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Jacques-P. Tremblay

Professeur titulaire

jacques-p.tremblay@fmed.ulaval.ca

Site personnel

Département de médecine moléculaire

Centre thématique de recherche en neurosciences

Centre de recherche du CHU de Québec - Université Laval

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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale

Domaines de recherche

Thérapie génique et moléculaire
Biotechnologies médicales, n.c.a.

Projets de recherche en cours

Correction by Prime editing of point mutations responsible for Cystic fibrosis in Quebec province - Génome Québec - Cibler des mutations rares, orphelines de CFTR, McGill University, co-chercheur - 2025-04-01 au 2028-03-30
In vivo correction by CRISPR PRIME editing of mutations responsible for Duchenne Muscular Dystrophy - Vaincre Duchenne Canada, chercheur principal - 2023-12-01 au 2026-11-30
Correction of point mutations responsible for Dysferlinopathy using Prime Editing Renouvellement 2025-2026 - Jain Foundation Inc., chercheur principal - 2025-02-01 au 2026-01-31

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Financements des 2 dernières années

Removal of the GAA repeat with the CRISPR/Cas9 system in Friedreich patient cells and in the YG8sR mouse model - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
Correcting point mutations responsible for Dysferlinopathy using Prime Editing - Jain Foundation Inc., chercheur principal - 2023-08-01 au 2024-07-31
Développement de microdispositifs transdermiques peu invasifs pour l’administration d'acides nucléiques : vaccination et thérapie génique - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université de Montréal, co-chercheur - 2023-04-01 au 2024-03-31
Development of an AAV library - Conseil national de recherches du Canada - Programmes et initiatives de R&D collaboratifs, chercheur principal - 2022-04-01 au 2024-03-31
Développement d'un traitement pour prévenir ou ralentir la progression de la maladie d'Alzheimer - Fondation Famille Lemaire, chercheur principal - 2023-11-08 au 2024-03-31
Correction with the Prime editing technology of point mutations responsible for Duchenne Muscular Dystrophy - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-03-01 au 2024-02-29
PRIME editing correction of the T1709M mutation responsible for some cases of Ryanodine receptor type I-related myopathies - RYR-1 Foundation, chercheur principal - 2021-07-01 au 2023-06-30
Development of a rapid and simple test to detect the COVID-19 variants that can be used in remote areas and developing countries - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement sur les nouveaux besoins prioritaires en recherche sur la COVID-19, chercheur principal - 2021-06-01 au 2022-05-31

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Publications

A Potential New Therapeutic Approach for Friedreich Ataxia: Induction of Frataxin Expression With TALE Proteins, , Molecular therapy. Nucleic acids, 2013, 10.1038/mtna.2013.41
Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160, , Molecular therapy. Nucleic acids, 2017, 10.1016/j.omtn.2016.11.004
A synthetic mechano growth factor E Peptide enhances myogenic precursor cell transplantation success, , American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2007, 10.1111/j.1600-6143.2007.01927.x
RCAS1 is associated with ductal breast cancer progression, , Biochemical and biophysical research communications, 2002, 10.1016/S0006-291X(02)00401-1
Fibrin gel improves the survival of transplanted myoblasts, , Cell transplantation, 2012, 10.3727/096368911X576018
Human myoblast transplantation in immunodeficient and immunosuppressed mice: evidence of rejection, , Muscle & nerve, 1994, 10.1002/mus.880170214
Use of normal and genetically modified myoblasts for the treatment of myopathies, , 2000
Overexpression of follistatin in human myoblasts increases their proliferation and differentiation, and improves the graft success in SCID mice, , Cell transplantation, 2009, 10.3727/096368909X470865
Efficacy and site-specificity of adenoviral vector integration mediated by the phage φC31 integrase, , Human gene therapy methods, 2012, 10.1089/hgtb.2012.122
Incorporation of vesicular antigens into the presynaptic membrane during exocytosis at the frog neuromuscular junction: a light and electron microscopy immunochemical study, , Neuroscience, 1987, 10.1016/0306-4522(87)90147-3
Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures, , Journal of biomedical optics, 2019, 10.1117/1.JBO.24.2.025001
A monoclonal antibody to beta-tubulin distinguishes a subset of neurons and axons in the chick ciliary ganglion, , Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, 10.1139/o85-065
Depression and frequency facilitation at a synapse in Aplysia californica: evidence for regulation by availability of transmitter, , Brain research, 1974, 10.1016/0006-8993(74)90459-4
Myoblast allotransplantation in mice: degree of success varies depending on the efficacy of various immunosuppressive treatments, , Transplantation proceedings, 1994
Transcription activator-like effector proteins induce the expression of the frataxin gene, , Human gene therapy, 2012, 10.1089/hum.2012.034
Cyclophosphamide immunosuppression does not permit successful myoblast allotransplantation in mouse, , Neuromuscular disorders : NMD, 1995, 10.1016/0960-8966(95)00011-b
Frequency facilitation and post-tetanic potentiation of a unitary synaptic potential in Aplysia californica are limited by different processes, , Brain research, 1976, 10.1016/0006-8993(76)90377-2
Confirmation of donor-derived dystrophin in a duchenne muscular dystrophy patient allotransplanted with normal myoblasts, , Muscle & nerve, 2016, 10.1002/mus.25129
Combined immunosuppression of mycophenolate mofetil and FK506 for myoblast transplantation in mdx mice, , Transplantation, 2001, 10.1097/00007890-200107150-00010
Muscle glucose-6-phosphate dehydrogenase deficiency: restoration of enzymatic activity in hybrid myotubes, , Muscle & nerve, 1993, 10.1002/mus.880160604
Mosaic expression of dystrophin in the cerebellum of heterozygote dystrophic (mdx) mice, , Neuromuscular disorders : NMD, 1992, 10.1016/s0960-8966(06)80002-7
Transplantation of myoblasts from a transgenic mouse overexpressing dystrophin prduced only a relatively small increase of dystrophin-positive membrane, , Muscle & nerve, 1998, 10.1002/(sici)1097-4598(199801)21:13.0.co;2-3
An electron microscope study of synaptic contacts in the abdominal ganglion of Aplysia californica, , The Journal of comparative neurology, 1979, 10.1002/cne.901880303
De Novo Circulating Antidonor's Cell Antibodies During Induced Acute Rejection of Allogeneic Myofibers in Myogenic Cell Transplantation: A Study in Nonhuman Primates, , Transplantation direct, 2017, 10.1097/TXD.0000000000000740
Control of inflammatory damage by anti-LFA-1: increase success of myoblast transplantation, , Cell transplantation, 1997
Myoblast survival enhancement and transplantation success improvement by heat-shock treatment in mdx mice, , Transplantation, 2004, 10.1097/01.tp.0000121503.01535.f5
From gRNA Identification to the Restoration of Dystrophin Expression: A Dystrophin Gene Correction Strategy for Duchenne Muscular Dystrophy Mutations Using the CRISPR-Induced Deletion Method, , Methods in molecular biology (Clifton, N.J.), 2018, 10.1007/978-1-4939-7374-3_19
Percutaneous versus surgical delivery of autologous myoblasts after chronic myocardial infarction: an in vivo cardiovascular magnetic resonance study, , Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2010, 10.1002/ccd.22204
Base editing strategy allows insertion of the A673T mutation in APP gene to prevent the development of Alzheimer’s disease, Jacques P. Tremblay, Gabriel Lamothe, Tom Bertin, Francis-Gabriel Bégin, Joël Rousseau, Antoine Guyon, 2020, 10.1101/2020.10.27.357830
Administration of a soluble activin type IIB receptor promotes the transplantation of human myoblasts in dystrophic mice, , Cell transplantation, 2012, 10.3727/096368911X627480
Myoblast transplantation in monkeys: control of immune response by FK506, , Journal of neuropathology and experimental neurology, 1996, 10.1097/00005072-199606000-00002
Lymphocyte infiltration following allo- and xenomyoblast transplantation in mice, , Transplantation proceedings, 1994
Non-uniform release at the frog neuromuscular junction: evidence of morphological and physiological plasticity, , Brain research, 1987, 10.1016/0165-0173(87)90019-1
Scale-up of a myoblast culture process, , Journal of biotechnology, 2001, 10.1016/s0168-1656(01)00291-7
Myocardial regeneration : which cell and why, , 2006
Results of a triple blind clinical study of myoblast transplantations without immunosuppressive treatment in young boys with Duchenne muscular dystrophy, , Cell transplantation, 1993, 10.1177/096368979300200203
Development and characterization of a simian virus 40 immortalized bovine endometrial stromal cell line, , Endocrinology, 2009, 10.1210/en.2008-0744
Myogenesis: where and how can we get skeletal myoblasts?, , Dialogues in cardiovascular medicine : DCM, 2003
Dystrophin expression in host muscle following transplantation of muscle precursor cells modified with the phiC31 integrase, , Gene therapy, 2007, 10.1038/sj.gt.3302887
Transplantation of human myoblasts in SCID mice as a potential muscular model for myotonic dystrophy, , Journal of neuropathology and experimental neurology, 1999, 10.1097/00005072-199909000-00003
CSCI/RCPSC Henry Friesen Lecture: Cell therapy for Duchenne muscular dystrophy, , Clinical and investigative medicine. Medecine clinique et experimentale, 2006
Generation of human endometrial knockout cell lines with the CRISPR/Cas9 system confirms the prostaglandin F2α synthase activity of aldo-ketoreductase 1B1, , Molecular human reproduction, 2014, 10.1093/molehr/gau023
Evaluation of various gene transfection methods into human myoblast clones, , Transplantation proceedings, 1992
Limb–Girdle Muscular Dystrophies Classification and Therapies, Jacques P. Tremblay, Camille Bouchard, Journal of Clinical Medicine, 2023, 10.3390/jcm12144769
Inhibiting myostatin with follistatin improves the success of myoblast transplantation in dystrophic mice, , Cell transplantation, 2008, 10.3727/096368908784153913
Electrotransfer of naked DNA in the skeletal muscles of animal models of muscular dystrophies, , Gene therapy, 2001, 10.1038/sj.gt.3301484
Efficient myoblast transplantation in mice immunosuppressed with monoclonal antibodies and CTLA4 Ig, , Transplantation proceedings, 1997, 10.1016/s0041-1345(97)00166-8
Assessment of a symptomatic Duchenne muscular dystrophy carrier 20 years after myoblast transplantation from her asymptomatic identical twin sister, , Neuromuscular disorders : NMD, 2013, 10.1016/j.nmd.2013.04.007
Growth factor coinjection improves the migration potential of monkey myogenic precursors without affecting cell transplantation success, , Cell transplantation, 2009, 10.3727/096368909X470900
Resting and stimulated values of model parameters governing transmitter release at a synapse in Aplysia californica, , Brain research, 1976, 10.1016/0006-8993(76)90378-4
Is the MEPP due to the release of one vesicle or to the simultaneous release of several vesicles at one active zone?, , Brain research, 1983, 10.1016/0165-0173(83)90009-7
Expression of major histocompatibility complex antigens on human myoblasts, , Transplantation proceedings, 1991
