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Jacques-P. Tremblay

Professeur titulaire

jacques-p.tremblay@fmed.ulaval.ca

Site personnel

Département de médecine moléculaire

Centre thématique de recherche en neurosciences

Centre de recherche du CHU de Québec - Université Laval

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale

Domaines de recherche

Thérapie génique et moléculaire
Biotechnologies médicales, n.c.a.

Projets de recherche en cours

Correction by Prime editing of point mutations responsible for Cystic fibrosis in Quebec province - Génome Québec - Cibler des mutations rares, orphelines de CFTR, McGill University, co-chercheur - 2025-04-01 au 2028-03-30
In vivo correction by CRISPR PRIME editing of mutations responsible for Duchenne Muscular Dystrophy - Vaincre Duchenne Canada, chercheur principal - 2023-12-01 au 2026-11-30
Correction of point mutations responsible for Dysferlinopathy using Prime Editing Renouvellement 2025-2026 - Jain Foundation Inc., chercheur principal - 2025-02-01 au 2026-01-31

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Financements des 2 dernières années

Removal of the GAA repeat with the CRISPR/Cas9 system in Friedreich patient cells and in the YG8sR mouse model - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
Correcting point mutations responsible for Dysferlinopathy using Prime Editing - Jain Foundation Inc., chercheur principal - 2023-08-01 au 2024-07-31
Développement de microdispositifs transdermiques peu invasifs pour l’administration d'acides nucléiques : vaccination et thérapie génique - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université de Montréal, co-chercheur - 2023-04-01 au 2024-03-31
Development of an AAV library - Conseil national de recherches du Canada - Programmes et initiatives de R&D collaboratifs, chercheur principal - 2022-04-01 au 2024-03-31
Développement d'un traitement pour prévenir ou ralentir la progression de la maladie d'Alzheimer - Fondation Famille Lemaire, chercheur principal - 2023-11-08 au 2024-03-31
Correction with the Prime editing technology of point mutations responsible for Duchenne Muscular Dystrophy - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
PRIME editing correction of the T1709M mutation responsible for some cases of Ryanodine receptor type I-related myopathies - RYR-1 Foundation, chercheur principal - 2021-07-01 au 2023-06-30
Development of a rapid and simple test to detect the COVID-19 variants that can be used in remote areas and developing countries - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31

