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Guy Poirier

Professeur titulaire

Guy Poirier
Centre de recherche sur le cancer
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO) - Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, co-chercheur - 2015-04-01 au 2022-03-31
  • Solution d'imagerie cellulaire en temps réel pour améliorer la létalité synthétique des inhibiteurs de PARP dans le traitement du cancer - Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2021-04-01 au 2022-03-31
  • Cibler l’instabilité génomique en tant que vulnérabilité essentielle du cancer de l’ovaire - Fonds de recherche du Québec - Santé, IRICoR - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, Université de Montréal, co-chercheur - 2018-10-01 au 2021-09-30

Publications

  • Identification of mitofusin 1 and complement component 1q subcomponent-binding protein as mitochondrial targets in systemic lupus erythematosus., , Arthritis & rheumatology (Hoboken, N.J.), 2022, 10.1002/art.42082
  • ADP-ribosyltransferases, an update on function and nomenclature., , The FEBS journal, 2021, 10.1111/febs.16142
  • CARM1 regulates replication fork speed and stress response by stimulating PARP1., , Molecular cell, 2021, 10.1016/j.molcel.2020.12.010
  • Drosophila Tubulin-Specific Chaperone E Recruits Tubulin around Chromatin to Promote Mitotic Spindle Assembly., , Current biology : CB, 2021, 10.1016/j.cub.2020.11.009
  • PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons., , Neurochemistry international, 2021, 10.1016/j.neuint.2021.105077
  • Platelets release mitochondrial antigens in systemic lupus erythematosus., , Science translational medicine, 2021, 10.1126/scitranslmed.aav5928
  • The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase., , Journal of virology, 2021, 10.1128/JVI.01969-20
  • Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2021, 10.1073/pnas.2019408118
  • Aurora-A phosphorylates splicing factors and regulates alternative splicing, Arun Prasath Damodaran, Olivia Gavard, Jean-Philippe Gagné, Malgorzata Ewa Rogalska, Estefania Mancini, Thibault Courtheoux, Justine Cailloce, Agnès Mereau, Guy G. Poirier, Juan Valcárcel, Erwan Watrin, Claude Prigent, 2020, 10.1101/2020.11.04.368498
  • The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase, Yousef M.O. Alhammad, Maithri M. Kashipathy, Anuradha Roy, Jean-Philippe Gagné, Peter McDonald, Philip Gao, Louis Nonfoux, Kevin P. Battaile, David K. Johnson, Erik D. Holmstrom, Guy G. Poirier, Scott Lovell, Anthony R. Fehr, 2020, 10.1101/2020.05.11.089375
  • Drosophila dTBCE recruits tubulin around chromatin to promote mitotic spindle assembly, Mathieu Métivier, Emmanuel Gallaud, Aude Pascal, Jean-Philippe Gagné, Guy G. Poirier, Denis Chrétien, Romain Gibeaux, Laurent Richard-Parpaillon, Christelle Benaud, Régis Giet, 2020, 10.1101/2020.01.21.912428
  • Assessment of PARP-1 Distribution in Tissues of Cynomolgus Monkeys., , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2020, 10.1369/0022155420926022
  • The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation., , PLoS genetics, 2020, 10.1371/journal.pgen.1009183
  • A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in ., , Genetics, 2019, 10.1534/genetics.118.301393
  • Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation., , Nature communications, 2019, 10.1038/s41467-019-08859-x
  • Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination., , Genes & development, 2019, 10.1101/gad.324053.119
  • Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination., , Genes & development, 2019, 10.1101/gad.315978.118
  • Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks., , Nature communications, 2019, 10.1038/s41467-019-10741-9
  • SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells., , Drug metabolism and disposition: the biological fate of chemicals, 2019, 10.1124/dmd.119.088047
  • A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors., , Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 10.1158/1078-0432.CCR-17-1590
  • Aurora kinase A localises to mitochondria to control organelle dynamics and energy production., , eLife, 2018, 10.7554/eLife.38111
  • Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks., , Molecular cell, 2018, 10.1016/j.molcel.2018.05.013
  • Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS., , Journal of proteome research, 2018, 10.1021/acs.jproteome.8b00146
  • Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration., , Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1720553115
  • Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease., , Science (New York, N.Y.), 2018, 10.1126/science.aat8407
  • Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions., , Canadian journal of gastroenterology & hepatology, 2018, 10.1155/2018/8096314
  • Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities., , Oncotarget, 2016, 10.18632/oncotarget.13341
  • Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation., , The Journal of biological chemistry, 2016, 10.1074/jbc.M115.694992
  • Selective and sensitive quantification of the cytochrome P450 3A4 protein in human liver homogenates through multiple reaction monitoring mass spectrometry., , Proteomics, 2016, 10.1002/pmic.201500386
  • DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer., , Biomolecules, 2015, 10.3390/biom5043204
  • DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair., , Nucleic acids research, 2015, 10.1093/nar/gku1307
  • Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs., , DNA repair, 2015, 10.1016/j.dnarep.2015.02.004
  • Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2015, 10.1093/nar/gkv118
  • The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice., , Nature cell biology, 2015, 10.1038/ncb3259
  • The von Hippel-Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform., , British journal of cancer, 2015, 10.1038/bjc.2015.189
  • ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion., , Cell reports, 2014, 10.1016/j.celrep.2014.08.036
  • Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase., , PloS one, 2014, 10.1371/journal.pone.0086010
  • Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells., , The Journal of cell biology, 2014, 10.1083/jcb.201311094
  • Germline mutations in BAP1 impair its function in DNA double-strand break repair., , Cancer research, 2014, 10.1158/0008-5472.CAN-13-3109
  • Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis., , Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1405158111
  • Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum., , International journal for parasitology. Drugs and drug resistance., 2014, 10.1016/j.ijpddr.2014.05.002
  • Mapping PARP-1 auto-ADP-ribosylation sites by liquid chromatography-tandem mass spectrometry., , Journal of proteome research, 2013, 10.1021/pr301219h
  • Polycomb repressive complex 2 contributes to DNA double-strand break repair., , Cell cycle (Georgetown, Tex.), 2013, 10.4161/cc.25795
  • Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant., , PloS one, 2013, 10.1371/journal.pone.0081899
  • Reprogramming cellular events by poly(ADP-ribose)-binding proteins., , Molecular aspects of medicine, 2013, 10.1016/j.mam.2012.12.005
  • The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy., , Journal of cell science, 2013, 10.1242/jcs.114595
  • CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage., , Nucleic acids research, 2012, 10.1093/nar/gks222
  • Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes., , The Journal of biological chemistry, 2012, 10.1074/jbc.M111.296475
  • Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro., , Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 10.1158/1078-0432.CCR-11-2890
  • PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks., , Nucleic acids research, 2012, 10.1093/nar/gks798
  • PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent., , PloS one, 2012, 10.1371/journal.pone.0047978
  • PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed., , Molecular cell, 2012, 10.1016/j.molcel.2012.03.012
  • Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair, , Advances in DNA Repair in Cancer Therapy, 2012
  • Proteomics reveals a switch in CDK1-associated proteins upon M-phase exit during the Xenopus laevis oocyte to embryo transition., , The international journal of biochemistry & cell biology, 2012, 10.1016/j.biocel.2011.09.003
  • Quantitative proteomics and dynamic imaging reveal that G3BP-mediated stress granule assembly is poly(ADP-ribose)-dependent following exposure to MNNG-induced DNA alkylation., , Journal of cell science, 2012, 10.1242/jcs.106963
  • Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress., , Nucleic acids research, 2012, 10.1093/nar/gks486
  • Structural biology. PARP-1 activation--bringing the pieces together., , Science (New York, N.Y.), 2012, 10.1126/science.1221870
  • A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development., , PloS one, 2011, 10.1371/journal.pone.0015834
  • Affinity-based assays for the identification and quantitative evaluation of noncovalent poly(ADP-ribose)-binding proteins., , Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61779-270-0_7
  • Focus on computational proteomics., , Proteomics, 2011, 10.1002/pmic.201190099
  • Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage., , Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1108799108
  • Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death., , Nature medicine, 2011, 10.1038/nm.2387
  • Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1., , Expert review of proteomics, 2011, 10.1586/epr.11.63
  • PARP-3 and APLF function together to accelerate nonhomologous end-joining., , Molecular cell, 2011, 10.1016/j.molcel.2010.12.006
  • Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)., , Science signaling, 2011, 10.1126/scisignal.2000902
  • Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples., , Journal of proteome research, 2011, 10.1021/pr100990s
  • An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain., , Development (Cambridge, England), 2010, 10.1242/dev.051052
  • Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry., , Proteome science, 2010, 10.1186/1477-5956-8-22
  • PARP inhibition: PARP1 and beyond., , Nature reviews. Cancer, 2010, 10.1038/nrc2812
  • The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver., , The Journal of biological chemistry, 2010, 10.1074/jbc.M109.073908
  • A HUPO test sample study reveals common problems in mass spectrometry-based proteomics., , Nature methods, 2009, 10.1038/nmeth.1333
  • A novel approach to denoising ion trap tandem mass spectra., , Proteome science, 2009, 10.1186/1477-5956-7-9
  • Assessment of PARP-3 distribution in tissues of cynomolgous monkeys., , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009, 10.1369/jhc.2009.953380
  • Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells., , Journal of proteomics, 2009, 10.1016/j.jprot.2009.04.003
  • Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase., , Journal of proteome research, 2009, 10.1021/pr800810n
  • Quality assessment of tandem mass spectra using support vector machine (SVM)., , BMC bioinformatics, 2009, 10.1186/1471-2105-10-S1-S49
  • An approach to assessing peptide mass spectral quality without prior information, , International Journal of Functional Informatics and Personalised Medicine IJFIPM, 2008
  • Differential proteomic screen to evidence proteins ubiquitinated upon mitotic exit in cell-free extract of Xenopus laevis embryos., , Journal of proteome research, 2008, 10.1021/pr800250x
  • Effect of potato suberin on Streptomyces scabies proteome., , Molecular plant pathology, 2008, 10.1111/j.1364-3703.2008.00493.x
