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Jean Charron

Professeur titulaire

Jean Charron
jean.charron@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Immunologie-infectiologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Maladies auto-immunes
  • Défense cellulaire
  • Maladies du système immunitaire
  • Système immunitaire
Cancer
  • Différenciation cellulaire
  • Division cellulaire
  • Lymphomes
  • Signalisation cellulaire et cancer
Organisation et fonctions biologiques

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Role of the ERK/MAPK pathway in intestine development and homeostasis. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31

Publications

  • MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis, , Diabetes, 2021, 10.2337/db20-1295
  • Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells, , Nature, 2017, 10.1038/nature23274
  • MEK1/2 Inhibition Promotes Macrophage Reparative Properties, , The Journal of Immunology, 2017, 10.4049/jimmunol.1601059
  • Lung development requires an active ERK/MAPK pathway in the lung mesenchyme, , Developmental Dynamics, 2017, 10.1002/dvdy.24464
  • MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages., Bouhamdan M, Bauerfeld C, Talreja J, Beuret L, Charron J, Samavati L, 2015, 10.1016/j.cellsig.2015.07.015
  • Crucial requirement of ERK/MAPK signaling in respiratory tract development., Boucherat O, Nadeau V, Bérubé-Simard FA, Charron J, Jeannotte L, 2014, 10.1242/dev.110254
  • Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways., Rastogi R, Jiang Z, Ahmad N, Rosati R, Liu Y, Beuret L, Monks R, Charron J, Birnbaum MJ, Samavati L, 2013, 10.1074/jbc.M113.492702
  • Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts., Shim JH, Greenblatt MB, Zou W, Huang Z, Wein MN, Brady N, Hu D, Charron J, Brodkin HR, Petsko GA, Zaller D, Zhai B, Gygi S, Glimcher LH, Jones DC, 2013, 10.1172/JCI69443
  • Cooperative Action of Multiple cis-Acting Elements Is Required for N-myc Expression in Branchial Arches: Specific Contribution of GATA3., Potvin É, Beuret L, Cadrin-Girard J, Carter M, Roy S, Tremblay M, Charron J, 2012
  • c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma., Blasco RB, Francoz S, Santamaría D, Cañamero M, Dubus P, Charron J, Baccarini M, Barbacid M, 2011, 10.1016/j.ccr.2011.04.002
  • Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia., Scholl FA, Dumesic PA, Barragan DI, Harada K, Charron J, Khavari PA, 2009, 10.1158/0008-5472.CAN-08-1963
  • Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development., Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE, 2008, 10.1073/pnas.0805239105
  • Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis., Bissonauth V, Roy S, Gravel M, Guillemette S, Charron J, 2006, 10.1242/dev.02526
  • Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1., Smith KD, Mezhir JJ, Bickenbach K, Veerapong J, Charron J, Posner MC, Roizman B, Weichselbaum RR, 2006, 10.1128/JVI.80.3.1110-1120.2006
  • Mek2 is dispensable for mouse growth and development., Bélanger LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J, 2003, 10.1128/MCB.23.14.4778-4787.2003
  • MEK1 is involved in placental angiogenesis during embryogenesis., , M S-MEDECINE SCIENCES, 1999
  • Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene., Jeannotte L, Lemieux M, Charron J, Poirier F, Robertson EJ, 1993, 10.1101/gad.7.11.2085
  • FUNCTION OF DIFFERENTIAL MYC-FAMILY GENE-EXPRESSION - TRANSGENIC AND HOMOLOGOUS RECOMBINATION MODELS, , GROWTH REGULATION OF CANCER II, 1990
  • High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination., Charron J, Malynn BA, Robertson EJ, Goff SP, Alt FW, 1990
  • Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids., Drouin J, Nemer M, Charron J, Gagner JP, Jeannotte L, Sun YL, Therrien M, Tremblay Y, 1989
  • Structure of the rat pro-opiomelanocortin (POMC) gene., Drouin J, Chamberland M, Charron J, Jeannotte L, Nemer M, 1985, 10.1016/0014-5793(85)80078-8
  • Bromodeoxyuridine resistance in CHO cells occurs in three discrete steps., Bradley WE, Dinelle C, Charron J, Langelier Y, 1982, 10.1007/BF01538678
  • Implication des kinases MEK1 et MEK2 dans la maturation du système immunitaire chez la souris, Nicolas Houde, Marion Espéli, Jean Charron, médecine/sciences, 2022, 10.1051/medsci/2022071
  • MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with ARDS Outcome, , American Journal of Respiratory Cell and Molecular Biology, 2022, 10.1165/rcmb.2021-0252oc
  • Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation, , Cell Reports, 2022, 10.1016/j.celrep.2021.110223
  • mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK, , Cancer Research, 2021, 10.1158/0008-5472.can-20-3979
  • mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways, , Cell Reports, 2021, 10.1016/j.celrep.2021.109069
  • Mek1 Y130C mice recapitulate aspects of human cardio-facio-cutaneous syndrome, , Disease Models & Mechanisms, 2018, 10.1242/dmm.031278
  • ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro., Noël A, Poitras I, Julien J, Petry FR, Morin F, Charron J, Planel E, 2015, 10.1016/j.neurobiolaging.2014.11.005
  • Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion., Ihermann-Hella A, Lume M, Miinalainen IJ, Pirttiniemi A, Gui Y, Peränen J, Charron J, Saarma M, Costantini F, Kuure S, 2014, 10.1371/journal.pgen.1004193
  • Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation., Whittington RA, Bretteville A, Virág L, Emala CW, Maurin TO, Marcouiller F, Julien C, Petry FR, El-Khoury NB, Morin F, Charron J, Planel E, 2013, 10.1038/srep01388
  • MEK Is a Key Regulator of Gliogenesis in the Developing Brain., Li X, Newbern JM, Wu Y, Morgan-Smith M, Zhong J, Charron J, Snider WD, 2012, 10.1016/j.neuron.2012.08.031
  • Implication of MEK1 and MEK2 in the establishment of the blood-placenta barrier during placentogenesis in mouse., Charron J, Bissonauth V, Nadeau V, 2012, 10.1016/j.rbmo.2012.02.012
  • The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility., Yamashita S, Tai P, Charron J, Ko C, Ascoli M, 2011, 10.1210/me.2011-0059
  • Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation., Nadeau V, Guillemette S, Bélanger LF, Jacob O, Roy S, Charron J, 2009, 10.1242/dev.031872
  • Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin., Scholl FA, Dumesic PA, Barragan DI, Charron J, Khavari PA, 2009, 10.1038/onc.2008.459
  • Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia., Scholl FA, Dumesic PA, Barragan DI, Harada K, Bissonauth V, Charron J, Khavari PA, 2007, 10.1016/j.devcel.2007.03.009
  • Reduced fertility in male mice deficient in the zinc metallopeptidase NL1., Carpentier M, Guillemette C, Bailey JL, Boileau G, Jeannotte L, DesGroseillers L, Charron J, 2004, 10.1128/MCB.24.10.4428-4437.2004
  • Role of Plk2 (Snk) in mouse development and cell proliferation., Ma S, Charron J, Erikson RL, 2003, 10.1128/MCB.23.19.6936-6943.2003
  • Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions., LaRochelle O, Gagné V, Charron J, Soh JW, Séguin C, 2001, 10.1074/jbc.M108313200
  • N-Myc shares cellular functions wiht c-Myc., Aubry S, Charron J, 2000, 10.1089/10445490050043326
  • Defective development of the embryonic liver in N-myc-deficient mice., Giroux S, Charron J, 1998, 10.1006/dbio.1997.8823
  • Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene., Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW, 1992, 10.1101/gad.6.12a.2248
  • Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter., Charron J, Drouin J, 1986, 10.1073/pnas.83.23.8903
  • Herpes simplex virus ribonucleotide reductase induced in infected BHK-21/C13 cells: biochemical evidence for the existence of two non-identical subunits, H1 and H2., Cohen EA, Charron J, Perret J, Langelier Y, 1985
  • Mek1 and Mek2 Functional Redundancy in Erythropoiesis, , Frontiers in Cell and Developmental Biology, 2021, 10.3389/fcell.2021.639022
  • MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury, Matthew E. Long, Ke-Qin Gong, William E. Eddy, Joseph S. Volk, Eric D. Morrell, Carmen Mikacenic, T. Eoin West, Shawn J. Skerrett, Jean Charron, W. Conrad Liles, Anne M. Manicone, JCI Insight, 2019, 10.1172/jci.insight.132377
  • MEK2 Negatively Regulates Lipopolysaccharide-Mediated IL-1β Production through HIF-1α Expression, Harvinder Talwar, Mohamad Bouhamdan, Christian Bauerfeld, Jaya Talreja, Rifdat Aoidi, Nicolas Houde, Jean Charron, Lobelia Samavati, The Journal of Immunology, 2019, 10.4049/jimmunol.1801477
  • Functional redundancy of the kinases MEK1 and MEK2: Rescue of theMek1mutant phenotype byMek2knock-in reveals a protein threshold effect, , Science Signaling, 2016, 10.1126/scisignal.aad5658
  • Epithelial inactivation of Yy1 abrogates lung branching morphogenesis, , Development, 2015, 10.1242/dev.120469
  • Essential role of the ERK/MAPK pathway in blood-placental barrier formation., Nadeau V, Charron J, 2014, 10.1242/dev.107409
  • B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS., O'Donovan KJ, Ma K, Guo H, Wang C, Sun F, Han SB, Kim H, Wong JK, Charron J, Zou H, Son YJ, He Z, Zhong J, 2014, 10.1084/jem.20131780
  • [Mek1 and Mek2 functions in the formation of the blood placental barrier]., Nadeau V, Bissonauth V, Charron J, 2012, 10.1051/medsci/2012284019
  • Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3., Potvin E, Beuret L, Cadrin-Girard JF, Carter M, Roy S, Tremblay M, Charron J, 2010, 10.1128/MCB.00353-09
  • Identification of N-myc regulatory regions involved in embryonic expression., Charron J, Gagnon JF, Cadrin-Girard JF, 2002, 10.1203/00006450-200201000-00010
  • Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta., Giroux S, Tremblay M, Bernard D, Cardin-Girard JF, Aubry S, Larouche L, Rousseau S, Huot J, Landry J, Jeannotte L, Charron J, 1999, 10.1016/S0960-9822(99)80164-X
  • Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells., Malynn BA, Demengeot J, Stewart V, Charron J, Alt FW, 1995, 10.1093/intimm/7.10.1637
  • RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement., Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM, 1992, 10.1016/0092-8674(92)90029-C
  • Independent glucocorticoid induction and repression of two contiguous responsive genes., Charron J, Richard-Foy H, Berard DS, Hager GL, Drouin J, 1989
  • Pro-opiomelanocortin gene: a model for negative regulation of transcription by glucocorticoids., Drouin J, Charron J, Gagner JP, Jeannotte L, Nemer M, Plante RK, Wrange O, 1987, 10.1002/jcb.240350404
  • REGULATION OF THE EXPRESSION OF GENES OF PRO-OPIOMELANOCORTIN, , REVUE CANADIENNE DE BIOLOGIE EXPERIMENTALE, 1983
  • Analysis of deoxycytidine (dC) deaminase activity in herpes simplex virus-infected or HSV TK-transformed cells: association with mycoplasma contamination but not with virus infection., Charron J, Langelier Y, 1981

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Simon-Pierre Fortier Beaulieu - Maîtrise avec mémoire - En cours
  • Rifdat Aoidi - Doctorat - 2016/09

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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