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Publications

Cytomegalovirus and myoblast transplantation, , Lancet (London, England), 1991, 10.1016/0140-6736(91)93090-v
Dopamine, serotonin and related compounds: presynaptic effects on synaptic depression, frequency facilitation, and post-tetanic potentiation at a synapse in Aplysia californica, , Brain research, 1976, 10.1016/0006-8993(76)90380-2
Dystrophin expression in myotubes formed by the fusion of normal and dystrophic myoblasts, , Muscle & nerve, 1991, 10.1002/mus.880140213
The Process of Engraftment of Myogenic Cells in Skeletal Muscles of Primates: Understanding Clinical Observations and Setting Directions in Cell Transplantation Research, , Cell transplantation, 2017, 10.1177/0963689717724798
Baclofen modifies via the release of monoamines the synaptic depression, frequency facilitation, and posttetanic potentiation observed at an identified cholinergic synapse of Aplysia californica, , Canadian journal of physiology and pharmacology, 1981, 10.1139/y81-039
Human Muscle Precursor Cells Form Human-Derived Myofibers in Skeletal Muscles of Nonhuman Primates: A Potential New Preclinical Setting to Test Myogenic Cells of Human Origin for Cell Therapy of Myopathies, , Journal of neuropathology and experimental neurology, 2020, 10.1093/jnen/nlaa110
Anti-inflammatory effect of transforming growth factor-beta1 in myoblast transplantation, , Transplantation, 1998, 10.1097/00007890-199803270-00005
Myogenesis: where and how can we get skeletal myoblasts?, , Dialogues in cardiovascular medicine : DCM, 2003
FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer, , Human gene therapy, 1995, 10.1089/hum.1995.6.11-1391
Generation of human endometrial knockout cell lines with the CRISPR/Cas9 system confirms the prostaglandin F2α synthase activity of aldo-ketoreductase 1B1, , Molecular human reproduction, 2014, 10.1093/molehr/gau023
Very efficient myoblast allotransplantation in mice under FK506 immunosuppression, , Muscle & nerve, 1994, 10.1002/mus.880171210
A new technique to identify hybrid myotubes in vitro without culture fixation, , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1991, 10.1177/39.1.1701185
Lymphocyte infiltration following allo- and xenomyoblast transplantation in mdx mice, , Muscle & nerve, 1995, 10.1002/mus.880180107
Myoblast Transplantation in skeletal muscles, , 2010
Non-uniform distribution of miniature endplate potential amplitudes along the length of the frog neuromuscular junction, , Neuroscience letters, 1987, 10.1016/0304-3940(87)90147-9
1,25-dihydroxyvitamin D3 increases the transplantation success of human muscle precursor cells in SCID mice, , Cell transplantation, 2007, 10.3727/000000007783464876
Past, present and future of myoblast transplantation in the treatment of Duchenne muscular dystrophy, , Pediatric transplantation, 2010, 10.1111/j.1399-3046.2010.01377.x
Dystrophin expression in muscles of duchenne muscular dystrophy patients after high-density injections of normal myogenic cells, , Journal of neuropathology and experimental neurology, 2006, 10.1097/01.jnen.0000218443.45782.81
Depression and frequency facilitation at a synapse in Aplysia californica: evidence for regulation by availability of transmitter, , Brain research, 1974, 10.1016/0006-8993(74)90459-4
The urokinase plasminogen activator: an interesting way to improve myoblast migration following their transplantation, , Experimental cell research, 2002, 10.1006/excr.2002.5642
Electrotransfer of the full-length dog dystrophin into mouse and dystrophic dog muscles, , Human gene therapy, 2010, 10.1089/hum.2010.024
Muscle glucose-6-phosphate dehydrogenase deficiency: restoration of enzymatic activity in hybrid myotubes, , Muscle & nerve, 1993, 10.1002/mus.880160604
Therapeutic Strategies for Dystrophin Replacement in Duchenne Muscular Dystrophy, , Frontiers in medicine, 2022, 10.3389/fmed.2022.859930
Myoblast transplantation: the current status of a potential therapeutic tool for myopathies, , Journal of muscle research and cell motility, 2003
Tubulyzine, a novel tri-substituted triazine, prevents the early cell death of transplanted myogenic cells and improves transplantation success, , Biochemistry and cell biology = Biochimie et biologie cellulaire, 2003, 10.1139/o03-054
Expression of dog microdystrophin in mouse and dog muscles by gene therapy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.23