Myotubes Formed De Novo by Myoblasts Injected into the Scar of Myocardial Infarction Persisted for 16 Years in a Patient: Importance for Regenerative Medicine in Degenerative Myopathies, , Stem cells translational medicine, 2019, 10.1002/sctm.18-0202
Synaptic contacts on glial cells in the abdominal ganglion of Aplysia californica, , The Journal of comparative neurology, 1979, 10.1002/cne.901880304
Small-molecule inhibitors of proteasome increase CjCas9 protein stability, Jacques P. Tremblay, Cedric Happi Mbakam, Nathalie Majeau, Pouiré Yaméogo, PLOS ONE, 2023, 10.1371/journal.pone.0280353
Morphine and related compounds: evidence that they decrease available neurotransmitter in Aplysia californica, , Brain research, 1974, 10.1016/0006-8993(74)90481-8
Sensorimotor skills in Fxn KO/Mck mutants deficient for frataxin in muscle, , Brain research, 2015, 10.1016/j.brainres.2015.03.001
Expression of human dystrophin following the transplantation of genetically modified mdx myoblasts, , Gene therapy, 1998, 10.1038/sj.gt.3300753
Myoblast Transplantation in skeletal muscles, , 2010
Prime Editing for Human Gene Therapy: Where Are We Now?, Jacques P. Tremblay, Kelly Godbout, Cells, 2023, 10.3390/cells12040536
Distribution of spontaneous release along the frog neuromuscular junction, , Neuroscience letters, 1984, 10.1016/0304-3940(84)90559-7
Finding an Appropriate Mouse Model to Study the Impact of a Treatment for Friedreich Ataxia on the Behavioral Phenotype, Jacques P. Tremblay, Vanessa Couture, Pouiré Yameogo, Gabrielle Buisson, Malek Aloui, Nathalie Majeau, Solange Gni-fiene Yanyabé, Catherine Gérard, Camille Bouchard, Genes, 2023, 10.3390/genes14081654
A new pro-migratory activity on human myogenic precursor cells for a synthetic peptide within the E domain of the mechano growth factor, , Experimental cell research, 2007, 10.1016/j.yexcr.2006.10.032
Early and massive death of myoblasts transplanted into skeletal muscle : responsible factors and potential solutions, , Current opinion in organ transplantation, 2007
Scanning electron microscopic study of the neuromuscular junction of dystrophic mice, , Experimental neurology, 1988, 10.1016/0014-4886(88)90200-2
Non-uniform responses to Ca2+ along the frog neuromuscular junction: effects on the probability of spontaneous and evoked transmitter release, , Neuroscience, 1991, 10.1016/0306-4522(91)90142-b
Prior culture with concanavalin A increases intramuscular migration of transplanted myoblast, , Muscle & nerve, 1998, 10.1002/(sici)1097-4598(199803)21:33.0.co;2-5
The effects of hemicholinium-3 on synaptic depression, facilitation, and post-tetanic potentiation at an identified synapse of Aplysia californica, , Canadian journal of physiology and pharmacology, 1980, 10.1139/y80-064
Meganucleases can restore the reading frame of a mutated dystrophin, , Gene therapy, 2010, 10.1038/gt.2010.26
The first Joint Conference of the Cell Transplant Society (CTS), International Pancreas and Islet Transplant Association (IPITA), and International Xenotransplantation Association (IXA), all sections of The Transplantation Society (TTS), took place in Minneapolis, Minn, USA, from September 15-20, 2007. Preface, , Transplantation proceedings, 2008, 10.1016/j.transproceed.2008.02.021
Myoblast transplantation: techniques in nonhuman primates as a bridge to clinical trials, , 2011
Mechanism of increasing dystrophin-positive myofibers by myoblast transplantation: study using mdx/beta-galactosidase transgenic mice, , Acta neuropathologica, 1996, 10.1007/s004010050456
Intramuscular transplantation of human postnatal myoblasts generates functional donor-derived satellite cells, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.128
Ischemic central necrosis in pockets of transplanted myoblasts in nonhuman primates: implications for cell-transplantation strategies, , Transplantation, 2007, 10.1097/01.tp.0000288322.94252.22
Laminin-111: a potential therapeutic agent for Duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2010, 10.1038/mt.2010.165
Gaba and benzodiazepines in invertebrate species, , 1988
Characterization of frataxin gene network in Friedreich's ataxia fibroblasts using the RNA-Seq technique, , Mitochondrion, 2016, 10.1016/j.mito.2016.06.003
Stem and progenitor cells in skeletal muscle development, maintenance, and therapy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2007, 10.1038/mt.sj.6300145
