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Guy Poirier

Professeur titulaire

Guy Poirier
guy.poirier@fmed.ulaval.ca
Centre de recherche sur le cancer
Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Solution d'imagerie cellulaire en temps réel pour améliorer la létalité synthétique des inhibiteurs de PARP dans le traitement du cancer - Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2021-04-01 au 2022-03-31

Publications

  • Stimulation of adenohypophyseal adenylate cyclase activity by synthetic luteinizing hormone-releasing hormone (LHRH) and purified growth hormone (GH-RH), , Hypothalamic hypophysiotropic hormones; physiological and clinical studies. Proceedings of the conference held at Acapulco, Gro., Mexico, June 29-July 1, 1972, 1973
  • Adenohypophyseal secretory granules. I. Their phosphorylation and association with protein kinase., , The Journal of biological chemistry, 1971
  • Comparative inhibitory effects of 3-quinuclidinyl benzilate (QNB) and atropine on amylase release from rat pancreas., , British journal of pharmacology, 1977, 10.1111/j.1476-5381.1977.tb09745.x
  • Hypophysiotropic hormones, cyclic AMP and adenohypophyseal protein synthesis and release, , Hormones and brain function. [Proceedings of the second congress of the International Society of Psychoneuroendocrinology held in Budapest (Hungary) from July 1 to 3, 1971] Edited by K. Lissâak, 1973
  • Separation of poly(ADP-ribosylated) nuclear proteins by polyacrylamide gel electrophoresis at acidic pH and low temperature., , Analytical biochemistry, 1981, 10.1016/0003-2697(81)90489-9
  • Delayed weaning and denial of solid food nibbling upon pancreatic acinar cell responsiveness to urecholine in neonatal rats., , Digestion, 1978, 10.1159/000198188
  • Adenosine diphosphoribosylation of certain basic chromosomal proteins in isolated trout testis nuclei., , European journal of biochemistry, 1977, 10.1111/j.1432-1033.1977.tb11635.x
  • Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation., , The EMBO journal, 1983
  • Nucleosomal poly(ADP-ribose) polymerase: properties and relaxation of the chromatin structure., , Princess Takamatsu symposia., 1983
  • Maturation of muscarinic agonist receptors in rat developing pancreas and its relation to maximal enzyme secretion., , Life sciences, 1981, 10.1016/0024-3205(81)90537-3
  • Parallel maturation of the pancreatic secretory response to cholinergic stimulation and the muscarinic receptor population., , British journal of pharmacology, 1981, 10.1111/j.1476-5381.1981.tb10428.x
  • Poly(ADP-ribose) polymerase activity in mouse cells which exhibit temperature-sensitive DNA synthesis., , Biochimica et biophysica acta, 1981, 10.1016/0005-2787(81)90162-3
  • Poly(adenosine diphosphoribose) polymerase activity and adenosine diphosphate ribosylation of proteins during pancreatic degeneration and regeneration., , Cancer research, 1981
  • Modulation of rat pancreatic muscarinic cholinergic receptors by caerulein., , Biochemical pharmacology, 1985, 10.1016/0006-2952(85)90609-4
  • Muscarinic cholinergic receptors in pancreatic acinar carcinoma of rat., , International journal of cancer, 1985, 10.1002/ijc.2910350412
  • Poly(ADP-ribosyl)ation of chromatin: kinetics of relaxation and its effect on chromatin solubility., , Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, 10.1139/o85-096
  • Sequential ADP-ribosylation pattern of nucleosomal histones. ADP-ribosylation of nucleosomal histones., , European journal of biochemistry, 1985, 10.1111/j.1432-1033.1985.tb08650.x
  • Changes in acetylcholinesterase and cholinesterase activities in rat pancreas during postnatal development. Lack of relation with muscarinic receptor maturation., , Pharmacology, 1984, 10.1159/000137990
  • Poly(ADP-ribose) accessibility to poly(ADP-ribose) glycohydrolase activity on poly(ADP-ribosyl)ated nucleosomal proteins., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1986, 10.1139/o86-023
  • Production and characterization of monoclonal antibodies specific for the functional domains of poly(ADP-ribose) polymerase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1986, 10.1139/o86-051
  • Rapid assay of poly(ADP-ribose) glycohydrolase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1987, 10.1139/o87-088
  • Cell cycle regulation of poly(ADP-ribose) synthetase in FR3T3 cells., , Biochimica et biophysica acta, 1988, 10.1016/0167-4889(88)90018-3
  • Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study., , Biochimica et biophysica acta, 1988, 10.1016/0167-4781(88)90007-3
  • Molecular and biochemical features of poly (ADP-ribose) metabolism., , Molecular and cellular biochemistry, 1993, 10.1007/BF01076101
  • NAD(+)-dependent repair of damaged DNA by human cell extracts., , The Journal of biological chemistry, 1993
  • Expression of poly(ADP-ribose) polymerase in differentiating HL-60 cells, , ADP-ribosylation Reactions, 1992
  • Molecular Cloning of the rat poly(ADP-ribose)polymerase gene and preliminary characterization of its promoter and 5'-flanking region, , ADP-ribosylation Reactions, 1992
  • Resistance of ADP-ribosylated histones and HMG proteins to proteases., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1992, 10.1139/o92-172
  • Association of poly(ADP-ribose) polymerase with the nuclear matrix: the role of intermolecular disulfide bond formation, RNA retention, and cell type., , Experimental cell research, 1991, 10.1016/0014-4827(91)90072-3
  • Enzymological properties of poly(ADP-ribose)polymerase: characterization of automodification sites and NADase activity., , Biochimica et biophysica acta, 1991, 10.1016/0167-4838(91)99007-f
  • Poly(ADP-ribosyl)ation reactions and modulation of chromatin structure, , DNA repair mechanisms and their biological implications in mammalian cells, 1990
  • Stimulation of poly(ADP-ribose) synthesis by free radicals in C3H10T1/2 cells: relationship with NAD metabolism and DNA breakage., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1990, 10.1139/o90-085
  • Purification of poly(ADP-ribose) glycohydrolase and detection of its isoforms by a zymogram following one- or two-dimensional electrophoresis., , Analytical biochemistry, 1994, 10.1006/abio.1994.1177
  • Poly(ADP-ribose)polymerase: a novel finger protein., , Nucleic acids research, 1989, 10.1093/nar/17.12.4689
  • Reconstitution of an in vitro poly(ADP)-ribose turnover system, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Hyperthermia and poly(ADP-ribose) metabolism, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Ethoxyresorufin O-deethylase (EROD) activity in placental tissue from Inuit women exposed to organochlorines through the arctic food chain, , Organohalogen Compounds, 1996