Fibrin gel improves the survival of transplanted myoblasts, , Cell transplantation, 2012, 10.3727/096368911X576018
Male-specific competitive PCR for the quantification of transplanted cells in mice, , BioTechniques, 1999, 10.2144/99273bm05
Nucleofection of muscle-derived stem cells and myoblasts with phiC31 integrase: stable expression of a full-length-dystrophin fusion gene by human myoblasts, , Molecular therapy : the journal of the American Society of Gene Therapy, 2004, 10.1016/j.ymthe.2004.05.034
Dystrophin expression following the transplantation of normal muscle precursor cells protects mdx muscle from contraction-induced damage, , Cell transplantation, 2010, 10.3727/096368910X4863235
Intramuscular migration of myoblasts transplanted after muscle pretreatment with metalloproteinases, , Cell transplantation, 2000, 10.1177/096368970000900410
Incorporation of vesicular antigens into the presynaptic membrane during exocytosis at the frog neuromuscular junction: a light and electron microscopy immunochemical study, , Neuroscience, 1987, 10.1016/0306-4522(87)90147-3
Successful myoblast allotransplantation in mdx mice using rapamycin, , Transplantation, 1995
Interrelation between MEPP amplitude and MEPP frequency in different regions along the frog neuromuscular junction, , Brain research, 1987, 10.1016/0006-8993(87)90404-5
Miniature endplate potential amplitudes corrected for spatial decay are not normally distributed, , Brain research, 1985, 10.1016/0006-8993(85)91339-3
A monoclonal antibody to conotoxin reveals the distribution of a subset of calcium channels in the rat cerebellar cortex, , Brain research. Molecular brain research, 1991, 10.1016/0169-328x(91)90004-h
Intramuscular transplantation of myogenic cells in primates: importance of needle size, cell number, and injection volume, , Cell transplantation, 2014, 10.3727/096368912X661337
Quantification of normal dystrophin mRNA following myoblast transplantation in mdx mice, , Muscle & nerve, 1995, 10.1002/mus.880180909
CRISPR-Induced Deletion with SaCas9 Restores Dystrophin Expression in Dystrophic Models In Vitro and In Vivo, , Molecular therapy : the journal of the American Society of Gene Therapy, 2018, 10.1016/j.ymthe.2018.08.010
Non monotonic morphometric changes produced at mouse neuromuscular junctions following in vivo stimulation at various frequencies, , Experimental brain research, 1986, 10.1007/BF00237590
Successful Correction by Prime Editing of a Mutation in the RYR1 Gene Responsible for a Myopathy, Jacques P. Tremblay, Joël Rousseau, Kelly Godbout, Cells, 2023, 10.3390/cells13010031
Combined immunosuppression of mycophenolate mofetil and FK506 for myoblast transplantation in mdx mice, , Transplantation, 2001, 10.1097/00007890-200107150-00010
First study of intra-arterial delivery of myogenic mononuclear cells to skeletal muscles in primates, , Cell transplantation, 2014, 10.3727/096368914X685032
Transplantation of myoblasts from a transgenic mouse overexpressing dystrophin prduced only a relatively small increase of dystrophin-positive membrane, , Muscle & nerve, 1998, 10.1002/(sici)1097-4598(199801)21:13.0.co;2-3
A Historic Recapitulation of Myoblast Transplantation, , 2006
Meeting of the Cell Transplantation Society in Miami, , Cell transplantation, 1997
Heterosynaptic inhibition modifies the presynaptic plasticities of the transmission process at the synapse in Aplysia californica, , Brain research, 1976, 10.1016/0006-8993(76)90381-4
Novel Duchenne muscular dystrophy treatment through myoblast transplantation tolerance with anti-CD45RB, anti-CD154 and mixed chimerism, , American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2004, 10.1111/j.1600-6143.2004.00501.x
AG490 improves the survival of human myoblasts in vitro and in vivo, , Cell transplantation, 2012, 10.3727/096368912X655028
Synaptic depression at a synapse in Aplysia californica: analysis in terms of a material flow model of neurotransmitter, , Brain research, 1976, 10.1016/0006-8993(76)90379-6
Increased myogenic potential and fusion of matrilysin-expressing myoblasts transplanted in mice, , Cell transplantation, 1999, 10.1177/096368979900800502
Necrosis, sarcolemmal damage and apoptotic events in myofibers rejected by CD8+ lymphocytes: Observations in nonhuman primates, , Neuromuscular disorders : NMD, 2012, 10.1016/j.nmd.2012.05.005
High efficiency of muscle regeneration after human myoblast clone transplantation in SCID mice, , The Journal of clinical investigation, 1994, 10.1172/JCI117011
