, 10.1016/j.preghy.2021.06.009
  • F2-isoprostanes are correlated with trans fatty acids in the plasma of pregnant women, Bilodeau, J.-F., Wei, S.Q., Audibert, F., Fraser, W.D., Greffard, K., Julien, P., Larose, J., Prostaglandins Leukotrienes and Essential Fatty Acids, 2014, 10.1016/j.plefa.2014.09.010
  • Increased placental phospholipase A2 gene expression and free F2-isoprostane levels in response to oxidative stress in preeclampsia, Bilodeau, J.F., Julien, P., Greffard, K., Larose, J., Brien, M., Placenta, 2017, 10.1016/j.placenta.2017.05.004
  • Antioxidant defenses are modulated in the cow oviduct during the estrous cycle, Bilodeau, J.-F., Lapointe, J., Biology of Reproduction, 2003, 10.1095/biolreprod.102.007476
  • Effects of nonsteroidal antiinflammatory drugs on oxidative pathways in A/J mice, Castonguay, A., Chung, F.-L., Wang, M., Bilodeau, J.-F., Free Radical Biology and Medicine, 1995, 10.1016/0891-5849(94)00099-6
  • Epithelial and stromal uterine cells cultured in vitro protect bovine sperm from hydrogen peroxide, Sirard, M.-A., Fortier, M., Asselin, E., Lemieux, D., Bilodeau, J.-F., Lapointe, S., Theriogenology, 2000, 10.1016/S0093-691X(00)00354-X
  • Minireview: Semen cryopreservation in domestic animals: A damaging and capacitating phenomenon, Cormier, N., Bilodeau, J.-F., Bailey, J.L., Journal of Andrology, 2000
  • Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growth, Fradet, V., Julien, P., Fradet, Y., Durand, T., Bergeron, A., Galano, J.-M., Oger, C., Roy, J., Robitaille, K., Larose, J., Gevariya, N., Bilodeau, J.-F., Prostaglandins Leukotrienes and Essential Fatty Acids, 2021, 10.1016/j.plefa.2020.102215
  • Statistical and machine-learning analyses in nutritional genomics studies, Rudkowska, I., Bilodeau, J.-F., Droit, A., Leclercq, M., Khorraminezhad, L., Nutrients, 2020, 10.3390/nu12103140
  • Review: Maternal and placental antioxidant response to preeclampsia - Impact on vasoactive eicosanoids, Bilodeau, J.-F., Placenta, 2014, 10.1016/j.placenta.2013.11.013
  • Maternal vitamin D, oxidative stress, and pre-eclampsia, Fraser, W.D., Audibert, F., Leduc, L., Nuyt, A.M., Bi, W.G., Abenhaim, H.A., Luo, Z.-C., Julien, P., Bilodeau, J.-F., Wei, S.Q., International Journal of Gynecology and Obstetrics, 2021, 10.1002/ijgo.13559

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/04
  • Leila Khorraminezhad - Doctorat - 2022/09

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Direction de recherche dans les domaines suivants :

  • Médecine moléculaire

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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