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Jean Charron

Professeur titulaire

Jean Charron
jean.charron@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Immunologie-infectiologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires
  • Maladies auto-immunes
  • Défense cellulaire
  • Maladies du système immunitaire
  • Système immunitaire
Cancer
  • Différenciation cellulaire
  • Division cellulaire
  • Lymphomes
  • Signalisation cellulaire et cancer
Organisation et fonctions biologiques

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31

Publications

  • MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and Associates with ARDS Outcome, , American Journal of Respiratory Cell and Molecular Biology, 2022, 10.1165/rcmb.2021-0252oc
  • mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK, , Cancer Research, 2021, 10.1158/0008-5472.can-20-3979
  • MEK1 regulates pulmonary macrophage inflammatory responses and resolution of acute lung injury, Anne M. Manicone, W. Conrad Liles, Jean Charron, Shawn J. Skerrett, T. Eoin West, Carmen Mikacenic, Eric D. Morrell, Joseph S. Volk, William E. Eddy, Ke-Qin Gong, Matthew E. Long, JCI Insight, 2019, 10.1172/jci.insight.132377
  • Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation., Planel E, Charron J, Morin F, El-Khoury NB, Petry FR, Julien C, Marcouiller F, Maurin TO, Emala CW, Virág L, Bretteville A, Whittington RA, 2013, 10.1038/srep01388
  • Implication des kinases MEK1 et MEK2 dans la maturation du système immunitaire chez la souris, Jean Charron, Marion Espéli, Nicolas Houde, médecine/sciences, 2022, 10.1051/medsci/2022071
  • High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination., Alt FW, Robertson EJ, Goff SP, Malynn BA, Charron J, 1990
  • Pro-opiomelanocortin gene: a model for negative regulation of transcription by glucocorticoids., Wrange O, Plante RK, Nemer M, Jeannotte L, Gagner JP, Charron J, Drouin J, 1987, 10.1002/jcb.240350404
  • Mek1/2 gene dosage determines tissue response to oncogenic Ras signaling in the skin., Khavari PA, Charron J, Barragan DI, Dumesic PA, Scholl FA, 2009, 10.1038/onc.2008.459
  • Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts., Jones DC, Glimcher LH, Gygi S, Zhai B, Zaller D, Petsko GA, Brodkin HR, Charron J, Hu D, Brady N, Wein MN, Huang Z, Zou W, Greenblatt MB, Shim JH, 2013, 10.1172/JCI69443
  • Analysis of deoxycytidine (dC) deaminase activity in herpes simplex virus-infected or HSV TK-transformed cells: association with mycoplasma contamination but not with virus infection., Langelier Y, Charron J, 1981
  • Mek1 Y130C mice recapitulate aspects of human cardio-facio-cutaneous syndrome, , Disease Models & Mechanisms, 2018, 10.1242/dmm.031278
  • Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta., Charron J, Jeannotte L, Landry J, Huot J, Rousseau S, Larouche L, Aubry S, Cardin-Girard JF, Bernard D, Tremblay M, Giroux S, 1999, 10.1016/S0960-9822(99)80164-X
  • MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis, , Diabetes, 2021, 10.2337/db20-1295
  • The Leydig cell MEK/ERK pathway is critical for maintaining a functional population of adult Leydig cells and for fertility., Ko C, Ascoli M, Charron J, Tai P, Yamashita S, 2011, 10.1210/me.2011-0059
  • Phosphorylation is involved in the activation of metal-regulatory transcription factor 1 in response to metal ions., Séguin C, Soh JW, Charron J, Gagné V, LaRochelle O, 2001, 10.1074/jbc.M108313200
  • MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages., Samavati L, Charron J, Beuret L, Talreja J, Bauerfeld C, Bouhamdan M, 2015, 10.1016/j.cellsig.2015.07.015
  • mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways, , Cell Reports, 2021, 10.1016/j.celrep.2021.109069