Current status of pharmaceutical and genetic therapeutic approaches to treat DMD, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2011.59
Myoblast survival enhancement and transplantation success improvement by heat-shock treatment in mdx mice, , Transplantation, 2004, 10.1097/01.tp.0000121503.01535.f5
Evaluation of various gene transfection methods into human myoblast clones, , Transplantation proceedings, 1992
Repeated stimulation of the dystrophic mouse neuromuscular junctions, , Muscle & nerve, 1987, 10.1002/mus.880100405
Intramuscular transplantation of human postnatal myoblasts generates functional donor-derived satellite cells, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.128
Development of a web course on gene therapy by the international consortium of gene therapy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2014, 10.1038/mt.2014.11
Preservation of muscle spindles in a 27-year-old Duchenne muscular dystrophy patient: importance for regenerative medicine strategies, , Muscle & nerve, 2010, 10.1002/mus.21644
Heterogeneous labeling of mitochondrial membrane, endoplasmic reticulum, neurofilaments and synaptic vesicles with a lectin (DBA-peroxidase), , Neuroscience letters, 1982, 10.1016/0304-3940(82)90003-9
Improved success of myoblast transplantation in mdx mice by blocking the myostatin signal, , Transplantation, 2005, 10.1097/01.tp.0000167379.27872.2b
Meganucleases can restore the reading frame of a mutated dystrophin, , Gene therapy, 2010, 10.1038/gt.2010.26
Prime Editing for Human Gene Therapy: Where Are We Now?, Jacques P. Tremblay, Kelly Godbout, Cells, 2023, 10.3390/cells12040536
Electroporation as a method to induce myofiber regeneration and increase the engraftment of myogenic cells in skeletal muscles of primates, , Journal of neuropathology and experimental neurology, 2013, 10.1097/NEN.0b013e31829bac22
Myoblast transplantation: a possible surgical treatment for a severe pediatric disease, , Surgery today, 2010, 10.1007/s00595-009-4242-z
Stem and progenitor cells in skeletal muscle development, maintenance, and therapy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2007, 10.1038/mt.sj.6300145
Fast turnover of clear vesicle membrane in frog sympathetic ganglion, , Neuroscience, 1986, 10.1016/0306-4522(86)90093-x
In vivo migration of transplanted myoblasts requires matrix metalloproteinase activity, , Experimental cell research, 2000, 10.1006/excr.2000.4962
Successive injections in mdx mice of myoblasts grown with bFGF, , Neuromuscular disorders : NMD, 1996, 10.1016/0960-8966(96)00004-1
Myoblast allotransplantation in mice: degree of success varies depending on the efficacy of various immunosuppressive treatments, , Transplantation proceedings, 1994
Resetting the problem of cell death following muscle-derived cell transplantation: detection, dynamics and mechanisms, , Journal of neuropathology and experimental neurology, 2003, 10.1093/jnen/62.9.951
Growth factors improve the in vivo migration of human skeletal myoblasts by modulating their endogenous proteolytic activity, , Transplantation, 2004, 10.1097/01.tp.0000131175.60047.eb
Immune Reaction Following Cell and Gene Therapy, , 2000
Partial laminin alpha2 chain restoration in alpha2 chain-deficient dy/dy mouse by primary muscle cell culture transplantation, , The Journal of cell biology, 1996, 10.1083/jcb.133.1.185
The paracrine effect: pivotal mechanism in cell-based cardiac repair, , Journal of cardiovascular translational research, 2010, 10.1007/s12265-010-9198-2
Treatment with anti-CD154 antibody and donor-specific transfusion prevents acute rejection of myoblast transplantation, , Transplantation, 2002, 10.1097/00007890-200202150-00021
Role of non-major histocompatibility complex antigens in the rejection of transplanted myoblasts, , Transplantation, 1997, 10.1097/00007890-199703270-00016
Immunosuppression with monoclonal antibodies and CTLA4-Ig after myoblast transplantation in mice, , Transplantation, 1996, 10.1097/00007890-199610150-00015
Myoblast transplantation in monkeys: control of immune response by FK506, , Journal of neuropathology and experimental neurology, 1996, 10.1097/00005072-199606000-00002
Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype, Jacques P. Tremblay, Vanessa Couture, Pouiré Yameogo, Gabrielle Buisson, Malek Aloui, Nathalie Majeau, Solange Gni-fiene Yanyabé, Catherine Gérard, Camille Bouchard, Genes, 2023, 10.3390/genes14081654
Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506, , Muscle & nerve, 1996, 10.1002/(SICI)1097-4598(199607)19:73.0.CO;2-B
Dystrophin-like immunoreactivity in monkey and human brain areas involved in learning and motor functions, , Neuroscience letters, 1992, 10.1016/0304-3940(92)90890-j
Modulation of synapse RC1-R15 of Aplysia californica by fiber(s) of the right connective, , Canadian journal of physiology and pharmacology, 1982, 10.1139/y82-094
CRISPR/Cas9 delivery strategies with engineered extracellular vesicles, Jacques P. Tremblay, Gabriel Lamothe, Kelly Godbout, Yaoyao Lu, Molecular Therapy - Nucleic Acids, 2023, 10.1016/j.omtn.2023.102040
Labelling of an intermediate saccule of the Golgi apparatus and of parts of the endoplasmic reticulum by a lectin (soybean agglutinin) in the chick ciliary ganglion, , Neuroscience letters, 1983, 10.1016/0304-3940(83)90538-4
RCAS1 is associated with ductal breast cancer progression, , Biochemical and biophysical research communications, 2002, 10.1016/S0006-291X(02)00401-1
Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation, , Molecular therapy : the journal of the American Society of Gene Therapy, 2012, 10.1038/mt.2012.188
Increased granzyme B mRNA after alloincompatible myoblast transplantation, , Transplantation, 1995
Morphine and related compounds: evidence that they decrease available neurotransmitter in Aplysia californica, , Brain research, 1974, 10.1016/0006-8993(74)90481-8
Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice, , Transplantation proceedings, 1994
Is the MEPP due to the release of one vesicle or to the simultaneous release of several vesicles at one active zone?, , Brain research, 1983, 10.1016/0165-0173(83)90009-7
In Vitro Correction of Point Mutations in the DYSF Gene Using Prime Editing, Jacques P. Tremblay, Sina Ramezani, Laura Bastrenta, Marie Dubost, Gabriel Lamothe, Joël Rousseau, Camille Bouchard, International Journal of Molecular Sciences, 2025, 10.3390/ijms26125647
Muscle fibers of mdx mice are more vulnerable to exercise than those of normal mice, , Neuromuscular disorders : NMD, 1997, 10.1016/s0960-8966(97)00115-6
Systemic production of human granulocyte colony-stimulating factor in nonhuman primates by transplantation of genetically modified myoblasts, , Human gene therapy, 2000, 10.1089/10430340050032384
Myoblast transplantation: techniques in nonhuman primates as a bridge to clinical trials, , 2011
Decidualization and maintenance of a functional prostaglandin system in human endometrial cell lines following transformation with SV40 large T antigen, , Molecular human reproduction, 2006, 10.1093/molehr/gal034
Telomerase allows the immortalization of T antigen-positive DMD myoblasts: a new source of cells for gene transfer application, , Gene therapy, 2000, 10.1038/sj.gt.3301132
Myopathy in a rhesus monkey with biopsy findings similar to human sporadic inclusion body myositis, , Neuromuscular disorders : NMD, 2013, 10.1016/j.nmd.2012.10.020
Intramuscular Transplantation of Muscle Precursor Cells over-expressing MMP-9 improves Transplantation Success, , PLoS currents, 2011, 10.1371/currents.RRN1275
Overexpression of follistatin in human myoblasts increases their proliferation and differentiation, and improves the graft success in SCID mice, , Cell transplantation, 2009, 10.3727/096368909X470865
Scale-up of a myoblast culture process, , Journal of biotechnology, 2001, 10.1016/s0168-1656(01)00291-7
Characterization of frataxin gene network in Friedreich's ataxia fibroblasts using the RNA-Seq technique, , Mitochondrion, 2016, 10.1016/j.mito.2016.06.003
Efficient myoblast transplantation in mice immunosuppressed with monoclonal antibodies and CTLA4 Ig, , Transplantation proceedings, 1997, 10.1016/s0041-1345(97)00166-8
Non-uniform release at the frog neuromuscular junction: evidence of morphological and physiological plasticity, , Brain research, 1987, 10.1016/0165-0173(87)90019-1
Effects of vitamin C on cytotherapy-mediated muscle regeneration, , Cell transplantation, 2013, 10.3727/096368912X657846
Intramuscular cell transplantation as a potential treatment of myopathies: clinical and preclinical relevant data, , Expert opinion on biological therapy, 2011, 10.1517/14712598.2011.548800
Prime editing optimized RTT permits the correction of the c.8713C>T mutation in DMD gene, Jacques P. Tremblay, Vincent Mouly, Kamel Mamchaoui, Anne Bigot, Yaoyao Lu, Joel Rousseau, Cedric Happi Mbakam, Molecular Therapy - Nucleic Acids, 2022, 10.1016/j.omtn.2022.09.022
