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Jacques-P. Tremblay

Professeur titulaire

Jacques-P. Tremblay
jacques-p.tremblay@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Maladies musculaires
  • Lésions musculosquelettiques et réparations
Génétique humaine
  • Thérapie génique
  • Génétique moléculaire
  • Maladies génétiques
Neurosciences, santé mentale et toxicomanies
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Maladies neuromusculaires

Projets de recherche

  • Removal of the GAA repeat with the CRISPR/Cas9 system in Friedreich patient cells and in the YG8sR mouse model - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-02-06 au 2027-03-31
  • In vivo correction by CRISPR PRIME editing of mutations responsible for Duchenne Muscular Dystrophy - Vaincre Duchenne Canada, chercheur principal - 2023-12-01 au 2026-11-30
  • Development of a CRISPR-powered instrument for specific, rapid and simple detection of emerging respiratory pathogens - Génome Québec, Groupe BenDavid - Solutions génomiques pour l’identification, la caractérisation et la surveillance de la résistance aux antimicrobiens et des pathogènes émergents, chercheur principal - 2023-09-01 au 2025-08-31
  • Removal of the GAA repeat with the CRISPR/Cas9 system in Friedreich patient cells and in the YG8sR mouse model - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
  • Correcting point mutations responsible for Dysferlinopathy using Prime Editing - Jain Foundation Inc., chercheur principal - 2023-08-01 au 2024-07-31
  • Développement de microdispositifs transdermiques peu invasifs pour l’administration d'acides nucléiques : vaccination et thérapie génique - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université de Montréal, co-chercheur - 2023-04-01 au 2024-03-31
  • Development of an AAV library - Conseil national de recherches du Canada - Programmes et initiatives de R&D collaboratifs, chercheur principal - 2022-04-01 au 2024-03-31
  • Développement d'un traitement pour prévenir ou ralentir la progression de la maladie d'Alzheimer - Fondation Famille Lemaire, chercheur principal - 2023-11-08 au 2024-03-31
  • Correction with the Prime editing technology of point mutations responsible for Duchenne Muscular Dystrophy - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
  • PRIME editing correction of the T1709M mutation responsible for some cases of Ryanodine receptor type I-related myopathies - RYR-1 Foundation, chercheur principal - 2021-07-01 au 2023-06-30
  • Développement d’une thérapie génique pour l’ataxie de Friedreich - Ataxie Canada, chercheur principal - 2021-05-31 au 2023-05-31
  • Deciphering the role of DCIR in HIV-1 pathogenesis - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-04-01 au 2023-03-31
  • Les cellules souches pluripotentes génétiquement corrigées comme thérapie pour l’epidermolyse bulleuse simplex - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université du Québec à Chicoutimi - UQAC , co-chercheur - 2022-04-01 au 2023-03-31
  • Correction by CRISPR base editing of point mutations responsible for Duchenne Muscular Dystrophy - The Foundation for gene and cell therapy Jesse's Journey, chercheur principal - 2020-06-01 au 2022-05-31
  • Development of a rapid and simple test to detect the COVID-19 variants that can be used in remote areas and developing countries - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31
  • Correction of the c. 121 A to T mutation in the NKX6-2 gene by PRIME editing - Ataxia UK, chercheur principal - 2021-01-26 au 2022-01-25

Publications

  • Myoblast transplantation: a brief review of the problems and of some solutions, , Basic and applied myology : BAM, 1997
  • Human myoblast transplantation: a simple assay for tumorigenicity, , Neuromuscular disorders : NMD, 1991, 10.1016/0960-8966(91)90120-h
  • Localization of dystrophin in the Purkinje cells of normal mice, , Neuroscience letters, 1992, 10.1016/0304-3940(92)90309-u
  • The effects of hemicholinium-3 on synaptic depression, facilitation, and post-tetanic potentiation at an identified synapse of Aplysia californica, , Canadian journal of physiology and pharmacology, 1980, 10.1139/y80-064
  • Gaba and benzodiazepines in invertebrate species, , 1988