  • Mek2 is dispensable for mouse growth and development., Charron J, Erikson R, Hugo P, Mourad W, Steff AM, Brott B, Tremblay M, Roy S, Bélanger LF, 2003, 10.1128/MCB.23.14.4778-4787.2003
  • B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS., Zhong J, He Z, Son YJ, Zou H, Charron J, Wong JK, Kim H, Han SB, Sun F, Wang C, Guo H, Ma K, O'Donovan KJ, 2014, 10.1084/jem.20131780
  • MEK1 is involved in placental angiogenesis during embryogenesis., , M S-MEDECINE SCIENCES, 1999
  • REGULATION OF THE EXPRESSION OF GENES OF PRO-OPIOMELANOCORTIN, , REVUE CANADIENNE DE BIOLOGIE EXPERIMENTALE, 1983
  • [Mek1 and Mek2 functions in the formation of the blood placental barrier]., Charron J, Bissonauth V, Nadeau V, 2012, 10.1051/medsci/2012284019
  • Lung development requires an active ERK/MAPK pathway in the lung mesenchyme, , Developmental Dynamics, 2017, 10.1002/dvdy.24464
  • Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene., Robertson EJ, Poirier F, Charron J, Lemieux M, Jeannotte L, 1993, 10.1101/gad.7.11.2085
  • Herpes simplex virus ribonucleotide reductase induced in infected BHK-21/C13 cells: biochemical evidence for the existence of two non-identical subunits, H1 and H2., Langelier Y, Perret J, Charron J, Cohen EA, 1985
  • Mek1 and Mek2 Functional Redundancy in Erythropoiesis, , Frontiers in Cell and Developmental Biology, 2021, 10.3389/fcell.2021.639022
  • Independent glucocorticoid induction and repression of two contiguous responsive genes., Drouin J, Hager GL, Berard DS, Richard-Foy H, Charron J, 1989
  • MEK2 Negatively Regulates Lipopolysaccharide-Mediated IL-1β Production through HIF-1α Expression, Lobelia Samavati, Jean Charron, Nicolas Houde, Rifdat Aoidi, Jaya Talreja, Christian Bauerfeld, Mohamad Bouhamdan, Harvinder Talwar, The Journal of Immunology, 2019, 10.4049/jimmunol.1801477
  • Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways., Samavati L, Birnbaum MJ, Charron J, Monks R, Beuret L, Liu Y, Rosati R, Ahmad N, Jiang Z, Rastogi R, 2013, 10.1074/jbc.M113.492702
  • Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation., Charron J, Roy S, Jacob O, Bélanger LF, Guillemette S, Nadeau V, 2009, 10.1242/dev.031872
  • Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids., Tremblay Y, Therrien M, Sun YL, Jeannotte L, Gagner JP, Charron J, Nemer M, Drouin J, 1989
  • Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1., Weichselbaum RR, Roizman B, Posner MC, Charron J, Veerapong J, Bickenbach K, Mezhir JJ, Smith KD, 2006, 10.1128/JVI.80.3.1110-1120.2006
  • Defective development of the embryonic liver in N-myc-deficient mice., Charron J, Giroux S, 1998, 10.1006/dbio.1997.8823
  • Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis., Charron J, Guillemette S, Gravel M, Roy S, Bissonauth V, 2006, 10.1242/dev.02526
  • Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells., Alt FW, Charron J, Stewart V, Demengeot J, Malynn BA, 1995, 10.1093/intimm/7.10.1637
  • Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development., Landreth GE, Snider WD, Saitta SC, Watanabe M, Ginty DD, Charron J, Doughman YQ, Gargesha M, Wikenheiser J, O'Loughlin B, Karlo JC, Cherosky N, Samuels I, Wu Y, Li X, Wickramasinghe RS, Zhong J, Newbern J, 2008, 10.1073/pnas.0805239105
  • Functional redundancy of the kinases MEK1 and MEK2: Rescue of theMek1mutant phenotype byMek2knock-in reveals a protein threshold effect, , Science Signaling, 2016, 10.1126/scisignal.aad5658
  • RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement., Stall AM, Young F, Datta M, Charron J, Mendelsohn M, Stewart V, Oltz EM, Lam KP, Rathbun G, Shinkai Y, 1992, 10.1016/0092-8674(92)90029-C
  • Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene., Alt FW, Robertson EJ, Goff SP, Jeannotte L, Stewart V, Fisher P, Malynn BA, Charron J, 1992, 10.1101/gad.6.12a.2248