A Comment on Muscle Xenografts Reproduce Key Molecular Features of Facioscapulohumeral Muscular Dystrophy : What Is New and What Has Already been Done and Reported but Was Not Quoted?, , Cell transplantation, 2020, 10.1177/0963689720939120
Transplantation of human myoblasts in SCID mice as a potential muscular model for myotonic dystrophy, , Journal of neuropathology and experimental neurology, 1999, 10.1097/00005072-199909000-00003
Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease, , PloS one, 2010, 10.1371/journal.pone.0010055
Exercise improves the success of myoblast transplantation in mdx mice, , Neuromuscular disorders : NMD, 2006, 10.1016/j.nmd.2006.06.003
Rapid selection of donor myoblast clones for muscular dystrophy therapy using cell surface expression of NCAM, , European journal of histochemistry : EJH, 1993
Assessment of a symptomatic Duchenne muscular dystrophy carrier 20 years after myoblast transplantation from her asymptomatic identical twin sister, , Neuromuscular disorders : NMD, 2013, 10.1016/j.nmd.2013.04.007
Deletion of the GAA repeats from the human frataxin gene using the CRISPR-Cas9 system in YG8R-derived cells and mouse models of Friedreich ataxia, , Gene therapy, 2017, 10.1038/gt.2016.89
Cerebroside may be falsely identified as a soluble 'brain specific protein', , Journal of neurochemistry, 1974, 10.1111/j.1471-4159.1974.tb04360.x
Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation, , Molecular therapy. Nucleic acids, 2013, 10.1038/mtna.2012.55
Cell therapy in muscular dystrophies: many promises in mice and dogs, few facts in patients, , Expert opinion on biological therapy, 2015, 10.1517/14712598.2015.1057564
Mechanism of increasing dystrophin-positive myofibers by myoblast transplantation: study using mdx/beta-galactosidase transgenic mice, , Acta neuropathologica, 1996, 10.1007/s004010050456
Proximodistal gradients of the postjunctional folds at the frog neuromuscular junction: a scanning electron microscopic study, , Neuroscience, 1989, 10.1016/0306-4522(89)90271-6
Progress in myoblast transplantation: a potential treatment of dystrophies, , Microscopy research and technique, 2000, 10.1002/(SICI)1097-0029(20000201/15)48:3/43.0.CO;2-Z
Frequency facilitation and post-tetanic potentiation of a unitary synaptic potential in Aplysia californica are limited by different processes, , Brain research, 1976, 10.1016/0006-8993(76)90377-2
Section VI - Novel Genetic Technologies. 6.2 Gene Therapy, , 2009
Portrait of Dysferlinopathy: Diagnosis and Development of Therapy, Jacques P. Tremblay, Camille Bouchard, Journal of Clinical Medicine, 2023, 10.3390/jcm12186011
Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients, , Molecular therapy : the journal of the American Society of Gene Therapy, 2013, 10.1038/mt.2013.111
Ex vivo modification of cells to induce a muscle-based expression, , Current gene therapy, 2006, 10.2174/156652306779010651
Reduction of postjunctional fold density and depth in dystrophic mice, , Synapse (New York, N.Y.), 1988, 10.1002/syn.890020206
Central tolerance to myogenic cell transplants does not include muscle neoantigens, , Transplantation, 2008, 10.1097/TP.0b013e31817726bc
A case for immunosuppression for myoblast transplantation in duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2009, 10.1038/mt.2009.125
Gene Therapy in Duchenne’s Muscular Dystrophy, , 2009
Postsynaptic structure may account for variations in miniature endplate current shapes along frog neuromuscular junctions, , Synapse (New York, N.Y.), 1990, 10.1002/syn.890050402
Approche Thérapeutique de la myopathie de Duchenne par transplantation de myoblastes, , Medecine sciences : M/S, 1991
Endonucleases: tools to correct the dystrophin gene, , The journal of gene medicine, 2011, 10.1002/jgm.1611
Human myoblast transplantation: preliminary results of 4 cases, , Muscle & nerve, 1992, 10.1002/mus.880150504
De Novo Circulating Antidonor's Cell Antibodies During Induced Acute Rejection of Allogeneic Myofibers in Myogenic Cell Transplantation: A Study in Nonhuman Primates, , Transplantation direct, 2017, 10.1097/TXD.0000000000000740
Inhibiting myostatin with follistatin improves the success of myoblast transplantation in dystrophic mice, , Cell transplantation, 2008, 10.3727/096368908784153913
Human myoblast transplantation: a simple assay for tumorigenicity, , Neuromuscular disorders : NMD, 1991, 10.1016/0960-8966(91)90120-h
Use of normal and genetically modified myoblasts for the treatment of myopathies, , 2000