  • Myoblast survival enhancement and transplantation success improvement by heat-shock treatment in mdx mice, , Transplantation, 2004, 10.1097/01.tp.0000121503.01535.f5
  • Myogenesis: where and how can we get skeletal myoblasts?, , Dialogues in cardiovascular medicine : DCM, 2003
  • Gene therapy: a strategy for the treatment of inherited muscle diseases?, , Current opinion in pharmacology, 2001, 10.1016/s1471-4892(01)00052-2
  • Gene transfer using HACs: a key step closer to ex vivo gene therapy using autologous gene-corrected cells to treat muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2011.254
  • Gene Therapy in Duchenne’s Muscular Dystrophy, , 2009
  • Successful myoblast transplantation in fibrotic muscles: no increased impairment by the connective tissue, , Transplantation, 1999, 10.1097/00007890-199906270-00018
  • Non-uniform responses to Ca2+ along the frog neuromuscular junction: effects on the probability of spontaneous and evoked transmitter release, , Neuroscience, 1991, 10.1016/0306-4522(91)90142-b
  • A light and electron microscopic study of dystrophin localization at the mouse neuromuscular junction, , Synapse (New York, N.Y.), 1992, 10.1002/syn.890100202
  • The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer's Disease in SH-SY5Y cells, , PloS one, 2020, 10.1371/journal.pone.0237122
  • Resting and stimulated values of model parameters governing transmitter release at a synapse in Aplysia californica, , Brain research, 1976, 10.1016/0006-8993(76)90378-4
  • Mechanism of increasing dystrophin-positive myofibers by myoblast transplantation: study using mdx/beta-galactosidase transgenic mice, , Acta neuropathologica, 1996, 10.1007/s004010050456
  • Autologous transplantation of muscle precursor cells modified with a lentivirus for muscular dystrophy: human cells and primate models, , Molecular therapy : the journal of the American Society of Gene Therapy, 2007, 10.1038/sj.mt.6300047
  • Utilization of myoblasts from transgenic mice to evaluate the efficacy of myoblast transplantation, , Muscle & nerve, 1994, 10.1002/mus.880170903
  • Inhibiting myostatin with follistatin improves the success of myoblast transplantation in dystrophic mice, , Cell transplantation, 2008, 10.3727/096368908784153913
  • Transfection of large plasmids in primary human myoblasts, , Gene therapy, 2001, 10.1038/sj.gt.3301532
  • Prime Editing for Human Gene Therapy: Where Are We Now?, Jacques P. Tremblay, Kelly Godbout, Cells, 2023, 10.3390/cells12040536
  • Central tolerance to myogenic cell transplants does not include muscle neoantigens, , Transplantation, 2008, 10.1097/TP.0b013e31817726bc
  • Anti-inflammatory effect of transforming growth factor-beta1 in myoblast transplantation, , Transplantation, 1998, 10.1097/00007890-199803270-00005
  • Interrelation between MEPP amplitude and MEPP frequency in different regions along the frog neuromuscular junction, , Brain research, 1987, 10.1016/0006-8993(87)90404-5
  • Insertion of the Icelandic Mutation (A673T) by Prime Editing: A Potential Preventive Treatment for Familial and Sporadic Alzheimer's Disease, , The CRISPR journal, 2022, 10.1089/crispr.2021.0085
  • Fibrin gel improves the survival of transplanted myoblasts, , Cell transplantation, 2012, 10.3727/096368911X576018
  • Polymerase chain reaction-based assay to assess the success of myoblast transplantation in mdx mice, , Transplantation proceedings, 1994
  • The CRISPR system can correct or modify the expression of genes responsible for hereditary diseases, , Medecine sciences : M/S, 2015, 10.1051/medsci/20153111016
  • In vivo migration of transplanted myoblasts requires matrix metalloproteinase activity, , Experimental cell research, 2000, 10.1006/excr.2000.4962
  • Preservation of muscle spindles in a 27-year-old Duchenne muscular dystrophy patient: importance for regenerative medicine strategies, , Muscle & nerve, 2010, 10.1002/mus.21644
  • Small-molecule inhibitors of proteasome increase CjCas9 protein stability, Jacques P. Tremblay, Cedric Happi Mbakam, Nathalie Majeau, Pouiré Yaméogo, PLOS ONE, 2023, 10.1371/journal.pone.0280353
  • Therapeutic effects of exon skipping and losartan on skeletal muscle of mdx mice, , Pathology international, 2014, 10.1111/pin.12190
  • CRISPR-Cas9 Gene Therapy for Duchenne Muscular Dystrophy, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2022, 10.1007/s13311-022-01197-9
  • Myopathy in a rhesus monkey with biopsy findings similar to human sporadic inclusion body myositis, , Neuromuscular disorders : NMD, 2013, 10.1016/j.nmd.2012.10.020
  • Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome, , Brain, behavior, and immunity, 2018, 10.1016/j.bbi.2018.06.007
  • Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation, , Molecular therapy. Nucleic acids, 2013, 10.1038/mtna.2012.55
  • The paracrine effect: pivotal mechanism in cell-based cardiac repair, , Journal of cardiovascular translational research, 2010, 10.1007/s12265-010-9198-2
  • Successful transplantation of genetically corrected DMD myoblasts following ex vivo transduction with the dystrophin minigene, , Biochemical and biophysical research communications, 1998, 10.1006/bbrc.1998.8739
  • Use of normal and genetically modified myoblasts for the treatment of myopathies, , 2000
  • Therapeutic Strategies for Dystrophin Replacement in Duchenne Muscular Dystrophy, , Frontiers in medicine, 2022, 10.3389/fmed.2022.859930
  • Myoblast transplantation in skeletal muscles, , 2012
  • Rapid selection of donor myoblast clones for muscular dystrophy therapy using cell surface expression of NCAM, , European journal of histochemistry : EJH, 1993
  • Postsynaptic structure may account for variations in miniature endplate current shapes along frog neuromuscular junctions, , Synapse (New York, N.Y.), 1990, 10.1002/syn.890050402
  • Enzymatic activity and morphological differentiation in de novo innervated human muscle cultures, , European journal of histochemistry : EJH, 1994
  • Lymphocyte infiltration following allo- and xenomyoblast transplantation in mice, , Transplantation proceedings, 1994
  • Ischemic central necrosis in pockets of transplanted myoblasts in nonhuman primates: implications for cell-transplantation strategies, , Transplantation, 2007, 10.1097/01.tp.0000288322.94252.22
  • Sarcolemmal Complement Membrane Attack Complex Deposits During Acute Rejection of Myofibers in Nonhuman Primates, , Journal of neuropathology and experimental neurology, 2019, 10.1093/jnen/nly106
  • A new technique to identify hybrid myotubes in vitro without culture fixation, , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1991, 10.1177/39.1.1701185
  • Myogenic progenitor cells derived from human induced pluripotent stem cell are immune-tolerated in humanized mice, , Stem cells translational medicine, 2021, 10.1002/sctm.19-0452
  • FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer, , Human gene therapy, 1995, 10.1089/hum.1995.6.11-1391
  • First test of a high-density injection protocol for myogenic cell transplantation throughout large volumes of muscles in a Duchenne muscular dystrophy patient: eighteen months follow-up, , Neuromuscular disorders : NMD, 2007, 10.1016/j.nmd.2006.10.003
  • Myoblast transplantation in non-dystrophic dog, , Neuromuscular disorders : NMD, 1998, 10.1016/s0960-8966(97)00148-x
  • Successful myoblast allotransplantation in mdx mice using rapamycin, , Transplantation, 1995
  • Early and massive death of myoblasts transplanted into skeletal muscle : responsible factors and potential solutions, , Current opinion in organ transplantation, 2007
  • Myoblast allotransplantation in primates, , Muscle & nerve, 1995
  • Benzodiazepines modify synaptic depression, frequency facilitation and PTP an identified cholinergic synapse of Aplysia, , Life sciences, 1980, 10.1016/0024-3205(80)90130-7
  • Presynaptic modulating effects of GABA on depression, facilitation, and posttetanic potentiation of a cholinergic synapse in Aplysia californica, , Canadian journal of physiology and pharmacology, 1977, 10.1139/y77-174
  • Generation of lentiviral vectors for use in skeletal muscle research, , Methods in molecular biology (Clifton, N.J.), 2012, 10.1007/978-1-61779-343-1_16
  • Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4Ig, , Human gene therapy, 1996, 10.1089/hum.1996.7.12-1455
  • Tumor necrosis factor-alpha (TNF-alpha) stimulates chemotactic response in mouse myogenic cells, , Cell transplantation, 2003, 10.3727/000000003783985115
  • Current status of pharmaceutical and genetic therapeutic approaches to treat DMD, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2011.59
  • Myoblast transplantation in whole muscle of nonhuman primates, , Journal of neuropathology and experimental neurology, 2000, 10.1093/jnen/59.3.197
  • Nucleofection of muscle-derived stem cells and myoblasts with phiC31 integrase: stable expression of a full-length-dystrophin fusion gene by human myoblasts, , Molecular therapy : the journal of the American Society of Gene Therapy, 2004, 10.1016/j.ymthe.2004.05.034
  • Immunosuppression with monoclonal antibodies and CTLA4-Ig after myoblast transplantation in mice, , Transplantation, 1996, 10.1097/00007890-199610150-00015
  • Functional EGFP-dystrophin fusion proteins for gene therapy vector development, , Protein engineering, 2000, 10.1093/protein/13.9.611
  • Cerebroside may be falsely identified as a soluble 'brain specific protein', , Journal of neurochemistry, 1974, 10.1111/j.1471-4159.1974.tb04360.x
  • Characterization of frataxin gene network in Friedreich's ataxia fibroblasts using the RNA-Seq technique, , Mitochondrion, 2016, 10.1016/j.mito.2016.06.003
  • Losartan enhances the success of myoblast transplantation, , Cell transplantation, 2012, 10.3727/096368911X576045
  • Systemic production of human granulocyte colony-stimulating factor in nonhuman primates by transplantation of genetically modified myoblasts, , Human gene therapy, 2000, 10.1089/10430340050032384
  • Proximodistal gradients of the postjunctional folds at the frog neuromuscular junction: a scanning electron microscopic study, , Neuroscience, 1989, 10.1016/0306-4522(89)90271-6
  • Intraarterial injection of muscle-derived CD34(+)Sca-1(+) stem cells restores dystrophin in mdx mice, , The Journal of cell biology, 2001, 10.1083/jcb.152.2.335
  • Gene Editing for Duchenne Muscular Dystrophy Using the CRISPR/Cas9 Technology: The Importance of Fine-tuning the Approach, , Molecular therapy : the journal of the American Society of Gene Therapy, 2016, 10.1038/mt.2016.191
  • In vitro bromodeoxyuridine labeling of nuclei: application to myotube hybridization, , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1991, 10.1177/39.10.1940314
  • In vivo stimulation of a cholinergic synapse of the chick ciliary ganglion induces a reduction in the number of dense core vesicles, , Neuroscience letters, 1981, 10.1016/0304-3940(81)90176-2
  • Non-uniform distribution of miniature endplate potential amplitudes along the length of the frog neuromuscular junction, , Neuroscience letters, 1987, 10.1016/0304-3940(87)90147-9
  • Myotubes can be formed within implanted adipose tissue, , Transplantation proceedings, 1992
  • Removal of the GAA repeat in the heart of a Friedreich’s ataxia mouse model using CjCas9, Jacques P. Tremblay, Nathalie Majeau, Catherine Gérard, Pouiré Yaméogo, Gene Therapy, 2023, 10.1038/s41434-023-00387-0
  • Myoblast allotransplantation in mice: degree of success varies depending on the efficacy of various immunosuppressive treatments, , Transplantation proceedings, 1994
  • Myotubes Formed De Novo by Myoblasts Injected into the Scar of Myocardial Infarction Persisted for 16 Years in a Patient: Importance for Regenerative Medicine in Degenerative Myopathies, , Stem cells translational medicine, 2019, 10.1002/sctm.18-0202
  • Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies, , Gene therapy, 2001, 10.1038/sj.gt.3301484
  • Prime editing optimized RTT permits the correction of the c.8713C>T mutation in DMD gene, Jacques P. Tremblay, Vincent Mouly, Kamel Mamchaoui, Anne Bigot, Yaoyao Lu, Joel Rousseau, Cedric Happi Mbakam, Molecular Therapy - Nucleic Acids, 2022, 10.1016/j.omtn.2022.09.022
  • Scale-up of a myoblast culture process, , Journal of biotechnology, 2001, 10.1016/s0168-1656(01)00291-7
  • Laminin-111: a potential therapeutic agent for Duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.165
  • Cytoplasmic restoration and persistence of glucose-6-phosphate dehydrogenase activity in stable hybrid myotubes, , European journal of histochemistry : EJH, 1993
  • Online Manuscript Processing for Cell Transplantation, , Cell transplantation, 2006, 10.3727/000000006783981738
  • A case for immunosuppression for myoblast transplantation in duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2009, 10.1038/mt.2009.125
  • Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases, , Molecular therapy : the journal of the American Society of Gene Therapy, 2013, 10.1038/mt.2013.4
  • Baclofen modifies via the release of monoamines the synaptic depression, frequency facilitation, and posttetanic potentiation observed at an identified cholinergic synapse of Aplysia californica, , Canadian journal of physiology and pharmacology, 1981, 10.1139/y81-039
  • Control of inflammatory damage by anti-LFA-1: increase success of myoblast transplantation, , Cell transplantation, 1997
  • Identification of a putative pathway for the muscle homing of stem cells in a muscular dystrophy model, , The Journal of cell biology, 2003, 10.1083/jcb.200210006
  • CRISPR-Induced Deletion with SaCas9 Restores Dystrophin Expression in Dystrophic Models In Vitro and In Vivo, , Molecular therapy : the journal of the American Society of Gene Therapy, 2018, 10.1016/j.ymthe.2018.08.010
  • AG490 improves the survival of human myoblasts in vitro and in vivo, , Cell transplantation, 2012, 10.3727/096368912X655028
  • Use of repeating dispensers to increase the efficiency of the intramuscular myogenic cell injection procedure, , Cell transplantation, 2006, 10.3727/000000006783981648
  • Not an inside job: how can transplantation of relatively few exogenous satellite cells do what thousands of endogenous cells cannot?, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2010.276
  • Meganucleases can restore the reading frame of a mutated dystrophin, , Gene therapy, 2010, 10.1038/gt.2010.26
  • Prior culture with concanavalin A increases intramuscular migration of transplanted myoblast, , Muscle & nerve, 1998, 10.1002/(sici)1097-4598(199803)21:33.0.co;2-5
  • Stem and progenitor cells in skeletal muscle development, maintenance, and therapy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2007, 10.1038/mt.sj.6300145
  • CD56+ Muscle Derived Cells but Not Retinal NG2+ Perivascular Cells of Nonhuman Primates are Myogenic after Intramuscular Transplantation in Immunodeficient Mice, , Journal of stem cell research & therapy, 2017, 10.4172/2157-7633.1000377
  • Electroporation as a method to induce myofiber regeneration and increase the engraftment of myogenic cells in skeletal muscles of primates, , Journal of neuropathology and experimental neurology, 2013, 10.1097/NEN.0b013e31829bac22
  • The first Joint Conference of the Cell Transplant Society (CTS), International Pancreas and Islet Transplant Association (IPITA), and International Xenotransplantation Association (IXA), all sections of The Transplantation Society (TTS), took place in Minneapolis, Minn, USA, from September 15-20, 2007. Preface, , Transplantation proceedings, 2008, 10.1016/j.transproceed.2008.02.021
  • A new pro-migratory activity on human myogenic precursor cells for a synthetic peptide within the E domain of the mechano growth factor, , Experimental cell research, 2007, 10.1016/j.yexcr.2006.10.032
  • Experimental and therapeutic approaches to muscular dystrophies, , Current opinion in neurology, 2002, 10.1097/00019052-200210000-00007
  • Macrophages improve survival, proliferation and migration of engrafted myogenic precursor cells into MDX skeletal muscle, , PloS one, 2012, 10.1371/journal.pone.0046698
  • Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization, , Molecular cancer research : MCR, 2003
  • Delivery of RNAs to Specific Organs by Lipid Nanoparticles for Gene Therapy, Jacques P. Tremblay, Kelly Godbout, Pharmaceutics, 2022, 10.3390/pharmaceutics14102129
  • Successful myoblast transplantation in primates depends on appropriate cell delivery and induction of regeneration in the host muscle, , Experimental neurology, 1999, 10.1006/exnr.1998.6973
  • Lymphocyte infiltration following allo- and xenomyoblast transplantation in mdx mice, , Muscle & nerve, 1995, 10.1002/mus.880180107
  • Past, present and future of myoblast transplantation in the treatment of Duchenne muscular dystrophy, , Pediatric transplantation, 2010, 10.1111/j.1399-3046.2010.01377.x
  • Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro, , Molecular therapy. Nucleic acids, 2021, 10.1016/j.omtn.2021.02.032
  • Scanning electron microscopic study of the neuromuscular junction of dystrophic mice, , Experimental neurology, 1988, 10.1016/0014-4886(88)90200-2
  • Dystrophin expression in myofibers of Duchenne muscular dystrophy patients following intramuscular injections of normal myogenic cells, , Molecular therapy : the journal of the American Society of Gene Therapy, 2004, 10.1016/j.ymthe.2003.11.023
  • Transplantation of human myoblasts in SCID mice as a potential muscular model for myotonic dystrophy, , Journal of neuropathology and experimental neurology, 1999, 10.1097/00005072-199909000-00003
  • Depression and frequency facilitation at a synapse in Aplysia californica: evidence for regulation by availability of transmitter, , Brain research, 1974, 10.1016/0006-8993(74)90459-4
  • Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506, , Muscle & nerve, 1996, 10.1002/(SICI)1097-4598(199607)19:73.0.CO;2-B
  • A monoclonal antibody to conotoxin reveals the distribution of a subset of calcium channels in the rat cerebellar cortex, , Brain research. Molecular brain research, 1991, 10.1016/0169-328x(91)90004-h
  • Electrotransfer of the full-length dog dystrophin into mouse and dystrophic dog muscles, , Human gene therapy, 2010, 10.1089/hum.2010.024
  • Mosaic expression of dystrophin in the cerebellum of heterozygote dystrophic (mdx) mice, , Neuromuscular disorders : NMD, 1992, 10.1016/s0960-8966(06)80002-7
  • Transplantation of normal and DMD myoblasts expressing the telomerase gene in SCID mice, , Biochemical and biophysical research communications, 2000, 10.1006/bbrc.2000.2735
  • Pretreatment of myoblast cultures with basic fibroblast growth factor increases the efficacy of their transplantation in mdx mice, , Muscle & nerve, 1995, 10.1002/mus.880180806
  • Partial laminin alpha2 chain restoration in alpha2 chain-deficient dy/dy mouse by primary muscle cell culture transplantation, , The Journal of cell biology, 1996, 10.1083/jcb.133.1.185
  • Percutaneous versus surgical delivery of autologous myoblasts after chronic myocardial infarction: an in vivo cardiovascular magnetic resonance study, , Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2010, 10.1002/ccd.22204
  • Transcription activator-like effector proteins induce the expression of the frataxin gene, , Human gene therapy, 2012, 10.1089/hum.2012.034
  • Overexpression of follistatin in human myoblasts increases their proliferation and differentiation, and improves the graft success in SCID mice, , Cell transplantation, 2009, 10.3727/096368909X470865
  • Quantification of normal dystrophin mRNA following myoblast transplantation in mdx mice, , Muscle & nerve, 1995, 10.1002/mus.880180909
  • Morphological changes in presynaptic terminals of the chick ciliary ganglion after stimulation in vivo. A stereological study showing a net loss of total membrane, , Experimental brain research, 1981, 10.1007/BF00238388
  • Marked prolongation of post-tetanic potentiation at a transition temperature in its adaption, , Nature, 1975, 10.1038/258623a0
  • Effects of vitamin C on cytotherapy-mediated muscle regeneration, , Cell transplantation, 2013, 10.3727/096368912X657846
  • The advances and challenges of Gene Therapy for Duchenne Muscular Dystrophy, , Journal of Genetic Medicine and Gene Therapy, 2017, 10.29328/journal.jgmgt.1001003
  • Labelling of an intermediate saccule of the Golgi apparatus and of parts of the endoplasmic reticulum by a lectin (soybean agglutinin) in the chick ciliary ganglion, , Neuroscience letters, 1983, 10.1016/0304-3940(83)90538-4
  • Non-uniform release at the frog neuromuscular junction: evidence of morphological and physiological plasticity, , Brain research, 1987, 10.1016/0165-0173(87)90019-1
  • Evidence of mdx mouse skeletal muscle fragility in vivo by eccentric running exercise, , Muscle & nerve, 1998, 10.1002/(sici)1097-4598(199805)21:53.0.co;2-6
  • Vascular endothelial growth factor reduced hypoxia-induced death of human myoblasts and improved their engraftment in mouse muscles, , Gene therapy, 2008, 10.1038/sj.gt.3303059
  • Another new super muscle stem cell leaves unaddressed the real problems of cell therapy for duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2008, 10.1038/mt.2008.243
