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Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche
Projets de recherche
Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval- Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Poly(ADP-ribose) writers, readers, and erasers: Functions in DNA double-strand break repair and synthetic lethality- Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-10-01 au 2024-09-30
PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO)- Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, co-chercheur - 2015-04-01 au 2022-03-31
Solution d'imagerie cellulaire en temps réel pour améliorer la létalité synthétique des inhibiteurs de PARP dans le traitement du cancer- Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2021-04-01 au 2022-03-31
Cibler l’instabilité génomique en tant que vulnérabilité essentielle du cancer de l’ovaire- Fonds de recherche du Québec - Santé, IRICoR - ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, Université de Montréal, co-chercheur - 2018-10-01 au 2021-09-30
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Publications
Identification of mitofusin 1 and complement component 1q subcomponent-binding protein as mitochondrial targets in systemic lupus erythematosus., , Arthritis & rheumatology (Hoboken, N.J.), 2022, 10.1002/art.42082
ADP-ribosyltransferases, an update on function and nomenclature., , The FEBS journal, 2021, 10.1111/febs.16142
CARM1 regulates replication fork speed and stress response by stimulating PARP1., , Molecular cell, 2021, 10.1016/j.molcel.2020.12.010
Drosophila Tubulin-Specific Chaperone E Recruits Tubulin around Chromatin to Promote Mitotic Spindle Assembly., , Current biology : CB, 2021, 10.1016/j.cub.2020.11.009
PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons., , Neurochemistry international, 2021, 10.1016/j.neuint.2021.105077
The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase., , Journal of virology, 2021, 10.1128/JVI.01969-20
Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair., , Proceedings of the National Academy of Sciences of the United States of America, 2021, 10.1073/pnas.2019408118
Aurora-A phosphorylates splicing factors and regulates alternative splicing, Arun Prasath Damodaran, Olivia Gavard, Jean-Philippe Gagné, Malgorzata Ewa Rogalska, Estefania Mancini, Thibault Courtheoux, Justine Cailloce, Agnès Mereau, Guy G. Poirier, Juan Valcárcel, Erwan Watrin, Claude Prigent, 2020, 10.1101/2020.11.04.368498
The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase, Yousef M.O. Alhammad, Maithri M. Kashipathy, Anuradha Roy, Jean-Philippe Gagné, Peter McDonald, Philip Gao, Louis Nonfoux, Kevin P. Battaile, David K. Johnson, Erik D. Holmstrom, Guy G. Poirier, Scott Lovell, Anthony R. Fehr, 2020, 10.1101/2020.05.11.089375
Drosophila dTBCE recruits tubulin around chromatin to promote mitotic spindle assembly, Mathieu Métivier, Emmanuel Gallaud, Aude Pascal, Jean-Philippe Gagné, Guy G. Poirier, Denis Chrétien, Romain Gibeaux, Laurent Richard-Parpaillon, Christelle Benaud, Régis Giet, 2020, 10.1101/2020.01.21.912428
Assessment of PARP-1 Distribution in Tissues of Cynomolgus Monkeys., , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2020, 10.1369/0022155420926022
The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation., , PLoS genetics, 2020, 10.1371/journal.pgen.1009183
A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in ., , Genetics, 2019, 10.1534/genetics.118.301393
Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation., , Nature communications, 2019, 10.1038/s41467-019-08859-x
Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination., , Genes & development, 2019, 10.1101/gad.324053.119
Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination., , Genes & development, 2019, 10.1101/gad.315978.118
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks., , Nature communications, 2019, 10.1038/s41467-019-10741-9
SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells., , Drug metabolism and disposition: the biological fate of chemicals, 2019, 10.1124/dmd.119.088047
A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors., , Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 10.1158/1078-0432.CCR-17-1590
Aurora kinase A localises to mitochondria to control organelle dynamics and energy production., , eLife, 2018, 10.7554/eLife.38111
Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks., , Molecular cell, 2018, 10.1016/j.molcel.2018.05.013
Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS., , Journal of proteome research, 2018, 10.1021/acs.jproteome.8b00146
Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration., , Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1720553115
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease., , Science (New York, N.Y.), 2018, 10.1126/science.aat8407
Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions., , Canadian journal of gastroenterology & hepatology, 2018, 10.1155/2018/8096314
Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities., , Oncotarget, 2016, 10.18632/oncotarget.13341
Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation., , The Journal of biological chemistry, 2016, 10.1074/jbc.M115.694992
Selective and sensitive quantification of the cytochrome P450 3A4 protein in human liver homogenates through multiple reaction monitoring mass spectrometry., , Proteomics, 2016, 10.1002/pmic.201500386
DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer., , Biomolecules, 2015, 10.3390/biom5043204
DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair., , Nucleic acids research, 2015, 10.1093/nar/gku1307
Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs., , DNA repair, 2015, 10.1016/j.dnarep.2015.02.004
Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum., , Nucleic acids research, 2015, 10.1093/nar/gkv118
The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice., , Nature cell biology, 2015, 10.1038/ncb3259
The von Hippel-Lindau tumour suppressor gene: uncovering the expression of the pVHL172 isoform., , British journal of cancer, 2015, 10.1038/bjc.2015.189
ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion., , Cell reports, 2014, 10.1016/j.celrep.2014.08.036
Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase., , PloS one, 2014, 10.1371/journal.pone.0086010
Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells., , The Journal of cell biology, 2014, 10.1083/jcb.201311094
Germline mutations in BAP1 impair its function in DNA double-strand break repair., , Cancer research, 2014, 10.1158/0008-5472.CAN-13-3109
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis., , Proceedings of the National Academy of Sciences of the United States of America, 2014, 10.1073/pnas.1405158111
Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum., , International journal for parasitology. Drugs and drug resistance., 2014, 10.1016/j.ijpddr.2014.05.002
Mapping PARP-1 auto-ADP-ribosylation sites by liquid chromatography-tandem mass spectrometry., , Journal of proteome research, 2013, 10.1021/pr301219h
Polycomb repressive complex 2 contributes to DNA double-strand break repair., , Cell cycle (Georgetown, Tex.), 2013, 10.4161/cc.25795
Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant., , PloS one, 2013, 10.1371/journal.pone.0081899
Reprogramming cellular events by poly(ADP-ribose)-binding proteins., , Molecular aspects of medicine, 2013, 10.1016/j.mam.2012.12.005
The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy., , Journal of cell science, 2013, 10.1242/jcs.114595
CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage., , Nucleic acids research, 2012, 10.1093/nar/gks222
Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes., , The Journal of biological chemistry, 2012, 10.1074/jbc.M111.296475
Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro., , Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 10.1158/1078-0432.CCR-11-2890
PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks., , Nucleic acids research, 2012, 10.1093/nar/gks798
PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent., , PloS one, 2012, 10.1371/journal.pone.0047978
PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed., , Molecular cell, 2012, 10.1016/j.molcel.2012.03.012
Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair, , Advances in DNA Repair in Cancer Therapy, 2012
Proteomics reveals a switch in CDK1-associated proteins upon M-phase exit during the Xenopus laevis oocyte to embryo transition., , The international journal of biochemistry & cell biology, 2012, 10.1016/j.biocel.2011.09.003
Quantitative proteomics and dynamic imaging reveal that G3BP-mediated stress granule assembly is poly(ADP-ribose)-dependent following exposure to MNNG-induced DNA alkylation., , Journal of cell science, 2012, 10.1242/jcs.106963
Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress., , Nucleic acids research, 2012, 10.1093/nar/gks486
Structural biology. PARP-1 activation--bringing the pieces together., , Science (New York, N.Y.), 2012, 10.1126/science.1221870
A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development., , PloS one, 2011, 10.1371/journal.pone.0015834
Affinity-based assays for the identification and quantitative evaluation of noncovalent poly(ADP-ribose)-binding proteins., , Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61779-270-0_7
Focus on computational proteomics., , Proteomics, 2011, 10.1002/pmic.201190099
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage., , Proceedings of the National Academy of Sciences of the United States of America, 2011, 10.1073/pnas.1108799108
Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death., , Nature medicine, 2011, 10.1038/nm.2387
Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1., , Expert review of proteomics, 2011, 10.1586/epr.11.63
PARP-3 and APLF function together to accelerate nonhomologous end-joining., , Molecular cell, 2011, 10.1016/j.molcel.2010.12.006
Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)., , Science signaling, 2011, 10.1126/scisignal.2000902
Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples., , Journal of proteome research, 2011, 10.1021/pr100990s
An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain., , Development (Cambridge, England), 2010, 10.1242/dev.051052
Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry., , Proteome science, 2010, 10.1186/1477-5956-8-22
The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver., , The Journal of biological chemistry, 2010, 10.1074/jbc.M109.073908
A HUPO test sample study reveals common problems in mass spectrometry-based proteomics., , Nature methods, 2009, 10.1038/nmeth.1333
A novel approach to denoising ion trap tandem mass spectra., , Proteome science, 2009, 10.1186/1477-5956-7-9