Inflammatory damage following first-generation replication-defective adenovirus controlled by anti-LFA-1, , Journal of leukocyte biology, 1997, 10.1002/jlb.61.4.533
Prior culture with concanavalin A increases intramuscular migration of transplanted myoblast, , Muscle & nerve, 1998, 10.1002/(sici)1097-4598(199803)21:33.0.co;2-5
Successful histocompatible myoblast transplantation in dystrophin-deficient mdx mouse despite the production of antibodies against dystrophin, , The Journal of cell biology, 1995, 10.1083/jcb.131.4.975
CD56+ Muscle Derived Cells but Not Retinal NG2+ Perivascular Cells of Nonhuman Primates are Myogenic after Intramuscular Transplantation in Immunodeficient Mice, , Journal of stem cell research & therapy, 2017, 10.4172/2157-7633.1000377
Transcription activator-like effector proteins induce the expression of the frataxin gene, , Human gene therapy, 2012, 10.1089/hum.2012.034
Confirmation of donor-derived dystrophin in a duchenne muscular dystrophy patient allotransplanted with normal myoblasts, , Muscle & nerve, 2016, 10.1002/mus.25129
Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro, , Molecular therapy. Nucleic acids, 2021, 10.1016/j.omtn.2021.02.032
The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer's Disease in SH-SY5Y cells, , PloS one, 2020, 10.1371/journal.pone.0237122
Vascular endothelial growth factor reduced hypoxia-induced death of human myoblasts and improved their engraftment in mouse muscles, , Gene therapy, 2008, 10.1038/sj.gt.3303059
Human myoblast transplantation in immunodeficient and immunosuppressed mice: evidence of rejection, , Muscle & nerve, 1994, 10.1002/mus.880170214
Not an inside job: how can transplantation of relatively few exogenous satellite cells do what thousands of endogenous cells cannot?, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2010.276
Functional EGFP-dystrophin fusion proteins for gene therapy vector development, , Protein engineering, 2000, 10.1093/protein/13.9.611
Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases, , Molecular therapy : the journal of the American Society of Gene Therapy, 2013, 10.1038/mt.2013.4
Identification of a putative pathway for the muscle homing of stem cells in a muscular dystrophy model, , The Journal of cell biology, 2003, 10.1083/jcb.200210006
Utilization of myoblasts from transgenic mice to evaluate the efficacy of myoblast transplantation, , Muscle & nerve, 1994, 10.1002/mus.880170903
Increased number per area of peptidergic and cholinergic vesicles in synapses of the chick ciliary ganglion following 10 Hz in vivo stimulation, , Neuroscience letters, 1983, 10.1016/0304-3940(83)90542-6
Evidence of mdx mouse skeletal muscle fragility in vivo by eccentric running exercise, , Muscle & nerve, 1998, 10.1002/(sici)1097-4598(199805)21:53.0.co;2-6
Increased Frataxin Expression Induced in Friedreich Ataxia Cells by Platinum TALE-VP64s or Platinum TALE-SunTag, , Molecular therapy. Nucleic acids, 2018, 10.1016/j.omtn.2018.04.009
Development of an AAV9 coding for a 3XFLAG-TALEfrat#8-VP64 able to increase in vivo the human frataxin in YG8R mice, , Gene therapy, 2016, 10.1038/gt.2016.36
Utilization of an antibody specific for human dystrophin to follow myoblast transplantation in nude mice, , Cell transplantation, 1993, 10.1177/096368979300200204
Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160, , Molecular therapy. Nucleic acids, 2017, 10.1016/j.omtn.2016.11.004
Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization, , Molecular cancer research : MCR, 2003
Early and massive death of myoblasts transplanted into skeletal muscle : responsible factors and potential solutions, , Current opinion in organ transplantation, 2007
Myotubes can be formed within implanted adipose tissue, , Transplantation proceedings, 1992
Generation of lentiviral vectors for use in skeletal muscle research, , Methods in molecular biology (Clifton, N.J.), 2012, 10.1007/978-1-61779-343-1_16
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Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel, Jacques P. Tremblay, Andrew R. Marks, Emmanuel Planel, Yaoyao Lu, Geoffrey CANET, Gabriel Lamothe, Anetta E. Wronska, Joël Rousseau, Alexia Falle, Sina Ramezani, STEVEN Reiken, Mathieu Dugas, Kelly Godbout, International Journal of Molecular Sciences, 2025, 10.3390/ijms26072835