  • High Performance Electrophoresis Chromatography, , The protein protocols handbook, 1996
  • Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.9.4573
  • Binding capacity of various fibre to pesticide residues under simulated gastrointestinal conditions., , Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1999, 10.1016/s0278-6915(99)00110-6
  • Fanconi anemia C protein acts at a switch between apoptosis and necrosis in mitomycin C-induced cell death., , Experimental cell research, 1999, 10.1006/excr.1998.4316
  • Liver poly(ADP-ribose)polymerase is resistant to cleavage by caspases., , Biochemical and biophysical research communications, 1999, 10.1006/bbrc.1999.0313
  • Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment., , Molecular and cellular biochemistry, 1999
  • Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110-kDa protein., , Experimental cell research, 1999, 10.1006/excr.1998.4321
  • Poly(ADP-ribosylation) and apoptosis., , Molecular and cellular biochemistry, 1999, 10.1023/a:1006962716377
  • Preferential perinuclear localization of poly(ADP-ribose) glycohydrolase., , Experimental cell research, 1999, 10.1006/excr.1999.4594
  • 6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin., , Clinical cancer research : an official journal of the American Association for Cancer Research, 1998
  • Isolation, purification and partial characterization of chloragocytes from the earthworm species Lumbricus terrestris., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006882207581
  • Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis., , European journal of biochemistry, 1998, 10.1046/j.1432-1327.1998.2510295.x
  • ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase., , The EMBO journal, 1997, 10.1093/emboj/16.19.6018
  • Mode of action of poly(ADP-ribose) glycohydrolase., , Biochimica et biophysica acta, 1994, 10.1016/0167-4781(94)90058-2
  • Autoantibodies reacting with poly(ADP-ribose) and with a zinc-finger functional domain of poly(ADP-ribose) polymerase involved in the recognition of damaged DNA., , Clinical immunology and immunopathology, 1994, 10.1006/clin.1994.1187
  • Erasable blot of poly(ADP-ribose) polymerase., , Analytical biochemistry, 1994, 10.1006/abio.1994.1212
  • The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis., , The Journal of biological chemistry, 1995, 10.1074/jbc.270.28.16526
  • Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution., , Proceedings of the National Academy of Sciences of the United States of America, 1995, 10.1073/pnas.92.20.9042
  • Proteasomes play an essential role in thymocyte apoptosis., , The EMBO journal, 1996
  • Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo., , Analytical biochemistry, 1995, 10.1006/abio.1995.1245
  • Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.0597
  • Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase., , Oncogene, 1996
  • Transcriptional regulation of the rat poly(ADP-ribose) polymerase gene by Sp1., , European journal of biochemistry, 1997, 10.1111/j.1432-1033.1997.0342a.x
  • Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway., , Blood, 1997
  • Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis., , Proceedings of the National Academy of Sciences of the United States of America, 1997, 10.1073/pnas.94.10.5073
  • Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks., , Radiation research, 1997
  • Extrusion of earthworm coelomocytes: comparison of the cell populations recovered from the species Lumbricus terrestris, Eisenia fetida and Octolasion tyrtaeum., , Laboratory animals, 1997, 10.1258/002367797780596068
  • Bcl-2 acts upstream of the PARP protease and prevents its activation., , Cell death and differentiation, 1997, 10.1038/sj.cdd.4400200
  • Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway., , The Journal of experimental medicine, 1997, 10.1084/jem.185.3.481
  • Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality., , Proceedings of the National Academy of Sciences of the United States of America, 2004, 10.1073/pnas.0406182101
  • Poly(ADP-ribosyl)ated chromatin domains: access granted., , Journal of cell science, 2004, 10.1242/jcs.01080
  • Alteration of poly(ADP-ribose) glycohydrolase nucleocytoplasmic shuttling characteristics upon cleavage by apoptotic proteases., , Biology of the cell, 2003, 10.1016/j.biolcel.2003.10.003
  • Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia., , The Journal of nutrition, 2000, 10.1093/jn/130.5.1102
  • Determination of Poly(ADP-Ribose) polymerase activation and cleavage during cell death, , Cell death. The role of PARP, 2000
  • Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases., , Cell death and differentiation, 2001, 10.1038/sj.cdd.4400851
  • Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks., , The Journal of biological chemistry, 2000, 10.1074/jbc.275.20.15504
  • tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator., , Developmental cell, 2002, 10.1016/s1534-5807(02)00200-9
  • Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec., , Environmental health perspectives, 2002, 10.1289/ehp.02110607
  • Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase., , The Journal of biological chemistry, 2002, 10.1074/jbc.C200366200
  • Differential proteomic screen to evidence proteins ubiquitinated upon mitotic exit in cell-free extract of Xenopus laevis embryos., , Journal of proteome research, 2008, 10.1021/pr800250x
  • Genomic location of the human RNA polymerase II general machinery: evidence for a role of TFIIF and Rpb7 at both early and late stages of transcription., , The Biochemical journal, 2008, 10.1042/BJ20070751
  • A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance., , Cell death and differentiation, 2007, 10.1038/sj.cdd.4402116
  • PARPs database: a LIMS systems for protein-protein interaction data mining or laboratory information management system., , BMC bioinformatics, 2007, 10.1186/1471-2105-8-483
  • RT-PSM, a real-time program for peptide-spectrum matching with statistical significance., , Rapid communications in mass spectrometry : RCM, 2006, 10.1002/rcm.2435
  • Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles., , The Biochemical journal, 2005, 10.1042/BJ20050792
  • Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/JNEUROSCI.3461-04.2004
  • Focus on computational proteomics., , Proteomics, 2011, 10.1002/pmic.201190099