A first semimanual device for clinical intramuscular repetitive cell injections, , Cell transplantation, 2010, 10.3727/096368909X478812
Gene Editing for Duchenne Muscular Dystrophy Using the CRISPR/Cas9 Technology: The Importance of Fine-tuning the Approach, , Molecular therapy : the journal of the American Society of Gene Therapy, 2016, 10.1038/mt.2016.191
Intramuscular cell transplantation as a potential treatment of myopathies: clinical and preclinical relevant data, , Expert opinion on biological therapy, 2011, 10.1517/14712598.2011.548800
Real-time imaging of myoblast transplantation using the human sodium iodide symporter, , BioTechniques, 2005, 10.2144/05386IT01
Increased interferon-gamma mRNA expression following alloincompatible myoblast transplantation is inhibited by FK506, , Muscle & nerve, 1996, 10.1002/(SICI)1097-4598(199607)19:73.0.CO;2-B
Transplantation of normal and DMD myoblasts expressing the telomerase gene in SCID mice, , Biochemical and biophysical research communications, 2000, 10.1006/bbrc.2000.2735
Section VI - Novel Genetic Technologies. 6.2 Gene Therapy, , 2009
Serum Extracellular Vesicles for Delivery of Crispr-Cas9 Ribonucleoproteins to Modify the Dystrophin Gene, , Molecular therapy : the journal of the American Society of Gene Therapy, 2022, 10.1016/j.ymthe.2022.05.023
Heterosynaptic inhibition modifies the presynaptic plasticities of the transmission process at the synapse in Aplysia californica, , Brain research, 1976, 10.1016/0006-8993(76)90381-4
Benzodiazepines modify synaptic depression, frequency facilitation and PTP an identified cholinergic synapse of Aplysia, , Life sciences, 1980, 10.1016/0024-3205(80)90130-7
Autologous transplantation of muscle precursor cells modified with a lentivirus for muscular dystrophy: human cells and primate models, , Molecular therapy : the journal of the American Society of Gene Therapy, 2007, 10.1038/sj.mt.6300047
Induction of Anoikis following myoblast transplantation into SCID mouse muscles requires the Bit1 and FADD pathways, , American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2007, 10.1111/j.1600-6143.2007.01830.x
The urokinase plasminogen activator: an interesting way to improve myoblast migration following their transplantation, , Experimental cell research, 2002, 10.1006/excr.2002.5642
Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients, , Molecular therapy : the journal of the American Society of Gene Therapy, 2013, 10.1038/mt.2013.111
Telomerase can extend the proliferative capacity of human myoblasts, but does not lead to their immortalization, , Molecular cancer research : MCR, 2003
Emerging Perspectives on Prime Editor Delivery to the Brain, Jacques P. Tremblay, Marc Lavertu, Avi Schroeder, Joël Rousseau, Yaoyao Lu, Sina Ramezanian, Eli BenDavid, Pharmaceuticals, 2024, 10.3390/ph17060763
The CRISPR system can correct or modify the expression of genes responsible for hereditary diseases, , Medecine sciences : M/S, 2015, 10.1051/medsci/20153111016
Myoblast transplantation in whole muscle of nonhuman primates, , Journal of neuropathology and experimental neurology, 2000, 10.1093/jnen/59.3.197
Boutons originating from the same axon do not participate equally in synaptic transmission, , Neuroscience letters, 1982, 10.1016/0304-3940(82)90342-1
CRISPR/Cas9 delivery strategies with engineered extracellular vesicles, Jacques P. Tremblay, Gabriel Lamothe, Kelly Godbout, Yaoyao Lu, Molecular Therapy - Nucleic Acids, 2023, 10.1016/j.omtn.2023.102040
Vascular endothelial growth factor reduced hypoxia-induced death of human myoblasts and improved their engraftment in mouse muscles, , Gene therapy, 2008, 10.1038/sj.gt.3303059
Transplantation of Myogenic Cells in Duchenne Muscular Dystrophy Patients: Clinical Findings, , 2014, 10.1016/b978-0-12-410396-2.00026-8
Localization of dystrophin in the Purkinje cells of normal mice, , Neuroscience letters, 1992, 10.1016/0304-3940(92)90309-u
Normal myoblast implantation in MDX mice prevents muscle damage by exercise, , Biochemical and biophysical research communications, 1998, 10.1006/bbrc.1998.9276
Novel Duchenne muscular dystrophy treatment through myoblast transplantation tolerance with anti-CD45RB, anti-CD154 and mixed chimerism, , American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2004, 10.1111/j.1600-6143.2004.00501.x
Prevention by anti-LFA-1 of acute myoblast death following transplantation, , Journal of immunology (Baltimore, Md. : 1950), 1997
Cytomegalovirus and myoblast transplantation, , Lancet (London, England), 1991, 10.1016/0140-6736(91)93090-v
Necrosis, sarcolemmal damage and apoptotic events in myofibers rejected by CD8+ lymphocytes: Observations in nonhuman primates, , Neuromuscular disorders : NMD, 2012, 10.1016/j.nmd.2012.05.005
Blocking the myostatin signal with a dominant negative receptor improves the success of human myoblast transplantation in dystrophic mice, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2010.171
Endosome disruption enhances the functional nuclear delivery of Tat-fusion proteins, , Biochemical and biophysical research communications, 2004, 10.1016/j.bbrc.2004.04.180
Cell therapies for inherited myopathies, , Current opinion in rheumatology, 2003, 10.1097/00002281-200311000-00007
Gene Therapy in Duchenne’s Muscular Dystrophy, , 2009
Identification of homozygous and heterozygous dy2J mice by PCR, , Neuromuscular disorders : NMD, 2000, 10.1016/s0960-8966(99)00056-5
Endonucleases: tools to correct the dystrophin gene, , The journal of gene medicine, 2011, 10.1002/jgm.1611
Use of fluorescent latex microspheres (FLMs) to follow the fate of transplanted myoblasts, , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1993, 10.1177/41.10.8245416
Sarcolemmal Complement Membrane Attack Complex Deposits During Acute Rejection of Myofibers in Nonhuman Primates, , Journal of neuropathology and experimental neurology, 2019, 10.1093/jnen/nly106
Three Decades of Clinical Gene Therapy: From Experimental Technologies to Viable Treatments, , Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 10.1016/j.ymthe.2021.01.013
Use of repeating dispensers to increase the efficiency of the intramuscular myogenic cell injection procedure, , Cell transplantation, 2006, 10.3727/000000006783981648
Myoblast transplantation: a possible surgical treatment for a severe pediatric disease, , Surgery today, 2010, 10.1007/s00595-009-4242-z
Resetting the problem of cell death following muscle-derived cell transplantation: detection, dynamics and mechanisms, , Journal of neuropathology and experimental neurology, 2003, 10.1093/jnen/62.9.951
Immunosuppression with FK 506 insures good success of myoblast transplantation in MDX mice, , Transplantation proceedings, 1994
Role of non-major histocompatibility complex antigens in the rejection of transplanted myoblasts, , Transplantation, 1997, 10.1097/00007890-199703270-00016
Human myoblast transplantation: preliminary results of 4 cases, , Muscle & nerve, 1992, 10.1002/mus.880150504
First study of intra-arterial delivery of myogenic mononuclear cells to skeletal muscles in primates, , Cell transplantation, 2014, 10.3727/096368914X685032
CD56+ Muscle Derived Cells but Not Retinal NG2+ Perivascular Cells of Nonhuman Primates are Myogenic after Intramuscular Transplantation in Immunodeficient Mice, , Journal of stem cell research & therapy, 2017, 10.4172/2157-7633.1000377
CRISPR-Induced Deletion with SaCas9 Restores Dystrophin Expression in Dystrophic Models In Vitro and In Vivo, , Molecular therapy : the journal of the American Society of Gene Therapy, 2018, 10.1016/j.ymthe.2018.08.010
Decidualization and maintenance of a functional prostaglandin system in human endometrial cell lines following transformation with SV40 large T antigen, , Molecular human reproduction, 2006, 10.1093/molehr/gal034
Fast turnover of clear vesicle membrane in frog sympathetic ganglion, , Neuroscience, 1986, 10.1016/0306-4522(86)90093-x
Non-uniform distribution of miniature endplate potential amplitudes along the length of the frog neuromuscular junction, , Neuroscience letters, 1987, 10.1016/0304-3940(87)90147-9
First test of a high-density injection protocol for myogenic cell transplantation throughout large volumes of muscles in a Duchenne muscular dystrophy patient: eighteen months follow-up, , Neuromuscular disorders : NMD, 2007, 10.1016/j.nmd.2006.10.003
Cholinergic agents affect two receptors that modulate transmitter release at a central synapse in Aplsia californica, , Brain research, 1975, 10.1016/0006-8993(75)90657-5
Effects of vitamin C on cytotherapy-mediated muscle regeneration, , Cell transplantation, 2013, 10.3727/096368912X657846