  • Genomic location of the human RNA polymerase II general machinery: evidence for a role of TFIIF and Rpb7 at both early and late stages of transcription., , The Biochemical journal, 2008, 10.1042/BJ20070751
  • Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes., , Journal of virology, 2008, 10.1128/JVI.01405-07
  • Human Proteinpedia enables sharing of human protein data., , Nature biotechnology, 2008, 10.1038/nbt0208-164
  • PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites., , The Journal of biological chemistry, 2008, 10.1074/jbc.M706734200
  • Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes., , Nucleic acids research, 2008, 10.1093/nar/gkn771
  • Proteomic characterization of mouse cytosolic and membrane prostate fractions: high levels of free SUMO peptides are androgen-regulated., , Journal of proteome research, 2008, 10.1021/pr8002497
  • Quality assessment of peptide tandem mass spectra., , BMC bioinformatics, 2008, 10.1186/1471-2105-9-S6-S13
  • A framework for mass spectral quality assessment without prior information, , 7th IEEE International Conference on Bioinformatics and Bioengineering. Boston, MA (14-17 October 2007), 2007
  • A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance., , Cell death and differentiation, 2007, 10.1038/sj.cdd.4402116
  • Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4., , Virology, 2007, 10.1016/j.virol.2006.08.035
  • Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents., , The Journal of biological chemistry, 2007, 10.1074/jbc.M608406200
  • Comparative proteome analysis of human epithelial ovarian cancer., , Proteome science, 2007, 10.1186/1477-5956-5-16
  • Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains., , Journal of proteome research, 2007, 10.1021/pr070521m
  • Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus., , Neuroscience, 2007, 10.1016/j.neuroscience.2006.08.065
  • PARP-1-induced cell death through inhibition of the MEK/ERK pathway in MNNG-treated HeLa cells., , Apoptosis : an international journal on programmed cell death, 2007, 10.1007/s10495-007-0127-z
  • PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery., , Journal of cellular biochemistry, 2007, 10.1002/jcb.21051
  • PARPs database: a LIMS systems for protein-protein interaction data mining or laboratory information management system., , BMC bioinformatics, 2007, 10.1186/1471-2105-8-483
  • Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain., , Neuroscience, 2007, 10.1016/j.neuroscience.2007.04.062
  • Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme., , Molecular cell, 2007, 10.1016/j.molcel.2007.06.027
  • Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606528103
  • Bioinformatics standards for mass spectrometry, , Current Proteomics: the journal for current and in-depth reviews on proteomics, 2006
  • Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage., , Biochimica et biophysica acta, 2006, 10.1016/j.bbamcr.2005.11.015
  • Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src., , The FEBS journal, 2006, 10.1111/j.1742-4658.2006.05125.x
  • Poly(ADP-ribose) (PAR) polymer is a death signal., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606526103
  • RT-PSM, a real-time program for peptide-spectrum matching with statistical significance., , Rapid communications in mass spectrometry : RCM, 2006, 10.1002/rcm.2435
  • The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives., , Current opinion in cell biology, 2006, 10.1016/j.ceb.2006.02.013
  • Transcription. Gene expression needs a break to unwind before carrying on., , Science (New York, N.Y.), 2006, 10.1126/science.1129808
  • Experimental and bioinformatic approaches for interrogating protein-protein interactions to determine protein function., , Journal of molecular endocrinology, 2005, 10.1677/jme.1.01693
  • Inferring gene regulatory networks with time delays using a genetic algorithm., , Systems biology, 2005, 10.1049/ip-syb:20050006
  • Low hepatic ethoxyresorufin-O-deethylase activity correlates with high organochlorine concentrations in Atlantic tomcod from the Canadian east coast., , Environmental toxicology and chemistry, 2005, 10.1897/05-048r.1
  • Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles., , The Biochemical journal, 2005, 10.1042/BJ20050792
  • Proteome profiling of human epithelial ovarian cancer cell line TOV-112D., , Molecular and cellular biochemistry, 2005, 10.1007/s11010-005-7556-1
  • Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: where and when?, , Cellular and molecular life sciences : CMLS, 2005, 10.1007/s00018-004-4505-1
  • Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy., , Trends in molecular medicine, 2005, 10.1016/j.molmed.2005.08.003
  • A conserved initiator element on the mammalian poly(ADP-ribose) polymerase-1 promoters, in combination with flanking core elements, is necessary to obtain high transcriptional activity., , Biochimica et biophysica acta, 2004, 10.1016/j.bbaexp.2004.04.003
  • Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/JNEUROSCI.3461-04.2004
  • Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality., , Proceedings of the National Academy of Sciences of the United States of America, 2004, 10.1073/pnas.0406182101
  • Nonisotopic methods for determination of poly(ADP-ribose) levels and detection of poly(ADP-ribose) polymerase., , Current protocols in cell biology, 2004, 10.1002/0471143030.cb1807s21
  • Poly(ADP-ribosyl)ated chromatin domains: access granted., , Journal of cell science, 2004, 10.1242/jcs.01080
  • Potential role of PARP inhibitors in cancer treatment and cell death, , DNA repair in cancer therapy, 2004
  • A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins., , The Biochemical journal, 2003, 10.1042/BJ20021675
  • Alteration of poly(ADP-ribose) glycohydrolase nucleocytoplasmic shuttling characteristics upon cleavage by apoptotic proteases., , Biology of the cell, 2003, 10.1016/j.biolcel.2003.10.003
