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Centre de recherche du CHU de Québec - Université Laval
Partager la fiche :
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de
médecine :
Oncologie
Immunologie-infectiologie
Domaines et intérêts de recherche du (de la)
professeur(e) :
Maladies infectieuses et immunitaires
Maladies auto-immunes
Défense cellulaire
Maladies du système immunitaire
Système immunitaire
Cancer
Différenciation cellulaire
Division cellulaire
Lymphomes
Signalisation cellulaire et cancer
Organisation et fonctions biologiques
Projets de recherche
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval- Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Role of the ERK/MAPK pathway in intestine development and homeostasis.- Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31
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Publications
MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with ARDS Outcome, , American Journal of Respiratory Cell and Molecular Biology, 2022, 10.1165/rcmb.2021-0252oc
Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation, , Cell Reports, 2022, 10.1016/j.celrep.2021.110223
Mek1 and Mek2 Functional Redundancy in Erythropoiesis, , Frontiers in Cell and Developmental Biology, 2021, 10.3389/fcell.2021.639022
MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis, , Diabetes, 2021, 10.2337/db20-1295
mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK, , Cancer Research, 2021, 10.1158/0008-5472.can-20-3979
mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways, , Cell Reports, 2021, 10.1016/j.celrep.2021.109069
MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury, Matthew E. Long, Ke-Qin Gong, William E. Eddy, Joseph S. Volk, Eric D. Morrell, Carmen Mikacenic, T. Eoin West, Shawn J. Skerrett, Jean Charron, W. Conrad Liles, Anne M. Manicone, JCI Insight, 2019, 10.1172/jci.insight.132377
MEK2 Negatively Regulates Lipopolysaccharide-Mediated IL-1β Production through HIF-1α Expression, Harvinder Talwar, Mohamad Bouhamdan, Christian Bauerfeld, Jaya Talreja, Rifdat Aoidi, Nicolas Houde, Jean Charron, Lobelia Samavati, The Journal of Immunology, 2019, 10.4049/jimmunol.1801477
Mek1
Y130C
mice recapitulate aspects of human cardio-facio-cutaneous syndrome, , Disease Models & Mechanisms, 2018, 10.1242/dmm.031278
Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells, , Nature, 2017, 10.1038/nature23274
MEK1/2 Inhibition Promotes Macrophage Reparative Properties, , The Journal of Immunology, 2017, 10.4049/jimmunol.1601059
Lung development requires an active ERK/MAPK pathway in the lung mesenchyme, , Developmental Dynamics, 2017, 10.1002/dvdy.24464
Functional redundancy of the kinases MEK1 and MEK2: Rescue of theMek1mutant phenotype byMek2knock-in reveals a protein threshold effect, , Science Signaling, 2016, 10.1126/scisignal.aad5658
MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages., Bouhamdan M, Bauerfeld C, Talreja J, Beuret L, Charron J, Samavati L, 2015, 10.1016/j.cellsig.2015.07.015
ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro., Noël A, Poitras I, Julien J, Petry FR, Morin F, Charron J, Planel E, 2015, 10.1016/j.neurobiolaging.2014.11.005
Crucial requirement of ERK/MAPK signaling in respiratory tract development., Boucherat O, Nadeau V, Bérubé-Simard FA, Charron J, Jeannotte L, 2014, 10.1242/dev.110254
Essential role of the ERK/MAPK pathway in blood-placental barrier formation., Nadeau V, Charron J, 2014, 10.1242/dev.107409
B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS., O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J, 2014, 10.1084/jem.20131780
Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion., Ihermann-Hella A, Lume M, Miinalainen IJ, Pirttiniemi A, Gui Y, Peränen J, Charron J, Saarma M, Costantini F, Kuure S, 2014, 10.1371/journal.pgen.1004193
Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways., Rastogi R, Jiang Z, Ahmad N, Rosati R, Liu Y, Beuret L, Monks R, Charron J, Birnbaum MJ, Samavati L, 2013, 10.1074/jbc.M113.492702
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts., Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC, 2013, 10.1172/JCI69443
Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation., Whittington RA, Bretteville A, Virág L, Emala CW, Maurin TO, Marcouiller F, Julien C, Petry FR, El-Khoury NB, Morin F, Charron J, Planel E, 2013, 10.1038/srep01388
Cooperative Action of Multiple cis-Acting Elements Is Required for N-myc Expression in Branchial Arches: Specific Contribution of GATA3., Potvin É, Beuret L, Cadrin-Girard J, Carter M, Roy S, Tremblay M, Charron J, 2012
MEK Is a Key Regulator of Gliogenesis in the Developing Brain., Li X, Newbern JM, Wu Y, Morgan-Smith M, Zhong J, Charron J, Snider WD, 2012, 10.1016/j.neuron.2012.08.031
Implication of MEK1 and MEK2 in the establishment of the blood-placenta barrier during placentogenesis in mouse., Charron J, Bissonauth V, Nadeau V, 2012, 10.1016/j.rbmo.2012.02.012
[Mek1 and Mek2 functions in the formation of the blood placental barrier]., Nadeau V, Bissonauth V, Charron J, 2012, 10.1051/medsci/2012284019
The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility., Yamashita S, Tai P, Charron J, Ko C, Ascoli M, 2011, 10.1210/me.2011-0059