  • Dystrophin expression in myotubes formed by the fusion of normal and dystrophic myoblasts, , Muscle & nerve, 1991, 10.1002/mus.880140213
  • Intramuscular transplantation of myogenic cells in primates: importance of needle size, cell number, and injection volume, , Cell transplantation, 2014, 10.3727/096368912X661337
  • Current Clinical Applications of In Vivo Gene Therapy with AAVs, , Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 10.1016/j.ymthe.2020.12.007
  • Heterogeneous labeling of mitochondrial membrane, endoplasmic reticulum, neurofilaments and synaptic vesicles with a lectin (DBA-peroxidase), , Neuroscience letters, 1982, 10.1016/0304-3940(82)90003-9
  • Very efficient myoblast allotransplantation in mice under FK506 immunosuppression, , Muscle & nerve, 1994, 10.1002/mus.880171210
  • Treatment with anti-CD154 antibody and donor-specific transfusion prevents acute rejection of myoblast transplantation, , Transplantation, 2002, 10.1097/00007890-200202150-00021
  • Human myoblast transplantation in immunodeficient and immunosuppressed mice: evidence of rejection, , Muscle & nerve, 1994, 10.1002/mus.880170214
  • Expression of dog microdystrophin in mouse and dog muscles by gene therapy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.23
  • Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures, , Journal of biomedical optics, 2019, 10.1117/1.JBO.24.2.025001
  • An electron microscope study of synaptic contacts in the abdominal ganglion of Aplysia californica, , The Journal of comparative neurology, 1979, 10.1002/cne.901880303
  • A monoclonal antibody to beta-tubulin distinguishes a subset of neurons and axons in the chick ciliary ganglion, , Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, 10.1139/o85-065
  • Cell therapies for inherited myopathies, , Current opinion in rheumatology, 2003, 10.1097/00002281-200311000-00007
  • Myocardial regeneration : which cell and why, , 2006
  • De Novo Circulating Antidonor's Cell Antibodies During Induced Acute Rejection of Allogeneic Myofibers in Myogenic Cell Transplantation: A Study in Nonhuman Primates, , Transplantation direct, 2017, 10.1097/TXD.0000000000000740
  • Novel Duchenne muscular dystrophy treatment through myoblast transplantation tolerance with anti-CD45RB, anti-CD154 and mixed chimerism, , American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2004, 10.1111/j.1600-6143.2004.00501.x
  • Intramuscular cell transplantation as a potential treatment of myopathies: clinical and preclinical relevant data, , Expert opinion on biological therapy, 2011, 10.1517/14712598.2011.548800
  • Repeated stimulation of the dystrophic mouse neuromuscular junctions, , Muscle & nerve, 1987, 10.1002/mus.880100405
  • Serum Extracellular Vesicles for Delivery of Crispr-Cas9 Ribonucleoproteins to Modify the Dystrophin Gene, , Molecular therapy : the journal of the American Society of Gene Therapy, 2022, 10.1016/j.ymthe.2022.05.023
  • Intramuscular transplantation of human postnatal myoblasts generates functional donor-derived satellite cells, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.128
  • CRISPR-induced deletion with SaCas9 restores dystrophin expression in dystrophic models in vitro and in vivo, , 2018, 10.1101/378331
  • Approche Thérapeutique de la myopathie de Duchenne par transplantation de myoblastes, , Medecine sciences : M/S, 1991
  • Tubulyzine, a novel tri-substituted triazine, prevents the early cell death of transplanted myogenic cells and improves transplantation success, , Biochemistry and cell biology = Biochimie et biologie cellulaire, 2003, 10.1139/o03-054
  • Cell therapy in muscular dystrophies: many promises in mice and dogs, few facts in patients, , Expert opinion on biological therapy, 2015, 10.1517/14712598.2015.1057564
  • Intramuscular migration of myoblasts transplanted after muscle pretreatment with metalloproteinases, , Cell transplantation, 2000, 10.1177/096368970000900410
  • Improved success of myoblast transplantation in mdx mice by blocking the myostatin signal, , Transplantation, 2005, 10.1097/01.tp.0000167379.27872.2b
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  • Inflammatory damage following first-generation replication-defective adenovirus controlled by anti-LFA-1, , Journal of leukocyte biology, 1997, 10.1002/jlb.61.4.533