  • Identification of Streptomyces coelicolor proteins that are differentially expressed in the presence of plant material., , Applied and environmental microbiology, 2003, 10.1128/AEM.69.4.1884-1889.2003
  • PARP-1, a determinant of cell survival in response to DNA damage., , Experimental hematology, 2003, 10.1016/s0301-472x(03)00083-3
  • Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation., , The Journal of biological chemistry, 2003, 10.1074/jbc.M211641200
  • Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase., , The Journal of biological chemistry, 2002, 10.1074/jbc.C200366200
  • Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec., , Environmental health perspectives, 2002, 10.1289/ehp.02110607
  • In-situ analysis of cellular poly(ADP-ribose) production in scrapie-infected mouse neuroblastoma cells., , The Histochemical journal, 2002, 10.1023/a:1023398130945
  • Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor., , Science (New York, N.Y.), 2002, 10.1126/science.1072221
  • Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats., , The Journal of nutrition, 2002, 10.1093/jn/132.1.108
  • Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats., , The Journal of nutrition, 2002, 10.1093/jn/132.1.115
  • Poly(ADP-ribose) degradation by post-nuclear extracts from human cells., , Biochimie, 2002, 10.1016/s0300-9084(02)00017-2
  • tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator., , Developmental cell, 2002, 10.1016/s1534-5807(02)00200-9
  • Analysis of ADP-ribose polymer sizes in intact cells., , Molecular and cellular biochemistry, 2001, 10.1023/a:1011910329010
  • Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis., , The Journal of biological chemistry, 2001, 10.1074/jbc.M007269200
  • Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases., , Cell death and differentiation, 2001, 10.1038/sj.cdd.4400851
  • Cigarette smoking during pregnancy: comparison of biomarkers for inclusion in epidemiological studies, , Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2001
  • Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis., , Journal of cell science, 2001
  • Identification and analysis of caspase substrates: proteolytic cleavage of poly(ADP-ribose)polymerase and DNA fragmentation factor 45., , Methods in cell biology, 2001, 10.1016/s0091-679x(01)66013-8
  • Identification of sequence-specific DNA-binding proteins by southwestern blotting., , Methods in molecular biology (Clifton, N.J.), 2001, 10.1385/1-59259-208-2:255
  • Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism., , Experimental cell research, 2001, 10.1006/excr.2001.5263
  • Modulation of caspase-3 activity by zinc ions and by the cell redox state., , Experimental cell research, 2001, 10.1006/excr.2001.5222
  • Nuclear factor 1 interferes with Sp1 binding through a composite element on the rat poly(ADP-ribose) polymerase promoter to modulate its activity in vitro., , The Journal of biological chemistry, 2001, 10.1074/jbc.M010360200
  • Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1., , Nucleic acids research, 2000, 10.1093/nar/28.20.3887
  • Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks., , The Journal of biological chemistry, 2000, 10.1074/jbc.275.20.15504
  • Determination of Poly(ADP-Ribose) polymerase activation and cleavage during cell death, , Cell death. The role of PARP, 2000
  • Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains., , Brain research. Molecular brain research, 2000, 10.1016/s0169-328x(00)00122-4
  • Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption., , Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2000, 10.1016/s0278-6915(00)00089-2
  • LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis., , Oncogene, 2000, 10.1038/sj.onc.1203720
  • Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia., , The Journal of nutrition, 2000, 10.1093/jn/130.5.1102
  • NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
  • PARP degradation in apoptotic Syrian hamster embryo (SHE) cells compared to HL60 cell line., , Biochimie, 2000, 10.1016/s0300-9084(00)01194-9
  • Sources of nitrate exposure in residents of rural areas in Quebec, Canada., , Journal of exposure analysis and environmental epidemiology, 2000, 10.1038/sj.jea.7500079
  • Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid., , Experimental cell research, 1999, 10.1006/excr.1998.4350
  • Binding capacity of various fibre to pesticide residues under simulated gastrointestinal conditions., , Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1999, 10.1016/s0278-6915(99)00110-6
  • Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.7.4335
  • Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.40.28379
  • Cytochrome P450 CYP1A1 enzyme activity and DNA adducts in placenta of women environmentally exposed to organochlorines., , Environmental research, 1999, 10.1006/enrs.1998.3920
  • Fanconi anemia C protein acts at a switch between apoptosis and necrosis in mitomycin C-induced cell death., , Experimental cell research, 1999, 10.1006/excr.1998.4316
  • Immunological determination and size characterization of poly(ADP-ribose) synthesized in vitro and in vivo., , Biochimica et biophysica acta, 1999, 10.1016/s0304-4165(99)00054-9
  • Liver poly(ADP-ribose)polymerase is resistant to cleavage by caspases., , Biochemical and biophysical research communications, 1999, 10.1006/bbrc.1999.0313
  • Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment., , Molecular and cellular biochemistry, 1999
  • Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110-kDa protein., , Experimental cell research, 1999, 10.1006/excr.1998.4321
  • Poly(ADP-ribose) turnover in quail myoblast cells: relation between the polymer level and its catabolism by glycohydrolase., , Molecular and cellular biochemistry, 1999
  • Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions., , The Biochemical journal, 1999
  • Poly(ADP-ribosylation) and apoptosis., , Molecular and cellular biochemistry, 1999, 10.1023/a:1006962716377
  • Preferential perinuclear localization of poly(ADP-ribose) glycohydrolase., , Experimental cell research, 1999, 10.1006/excr.1999.4594
  • Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions., , Biochimica et biophysica acta, 1999, 10.1016/s0167-4838(98)00278-7
  • 6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin., , Clinical cancer research : an official journal of the American Association for Cancer Research, 1998
  • Activation of cysteine proteases in cowpea plants during the hypersensitive response--a form of programmed cell death., , Experimental cell research, 1998, 10.1006/excr.1998.4256
  • Apparent cleavage of poly(ADP-ribose) polymerase in non-apoptotic mouse LTA cells: an artifact of cross-reactive secondary antibody., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006808001462
  • Immunodot blot method for the detection of poly(ADP-ribose) synthesized in vitro and in vivo., , Analytical biochemistry, 1998, 10.1006/abio.1998.2664
  • Isolation, purification and partial characterization of chloragocytes from the earthworm species Lumbricus terrestris., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006882207581
  • Overexpression of bcl-2 or bcl-XL fails to inhibit apoptosis mediated by a novel retinoid., , Oncology research, 1998
  • Proteolysis of poly(ADP-ribose) polymerase by caspase 3: kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates., , Radiation research, 1998
  • Rapid detection of poly(ADP-ribose) polymerase by enzyme-linked immunosorbent assay during its purification and improvement of its purification., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006861015142
  • Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis., , European journal of biochemistry, 1998, 10.1046/j.1432-1327.1998.2510295.x
  • A microassay for the detection of low levels of cytochrome P450 O-deethylation activities with alkoxyresorufin substrates., , Molecular and cellular biochemistry, 1997, 10.1023/a:1006835712436
  • A nuclear factor other than Sp1 binds the GC-rich promoter of the gene encoding rat poly(ADP-ribose) polymerase in vitro., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • Alteration in methyl-methanesulfonate-induced poly(ADP-ribosyl)ation by 2-butoxyethanol in Syrian hamster embryo cells., , Carcinogenesis, 1997, 10.1093/carcin/18.12.2333
  • Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells., , Biochimica et biophysica acta, 1997, 10.1016/s0167-4838(96)00188-4
  • ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase., , The EMBO journal, 1997, 10.1093/emboj/16.19.6018
  • Bcl-2 acts upstream of the PARP protease and prevents its activation., , Cell death and differentiation, 1997, 10.1038/sj.cdd.4400200
  • Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase., , Biochimica et biophysica acta, 1997, 10.1016/s0304-4165(96)00077-3
  • Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997
  • Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway., , The Journal of experimental medicine, 1997, 10.1084/jem.185.3.481
  • Determination of genotoxicity of the metabolites of the pesticides Guthion, Sencor, Lorox, Reglone, Daconil and Admire by 32P-postlabeling., , Molecular and cellular biochemistry, 1997, 10.1023/a:1006861621031
  • Extrusion of earthworm coelomocytes: comparison of the cell populations recovered from the species Lumbricus terrestris, Eisenia fetida and Octolasion tyrtaeum., , Laboratory animals, 1997, 10.1258/002367797780596068
  • Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms., , The American journal of pathology, 1997
  • Glycol ethers induce death and necrosis in human leukemia cells., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres., , Current biology : CB, 1997, 10.1016/s0960-9822(06)00382-4
  • Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide., , Experimental cell research, 1997, 10.1006/excr.1996.3459
  • Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks., , Radiation research, 1997
  • Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis., , Proceedings of the National Academy of Sciences of the United States of America, 1997, 10.1073/pnas.94.10.5073
  • Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation., , European journal of biochemistry, 1997, 10.1111/j.1432-1033.1997.00015.x
  • Purification of the death substrate poly(ADP-ribose) polymerase., , Analytical biochemistry, 1997, 10.1006/abio.1997.2153
  • Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway., , Blood, 1997
  • Specific cleavage of the large subunit of replication factor C in apoptosis is mediated by CPP32-like protease., , Biochemical and biophysical research communications, 1997, 10.1006/bbrc.1997.6456
  • Transcriptional regulation of the rat poly(ADP-ribose) polymerase gene by Sp1., , European journal of biochemistry, 1997, 10.1111/j.1432-1033.1997.0342a.x
  • Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis., , The Journal of biological chemistry, 1997, 10.1074/jbc.272.30.18530
  • Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors., , Experimental cell research, 1996, 10.1006/excr.1996.0259
  • Association of poly(ADP-ribose) polymerase with nuclear subfractions catalyzed with sodium tetrathionate and hydrogene peroxide crosslinks., , Molecular and cellular biochemistry, 1996, 10.1007/BF00420918
  • Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase., , Oncogene, 1996
  • Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.0597
  • Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis., , Proceedings of the National Academy of Sciences of the United States of America, 1996, 10.1073/pnas.93.16.8395
  • Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H10T1/2 cells from oxidative stress., , Biochimica et biophysica acta, 1996, 10.1016/0167-4889(96)00004-3
  • CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.51.32487
  • Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3., , Current biology : CB, 1996, 10.1016/s0960-9822(02)00614-0
  • Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1889
  • Ethoxyresorufin O-deethylase (EROD) activity in placental tissue from Inuit women exposed to organochlorines through the arctic food chain, , Organohalogen Compounds, 1996
  • Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1565
  • High Performance Electrophoresis Chromatography, , The protein protocols handbook, 1996
  • High-performance electrophoresis chromatography., , Methods in molecular biology (Clifton, N.J.), 1996, 10.1385/0-89603-336-8:371
  • ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.28.16720
  • Identification of a 116 kDa protein able to bind 1,3-bis(2-chloroethyl)-1-nitrosourea-damaged DNA as poly(ADP-ribose) polymerase., , Mutation research, 1996, 10.1016/0921-8777(95)00030-5
  • Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.9.4573
  • prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2., , The Biochemical journal, 1996, 10.1042/bj3160025
  • Proteasomes play an essential role in thymocyte apoptosis., , The EMBO journal, 1996
  • Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B., , Proceedings of the National Academy of Sciences of the United States of America, 1996, 10.1073/pnas.93.5.1972
  • Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells., , Journal of virology, 1996, 10.1128/JVI.70.4.2215-2220.1996
  • 32P-postlabeling determination of DNA adducts in the earthworm Lumbricus terrestris exposed to PAH-contaminated soils., , Bulletin of environmental contamination and toxicology, 1995, 10.1007/BF00206095
  • Biochemical properties and function of poly(ADP-ribose) glycohydrolase., , Biochimie, 1995, 10.1016/0300-9084(96)88156-9
  • Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells., , Journal of cell science. Supplement, 1995, 10.1242/jcs.1995.supplement_19.6
  • Comparative study of DNA adducts levels in white sucker fish (Catostomus commersoni) from the basin of the St. Lawrence River (Canada)., , Molecular and cellular biochemistry, 1995, 10.1007/BF00928150
  • Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique., , Analytical biochemistry, 1995, 10.1006/abio.1995.0016
  • DNA base excision repair of 5-hydroxymethyl-2'-deoxyuridine stimulates poly(ADP-ribose) synthesis in Chinese hamster cells., , Carcinogenesis, 1995, 10.1093/carcin/16.5.1173
  • Equilibrium model in an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1995, 10.1016/0167-4781(95)00143-5
  • Isolation of genomic DNA from the earthworm species Eisenia fetida., , Molecular and cellular biochemistry, 1995, 10.1007/BF00928909
  • Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo., , Analytical biochemistry, 1995, 10.1006/abio.1995.1245
  • Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks., , Trends in biochemical sciences, 1995, 10.1016/s0968-0004(00)89089-1
  • Rapid removal of nonspecific background in silver-stained polyacrylamide gel., , Analytical biochemistry, 1995, 10.1006/abio.1995.9947
  • Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution., , Proceedings of the National Academy of Sciences of the United States of America, 1995, 10.1073/pnas.92.20.9042
  • The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis., , The Journal of biological chemistry, 1995, 10.1074/jbc.270.28.16526
  • The effect of niacin deficiency on diethylnitrosamine-induced hepatic poly(ADP-ribose) levels and altered hepatic foci in the Fischer-344 rat., , Nutrition and cancer, 1995, 10.1080/01635589509514399
  • Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase., , Cell, 1995, 10.1016/0092-8674(95)90541-3
  • Autoantibodies reacting with poly(ADP-ribose) and with a zinc-finger functional domain of poly(ADP-ribose) polymerase involved in the recognition of damaged DNA., , Clinical immunology and immunopathology, 1994, 10.1006/clin.1994.1187
  • Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE., , Nature, 1994, 10.1038/371346a0
  • Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage., , Biochemistry, 1994, 10.1021/bi00189a012
  • Erasable blot of poly(ADP-ribose) polymerase., , Analytical biochemistry, 1994, 10.1006/abio.1994.1212
  • Mode of action of poly(ADP-ribose) glycohydrolase., , Biochimica et biophysica acta, 1994, 10.1016/0167-4781(94)90058-2
  • One-step protein purification using micropreparative electrophoresis fully compatible with protein microsequencing., , Analytical biochemistry, 1994, 10.1006/abio.1994.1437
  • Poly(ADP-ribose) catabolism in mammalian cells., , Molecular and cellular biochemistry, 1994, 10.1007/BF00928442
  • Purification of poly(ADP-ribose) glycohydrolase and detection of its isoforms by a zymogram following one- or two-dimensional electrophoresis., , Analytical biochemistry, 1994, 10.1006/abio.1994.1177
  • The role of poly(ADP-ribose) metabolism in response to active oxygen cytotoxicity., , Biochimica et biophysica acta, 1994, 10.1016/0167-4889(94)90243-7
  • Diethylnitrosamine administration in vivo increases hepatic poly(ADP-ribose) levels in rats: results of a modified technique for poly(ADP-ribose) measurement., , Carcinogenesis, 1993, 10.1093/carcin/14.12.2513
  • Enzymatic mechanisms for joining DNA strand interruptions in human cells, , DNA repair mechanisms: proceedings of the Alfred Benzon Symposium 35, held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen, August 9-13, 1992, 1993
  • Expression in Escherichia coli of the 36 kDa domain of poly(ADP-ribose) polymerase and investigation of its DNA binding properties., , Biochimica et biophysica acta, 1993, 10.1016/0167-4838(93)90277-x