  • An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain., , Development (Cambridge, England), 2010, 10.1242/dev.051052
  • PARP inhibition: PARP1 and beyond., , Nature reviews. Cancer, 2010, 10.1038/nrc2812
  • The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver., , The Journal of biological chemistry, 2010, 10.1074/jbc.M109.073908
  • A HUPO test sample study reveals common problems in mass spectrometry-based proteomics., , Nature methods, 2009, 10.1038/nmeth.1333
  • Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase., , Journal of proteome research, 2009, 10.1021/pr800810n
  • Polycomb repressive complex 2 contributes to DNA double-strand break repair., , Cell cycle (Georgetown, Tex.), 2013, 10.4161/cc.25795
  • PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent., , PloS one, 2012, 10.1371/journal.pone.0047978
  • A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors., , Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 10.1158/1078-0432.CCR-17-1590
  • Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS., , Journal of proteome research, 2018, 10.1021/acs.jproteome.8b00146
  • Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions., , Canadian journal of gastroenterology & hepatology, 2018, 10.1155/2018/8096314
  • Mapping PARP-1 auto-ADP-ribosylation sites by liquid chromatography-tandem mass spectrometry., , Journal of proteome research, 2013, 10.1021/pr301219h
  • Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis., , Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1405158111
  • Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs., , DNA repair, 2015, 10.1016/j.dnarep.2015.02.004
  • ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion., , Cell reports, 2014, 10.1016/j.celrep.2014.08.036
  • Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities., , Oncotarget, 2016, 10.18632/oncotarget.13341
  • Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks., , Nature communications, 2019, 10.1038/s41467-019-10741-9
  • SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells., , Drug metabolism and disposition: the biological fate of chemicals, 2019, 10.1124/dmd.119.088047
  • The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase., , Journal of virology, 2021, 10.1128/JVI.01969-20
  • Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2021, 10.1073/pnas.2019408118
  • Aurora-A phosphorylates splicing factors and regulates alternative splicing, Claude Prigent, Erwan Watrin, Juan Valcárcel, Guy G. Poirier, Agnès Mereau, Justine Cailloce, Thibault Courtheoux, Estefania Mancini, Malgorzata Ewa Rogalska, Jean-Philippe Gagné, Olivia Gavard, Arun Prasath Damodaran, 2020, 10.1101/2020.11.04.368498
  • The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase, Anthony R. Fehr, Scott Lovell, Guy G. Poirier, Erik D. Holmstrom, David K. Johnson, Kevin P. Battaile, Louis Nonfoux, Philip Gao, Peter McDonald, Jean-Philippe Gagné, Anuradha Roy, Maithri M. Kashipathy, Yousef M.O. Alhammad, 2020, 10.1101/2020.05.11.089375
  • A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in ., , Genetics, 2019, 10.1534/genetics.118.301393
  • CARM1 regulates replication fork speed and stress response by stimulating PARP1., , Molecular cell, 2021, 10.1016/j.molcel.2020.12.010
  • Identification of mitofusin 1 and complement component 1q subcomponent-binding protein as mitochondrial targets in systemic lupus erythematosus., , Arthritis & rheumatology (Hoboken, N.J.), 2022, 10.1002/art.42082
  • Adenohypophyseal secretory granules. I. Their phosphorylation and association with protein kinase., , The Journal of biological chemistry, 1971
  • Stimulation of adenohypophyseal adenylate cyclase activity by synthetic luteinizing hormone-releasing hormone (LHRH) and purified growth hormone (GH-RH), , Hypothalamic hypophysiotropic hormones; physiological and clinical studies. Proceedings of the conference held at Acapulco, Gro., Mexico, June 29-July 1, 1972, 1973
  • Comparative inhibitory effects of 3-quinuclidinyl benzilate (QNB) and atropine on amylase release from rat pancreas., , British journal of pharmacology, 1977, 10.1111/j.1476-5381.1977.tb09745.x
  • Hypophysiotropic hormones, cyclic AMP and adenohypophyseal protein synthesis and release, , Hormones and brain function. [Proceedings of the second congress of the International Society of Psychoneuroendocrinology held in Budapest (Hungary) from July 1 to 3, 1971] Edited by K. Lissâak, 1973
  • Separation of poly(ADP-ribosylated) nuclear proteins by polyacrylamide gel electrophoresis at acidic pH and low temperature., , Analytical biochemistry, 1981, 10.1016/0003-2697(81)90489-9
  • Delayed weaning and denial of solid food nibbling upon pancreatic acinar cell responsiveness to urecholine in neonatal rats., , Digestion, 1978, 10.1159/000198188
  • Adenosine diphosphoribosylation of certain basic chromosomal proteins in isolated trout testis nuclei., , European journal of biochemistry, 1977, 10.1111/j.1432-1033.1977.tb11635.x
  • Poly(adenosine diphosphoribose) polymerase activity and adenosine diphosphate ribosylation of proteins during pancreatic degeneration and regeneration., , Cancer research, 1981
  • Poly(ADP-ribose) polymerase activity in mouse cells which exhibit temperature-sensitive DNA synthesis., , Biochimica et biophysica acta, 1981, 10.1016/0005-2787(81)90162-3
  • Parallel maturation of the pancreatic secretory response to cholinergic stimulation and the muscarinic receptor population., , British journal of pharmacology, 1981, 10.1111/j.1476-5381.1981.tb10428.x
  • Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation., , The EMBO journal, 1983
  • Nucleosomal poly(ADP-ribose) polymerase: properties and relaxation of the chromatin structure., , Princess Takamatsu symposia., 1983
  • Maturation of muscarinic agonist receptors in rat developing pancreas and its relation to maximal enzyme secretion., , Life sciences, 1981, 10.1016/0024-3205(81)90537-3
  • Changes in acetylcholinesterase and cholinesterase activities in rat pancreas during postnatal development. Lack of relation with muscarinic receptor maturation., , Pharmacology, 1984, 10.1159/000137990
  • Sequential ADP-ribosylation pattern of nucleosomal histones. ADP-ribosylation of nucleosomal histones., , European journal of biochemistry, 1985, 10.1111/j.1432-1033.1985.tb08650.x
  • Cell cycle regulation of poly(ADP-ribose) synthetase in FR3T3 cells., , Biochimica et biophysica acta, 1988, 10.1016/0167-4889(88)90018-3
  • Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study., , Biochimica et biophysica acta, 1988, 10.1016/0167-4781(88)90007-3
  • Rapid assay of poly(ADP-ribose) glycohydrolase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1987, 10.1139/o87-088
  • Poly(ADP-ribose) accessibility to poly(ADP-ribose) glycohydrolase activity on poly(ADP-ribosyl)ated nucleosomal proteins., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1986, 10.1139/o86-023
  • Production and characterization of monoclonal antibodies specific for the functional domains of poly(ADP-ribose) polymerase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1986, 10.1139/o86-051
  • Modulation of rat pancreatic muscarinic cholinergic receptors by caerulein., , Biochemical pharmacology, 1985, 10.1016/0006-2952(85)90609-4
  • Muscarinic cholinergic receptors in pancreatic acinar carcinoma of rat., , International journal of cancer, 1985, 10.1002/ijc.2910350412
  • Poly(ADP-ribosyl)ation of chromatin: kinetics of relaxation and its effect on chromatin solubility., , Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, 10.1139/o85-096
  • Reconstitution of an in vitro poly(ADP)-ribose turnover system, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Hyperthermia and poly(ADP-ribose) metabolism, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Poly(ADP-ribose)polymerase: a novel finger protein., , Nucleic acids research, 1989, 10.1093/nar/17.12.4689
  • Stimulation of poly(ADP-ribose) synthesis by free radicals in C3H10T1/2 cells: relationship with NAD metabolism and DNA breakage., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1990, 10.1139/o90-085
  • Poly(ADP-ribosyl)ation reactions and modulation of chromatin structure, , DNA repair mechanisms and their biological implications in mammalian cells, 1990
  • Enzymological properties of poly(ADP-ribose)polymerase: characterization of automodification sites and NADase activity., , Biochimica et biophysica acta, 1991, 10.1016/0167-4838(91)99007-f
  • Association of poly(ADP-ribose) polymerase with the nuclear matrix: the role of intermolecular disulfide bond formation, RNA retention, and cell type., , Experimental cell research, 1991, 10.1016/0014-4827(91)90072-3
  • Resistance of ADP-ribosylated histones and HMG proteins to proteases., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1992, 10.1139/o92-172
  • NAD(+)-dependent repair of damaged DNA by human cell extracts., , The Journal of biological chemistry, 1993
  • Expression of poly(ADP-ribose) polymerase in differentiating HL-60 cells, , ADP-ribosylation Reactions, 1992
  • Molecular Cloning of the rat poly(ADP-ribose)polymerase gene and preliminary characterization of its promoter and 5'-flanking region, , ADP-ribosylation Reactions, 1992
  • ADP-ribosylation of rye histones., , Canadian journal of biochemistry, 1980, 10.1139/o80-097
  • Characterization and purification of a calcium-sensitive ATP diphosphohydrolase from pig pancreas., , The Journal of biological chemistry, 1980
  • Effect of early weaning of the neonatal rat on pancreatic acinar cell responsiveness to urecholine., , Digestion, 1978, 10.1159/000198126
  • Properties of poly(ADP-ribose) synthetase from rat pancreas and poly(ADP-ribosylation) of basic nuclear proteins., , Canadian journal of biochemistry, 1978, 10.1139/o78-119
  • Polypeptide receptor mechanisms in anterior pituitary gland, , Anatomical neuroendocrinology: based on the International Conference on Neurobiology of CNS-Hormone Interactions, Chapel Hill, N. C., May 14-16, 1974, 1975
  • Stimulation of adenosine 3',5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by purified growth hormone-releasing hormone., , Transactions of the Association of American Physicians, 1973
  • Molecular and biochemical features of poly (ADP-ribose) metabolism., , Molecular and cellular biochemistry, 1993, 10.1007/BF01076101
  • Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation., , The Journal of biological chemistry, 1986
  • Poly ADP-ribosylation and DNA strand breakage in SV40 minichromosomes., , Carcinogenesis, 1985, 10.1093/carcin/6.2.283
  • Hyper(ADP-ribosyl)ation of histone H1., , Canadian journal of biochemistry, 1982, 10.1139/o82-139
  • Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure., , Proceedings of the National Academy of Sciences of the United States of America, 1982, 10.1073/pnas.79.11.3423
  • Immunoelectron microscopical distribution of poly(ADP-ribose)polymerase in the mammalian cell nucleus., , Experimental cell research, 1988, 10.1016/0014-4827(88)90289-3
  • Les réactions de poly(ADP-ribosyl)ation, , Regards sur la biochimie, 1988
  • Modulation of chromatin structure by poly(ADP-ribosyl)ation., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1988, 10.1139/o88-072
  • Monoclonal antibodies against poly(ADP- ribose) polymerase. Epitope mapping, inhibition of activity and interspecies immunoreactivity, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Effect of hyperthermia on poly(adenosine diphosphate-ribose) glycohydrolase., , Cancer research, 1988
  • Automodification and NADase activity of poly(ADP-ribose) polymerase, , ADP-ribosylation Reactions, 1992
  • Enzymatic properties of Poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase on chromatin, , ADP-ribosylation Reactions, 1992
  • Proteolytic cleavage of poly(ADP-ribose) polymerase in human leukemia cells treated with etoposide and other cytotoxic agents, , ADP-ribosylation Reactions, 1992
  • Proteolytic degradation of poly(ADP-ribose) polymerase by contaminating proteases in commercial preparations of DNAse I, , ADP-ribosylation Reactions, 1992
  • Structural analysis of the putative regulatory region of the rat gene encoding poly(ADP-ribose) polymerase., , FEBS letters, 1992, 10.1016/0014-5793(92)80457-r
  • Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase., , FEBS letters, 1990, 10.1016/0014-5793(90)80770-j
  • Reconstitution of an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1990, 10.1016/0167-4781(90)90083-e
  • Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1989, 10.1139/o89-097
  • Modulation of chromatin structure by poly(ADP-ribosyl)ation, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase., , Cell, 1995, 10.1016/0092-8674(95)90541-3
  • One-step protein purification using micropreparative electrophoresis fully compatible with protein microsequencing., , Analytical biochemistry, 1994, 10.1006/abio.1994.1437
  • Poly(ADP-ribose) catabolism in mammalian cells., , Molecular and cellular biochemistry, 1994, 10.1007/BF00928442