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Myotubes Formed De Novo by Myoblasts Injected into the Scar of Myocardial Infarction Persisted for 16 Years in a Patient: Importance for Regenerative Medicine in Degenerative Myopathies, , Stem cells translational medicine, 2019, 10.1002/sctm.18-0202
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Emerging Perspectives on Prime Editor Delivery to the Brain, Jacques P. Tremblay, Marc Lavertu, Avi Schroeder, Joël Rousseau, Yaoyao Lu, Sina Ramezanian, Eli BenDavid, Pharmaceuticals, 2024, 10.3390/ph17060763
Human myoblast transplantation between immunohistocompatible donors and recipients produces immune reactions, , Transplantation proceedings, 1992
Delivery of RNAs to Specific Organs by Lipid Nanoparticles for Gene Therapy, Jacques P. Tremblay, Kelly Godbout, Pharmaceutics, 2022, 10.3390/pharmaceutics14102129
Removal of the GAA repeat in the heart of a Friedreich’s ataxia mouse model using CjCas9, Jacques P. Tremblay, Nathalie Majeau, Catherine Gérard, Pouiré Yaméogo, Gene Therapy, 2023, 10.1038/s41434-023-00387-0
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Current Clinical Applications of In Vivo Gene Therapy with AAVs, , Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 10.1016/j.ymthe.2020.12.007
Losartan enhances the success of myoblast transplantation, , Cell transplantation, 2012, 10.3727/096368911X576045
Therapeutic effects of exon skipping and losartan on skeletal muscle of mdx mice, , Pathology international, 2014, 10.1111/pin.12190
Myoblast transplantations lead to the expression of the laminin alpha 2 chain in normal and dystrophic (dy/dy) mouse muscles, , Gene therapy, 1999, 10.1038/sj.gt.3300889
Pretreatment of myoblast cultures with basic fibroblast growth factor increases the efficacy of their transplantation in mdx mice, , Muscle & nerve, 1995, 10.1002/mus.880180806
Mosaic expression of dystrophin in the cerebellum of heterozygote dystrophic (mdx) mice, , Neuromuscular disorders : NMD, 1992, 10.1016/s0960-8966(06)80002-7
Tumor necrosis factor-alpha (TNF-alpha) stimulates chemotactic response in mouse myogenic cells, , Cell transplantation, 2003, 10.3727/000000003783985115
Prevention by anti-LFA-1 of acute myoblast death following transplantation, , Journal of immunology (Baltimore, Md. : 1950), 1997
Administration of a soluble activin type IIB receptor promotes the transplantation of human myoblasts in dystrophic mice, , Cell transplantation, 2012, 10.3727/096368911X627480
Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies, , Gene therapy, 2001, 10.1038/sj.gt.3301484
Sensorimotor skills in Fxn KO/Mck mutants deficient for frataxin in muscle, , Brain research, 2015, 10.1016/j.brainres.2015.03.001
Myoblast transplantation in non-dystrophic dog, , Neuromuscular disorders : NMD, 1998, 10.1016/s0960-8966(97)00148-x
CRISPR-Cas9 Gene Therapy for Duchenne Muscular Dystrophy, , Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2022, 10.1007/s13311-022-01197-9
Another new super muscle stem cell leaves unaddressed the real problems of cell therapy for duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2008, 10.1038/mt.2008.243
Myocardial regeneration : which cell and why, , 2006
The advances and challenges of Gene Therapy for Duchenne Muscular Dystrophy, , Journal of Genetic Medicine and Gene Therapy, 2017, 10.29328/journal.jgmgt.1001003
Induction of tolerance across fully mismatched barriers by a nonmyeloablative treatment excluding antibodies or irradiation use, , Cell transplantation, 2006, 10.3727/000000006783981521
Small-molecule inhibitors of proteasome increase CjCas9 protein stability, Jacques P. Tremblay, Cedric Happi Mbakam, Nathalie Majeau, Pouiré Yaméogo, PLOS ONE, 2023, 10.1371/journal.pone.0280353
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Development and characterization of a simian virus 40 immortalized bovine endometrial stromal cell line, , Endocrinology, 2009, 10.1210/en.2008-0744
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Depuis 2020/07

Gabriel Lamothe - Doctorat - En cours
Maheswaran Kesavan - Doctorat - En cours
Sina Ramezani - Doctorat - En cours
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Gege Zhao - Doctorat - En cours
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Jing Jiang - Doctorat - En cours
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Malek Aloui - Maîtrise avec mémoire - 2021/09
Solange Gni-Fiene Yanyabe - Maîtrise avec mémoire - 2022/01
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Pouiré Yameogo - Doctorat - 2023/01
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