  • Molecular and biochemical features of poly (ADP-ribose) metabolism., , Molecular and cellular biochemistry, 1993, 10.1007/BF01076101
  • NAD(+)-dependent repair of damaged DNA by human cell extracts., , The Journal of biological chemistry, 1993
  • Poly(ADP-ribose) polymerase can bind melphalan damaged DNA., , Cancer research, 1993
  • Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis., , Cancer research, 1993
  • The US-1 element from the gene encoding rat poly(ADP-ribose) polymerase binds the transcription factor Sp1., , European journal of biochemistry, 1993, 10.1111/j.1432-1033.1993.tb18008.x
  • ADP-ribosylation Reactions, , 1992
  • Automodification and NADase activity of poly(ADP-ribose) polymerase, , ADP-ribosylation Reactions, 1992
  • DNA base excision repair stimulates poly(ADP-ribose synthesis, , ADP-ribosylation Reactions, 1992
  • Enzymatic properties of Poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase on chromatin, , ADP-ribosylation Reactions, 1992
  • Expression of poly(ADP-ribose) polymerase in differentiating HL-60 cells, , ADP-ribosylation Reactions, 1992
  • Molecular Cloning of the rat poly(ADP-ribose)polymerase gene and preliminary characterization of its promoter and 5'-flanking region, , ADP-ribosylation Reactions, 1992
  • Poly(ADP-ribosyl)ation of chromatin in an in-vitro poly(ADP-ribose)-turnover system., , Biochimica et biophysica acta, 1992, 10.1016/0167-4889(92)90199-l
  • Proteolytic cleavage of poly(ADP-ribose) polymerase in human leukemia cells treated with etoposide and other cytotoxic agents, , ADP-ribosylation Reactions, 1992
  • Proteolytic degradation of poly(ADP-ribose) polymerase by contaminating proteases in commercial preparations of DNAse I, , ADP-ribosylation Reactions, 1992
  • Rearrangements of the nucleosome structure in chromatin by poly(ADP-ribose)., , Biochimica et biophysica acta, 1992, 10.1016/0167-4838(92)90163-8
  • Resistance of ADP-ribosylated histones and HMG proteins to proteases., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1992, 10.1139/o92-172
  • Structural analysis of the putative regulatory region of the rat gene encoding poly(ADP-ribose) polymerase., , FEBS letters, 1992, 10.1016/0014-5793(92)80457-r
  • Analysis of the activation of poly(ADP-ribose) polymerase by various types of DNA., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1991, 10.1139/o91-086
  • Association of poly(ADP-ribose) polymerase with the nuclear matrix: the role of intermolecular disulfide bond formation, RNA retention, and cell type., , Experimental cell research, 1991, 10.1016/0014-4827(91)90072-3
  • Enzymological properties of poly(ADP-ribose)polymerase: characterization of automodification sites and NADase activity., , Biochimica et biophysica acta, 1991, 10.1016/0167-4838(91)99007-f
  • An affinity matrix for the purification of poly(ADP-ribose) glycohydrolase., , Nucleic acids research, 1990, 10.1093/nar/18.16.4691
  • Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase., , FEBS letters, 1990, 10.1016/0014-5793(90)80770-j
  • Poly(ADP-ribosyl)ation reactions and modulation of chromatin structure, , DNA repair mechanisms and their biological implications in mammalian cells, 1990
  • Reconstitution of an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1990, 10.1016/0167-4781(90)90083-e
  • Stimulation of poly(ADP-ribose) synthesis by free radicals in C3H10T1/2 cells: relationship with NAD metabolism and DNA breakage., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1990, 10.1139/o90-085
  • Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1989, 10.1139/o89-097
  • DNA replication and poly(ADP-ribosyl)ation of chromatin., , Cytobios, 1989
  • Hyperthermia and poly(ADP-ribose) metabolism, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Localization of the zinc-binding sites in the DNA-binding domain of the bovine poly(ADP-ribose) polymerase, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Modulation of chromatin structure by poly(ADP-ribosyl)ation, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Monoclonal antibodies against poly(ADP- ribose) polymerase. Epitope mapping, inhibition of activity and interspecies immunoreactivity, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Poly(ADP-ribose)polymerase: a novel finger protein., , Nucleic acids research, 1989, 10.1093/nar/17.12.4689
  • Reconstitution of an in vitro poly(ADP)-ribose turnover system, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin. A role of poly(ADP-ribosyl)ation on core nucleosome structure., , The Journal of biological chemistry, 1989
  • Cell cycle regulation of poly(ADP-ribose) synthetase in FR3T3 cells., , Biochimica et biophysica acta, 1988, 10.1016/0167-4889(88)90018-3
  • Effect of hyperthermia on poly(adenosine diphosphate-ribose) glycohydrolase., , Cancer research, 1988
  • Immunoelectron microscopical distribution of poly(ADP-ribose)polymerase in the mammalian cell nucleus., , Experimental cell research, 1988, 10.1016/0014-4827(88)90289-3
  • Les réactions de poly(ADP-ribosyl)ation, , Regards sur la biochimie, 1988
  • Modulation of chromatin structure by poly(ADP-ribosyl)ation., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1988, 10.1139/o88-072
  • Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study., , Biochimica et biophysica acta, 1988, 10.1016/0167-4781(88)90007-3
  • Rapid assay of poly(ADP-ribose) glycohydrolase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1987, 10.1139/o87-088
  • Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation., , The Journal of biological chemistry, 1986
  • Poly(ADP-ribose) accessibility to poly(ADP-ribose) glycohydrolase activity on poly(ADP-ribosyl)ated nucleosomal proteins., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1986, 10.1139/o86-023
  • Possible role of ADP-ribosylation of adenovirus core proteins in virus infection., , Virus research, 1986, 10.1016/0168-1702(86)90078-x