  • Enzymatic mechanisms for joining DNA strand interruptions in human cells, , DNA repair mechanisms: proceedings of the Alfred Benzon Symposium 35, held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen, August 9-13, 1992, 1993
  • Expression in Escherichia coli of the 36 kDa domain of poly(ADP-ribose) polymerase and investigation of its DNA binding properties., , Biochimica et biophysica acta, 1993, 10.1016/0167-4838(93)90277-x
  • Poly(ADP-ribose) polymerase can bind melphalan damaged DNA., , Cancer research, 1993
  • Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis., , Cancer research, 1993
  • A novel approach to denoising ion trap tandem mass spectra., , Proteome science, 2009, 10.1186/1477-5956-7-9
  • Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells., , Journal of proteomics, 2009, 10.1016/j.jprot.2009.04.003
  • Quality assessment of tandem mass spectra using support vector machine (SVM)., , BMC bioinformatics, 2009, 10.1186/1471-2105-10-S1-S49
  • An approach to assessing peptide mass spectral quality without prior information, , International Journal of Functional Informatics and Personalised Medicine IJFIPM, 2008
  • PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites., , The Journal of biological chemistry, 2008, 10.1074/jbc.M706734200
  • A framework for mass spectral quality assessment without prior information, , 7th IEEE International Conference on Bioinformatics and Bioengineering. Boston, MA (14-17 October 2007), 2007
  • Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains., , Journal of proteome research, 2007, 10.1021/pr070521m
  • Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606528103
  • Bioinformatics standards for mass spectrometry, , Current Proteomics: the journal for current and in-depth reviews on proteomics, 2006
  • Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage., , Biochimica et biophysica acta, 2006, 10.1016/j.bbamcr.2005.11.015
  • Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src., , The FEBS journal, 2006, 10.1111/j.1742-4658.2006.05125.x
  • Poly(ADP-ribose) (PAR) polymer is a death signal., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606526103
  • The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives., , Current opinion in cell biology, 2006, 10.1016/j.ceb.2006.02.013
  • Inferring gene regulatory networks with time delays using a genetic algorithm., , Systems biology, 2005, 10.1049/ip-syb:20050006
  • Low hepatic ethoxyresorufin-O-deethylase activity correlates with high organochlorine concentrations in Atlantic tomcod from the Canadian east coast., , Environmental toxicology and chemistry, 2005, 10.1897/05-048r.1
  • Proteome profiling of human epithelial ovarian cancer cell line TOV-112D., , Molecular and cellular biochemistry, 2005, 10.1007/s11010-005-7556-1
  • Potential role of PARP inhibitors in cancer treatment and cell death, , DNA repair in cancer therapy, 2004
  • A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins., , The Biochemical journal, 2003, 10.1042/BJ20021675
  • Stimulation of adenosine 3',5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by purified growth hormone-releasing hormone., , Transactions of the Association of American Physicians, 1973
  • Rapid removal of nonspecific background in silver-stained polyacrylamide gel., , Analytical biochemistry, 1995, 10.1006/abio.1995.9947
  • Isolation of genomic DNA from the earthworm species Eisenia fetida., , Molecular and cellular biochemistry, 1995, 10.1007/BF00928909
  • Equilibrium model in an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1995, 10.1016/0167-4781(95)00143-5
  • Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique., , Analytical biochemistry, 1995, 10.1006/abio.1995.0016
  • Comparative study of DNA adducts levels in white sucker fish (Catostomus commersoni) from the basin of the St. Lawrence River (Canada)., , Molecular and cellular biochemistry, 1995, 10.1007/BF00928150
  • Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells., , Journal of cell science. Supplement, 1995, 10.1242/jcs.1995.supplement_19.6
  • Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells., , Journal of virology, 1996, 10.1128/JVI.70.4.2215-2220.1996
  • ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.28.16720
  • High-performance electrophoresis chromatography., , Methods in molecular biology (Clifton, N.J.), 1996, 10.1385/0-89603-336-8:371
  • Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1565
  • Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3., , Current biology : CB, 1996, 10.1016/s0960-9822(02)00614-0
  • CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.51.32487
  • Association of poly(ADP-ribose) polymerase with nuclear subfractions catalyzed with sodium tetrathionate and hydrogene peroxide crosslinks., , Molecular and cellular biochemistry, 1996, 10.1007/BF00420918
  • Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors., , Experimental cell research, 1996, 10.1006/excr.1996.0259
  • Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis., , The Journal of biological chemistry, 1997, 10.1074/jbc.272.30.18530
  • Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide., , Experimental cell research, 1997, 10.1006/excr.1996.3459
  • Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation., , European journal of biochemistry, 1997, 10.1111/j.1432-1033.1997.00015.x
  • Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres., , Current biology : CB, 1997, 10.1016/s0960-9822(06)00382-4
  • Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms., , The American journal of pathology, 1997
  • Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells., , Biochimica et biophysica acta, 1997, 10.1016/s0167-4838(96)00188-4
  • A nuclear factor other than Sp1 binds the GC-rich promoter of the gene encoding rat poly(ADP-ribose) polymerase in vitro., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • A microassay for the detection of low levels of cytochrome P450 O-deethylation activities with alkoxyresorufin substrates., , Molecular and cellular biochemistry, 1997, 10.1023/a:1006835712436
  • Immunodot blot method for the detection of poly(ADP-ribose) synthesized in vitro and in vivo., , Analytical biochemistry, 1998, 10.1006/abio.1998.2664
  • Rapid detection of poly(ADP-ribose) polymerase by enzyme-linked immunosorbent assay during its purification and improvement of its purification., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006861015142
  • Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions., , Biochimica et biophysica acta, 1999, 10.1016/s0167-4838(98)00278-7
  • Immunological determination and size characterization of poly(ADP-ribose) synthesized in vitro and in vivo., , Biochimica et biophysica acta, 1999, 10.1016/s0304-4165(99)00054-9
  • Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.40.28379
  • Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.7.4335
  • Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid., , Experimental cell research, 1999, 10.1006/excr.1998.4350
  • Sources of nitrate exposure in residents of rural areas in Quebec, Canada., , Journal of exposure analysis and environmental epidemiology, 2000, 10.1038/sj.jea.7500079
  • Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1., , Nucleic acids research, 2000, 10.1093/nar/28.20.3887
  • Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption., , Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2000, 10.1016/s0278-6915(00)00089-2
  • Poly(ADP-ribose) degradation by post-nuclear extracts from human cells., , Biochimie, 2002, 10.1016/s0300-9084(02)00017-2
  • Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats., , The Journal of nutrition, 2002, 10.1093/jn/132.1.115
  • Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor., , Science (New York, N.Y.), 2002, 10.1126/science.1072221
  • Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation., , The Journal of biological chemistry, 2003, 10.1074/jbc.M211641200
  • Identification of Streptomyces coelicolor proteins that are differentially expressed in the presence of plant material., , Applied and environmental microbiology, 2003, 10.1128/AEM.69.4.1884-1889.2003
  • PARP-3 and APLF function together to accelerate nonhomologous end-joining., , Molecular cell, 2011, 10.1016/j.molcel.2010.12.006
  • Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples., , Journal of proteome research, 2011, 10.1021/pr100990s
  • Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage., , Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1108799108
  • Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death., , Nature medicine, 2011, 10.1038/nm.2387
  • Structural biology. PARP-1 activation--bringing the pieces together., , Science (New York, N.Y.), 2012, 10.1126/science.1221870
  • A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development., , PloS one, 2011, 10.1371/journal.pone.0015834
  • Affinity-based assays for the identification and quantitative evaluation of noncovalent poly(ADP-ribose)-binding proteins., , Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61779-270-0_7
  • PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons., , Neurochemistry international, 2021, 10.1016/j.neuint.2021.105077
  • Effect of early weaning of the neonatal rat on pancreatic acinar cell responsiveness to urecholine., , Digestion, 1978, 10.1159/000198126
  • Properties of poly(ADP-ribose) synthetase from rat pancreas and poly(ADP-ribosylation) of basic nuclear proteins., , Canadian journal of biochemistry, 1978, 10.1139/o78-119
  • Polypeptide receptor mechanisms in anterior pituitary gland, , Anatomical neuroendocrinology: based on the International Conference on Neurobiology of CNS-Hormone Interactions, Chapel Hill, N. C., May 14-16, 1974, 1975
  • Proteomics reveals a switch in CDK1-associated proteins upon M-phase exit during the Xenopus laevis oocyte to embryo transition., , The international journal of biochemistry & cell biology, 2012, 10.1016/j.biocel.2011.09.003
  • Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair, , Advances in DNA Repair in Cancer Therapy, 2012
  • PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks., , Nucleic acids research, 2012, 10.1093/nar/gks798
  • Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro., , Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 10.1158/1078-0432.CCR-11-2890
  • Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes., , The Journal of biological chemistry, 2012, 10.1074/jbc.M111.296475
  • Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant., , PloS one, 2013, 10.1371/journal.pone.0081899
  • Reprogramming cellular events by poly(ADP-ribose)-binding proteins., , Molecular aspects of medicine, 2013, 10.1016/j.mam.2012.12.005
  • Germline mutations in BAP1 impair its function in DNA double-strand break repair., , Cancer research, 2014, 10.1158/0008-5472.CAN-13-3109
  • Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum., , International journal for parasitology. Drugs and drug resistance., 2014, 10.1016/j.ijpddr.2014.05.002
  • Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells., , The Journal of cell biology, 2014, 10.1083/jcb.201311094
  • Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase., , PloS one, 2014, 10.1371/journal.pone.0086010
  • The von Hippel-Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform., , British journal of cancer, 2015, 10.1038/bjc.2015.189
  • The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice., , Nature cell biology, 2015, 10.1038/ncb3259
  • Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination., , Genes & development, 2019, 10.1101/gad.315978.118
  • Aurora kinase A localises to mitochondria to control organelle dynamics and energy production., , eLife, 2018, 10.7554/eLife.38111
  • Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation., , Nature communications, 2019, 10.1038/s41467-019-08859-x
  • ADP-ribosylation of rye histones., , Canadian journal of biochemistry, 1980, 10.1139/o80-097
  • Characterization and purification of a calcium-sensitive ATP diphosphohydrolase from pig pancreas., , The Journal of biological chemistry, 1980
  • Modulation of chromatin structure by poly(ADP-ribosyl)ation., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1988, 10.1139/o88-072
  • Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation., , The Journal of biological chemistry, 1986
  • Poly ADP-ribosylation and DNA strand breakage in SV40 minichromosomes., , Carcinogenesis, 1985, 10.1093/carcin/6.2.283
  • Hyper(ADP-ribosyl)ation of histone H1., , Canadian journal of biochemistry, 1982, 10.1139/o82-139
  • Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure., , Proceedings of the National Academy of Sciences of the United States of America, 1982, 10.1073/pnas.79.11.3423
  • Immunoelectron microscopical distribution of poly(ADP-ribose)polymerase in the mammalian cell nucleus., , Experimental cell research, 1988, 10.1016/0014-4827(88)90289-3
  • Les réactions de poly(ADP-ribosyl)ation, , Regards sur la biochimie, 1988
  • Effect of hyperthermia on poly(adenosine diphosphate-ribose) glycohydrolase., , Cancer research, 1988