  • c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma., Barbacid M, Baccarini M, Charron J, Dubus P, Cañamero M, Santamaría D, Francoz S, Blasco RB, 2011, 10.1016/j.ccr.2011.04.002
  • FUNCTION OF DIFFERENTIAL MYC-FAMILY GENE-EXPRESSION - TRANSGENIC AND HOMOLOGOUS RECOMBINATION MODELS, , GROWTH REGULATION OF CANCER II, 1990
  • Essential role of the ERK/MAPK pathway in blood-placental barrier formation., Charron J, Nadeau V, 2014, 10.1242/dev.107409
  • Cooperative Action of Multiple cis-Acting Elements Is Required for N-myc Expression in Branchial Arches: Specific Contribution of GATA3., Charron J, Tremblay M, Roy S, Carter M, Cadrin-Girard J, Beuret L, Potvin É, 2012
  • Crucial requirement of ERK/MAPK signaling in respiratory tract development., Jeannotte L, Charron J, Bérubé-Simard FA, Nadeau V, Boucherat O, 2014, 10.1242/dev.110254
  • Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia., Khavari PA, Charron J, Harada K, Barragan DI, Dumesic PA, Scholl FA, 2009, 10.1158/0008-5472.CAN-08-1963
  • Structure of the rat pro-opiomelanocortin (POMC) gene., Nemer M, Jeannotte L, Charron J, Chamberland M, Drouin J, 1985, 10.1016/0014-5793(85)80078-8
  • Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3., Charron J, Tremblay M, Roy S, Carter M, Cadrin-Girard JF, Beuret L, Potvin E, 2010, 10.1128/MCB.00353-09
  • MEK1/2 Inhibition Promotes Macrophage Reparative Properties, , The Journal of Immunology, 2017, 10.4049/jimmunol.1601059
  • ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro., Planel E, Charron J, Morin F, Petry FR, Julien J, Poitras I, Noël A, 2015, 10.1016/j.neurobiolaging.2014.11.005
  • Implication of MEK1 and MEK2 in the establishment of the blood-placenta barrier during placentogenesis in mouse., Nadeau V, Bissonauth V, Charron J, 2012, 10.1016/j.rbmo.2012.02.012
  • MEK Is a Key Regulator of Gliogenesis in the Developing Brain., Snider WD, Charron J, Zhong J, Morgan-Smith M, Wu Y, Newbern JM, Li X, 2012, 10.1016/j.neuron.2012.08.031
  • Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia., Khavari PA, Charron J, Bissonauth V, Harada K, Barragan DI, Dumesic PA, Scholl FA, 2007, 10.1016/j.devcel.2007.03.009
  • N-Myc shares cellular functions wiht c-Myc., Charron J, Aubry S, 2000, 10.1089/10445490050043326
  • Glucocorticoid inhibition of transcription from episomal proopiomelanocortin gene promoter., Drouin J, Charron J, 1986, 10.1073/pnas.83.23.8903
  • Epithelial inactivation of Yy1 abrogates lung branching morphogenesis, , Development, 2015, 10.1242/dev.120469
  • Reduced fertility in male mice deficient in the zinc metallopeptidase NL1., Charron J, DesGroseillers L, Jeannotte L, Boileau G, Bailey JL, Guillemette C, Carpentier M, 2004, 10.1128/MCB.24.10.4428-4437.2004
  • Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation, , Cell Reports, 2022, 10.1016/j.celrep.2021.110223
  • Bromodeoxyuridine resistance in CHO cells occurs in three discrete steps., Langelier Y, Charron J, Dinelle C, Bradley WE, 1982, 10.1007/BF01538678
  • Role of Plk2 (Snk) in mouse development and cell proliferation., Erikson RL, Charron J, Ma S, 2003, 10.1128/MCB.23.19.6936-6943.2003
  • Identification of N-myc regulatory regions involved in embryonic expression., Cadrin-Girard JF, Gagnon JF, Charron J, 2002, 10.1203/00006450-200201000-00010
  • Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells, , Nature, 2017, 10.1038/nature23274
  • Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion., Kuure S, Costantini F, Saarma M, Charron J, Gui Y, Peränen J, Pirttiniemi A, Miinalainen IJ, Lume M, Ihermann-Hella A, 2014, 10.1371/journal.pgen.1004193

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Rifdat Aoidi - Doctorat - 2016/09

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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