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma., Blasco RB, Francoz S, Santamaría D, Cañamero M, Dubus P, Charron J, Baccarini M, Barbacid M, 2011, 10.1016/j.ccr.2011.04.002
Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3., Potvin E, Beuret L, Cadrin-Girard JF, Carter M, Roy S, Tremblay M, Charron J, 2010, 10.1128/MCB.00353-09
Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia., Scholl FA, Dumesic PA, Barragan DI, Harada K, Charron J, Khavari PA, 2009, 10.1158/0008-5472.CAN-08-1963
Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation., Nadeau V, Guillemette S, Bélanger LF, Jacob O, Roy S, Charron J, 2009, 10.1242/dev.031872
Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin., Scholl FA, Dumesic PA, Barragan DI, Charron J, Khavari PA, 2009, 10.1038/onc.2008.459
Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development., Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE, 2008, 10.1073/pnas.0805239105
Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia., Scholl FA, Dumesic PA, Barragan DI, Harada K, Bissonauth V, Charron J, Khavari PA, 2007, 10.1016/j.devcel.2007.03.009
Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis., Bissonauth V, Roy S, Gravel M, Guillemette S, Charron J, 2006, 10.1242/dev.02526
Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1., Smith KD, Mezhir JJ, Bickenbach K, Veerapong J, Charron J, Posner MC, Roizman B, Weichselbaum RR, 2006, 10.1128/JVI.80.3.1110-1120.2006
Reduced fertility in male mice deficient in the zinc metallopeptidase NL1., Carpentier M, Guillemette C, Bailey JL, Boileau G, Jeannotte L, DesGroseillers L, Charron J, 2004, 10.1128/MCB.24.10.4428-4437.2004
Role of Plk2 (Snk) in mouse development and cell proliferation., Ma S, Charron J, Erikson RL, 2003, 10.1128/MCB.23.19.6936-6943.2003
Mek2 is dispensable for mouse growth and development., Bélanger LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J, 2003, 10.1128/MCB.23.14.4778-4787.2003
Identification of N-myc regulatory regions involved in embryonic expression., Charron J, Gagnon JF, Cadrin-Girard JF, 2002, 10.1203/00006450-200201000-00010
Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions., LaRochelle O, Gagné V, Charron J, Soh JW, Séguin C, 2001, 10.1074/jbc.M108313200
MEK1 is involved in placental angiogenesis during embryogenesis., , M S-MEDECINE SCIENCES, 1999
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta., Giroux S, Tremblay M, Bernard D, Cardin-Girard JF, Aubry S, Larouche L, Rousseau S, Huot J, Landry J, Jeannotte L, Charron J, 1999, 10.1016/S0960-9822(99)80164-X
Defective development of the embryonic liver in N-myc-deficient mice., Giroux S, Charron J, 1998, 10.1006/dbio.1997.8823
Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells., Malynn BA, Demengeot J, Stewart V, Charron J, Alt FW, 1995, 10.1093/intimm/7.10.1637
Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene., Jeannotte L, Lemieux M, Charron J, Poirier F, Robertson EJ, 1993, 10.1101/gad.7.11.2085
Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene., Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW, 1992, 10.1101/gad.6.12a.2248
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement., Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM, 1992, 10.1016/0092-8674(92)90029-C
FUNCTION OF DIFFERENTIAL MYC-FAMILY GENE-EXPRESSION - TRANSGENIC AND
HOMOLOGOUS RECOMBINATION MODELS, , GROWTH REGULATION OF CANCER II, 1990
High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination., Charron J, Malynn BA, Robertson EJ, Goff SP, Alt FW, 1990
Independent glucocorticoid induction and repression of two contiguous responsive genes., Charron J, Richard-Foy H, Berard DS, Hager GL, Drouin J, 1989
Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids., Drouin J, Nemer M, Charron J, Gagner JP, Jeannotte L, Sun YL, Therrien M, Tremblay Y, 1989
Pro-opiomelanocortin gene: a model for negative regulation of transcription by glucocorticoids., Drouin J, Charron J, Gagner JP, Jeannotte L, Nemer M, Plante RK, Wrange O, 1987, 10.1002/jcb.240350404
Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter., Charron J, Drouin J, 1986, 10.1073/pnas.83.23.8903
Structure of the rat pro-opiomelanocortin (POMC) gene., Drouin J, Chamberland M, Charron J, Jeannotte L, Nemer M, 1985, 10.1016/0014-5793(85)80078-8
Herpes simplex virus ribonucleotide reductase induced in infected BHK-21/C13 cells: biochemical evidence for the existence of two non-identical subunits, H1 and H2., Cohen EA, Charron J, Perret J, Langelier Y, 1985
Bromodeoxyuridine resistance in CHO cells occurs in three discrete steps., Bradley WE, Dinelle C, Charron J, Langelier Y, 1982, 10.1007/BF01538678
Analysis of deoxycytidine (dC) deaminase activity in herpes simplex virus-infected or HSV TK-transformed cells: association with mycoplasma contamination but not with virus infection., Charron J, Langelier Y, 1981
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Simon-Pierre Fortier Beaulieu - Maitrîse avec mémoire - En cours
Rifdat Aoidi - Doctorat - 2016/09
Encadrement d'étudiant(e)s pour les programmes suivants :
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec, Québec G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail