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Jacques-P. Tremblay

Professeur titulaire

Jacques-P. Tremblay
jacques-p.tremblay@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Maladies musculaires
  • Lésions musculosquelettiques et réparations
Génétique humaine
  • Thérapie génique
  • Génétique moléculaire
  • Maladies génétiques
Neurosciences, santé mentale et toxicomanies
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Maladies neuromusculaires

Projets de recherche

  • Removal of the GAA repeat with the CRISPR/Cas9 system in Friedreich patient cells and in the YG8sR mouse model - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-02-06 au 2027-03-31
  • In vivo correction by CRISPR PRIME editing of mutations responsible for Duchenne Muscular Dystrophy - Vaincre Duchenne Canada, chercheur principal - 2023-12-01 au 2026-11-30
  • Development of a CRISPR-powered instrument for specific, rapid and simple detection of emerging respiratory pathogens - Génome Québec, Groupe BenDavid - Solutions génomiques pour l’identification, la caractérisation et la surveillance de la résistance aux antimicrobiens et des pathogènes émergents, chercheur principal - 2023-09-01 au 2025-08-31
  • Removal of the GAA repeat with the CRISPR/Cas9 system in Friedreich patient cells and in the YG8sR mouse model - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
  • Correcting point mutations responsible for Dysferlinopathy using Prime Editing - Jain Foundation Inc., chercheur principal - 2023-08-01 au 2024-07-31
  • Développement de microdispositifs transdermiques peu invasifs pour l’administration d'acides nucléiques : vaccination et thérapie génique - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université de Montréal, co-chercheur - 2023-04-01 au 2024-03-31
  • Development of an AAV library - Conseil national de recherches du Canada - Programmes et initiatives de R&D collaboratifs, chercheur principal - 2022-04-01 au 2024-03-31
  • Développement d'un traitement pour prévenir ou ralentir la progression de la maladie d'Alzheimer - Fondation Famille Lemaire, chercheur principal - 2023-11-08 au 2024-03-31
  • Correction with the Prime editing technology of point mutations responsible for Duchenne Muscular Dystrophy - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
  • PRIME editing correction of the T1709M mutation responsible for some cases of Ryanodine receptor type I-related myopathies - RYR-1 Foundation, chercheur principal - 2021-07-01 au 2023-06-30
  • Développement d’une thérapie génique pour l’ataxie de Friedreich - Ataxie Canada, chercheur principal - 2021-05-31 au 2023-05-31
  • Deciphering the role of DCIR in HIV-1 pathogenesis - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2018-04-01 au 2023-03-31
  • Les cellules souches pluripotentes génétiquement corrigées comme thérapie pour l’epidermolyse bulleuse simplex - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université du Québec à Chicoutimi - UQAC , co-chercheur - 2022-04-01 au 2023-03-31
  • Correction by CRISPR base editing of point mutations responsible for Duchenne Muscular Dystrophy - The Foundation for gene and cell therapy Jesse's Journey, chercheur principal - 2020-06-01 au 2022-05-31
  • Development of a rapid and simple test to detect the COVID-19 variants that can be used in remote areas and developing countries - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31
  • Correction of the c. 121 A to T mutation in the NKX6-2 gene by PRIME editing - Ataxia UK, chercheur principal - 2021-01-26 au 2022-01-25

Publications

  • Cytoplasmic restoration and persistence of glucose-6-phosphate dehydrogenase activity in stable hybrid myotubes, , European journal of histochemistry : EJH, 1993
  • Improved success of myoblast transplantation in mdx mice by blocking the myostatin signal, , Transplantation, 2005, 10.1097/01.tp.0000167379.27872.2b
  • Endonucleases: tools to correct the dystrophin gene, , The journal of gene medicine, 2011, 10.1002/jgm.1611
  • Gene Editing for Duchenne Muscular Dystrophy Using the CRISPR/Cas9 Technology: The Importance of Fine-tuning the Approach, , Molecular therapy : the journal of the American Society of Gene Therapy, 2016, 10.1038/mt.2016.191
  • Small-molecule inhibitors of proteasome increase CjCas9 protein stability, Jacques P. Tremblay, Cedric Happi Mbakam, Nathalie Majeau, Pouiré Yaméogo, PLOS ONE, 2023, 10.1371/journal.pone.0280353
  • A new technique to identify hybrid myotubes in vitro without culture fixation, , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1991, 10.1177/39.1.1701185
  • Localization of dystrophin in the Purkinje cells of normal mice, , Neuroscience letters, 1992, 10.1016/0304-3940(92)90309-u
  • Rapid selection of donor myoblast clones for muscular dystrophy therapy using cell surface expression of NCAM, , European journal of histochemistry : EJH, 1993
  • Myoblast transplantation produced dystrophin-positive muscle fibres in a 16-year-old patient with Duchenne muscular dystrophy, , Clinical science (London, England : 1979), 1991, 10.1042/cs0810287
  • Myoblast transplantation: the current status of a potential therapeutic tool for myopathies, , Journal of muscle research and cell motility, 2003
  • Complement deposition and cell death after myoblast transplantation, , Cell transplantation, 1998, 10.1016/s0963-6897(98)00029-3
  • The urokinase plasminogen activator: an interesting way to improve myoblast migration following their transplantation, , Experimental cell research, 2002, 10.1006/excr.2002.5642
  • Three Decades of Clinical Gene Therapy: From Experimental Technologies to Viable Treatments, , Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 10.1016/j.ymthe.2021.01.013
  • Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease, , PloS one, 2010, 10.1371/journal.pone.0010055
  • Identification of a putative pathway for the muscle homing of stem cells in a muscular dystrophy model, , The Journal of cell biology, 2003, 10.1083/jcb.200210006
  • Increased number per area of peptidergic and cholinergic vesicles in synapses of the chick ciliary ganglion following 10 Hz in vivo stimulation, , Neuroscience letters, 1983, 10.1016/0304-3940(83)90542-6
  • Muscle fibers of mdx mice are more vulnerable to exercise than those of normal mice, , Neuromuscular disorders : NMD, 1997, 10.1016/s0960-8966(97)00115-6
  • Quantification of normal dystrophin mRNA following myoblast transplantation in mdx mice, , Muscle & nerve, 1995, 10.1002/mus.880180909
  • Increased Frataxin Expression Induced in Friedreich Ataxia Cells by Platinum TALE-VP64s or Platinum TALE-SunTag, , Molecular therapy. Nucleic acids, 2018, 10.1016/j.omtn.2018.04.009
  • CRISPR-induced deletion with SaCas9 restores dystrophin expression in dystrophic models in vitro and in vivo, , 2018, 10.1101/378331
  • In vitro bromodeoxyuridine labeling of nuclei: application to myotube hybridization, , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1991, 10.1177/39.10.1940314
  • Insertion of the Icelandic Mutation (A673T) by Prime Editing: A Potential Preventive Treatment for Familial and Sporadic Alzheimer's Disease, , The CRISPR journal, 2022, 10.1089/crispr.2021.0085
  • 1,25-dihydroxyvitamin D3 increases the transplantation success of human muscle precursor cells in SCID mice, , Cell transplantation, 2007, 10.3727/000000007783464876
  • Dynamics of the early immune cellular reactions after myogenic cell transplantation, , Cell transplantation, 2002, 10.3727/000000002783985378
  • Successful myoblast transplantation in fibrotic muscles: no increased impairment by the connective tissue, , Transplantation, 1999, 10.1097/00007890-199906270-00018
  • First study of intra-arterial delivery of myogenic mononuclear cells to skeletal muscles in primates, , Cell transplantation, 2014, 10.3727/096368914X685032
  • CRISPR-Induced Deletion with SaCas9 Restores Dystrophin Expression in Dystrophic Models In Vitro and In Vivo, , Molecular therapy : the journal of the American Society of Gene Therapy, 2018, 10.1016/j.ymthe.2018.08.010
  • Anti-inflammatory effect of transforming growth factor-beta1 in myoblast transplantation, , Transplantation, 1998, 10.1097/00007890-199803270-00005
  • Intramuscular migration of myoblasts transplanted after muscle pretreatment with metalloproteinases, , Cell transplantation, 2000, 10.1177/096368970000900410
  • Limb–Girdle Muscular Dystrophies Classification and Therapies, Jacques P. Tremblay, Camille Bouchard, Journal of Clinical Medicine, 2023, 10.3390/jcm12144769
  • Current status of pharmaceutical and genetic therapeutic approaches to treat DMD, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2011.59
  • Sarcolemmal Complement Membrane Attack Complex Deposits During Acute Rejection of Myofibers in Nonhuman Primates, , Journal of neuropathology and experimental neurology, 2019, 10.1093/jnen/nly106
  • High efficiency of muscle regeneration after human myoblast clone transplantation in SCID mice, , The Journal of clinical investigation, 1994, 10.1172/JCI117011
  • The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer's Disease in SH-SY5Y cells, , PloS one, 2020, 10.1371/journal.pone.0237122
  • Not an inside job: how can transplantation of relatively few exogenous satellite cells do what thousands of endogenous cells cannot?, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2010.276
  • Experimental and therapeutic approaches to muscular dystrophies, , Current opinion in neurology, 2002, 10.1097/00019052-200210000-00007
  • Transplantation of human myoblasts in SCID mice as a potential muscular model for myotonic dystrophy, , Journal of neuropathology and experimental neurology, 1999, 10.1097/00005072-199909000-00003
  • Dystrophin expression in muscles of duchenne muscular dystrophy patients after high-density injections of normal myogenic cells, , Journal of neuropathology and experimental neurology, 2006, 10.1097/01.jnen.0000218443.45782.81
  • Cytomegalovirus and myoblast transplantation, , Lancet (London, England), 1991, 10.1016/0140-6736(91)93090-v
  • Presynaptic modulating effects of GABA on depression, facilitation, and posttetanic potentiation of a cholinergic synapse in Aplysia californica, , Canadian journal of physiology and pharmacology, 1977, 10.1139/y77-174
  • Scale-up of a myoblast culture process, , Journal of biotechnology, 2001, 10.1016/s0168-1656(01)00291-7
  • Cyclophosphamide immunosuppression does not permit successful myoblast allotransplantation in mouse, , Neuromuscular disorders : NMD, 1995, 10.1016/0960-8966(95)00011-b
  • Meganucleases can restore the reading frame of a mutated dystrophin, , Gene therapy, 2010, 10.1038/gt.2010.26
  • Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients, , Molecular therapy : the journal of the American Society of Gene Therapy, 2013, 10.1038/mt.2013.111
  • Human myoblast transplantation: preliminary results of 4 cases, , Muscle & nerve, 1992, 10.1002/mus.880150504
  • Utilization of myoblasts from transgenic mice to evaluate the efficacy of myoblast transplantation, , Muscle & nerve, 1994, 10.1002/mus.880170903
  • Successful Correction by Prime Editing of a Mutation in the RYR1 Gene Responsible for a Myopathy, Jacques P. Tremblay, Joël Rousseau, Kelly Godbout, Cells, 2023, 10.3390/cells13010031
  • Transcription activator-like effector proteins induce the expression of the frataxin gene, , Human gene therapy, 2012, 10.1089/hum.2012.034
  • Human myoblast transplantation: a simple assay for tumorigenicity, , Neuromuscular disorders : NMD, 1991, 10.1016/0960-8966(91)90120-h
  • Myoblast transplantation: techniques in nonhuman primates as a bridge to clinical trials, , 2011
  • Is the MEPP due to the release of one vesicle or to the simultaneous release of several vesicles at one active zone?, , Brain research, 1983, 10.1016/0165-0173(83)90009-7
  • Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4Ig, , Human gene therapy, 1996, 10.1089/hum.1996.7.12-1455
  • Myoblast transplantation: a brief review of the problems and of some solutions, , Basic and applied myology : BAM, 1997
  • FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer, , Human gene therapy, 1995, 10.1089/hum.1995.6.11-1391
  • Myoblast allotransplantation in mice: degree of success varies depending on the efficacy of various immunosuppressive treatments, , Transplantation proceedings, 1994
  • Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice, , Transplantation proceedings, 1994
  • Antibody formation after myoblast transplantation in Duchenne-dystrophic patients, donor HLA compatible, , Transplantation proceedings, 1993
  • Enzymatic activity and morphological differentiation in de novo innervated human muscle cultures, , European journal of histochemistry : EJH, 1994
  • Autotransplantation in mdx mice of mdx myoblasts genetically corrected by an HSV-1 amplicon vector, , Cell transplantation, 2002
  • Assessment of a symptomatic Duchenne muscular dystrophy carrier 20 years after myoblast transplantation from her asymptomatic identical twin sister, , Neuromuscular disorders : NMD, 2013, 10.1016/j.nmd.2013.04.007
  • Miniature endplate potential amplitudes corrected for spatial decay are not normally distributed, , Brain research, 1985, 10.1016/0006-8993(85)91339-3
  • Administration of a soluble activin type IIB receptor promotes the transplantation of human myoblasts in dystrophic mice, , Cell transplantation, 2012, 10.3727/096368911X627480
  • Increase in the proliferative capacity of human myoblasts by using the T antigen under the vimentin promoter control, , Muscle & nerve, 1997, 10.1002/(sici)1097-4598(199704)20:43.0.co;2-b
  • Myoblast transplantation between monozygotic twin girl carriers of Duchenne muscular dystrophy, , Neuromuscular disorders : NMD, 1993, 10.1016/0960-8966(93)90121-y
  • Non-uniform distribution of miniature endplate potential amplitudes along the length of the frog neuromuscular junction, , Neuroscience letters, 1987, 10.1016/0304-3940(87)90147-9
  • A monoclonal antibody to conotoxin reveals the distribution of a subset of calcium channels in the rat cerebellar cortex, , Brain research. Molecular brain research, 1991, 10.1016/0169-328x(91)90004-h
  • Inflammatory damage following first-generation replication-defective adenovirus controlled by anti-LFA-1, , Journal of leukocyte biology, 1997, 10.1002/jlb.61.4.533
  • Therapeutic Strategies for Dystrophin Replacement in Duchenne Muscular Dystrophy, , Frontiers in medicine, 2022, 10.3389/fmed.2022.859930
  • Role of non-major histocompatibility complex antigens in the rejection of transplanted myoblasts, , Transplantation, 1997, 10.1097/00007890-199703270-00016
  • Resting and stimulated values of model parameters governing transmitter release at a synapse in Aplysia californica, , Brain research, 1976, 10.1016/0006-8993(76)90378-4
  • Telomerase allows the immortalization of T antigen-positive DMD myoblasts: a new source of cells for gene transfer application, , Gene therapy, 2000, 10.1038/sj.gt.3301132
  • Evidence of mdx mouse skeletal muscle fragility in vivo by eccentric running exercise, , Muscle & nerve, 1998, 10.1002/(sici)1097-4598(199805)21:53.0.co;2-6
  • Normal myoblast implantation in MDX mice prevents muscle damage by exercise, , Biochemical and biophysical research communications, 1998, 10.1006/bbrc.1998.9276
  • Benzodiazepines modify synaptic depression, frequency facilitation and PTP an identified cholinergic synapse of Aplysia, , Life sciences, 1980, 10.1016/0024-3205(80)90130-7
  • Advances & challenges of using CRISPR-Cas9 gene editing for treating Duchenne muscular dystrophy, , Cell & gene therapy insights, 2017, 10.18609/cgti.2017.003
  • Scanning electron microscopic study of the neuromuscular junction of dystrophic mice, , Experimental neurology, 1988, 10.1016/0014-4886(88)90200-2
  • Cell therapies for inherited myopathies, , Current opinion in rheumatology, 2003, 10.1097/00002281-200311000-00007
  • Cell therapy in muscular dystrophies: many promises in mice and dogs, few facts in patients, , Expert opinion on biological therapy, 2015, 10.1517/14712598.2015.1057564
  • Tubulyzine, a novel tri-substituted triazine, prevents the early cell death of transplanted myogenic cells and improves transplantation success, , Biochemistry and cell biology = Biochimie et biologie cellulaire, 2003, 10.1139/o03-054
  • Generation of lentiviral vectors for use in skeletal muscle research, , Methods in molecular biology (Clifton, N.J.), 2012, 10.1007/978-1-61779-343-1_16
  • Section VI - Novel Genetic Technologies. 6.2 Gene Therapy, , 2009