Utilization of myoblasts from transgenic mice to evaluate the efficacy of myoblast transplantation, , Muscle & nerve, 1994, 10.1002/mus.880170903
Delivery of RNAs to Specific Organs by Lipid Nanoparticles for Gene Therapy, Jacques P. Tremblay, Kelly Godbout, Pharmaceutics, 2022, 10.3390/pharmaceutics14102129
Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases, , Molecular therapy : the journal of the American Society of Gene Therapy, 2013, 10.1038/mt.2013.4
Myoblast transplantations lead to the expression of the laminin alpha 2 chain in normal and dystrophic (dy/dy) mouse muscles, , Gene therapy, 1999, 10.1038/sj.gt.3300889
Prevention of immune reactions triggered by first-generation adenoviral vectors by monoclonal antibodies and CTLA4Ig, , Human gene therapy, 1996, 10.1089/hum.1996.7.12-1455
Myoblast transplantation in non-dystrophic dog, , Neuromuscular disorders : NMD, 1998, 10.1016/s0960-8966(97)00148-x
Gene therapy: a strategy for the treatment of inherited muscle diseases?, , Current opinion in pharmacology, 2001, 10.1016/s1471-4892(01)00052-2
Antibody formation after myoblast transplantation in Duchenne-dystrophic patients, donor HLA compatible, , Transplantation proceedings, 1993
Intramuscular transplantation of myogenic cells in primates: importance of needle size, cell number, and injection volume, , Cell transplantation, 2014, 10.3727/096368912X661337
Current Clinical Applications of In Vivo Gene Therapy with AAVs, , Molecular therapy : the journal of the American Society of Gene Therapy, 2021, 10.1016/j.ymthe.2020.12.007
A Comment on Muscle Xenografts Reproduce Key Molecular Features of Facioscapulohumeral Muscular Dystrophy : What Is New and What Has Already been Done and Reported but Was Not Quoted?, , Cell transplantation, 2020, 10.1177/0963689720939120
Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel, Jacques P. Tremblay, Andrew R. Marks, Emmanuel Planel, Yaoyao Lu, Geoffrey CANET, Gabriel Lamothe, Anetta E. Wronska, Joël Rousseau, Alexia Falle, Sina Ramezani, STEVEN Reiken, Mathieu Dugas, Kelly Godbout, International Journal of Molecular Sciences, 2025, 10.3390/ijms26072835
Is dystrophin present in the nerve terminal at the neuromuscular junction? An immunohistochemical study of the heterozygote dystrophic (mdx) mouse, , Synapse (New York, N.Y.), 1991, 10.1002/syn.890070207
Cerebroside may be falsely identified as a soluble 'brain specific protein', , Journal of neurochemistry, 1974, 10.1111/j.1471-4159.1974.tb04360.x
Successful histocompatible myoblast transplantation in dystrophin-deficient mdx mouse despite the production of antibodies against dystrophin, , The Journal of cell biology, 1995, 10.1083/jcb.131.4.975
Rapid selection of donor myoblast clones for muscular dystrophy therapy using cell surface expression of NCAM, , European journal of histochemistry : EJH, 1993
Treatment with anti-CD154 antibody and donor-specific transfusion prevents acute rejection of myoblast transplantation, , Transplantation, 2002, 10.1097/00007890-200202150-00021
Baclofen modifies via the release of monoamines the synaptic depression, frequency facilitation, and posttetanic potentiation observed at an identified cholinergic synapse of Aplysia californica, , Canadian journal of physiology and pharmacology, 1981, 10.1139/y81-039
Labelling of an intermediate saccule of the Golgi apparatus and of parts of the endoplasmic reticulum by a lectin (soybean agglutinin) in the chick ciliary ganglion, , Neuroscience letters, 1983, 10.1016/0304-3940(83)90538-4
Increased granzyme B mRNA after alloincompatible myoblast transplantation, , Transplantation, 1995
Another new super muscle stem cell leaves unaddressed the real problems of cell therapy for duchenne muscular dystrophy, , Molecular therapy : the journal of the American Society of Gene Therapy, 2008, 10.1038/mt.2008.243
In Vitro Correction of Point Mutations in the DYSF Gene Using Prime Editing, Jacques P. Tremblay, Sina Ramezani, Laura Bastrenta, Marie Dubost, Gabriel Lamothe, Joël Rousseau, Camille Bouchard, International Journal of Molecular Sciences, 2025, 10.3390/ijms26125647
Ex vivo modification of cells to induce a muscle-based expression, , Current gene therapy, 2006, 10.2174/156652306779010651
Successful Correction by Prime Editing of a Mutation in the RYR1 Gene Responsible for a Myopathy, Jacques P. Tremblay, Joël Rousseau, Kelly Godbout, Cells, 2023, 10.3390/cells13010031
Marked prolongation of post-tetanic potentiation at a transition temperature in its adaption, , Nature, 1975, 10.1038/258623a0
Dystrophin-like immunoreactivity in monkey and human brain areas involved in learning and motor functions, , Neuroscience letters, 1992, 10.1016/0304-3940(92)90890-j
Presynaptic modulating effects of GABA on depression, facilitation, and posttetanic potentiation of a cholinergic synapse in Aplysia californica, , Canadian journal of physiology and pharmacology, 1977, 10.1139/y77-174
Pretreatment of myoblast cultures with basic fibroblast growth factor increases the efficacy of their transplantation in mdx mice, , Muscle & nerve, 1995, 10.1002/mus.880180806
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Efficient Restoration of the Dystrophin Gene Reading Frame and Protein Structure in DMD Myoblasts Using the CinDel Method, , Molecular therapy. Nucleic acids, 2016, 10.1038/mtna.2015.58
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AG490 improves the survival of human myoblasts in vitro and in vivo, , Cell transplantation, 2012, 10.3727/096368912X655028
Human Muscle Precursor Cells Form Human-Derived Myofibers in Skeletal Muscles of Nonhuman Primates: A Potential New Preclinical Setting to Test Myogenic Cells of Human Origin for Cell Therapy of Myopathies, , Journal of neuropathology and experimental neurology, 2020, 10.1093/jnen/nlaa110
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Current status of pharmaceutical and genetic therapeutic approaches to treat DMD, , Molecular therapy : the journal of the American Society of Gene Therapy, 2011, 10.1038/mt.2011.59
Dynamics of the early immune cellular reactions after myogenic cell transplantation, , Cell transplantation, 2002, 10.3727/000000002783985378
Induction of tolerance across fully mismatched barriers by a nonmyeloablative treatment excluding antibodies or irradiation use, , Cell transplantation, 2006, 10.3727/000000006783981521
Dystrophin expression in myofibers of Duchenne muscular dystrophy patients following intramuscular injections of normal myogenic cells, , Molecular therapy : the journal of the American Society of Gene Therapy, 2004, 10.1016/j.ymthe.2003.11.023
Myogenic progenitor cells derived from human induced pluripotent stem cell are immune-tolerated in humanized mice, , Stem cells translational medicine, 2021, 10.1002/sctm.19-0452
Myopathy in a rhesus monkey with biopsy findings similar to human sporadic inclusion body myositis, , Neuromuscular disorders : NMD, 2013, 10.1016/j.nmd.2012.10.020
Increased Frataxin Expression Induced in Friedreich Ataxia Cells by Platinum TALE-VP64s or Platinum TALE-SunTag, , Molecular therapy. Nucleic acids, 2018, 10.1016/j.omtn.2018.04.009
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Tubulyzine, a novel tri-substituted triazine, prevents the early cell death of transplanted myogenic cells and improves transplantation success, , Biochemistry and cell biology = Biochimie et biologie cellulaire, 2003, 10.1139/o03-054
Myoblast transplantation between monozygotic twin girl carriers of Duchenne muscular dystrophy, , Neuromuscular disorders : NMD, 1993, 10.1016/0960-8966(93)90121-y
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Development of an AAV9 coding for a 3XFLAG-TALEfrat#8-VP64 able to increase in vivo the human frataxin in YG8R mice, , Gene therapy, 2016, 10.1038/gt.2016.36
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Depuis 2020/07

Gege Zhao - Doctorat - En cours
Seyed Mohammadreza Mirinezhad - Post-doctorat - En cours
Fatima El Husseiny - Doctorat - En cours
Gabriel Lamothe - Doctorat - En cours
Sina Ramezani - Doctorat - En cours
Jing Jiang - Doctorat - En cours
Yaoyao Lu - Doctorat - En cours
Maheswaran Kesavan - Doctorat - En cours
Félix Veillette - Maîtrise avec mémoire - En cours
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Ayesha Siddika - Doctorat - En cours
Antoine Guyon - Doctorat - 2021/01
Malek Aloui - Maîtrise avec mémoire - 2021/09
Solange Gni-Fiene Yanyabe - Maîtrise avec mémoire - 2022/01
Annabelle Fortin-Archambault - Maîtrise avec mémoire - 2022/05
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Pouiré Yameogo - Doctorat - 2023/01
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