  • Expression of major histocompatibility complex antigens on human myoblasts, , Transplantation proceedings, 1991
  • Telomerase allows the immortalization of T antigen-positive DMD myoblasts: a new source of cells for gene transfer application, , Gene therapy, 2000, 10.1038/sj.gt.3301132
  • Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation, , Molecular therapy : the journal of the American Society of Gene Therapy, 2012, 10.1038/mt.2012.188
  • Base editing strategy allows insertion of the A673T mutation in APP gene to prevent the development of Alzheimer’s disease, Jacques P. Tremblay, Gabriel Lamothe, Tom Bertin, Francis-Gabriel Bégin, Joël Rousseau, Antoine Guyon, 2020, 10.1101/2020.10.27.357830
  • The urokinase plasminogen activator: an interesting way to improve myoblast migration following their transplantation, , Experimental cell research, 2002, 10.1006/excr.2002.5642
  • Complement deposition and cell death after myoblast transplantation, , Cell transplantation, 1998, 10.1016/s0963-6897(98)00029-3
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  • Resetting the problem of cell death following muscle-derived cell transplantation: detection, dynamics and mechanisms, , Journal of neuropathology and experimental neurology, 2003, 10.1093/jnen/62.9.951
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  • Three Decades of Clinical Gene Therapy: From Experimental Technologies to Viable Treatments, , Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 10.1016/j.ymthe.2021.01.013
  • Myoblast Transplantation in skeletal muscles, , 2010
  • First study of intra-arterial delivery of myogenic mononuclear cells to skeletal muscles in primates, , Cell transplantation, 2014, 10.3727/096368914X685032
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  • Intracellular delivery of a Tat-eGFP fusion protein into muscle cells, , Molecular therapy : the journal of the American Society of Gene Therapy, 2001, 10.1006/mthe.2001.0279
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  • Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype, Jacques P. Tremblay, Vanessa Couture, Pouiré Yameogo, Gabrielle Buisson, Malek Aloui, Nathalie Majeau, Solange Gni-fiene Yanyabé, Catherine Gérard, Camille Bouchard, Genes, 2023, 10.3390/genes14081654
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  • Identification of homozygous and heterozygous dy2J mice by PCR, , Neuromuscular disorders : NMD, 2000, 10.1016/s0960-8966(99)00056-5
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  • A Comment on Muscle Xenografts Reproduce Key Molecular Features of Facioscapulohumeral Muscular Dystrophy : What Is New and What Has Already been Done and Reported but Was Not Quoted?, , Cell transplantation, 2020, 10.1177/0963689720939120
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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Sina Ramezani - Doctorat - En cours
  • Gabriel Lamothe - Maîtrise avec mémoire - En cours
  • Maheswaran Kesavan - Doctorat - En cours
  • Yaoyao Lu - Doctorat - En cours
  • Ayesha Siddika - Doctorat - En cours
  • Camille Bouchard - Doctorat - En cours
  • Kelly Godbout - Maîtrise avec mémoire - En cours
  • Racha Metlej - Maîtrise avec mémoire - 2012/05
  • Amina Dahmani - Maîtrise avec mémoire - 2013/01
  • Jean-Paul Iyombe - Maîtrise avec mémoire - 2013/09
  • Laetitia Mavinga - Maîtrise avec mémoire - 2013/09
  • Chantale Maltais - Maîtrise avec mémoire - 2014/01
  • Ken Bisabu Kelu - Maîtrise avec mémoire - 2015/09
  • Amina Chikh - Maîtrise avec mémoire - 2015/09
  • William-Édouard Gravel - Maîtrise avec mémoire - 2016/01
  • Arnaud Perrin - Maîtrise avec mémoire - 2016/09
  • Daniel Agudelo - Maîtrise avec mémoire - 2016/09
  • Khadija Cherif - Maîtrise avec mémoire - 2017/01
  • Antoine Guyon - Doctorat - 2021/01
  • Malek Aloui - Maîtrise avec mémoire - 2021/09
  • Solange Gni-Fiene Yanyabe - Maîtrise avec mémoire - 2022/01
  • Annabelle Fortin-Archambault - Maîtrise avec mémoire - 2022/05
  • Guillaume Tremblay - Maîtrise avec mémoire - 2022/05
  • Pouiré Yameogo - Doctorat - 2023/01
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  • Bo Song - Maîtrise avec mémoire - 2024/01

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