  • Base editing strategy allows insertion of the A673T mutation in APP gene to prevent the development of Alzheimer’s disease, Jacques P. Tremblay, Gabriel Lamothe, Tom Bertin, Francis-Gabriel Bégin, Joël Rousseau, Antoine Guyon, 2020, 10.1101/2020.10.27.357830
  • Dystrophin expression in host muscle following transplantation of muscle precursor cells modified with the phiC31 integrase, , Gene therapy, 2007, 10.1038/sj.gt.3302887
  • Exercise improves the success of myoblast transplantation in mdx mice, , Neuromuscular disorders : NMD, 2006, 10.1016/j.nmd.2006.06.003
  • A monoclonal antibody to beta-tubulin distinguishes a subset of neurons and axons in the chick ciliary ganglion, , Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, 10.1139/o85-065
  • Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro, , Molecular therapy. Nucleic acids, 2021, 10.1016/j.omtn.2021.02.032
  • Dystrophin-like immunoreactivity in monkey and human brain areas involved in learning and motor functions, , Neuroscience letters, 1992, 10.1016/0304-3940(92)90890-j
  • Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization, , Molecular cancer research : MCR, 2003
  • Very efficient myoblast allotransplantation in mice under FK506 immunosuppression, , Muscle & nerve, 1994, 10.1002/mus.880171210
  • Decidualization and maintenance of a functional prostaglandin system in human endometrial cell lines following transformation with SV40 large T antigen, , Molecular human reproduction, 2006, 10.1093/molehr/gal034
  • Efficient myoblast transplantation in mice immunosuppressed with monoclonal antibodies and CTLA4 Ig, , Transplantation proceedings, 1997, 10.1016/s0041-1345(97)00166-8
  • Non monotonic morphometric changes produced at mouse neuromuscular junctions following in vivo stimulation at various frequencies, , Experimental brain research, 1986, 10.1007/BF00237590
  • The CRISPR system can correct or modify the expression of genes responsible for hereditary diseases, , Medecine sciences : M/S, 2015, 10.1051/medsci/20153111016
  • Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice, , Neuromuscular disorders : NMD, 2002, 10.1016/s0960-8966(01)00254-1
  • Dystrophin expression in myotubes formed by the fusion of normal and dystrophic myoblasts, , Muscle & nerve, 1991, 10.1002/mus.880140213
  • Myoblast allotransplantation in primates, , Muscle & nerve, 1995
  • Immune Reaction Following Cell and Gene Therapy, , 2000
  • Is dystrophin present in the nerve terminal at the neuromuscular junction? An immunohistochemical study of the heterozygote dystrophic (mdx) mouse, , Synapse (New York, N.Y.), 1991, 10.1002/syn.890070207
  • CRISPR/Cas9 delivery strategies with engineered extracellular vesicles, Jacques P. Tremblay, Gabriel Lamothe, Kelly Godbout, Yaoyao Lu, Molecular Therapy - Nucleic Acids, 2023, 10.1016/j.omtn.2023.102040
  • Gene therapy: a strategy for the treatment of inherited muscle diseases?, , Current opinion in pharmacology, 2001, 10.1016/s1471-4892(01)00052-2
  • Transplantation of normal or genetically modified myoblasts for the treatment of hereditary or acquired diseases, , Journal de la Societe de biologie, 2001
  • Fast turnover of clear vesicle membrane in frog sympathetic ganglion, , Neuroscience, 1986, 10.1016/0306-4522(86)90093-x
  • Efficient Restoration of the Dystrophin Gene Reading Frame and Protein Structure in DMD Myoblasts Using the CinDel Method, , Molecular therapy. Nucleic acids, 2016, 10.1038/mtna.2015.58
  • Intramuscular transplantation of human postnatal myoblasts generates functional donor-derived satellite cells, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.128
  • CRISPR-SCReT (CRISPR-Stop Codon Read Through) method to control Cas9 expression for gene editing, , Gene therapy, 2022, 10.1038/s41434-021-00297-z
  • Induction of Anoikis following myoblast transplantation into SCID mouse muscles requires the Bit1 and FADD pathways, , American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2007, 10.1111/j.1600-6143.2007.01830.x
  • Overexpression of follistatin in human myoblasts increases their proliferation and differentiation, and improves the graft success in SCID mice, , Cell transplantation, 2009, 10.3727/096368909X470865
  • A new pro-migratory activity on human myogenic precursor cells for a synthetic peptide within the E domain of the mechano growth factor, , Experimental cell research, 2007, 10.1016/j.yexcr.2006.10.032
  • Real-time imaging of myoblast transplantation using the human sodium iodide symporter, , BioTechniques, 2005, 10.2144/05386IT01
  • Heterogeneous labeling of mitochondrial membrane, endoplasmic reticulum, neurofilaments and synaptic vesicles with a lectin (DBA-peroxidase), , Neuroscience letters, 1982, 10.1016/0304-3940(82)90003-9
  • Intramuscular transplantation of myogenic cells in primates: importance of needle size, cell number, and injection volume, , Cell transplantation, 2014, 10.3727/096368912X661337
  • Effects of vitamin C on cytotherapy-mediated muscle regeneration, , Cell transplantation, 2013, 10.3727/096368912X657846
  • Human Muscle Precursor Cells Form Human-Derived Myofibers in Skeletal Muscles of Nonhuman Primates: A Potential New Preclinical Setting to Test Myogenic Cells of Human Origin for Cell Therapy of Myopathies, , Journal of neuropathology and experimental neurology, 2020, 10.1093/jnen/nlaa110
  • Intraarterial injection of muscle-derived CD34(+)Sca-1(+) stem cells restores dystrophin in mdx mice, , The Journal of cell biology, 2001, 10.1083/jcb.152.2.335
  • Efficacy of myoblast transplantation in nonhuman primates following simple intramuscular cell injections: toward defining strategies applicable to humans, , Experimental neurology, 2002, 10.1006/exnr.2002.7899
  • Past, present and future of myoblast transplantation in the treatment of Duchenne muscular dystrophy, , Pediatric transplantation, 2010, 10.1111/j.1399-3046.2010.01377.x
  • Systemic production of human granulocyte colony-stimulating factor in nonhuman primates by transplantation of genetically modified myoblasts, , Human gene therapy, 2000, 10.1089/10430340050032384
  • Meeting of the Cell Transplantation Society in Miami, , Cell transplantation, 1997
  • Endosome disruption enhances the functional nuclear delivery of Tat-fusion proteins, , Biochemical and biophysical research communications, 2004, 10.1016/j.bbrc.2004.04.180
  • Frequency facilitation and post-tetanic potentiation of a unitary synaptic potential in Aplysia californica are limited by different processes, , Brain research, 1976, 10.1016/0006-8993(76)90377-2
  • Necrosis, sarcolemmal damage and apoptotic events in myofibers rejected by CD8+ lymphocytes: Observations in nonhuman primates, , Neuromuscular disorders : NMD, 2012, 10.1016/j.nmd.2012.05.005
  • CSCI/RCPSC Henry Friesen Lecture: Cell therapy for Duchenne muscular dystrophy, , Clinical and investigative medicine. Medecine clinique et experimentale, 2006
  • Prime Editing for Human Gene Therapy: Where Are We Now?, Jacques P. Tremblay, Kelly Godbout, Cells, 2023, 10.3390/cells12040536
  • Electrotransfer of the full-length dog dystrophin into mouse and dystrophic dog muscles, , Human gene therapy, 2010, 10.1089/hum.2010.024
  • Development of an AAV9 coding for a 3XFLAG-TALEfrat#8-VP64 able to increase in vivo the human frataxin in YG8R mice, , Gene therapy, 2016, 10.1038/gt.2016.36
  • Successive injections in mdx mice of myoblasts grown with bFGF, , Neuromuscular disorders : NMD, 1996, 10.1016/0960-8966(96)00004-1
  • Current Clinical Applications of In Vivo Gene Therapy with AAVs, , Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 10.1016/j.ymthe.2020.12.007
  • Treatment with anti-CD154 antibody and donor-specific transfusion prevents acute rejection of myoblast transplantation, , Transplantation, 2002, 10.1097/00007890-200202150-00021
  • Vascular endothelial growth factor reduced hypoxia-induced death of human myoblasts and improved their engraftment in mouse muscles, , Gene therapy, 2008, 10.1038/sj.gt.3303059
  • A Potential New Therapeutic Approach for Friedreich Ataxia: Induction of Frataxin Expression With TALE Proteins, , Molecular therapy. Nucleic acids, 2013, 10.1038/mtna.2013.41
  • Characterization of frataxin gene network in Friedreich's ataxia fibroblasts using the RNA-Seq technique, , Mitochondrion, 2016, 10.1016/j.mito.2016.06.003