  • Production and characterization of monoclonal antibodies specific for the functional domains of poly(ADP-ribose) polymerase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1986, 10.1139/o86-051
  • Visualization of poly(ADP-ribose) synthetase associated with polynucleosomes by immunoelectron microscopy., , Biochimica et biophysica acta, 1986, 10.1016/0167-4889(86)90239-9
  • Modulation of rat pancreatic muscarinic cholinergic receptors by caerulein., , Biochemical pharmacology, 1985, 10.1016/0006-2952(85)90609-4
  • Muscarinic cholinergic receptors in pancreatic acinar carcinoma of rat., , International journal of cancer, 1985, 10.1002/ijc.2910350412
  • Non-histone chromosomal protein acceptors for poly(ADP)-ribose in phorbol-12-myristate-13-acetate treated mouse embryo fibroblasts (C3H10T1/2)., , Carcinogenesis, 1985, 10.1093/carcin/6.10.1489
  • Poly ADP-ribosylation and DNA strand breakage in SV40 minichromosomes., , Carcinogenesis, 1985, 10.1093/carcin/6.2.283
  • Poly(ADP-ribosyl)ation of chromatin: kinetics of relaxation and its effect on chromatin solubility., , Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, 10.1139/o85-096
  • Sequential ADP-ribosylation pattern of nucleosomal histones. ADP-ribosylation of nucleosomal histones., , European journal of biochemistry, 1985, 10.1111/j.1432-1033.1985.tb08650.x
  • Tumor promoter phorbol-12-myristate-13-acetate induces poly ADP-ribosylation in human monocytes., , Biochemical and biophysical research communications, 1985, 10.1016/0006-291x(85)90314-6
  • Tumor promoter phorbol-12-myristate-13-acetate induces poly(ADP)-ribosylation in fibroblasts., , The EMBO journal, 1985
  • Changes in acetylcholinesterase and cholinesterase activities in rat pancreas during postnatal development. Lack of relation with muscarinic receptor maturation., , Pharmacology, 1984, 10.1159/000137990
  • Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation., , The EMBO journal, 1983
  • Modulation of rat pancreatic amylase secretion and muscarinic receptor populations by chronic bethanechol treatment., , European journal of pharmacology, 1983, 10.1016/0014-2999(83)90637-4
  • Nucleosomal poly(ADP-ribose) polymerase: properties and relaxation of the chromatin structure., , Princess Takamatsu symposia., 1983
  • Adenosine diphosphate ribosylation of chicken-erythrocyte histones H1, H5 and high-mobility-group proteins by purified calf-thymus poly(adenosinediphosphate-ribose) polymerase., , European journal of biochemistry, 1982, 10.1111/j.1432-1033.1982.tb06891.x
  • Chromosomal protein poly(ADP-ribosyl)ation in pancreatic nucleosomes., , Canadian journal of biochemistry, 1982, 10.1139/o82-036
  • Hyper(ADP-ribosyl)ation of histone H1., , Canadian journal of biochemistry, 1982, 10.1139/o82-139
  • Modulation of pancreatic muscarinic receptors by weaning., , Life sciences, 1982, 10.1016/0024-3205(82)90506-9
  • Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure., , Proceedings of the National Academy of Sciences of the United States of America, 1982, 10.1073/pnas.79.11.3423
  • Distribution of muscarinic receptors in the digestive tract organs., , Pharmacology, 1981, 10.1159/000137489
  • Maturation of muscarinic agonist receptors in rat developing pancreas and its relation to maximal enzyme secretion., , Life sciences, 1981, 10.1016/0024-3205(81)90537-3
  • Muscarinic receptor of rat pancreatic acini: [3H]QNB binding and amylase., , European journal of pharmacology, 1981, 10.1016/0014-2999(81)90508-2
  • Parallel maturation of the pancreatic secretory response to cholinergic stimulation and the muscarinic receptor population., , British journal of pharmacology, 1981, 10.1111/j.1476-5381.1981.tb10428.x
  • Poly(adenosine diphosphoribose) polymerase activity and adenosine diphosphate ribosylation of proteins during pancreatic degeneration and regeneration., , Cancer research, 1981
  • Poly(ADP-ribose) polymerase activity in mouse cells which exhibit temperature-sensitive DNA synthesis., , Biochimica et biophysica acta, 1981, 10.1016/0005-2787(81)90162-3
  • Separation of poly(ADP-ribosylated) nuclear proteins by polyacrylamide gel electrophoresis at acidic pH and low temperature., , Analytical biochemistry, 1981, 10.1016/0003-2697(81)90489-9
  • Adenosine diphosphate ribosylation of proteins in rat pancreas [proceedings]., , Biochemical Society transactions, 1980, 10.1042/bst0080192
  • ADP-ribosylation of pancreatic histone H1 and of other histones., , Canadian journal of biochemistry, 1980, 10.1139/o80-069
  • ADP-ribosylation of rye histones., , Canadian journal of biochemistry, 1980, 10.1139/o80-097
  • Characterization and purification of a calcium-sensitive ATP diphosphohydrolase from pig pancreas., , The Journal of biological chemistry, 1980
  • Muscarinic receptors of the pancreas: a correlation between displacement of (3 H)-quinuclidinyl benzilate binding and amylase secretion., , Pharmacology, 1979, 10.1159/000137262
  • A convenient method for the ATPase assay., , Analytical biochemistry, 1978, 10.1016/0003-2697(78)90277-4
  • Delayed weaning and denial of solid food nibbling upon pancreatic acinar cell responsiveness to urecholine in neonatal rats., , Digestion, 1978, 10.1159/000198188
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Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Olivia Gavard - Doctorat - En cours
  • Louis Marie Paul Michel Nonfoux - Doctorat - En cours
  • Charu Kothari - Post-doctorat - En cours
  • Maria Tedim Ferreira - Doctorat - 2018/09
  • Julia O'Sullivan - Doctorat - 2021/09
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4645
Québec (Québec) G1V 0A6
Canada

Renseignements - Secrétariat
418 656-2690
vdres@fmed.ulaval.ca

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

Volet recherche
Gestion financière
Volet études aux cycles supérieurs