Assessment of PARP-3 distribution in tissues of cynomolgous monkeys., , The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009, 10.1369/jhc.2009.953380
Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells., , Journal of proteomics, 2009, 10.1016/j.jprot.2009.04.003
Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase., , Journal of proteome research, 2009, 10.1021/pr800810n
Quality assessment of tandem mass spectra using support vector machine (SVM)., , BMC bioinformatics, 2009, 10.1186/1471-2105-10-S1-S49
An approach to assessing peptide mass spectral quality without prior information, , International Journal of Functional Informatics and Personalised Medicine IJFIPM, 2008
Differential proteomic screen to evidence proteins ubiquitinated upon mitotic exit in cell-free extract of Xenopus laevis embryos., , Journal of proteome research, 2008, 10.1021/pr800250x
Effect of potato suberin on Streptomyces scabies proteome., , Molecular plant pathology, 2008, 10.1111/j.1364-3703.2008.00493.x
Genomic location of the human RNA polymerase II general machinery: evidence for a role of TFIIF and Rpb7 at both early and late stages of transcription., , The Biochemical journal, 2008, 10.1042/BJ20070751
Human papillomavirus E1 helicase interacts with the WD repeat protein p80 to promote maintenance of the viral genome in keratinocytes., , Journal of virology, 2008, 10.1128/JVI.01405-07
Human Proteinpedia enables sharing of human protein data., , Nature biotechnology, 2008, 10.1038/nbt0208-164
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites., , The Journal of biological chemistry, 2008, 10.1074/jbc.M706734200
Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes., , Nucleic acids research, 2008, 10.1093/nar/gkn771
Proteomic characterization of mouse cytosolic and membrane prostate fractions: high levels of free SUMO peptides are androgen-regulated., , Journal of proteome research, 2008, 10.1021/pr8002497
Quality assessment of peptide tandem mass spectra., , BMC bioinformatics, 2008, 10.1186/1471-2105-9-S6-S13
A framework for mass spectral quality assessment without prior information, , 7th IEEE International Conference on Bioinformatics and Bioengineering. Boston, MA (14-17 October 2007), 2007
A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance., , Cell death and differentiation, 2007, 10.1038/sj.cdd.4402116
Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4., , Virology, 2007, 10.1016/j.virol.2006.08.035
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents., , The Journal of biological chemistry, 2007, 10.1074/jbc.M608406200
Comparative proteome analysis of human epithelial ovarian cancer., , Proteome science, 2007, 10.1186/1477-5956-5-16
Comparative proteomics analyses reveal a potential biomarker for the detection of vancomycin-intermediate Staphylococcus aureus strains., , Journal of proteome research, 2007, 10.1021/pr070521m
Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus., , Neuroscience, 2007, 10.1016/j.neuroscience.2006.08.065
PARP-1-induced cell death through inhibition of the MEK/ERK pathway in MNNG-treated HeLa cells., , Apoptosis : an international journal on programmed cell death, 2007, 10.1007/s10495-007-0127-z
PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery., , Journal of cellular biochemistry, 2007, 10.1002/jcb.21051
PARPs database: a LIMS systems for protein-protein interaction data mining or laboratory information management system., , BMC bioinformatics, 2007, 10.1186/1471-2105-8-483
Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain., , Neuroscience, 2007, 10.1016/j.neuroscience.2007.04.062
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme., , Molecular cell, 2007, 10.1016/j.molcel.2007.06.027
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606528103
Bioinformatics standards for mass spectrometry, , Current Proteomics: the journal for current and in-depth reviews on proteomics, 2006
Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage., , Biochimica et biophysica acta, 2006, 10.1016/j.bbamcr.2005.11.015
Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src., , The FEBS journal, 2006, 10.1111/j.1742-4658.2006.05125.x
Poly(ADP-ribose) (PAR) polymer is a death signal., , Proceedings of the National Academy of Sciences of the United States of America, 2006, 10.1073/pnas.0606526103
RT-PSM, a real-time program for peptide-spectrum matching with statistical significance., , Rapid communications in mass spectrometry : RCM, 2006, 10.1002/rcm.2435
The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives., , Current opinion in cell biology, 2006, 10.1016/j.ceb.2006.02.013
Transcription. Gene expression needs a break to unwind before carrying on., , Science (New York, N.Y.), 2006, 10.1126/science.1129808
Experimental and bioinformatic approaches for interrogating protein-protein interactions to determine protein function., , Journal of molecular endocrinology, 2005, 10.1677/jme.1.01693
Inferring gene regulatory networks with time delays using a genetic algorithm., , Systems biology, 2005, 10.1049/ip-syb:20050006
Low hepatic ethoxyresorufin-O-deethylase activity correlates with high organochlorine concentrations in Atlantic tomcod from the Canadian east coast., , Environmental toxicology and chemistry, 2005, 10.1897/05-048r.1
Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles., , The Biochemical journal, 2005, 10.1042/BJ20050792