  • Monoclonal antibodies against poly(ADP- ribose) polymerase. Epitope mapping, inhibition of activity and interspecies immunoreactivity, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Proteolytic degradation of poly(ADP-ribose) polymerase by contaminating proteases in commercial preparations of DNAse I, , ADP-ribosylation Reactions, 1992
  • Structural analysis of the putative regulatory region of the rat gene encoding poly(ADP-ribose) polymerase., , FEBS letters, 1992, 10.1016/0014-5793(92)80457-r
  • Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase., , FEBS letters, 1990, 10.1016/0014-5793(90)80770-j
  • Reconstitution of an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1990, 10.1016/0167-4781(90)90083-e
  • Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1989, 10.1139/o89-097
  • Modulation of chromatin structure by poly(ADP-ribosyl)ation, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
  • Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells., , Journal of cell science. Supplement, 1995, 10.1242/jcs.1995.supplement_19.6
  • Comparative study of DNA adducts levels in white sucker fish (Catostomus commersoni) from the basin of the St. Lawrence River (Canada)., , Molecular and cellular biochemistry, 1995, 10.1007/BF00928150
  • Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique., , Analytical biochemistry, 1995, 10.1006/abio.1995.0016
  • Equilibrium model in an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1995, 10.1016/0167-4781(95)00143-5
  • Isolation of genomic DNA from the earthworm species Eisenia fetida., , Molecular and cellular biochemistry, 1995, 10.1007/BF00928909
  • Immunodot blot method for the detection of poly(ADP-ribose) synthesized in vitro and in vivo., , Analytical biochemistry, 1998, 10.1006/abio.1998.2664
  • Rapid detection of poly(ADP-ribose) polymerase by enzyme-linked immunosorbent assay during its purification and improvement of its purification., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006861015142
  • A microassay for the detection of low levels of cytochrome P450 O-deethylation activities with alkoxyresorufin substrates., , Molecular and cellular biochemistry, 1997, 10.1023/a:1006835712436
  • Proteolytic cleavage of poly(ADP-ribose) polymerase in human leukemia cells treated with etoposide and other cytotoxic agents, , ADP-ribosylation Reactions, 1992
  • Automodification and NADase activity of poly(ADP-ribose) polymerase, , ADP-ribosylation Reactions, 1992
  • Enzymatic properties of Poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase on chromatin, , ADP-ribosylation Reactions, 1992
  • Poly(ADP-ribose) polymerase can bind melphalan damaged DNA., , Cancer research, 1993
  • Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis., , Cancer research, 1993
  • Expression in Escherichia coli of the 36 kDa domain of poly(ADP-ribose) polymerase and investigation of its DNA binding properties., , Biochimica et biophysica acta, 1993, 10.1016/0167-4838(93)90277-x
  • Enzymatic mechanisms for joining DNA strand interruptions in human cells, , DNA repair mechanisms: proceedings of the Alfred Benzon Symposium 35, held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen, August 9-13, 1992, 1993
  • Poly(ADP-ribose) catabolism in mammalian cells., , Molecular and cellular biochemistry, 1994, 10.1007/BF00928442
  • One-step protein purification using micropreparative electrophoresis fully compatible with protein microsequencing., , Analytical biochemistry, 1994, 10.1006/abio.1994.1437
  • Rapid removal of nonspecific background in silver-stained polyacrylamide gel., , Analytical biochemistry, 1995, 10.1006/abio.1995.9947
  • Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase., , Cell, 1995, 10.1016/0092-8674(95)90541-3
  • Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells., , Journal of virology, 1996, 10.1128/JVI.70.4.2215-2220.1996
  • High-performance electrophoresis chromatography., , Methods in molecular biology (Clifton, N.J.), 1996, 10.1385/0-89603-336-8:371
  • ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.28.16720
  • Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1565
  • Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3., , Current biology : CB, 1996, 10.1016/s0960-9822(02)00614-0
  • CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.51.32487
  • Association of poly(ADP-ribose) polymerase with nuclear subfractions catalyzed with sodium tetrathionate and hydrogene peroxide crosslinks., , Molecular and cellular biochemistry, 1996, 10.1007/BF00420918
  • Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors., , Experimental cell research, 1996, 10.1006/excr.1996.0259
  • Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation., , European journal of biochemistry, 1997, 10.1111/j.1432-1033.1997.00015.x
  • Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis., , The Journal of biological chemistry, 1997, 10.1074/jbc.272.30.18530
  • Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres., , Current biology : CB, 1997, 10.1016/s0960-9822(06)00382-4
  • Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide., , Experimental cell research, 1997, 10.1006/excr.1996.3459
  • Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms., , The American journal of pathology, 1997
  • Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells., , Biochimica et biophysica acta, 1997, 10.1016/s0167-4838(96)00188-4
  • Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • A nuclear factor other than Sp1 binds the GC-rich promoter of the gene encoding rat poly(ADP-ribose) polymerase in vitro., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.40.28379
  • Immunological determination and size characterization of poly(ADP-ribose) synthesized in vitro and in vivo., , Biochimica et biophysica acta, 1999, 10.1016/s0304-4165(99)00054-9
  • Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions., , Biochimica et biophysica acta, 1999, 10.1016/s0167-4838(98)00278-7
  • Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.7.4335
  • Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption., , Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2000, 10.1016/s0278-6915(00)00089-2
  • Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid., , Experimental cell research, 1999, 10.1006/excr.1998.4350
  • Sources of nitrate exposure in residents of rural areas in Quebec, Canada., , Journal of exposure analysis and environmental epidemiology, 2000, 10.1038/sj.jea.7500079
  • Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1., , Nucleic acids research, 2000, 10.1093/nar/28.20.3887
  • Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor., , Science (New York, N.Y.), 2002, 10.1126/science.1072221
  • Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats., , The Journal of nutrition, 2002, 10.1093/jn/132.1.115
  • Poly(ADP-ribose) degradation by post-nuclear extracts from human cells., , Biochimie, 2002, 10.1016/s0300-9084(02)00017-2
  • Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation., , The Journal of biological chemistry, 2003, 10.1074/jbc.M211641200
  • Identification of Streptomyces coelicolor proteins that are differentially expressed in the presence of plant material., , Applied and environmental microbiology, 2003, 10.1128/AEM.69.4.1884-1889.2003
  • Potential role of PARP inhibitors in cancer treatment and cell death, , DNA repair in cancer therapy, 2004
  • A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins., , The Biochemical journal, 2003, 10.1042/BJ20021675
  • The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives., , Current opinion in cell biology, 2006, 10.1016/j.ceb.2006.02.013
  • Inferring gene regulatory networks with time delays using a genetic algorithm., , Systems biology, 2005, 10.1049/ip-syb:20050006
  • Low hepatic ethoxyresorufin-O-deethylase activity correlates with high organochlorine concentrations in Atlantic tomcod from the Canadian east coast., , Environmental toxicology and chemistry, 2005, 10.1897/05-048r.1
  • Proteome profiling of human epithelial ovarian cancer cell line TOV-112D., , Molecular and cellular biochemistry, 2005, 10.1007/s11010-005-7556-1
  • PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites., , The Journal of biological chemistry, 2008, 10.1074/jbc.M706734200
  • A framework for mass spectral quality assessment without prior information, , 7th IEEE International Conference on Bioinformatics and Bioengineering. Boston, MA (14-17 October 2007), 2007
  • Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains., , Journal of proteome research, 2007, 10.1021/pr070521m
  • Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606528103
  • Bioinformatics standards for mass spectrometry, , Current Proteomics: the journal for current and in-depth reviews on proteomics, 2006
  • Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage., , Biochimica et biophysica acta, 2006, 10.1016/j.bbamcr.2005.11.015
  • Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src., , The FEBS journal, 2006, 10.1111/j.1742-4658.2006.05125.x
  • Poly(ADP-ribose) (PAR) polymer is a death signal., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606526103
  • An approach to assessing peptide mass spectral quality without prior information, , International Journal of Functional Informatics and Personalised Medicine IJFIPM, 2008
  • PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks., , Nucleic acids research, 2012, 10.1093/nar/gks798
  • Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair, , Advances in DNA Repair in Cancer Therapy, 2012
  • Proteomics reveals a switch in CDK1-associated proteins upon M-phase exit during the Xenopus laevis oocyte to embryo transition., , The international journal of biochemistry & cell biology, 2012, 10.1016/j.biocel.2011.09.003
  • Structural biology. PARP-1 activation--bringing the pieces together., , Science (New York, N.Y.), 2012, 10.1126/science.1221870
  • A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development., , PloS one, 2011, 10.1371/journal.pone.0015834
  • Affinity-based assays for the identification and quantitative evaluation of noncovalent poly(ADP-ribose)-binding proteins., , Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61779-270-0_7
  • Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage., , Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1108799108
  • Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death., , Nature medicine, 2011, 10.1038/nm.2387
  • Quality assessment of tandem mass spectra using support vector machine (SVM)., , BMC bioinformatics, 2009, 10.1186/1471-2105-10-S1-S49
  • A novel approach to denoising ion trap tandem mass spectra., , Proteome science, 2009, 10.1186/1477-5956-7-9
  • Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells., , Journal of proteomics, 2009, 10.1016/j.jprot.2009.04.003
  • Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples., , Journal of proteome research, 2011, 10.1021/pr100990s
  • PARP-3 and APLF function together to accelerate nonhomologous end-joining., , Molecular cell, 2011, 10.1016/j.molcel.2010.12.006
  • Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro., , Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 10.1158/1078-0432.CCR-11-2890
  • Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes., , The Journal of biological chemistry, 2012, 10.1074/jbc.M111.296475
  • Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant., , PloS one, 2013, 10.1371/journal.pone.0081899
  • Reprogramming cellular events by poly(ADP-ribose)-binding proteins., , Molecular aspects of medicine, 2013, 10.1016/j.mam.2012.12.005
  • Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum., , International journal for parasitology. Drugs and drug resistance., 2014, 10.1016/j.ijpddr.2014.05.002
  • Germline mutations in BAP1 impair its function in DNA double-strand break repair., , Cancer research, 2014, 10.1158/0008-5472.CAN-13-3109
  • Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase., , PloS one, 2014, 10.1371/journal.pone.0086010
  • Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells., , The Journal of cell biology, 2014, 10.1083/jcb.201311094
  • The von Hippel-Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform., , British journal of cancer, 2015, 10.1038/bjc.2015.189
  • Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation., , Nature communications, 2019, 10.1038/s41467-019-08859-x
  • Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination., , Genes & development, 2019, 10.1101/gad.315978.118
  • Aurora kinase A localises to mitochondria to control organelle dynamics and energy production., , eLife, 2018, 10.7554/eLife.38111
  • The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice., , Nature cell biology, 2015, 10.1038/ncb3259
  • PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons., , Neurochemistry international, 2021, 10.1016/j.neuint.2021.105077

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Louis Marie Paul Michel Nonfoux - Doctorat - En cours
  • Olivia Gavard - Doctorat - 2016/01
  • Maria Tedim Ferreira - Doctorat - 2018/09
  • Julia O'Sullivan - Doctorat - 2021/09
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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