  • Percutaneous versus surgical delivery of autologous myoblasts after chronic myocardial infarction: an in vivo cardiovascular magnetic resonance study, , Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2010, 10.1002/ccd.22204
  • Removal of the GAA repeat in the heart of a Friedreich’s ataxia mouse model using CjCas9, Jacques P. Tremblay, Nathalie Majeau, Catherine Gérard, Pouiré Yaméogo, Gene Therapy, 2023, 10.1038/s41434-023-00387-0
  • Use of normal and genetically modified myoblasts for the treatment of myopathies, , 2000
  • Myoblast transplantation in skeletal muscles, , 2012
  • An electron microscope study of synaptic contacts in the abdominal ganglion of Aplysia californica, , The Journal of comparative neurology, 1979, 10.1002/cne.901880303
  • Interrelation between MEPP amplitude and MEPP frequency in different regions along the frog neuromuscular junction, , Brain research, 1987, 10.1016/0006-8993(87)90404-5
  • Successful myoblast allotransplantation in mdx mice using rapamycin, , Transplantation, 1995
  • Central tolerance to myogenic cell transplants does not include muscle neoantigens, , Transplantation, 2008, 10.1097/TP.0b013e31817726bc
  • Confirmation of donor-derived dystrophin in a duchenne muscular dystrophy patient allotransplanted with normal myoblasts, , Muscle & nerve, 2016, 10.1002/mus.25129
  • Human myoblast transplantation in immunodeficient and immunosuppressed mice: evidence of rejection, , Muscle & nerve, 1994, 10.1002/mus.880170214
  • Postsynaptic structure may account for variations in miniature endplate current shapes along frog neuromuscular junctions, , Synapse (New York, N.Y.), 1990, 10.1002/syn.890050402
  • Human myoblast transplantation between immunohistocompatible donors and recipients produces immune reactions, , Transplantation proceedings, 1992
  • Baclofen modifies via the release of monoamines the synaptic depression, frequency facilitation, and posttetanic potentiation observed at an identified cholinergic synapse of Aplysia californica, , Canadian journal of physiology and pharmacology, 1981, 10.1139/y81-039
  • Development of a web course on gene therapy by the international consortium of gene therapy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2014, 10.1038/mt.2014.11
  • Mosaic expression of dystrophin in the cerebellum of heterozygote dystrophic (mdx) mice, , Neuromuscular disorders : NMD, 1992, 10.1016/s0960-8966(06)80002-7
  • In vivo stimulation of a cholinergic synapse of the chick ciliary ganglion induces a reduction in the number of dense core vesicles, , Neuroscience letters, 1981, 10.1016/0304-3940(81)90176-2
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  • Immune reactions after myoblast transplantation in mouse muscles, , Transplantation proceedings, 1992
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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Camille Bouchard - Doctorat - En cours
  • Gabriel Lamothe - Maîtrise avec mémoire - En cours
  • Maheswaran Kesavan - Doctorat - En cours
  • Kelly Godbout - Doctorat - En cours
  • Ayesha Siddika - Doctorat - En cours
  • Yaoyao Lu - Doctorat - En cours
  • Sina Ramezani - Doctorat - En cours
  • Racha Metlej - Maîtrise avec mémoire - 2012/05
  • Amina Dahmani - Maîtrise avec mémoire - 2013/01
  • Laetitia Mavinga - Maîtrise avec mémoire - 2013/09
  • Jean-Paul Iyombe - Maîtrise avec mémoire - 2013/09
  • Chantale Maltais - Maîtrise avec mémoire - 2014/01
  • Amina Chikh - Maîtrise avec mémoire - 2015/09
  • Ken Bisabu Kelu - Maîtrise avec mémoire - 2015/09
  • William-Édouard Gravel - Maîtrise avec mémoire - 2016/01
  • Arnaud Perrin - Maîtrise avec mémoire - 2016/09
  • Daniel Agudelo - Maîtrise avec mémoire - 2016/09
  • Khadija Cherif - Maîtrise avec mémoire - 2017/01
  • Antoine Guyon - Doctorat - 2021/01
  • Malek Aloui - Maîtrise avec mémoire - 2021/09
  • Solange Gni-Fiene Yanyabe - Maîtrise avec mémoire - 2022/01
  • Guillaume Tremblay - Maîtrise avec mémoire - 2022/05
  • Annabelle Fortin-Archambault - Maîtrise avec mémoire - 2022/05
  • Pouiré Yameogo - Doctorat - 2023/01
  • Cedric Happi Mbakam - Doctorat - 2023/05
  • Bo Song - Maîtrise avec mémoire - 2024/01

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