Proteome profiling of human epithelial ovarian cancer cell line TOV-112D., , Molecular and cellular biochemistry, 2005, 10.1007/s11010-005-7556-1
Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: where and when?, , Cellular and molecular life sciences : CMLS, 2005, 10.1007/s00018-004-4505-1
Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy., , Trends in molecular medicine, 2005, 10.1016/j.molmed.2005.08.003
A conserved initiator element on the mammalian poly(ADP-ribose) polymerase-1 promoters, in combination with flanking core elements, is necessary to obtain high transcriptional activity., , Biochimica et biophysica acta, 2004, 10.1016/j.bbaexp.2004.04.003
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/JNEUROSCI.3461-04.2004
Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality., , Proceedings of the National Academy of Sciences of the United States of America, 2004, 10.1073/pnas.0406182101
Nonisotopic methods for determination of poly(ADP-ribose) levels and detection of poly(ADP-ribose) polymerase., , Current protocols in cell biology, 2004, 10.1002/0471143030.cb1807s21
Potential role of PARP inhibitors in cancer treatment and cell death, , DNA repair in cancer therapy, 2004
A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins., , The Biochemical journal, 2003, 10.1042/BJ20021675
Alteration of poly(ADP-ribose) glycohydrolase nucleocytoplasmic shuttling characteristics upon cleavage by apoptotic proteases., , Biology of the cell, 2003, 10.1016/j.biolcel.2003.10.003
Identification of Streptomyces coelicolor proteins that are differentially expressed in the presence of plant material., , Applied and environmental microbiology, 2003, 10.1128/AEM.69.4.1884-1889.2003
PARP-1, a determinant of cell survival in response to DNA damage., , Experimental hematology, 2003, 10.1016/s0301-472x(03)00083-3
Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation., , The Journal of biological chemistry, 2003, 10.1074/jbc.M211641200
Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase., , The Journal of biological chemistry, 2002, 10.1074/jbc.C200366200
Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec., , Environmental health perspectives, 2002, 10.1289/ehp.02110607
In-situ analysis of cellular poly(ADP-ribose) production in scrapie-infected mouse neuroblastoma cells., , The Histochemical journal, 2002, 10.1023/a:1023398130945
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor., , Science (New York, N.Y.), 2002, 10.1126/science.1072221
Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats., , The Journal of nutrition, 2002, 10.1093/jn/132.1.108
Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats., , The Journal of nutrition, 2002, 10.1093/jn/132.1.115
Poly(ADP-ribose) degradation by post-nuclear extracts from human cells., , Biochimie, 2002, 10.1016/s0300-9084(02)00017-2
tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator., , Developmental cell, 2002, 10.1016/s1534-5807(02)00200-9
Analysis of ADP-ribose polymer sizes in intact cells., , Molecular and cellular biochemistry, 2001, 10.1023/a:1011910329010
Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis., , The Journal of biological chemistry, 2001, 10.1074/jbc.M007269200
Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases., , Cell death and differentiation, 2001, 10.1038/sj.cdd.4400851
Cigarette smoking during pregnancy: comparison of biomarkers for inclusion in epidemiological studies, , Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2001
Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis., , Journal of cell science, 2001
Identification and analysis of caspase substrates: proteolytic cleavage of poly(ADP-ribose)polymerase and DNA fragmentation factor 45., , Methods in cell biology, 2001, 10.1016/s0091-679x(01)66013-8
Identification of sequence-specific DNA-binding proteins by southwestern blotting., , Methods in molecular biology (Clifton, N.J.), 2001, 10.1385/1-59259-208-2:255
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism., , Experimental cell research, 2001, 10.1006/excr.2001.5263
Modulation of caspase-3 activity by zinc ions and by the cell redox state., , Experimental cell research, 2001, 10.1006/excr.2001.5222
Nuclear factor 1 interferes with Sp1 binding through a composite element on the rat poly(ADP-ribose) polymerase promoter to modulate its activity in vitro., , The Journal of biological chemistry, 2001, 10.1074/jbc.M010360200
Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1., , Nucleic acids research, 2000, 10.1093/nar/28.20.3887
Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks., , The Journal of biological chemistry, 2000, 10.1074/jbc.275.20.15504
Determination of Poly(ADP-Ribose) polymerase activation and cleavage during cell death, , Cell death. The role of PARP, 2000
Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains., , Brain research. Molecular brain research, 2000, 10.1016/s0169-328x(00)00122-4
Excretion of volatile nitrosamines in a rural population in relation to food and drinking water consumption., , Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2000, 10.1016/s0278-6915(00)00089-2
Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia., , The Journal of nutrition, 2000, 10.1093/jn/130.5.1102
NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000
PARP degradation in apoptotic Syrian hamster embryo (SHE) cells compared to HL60 cell line., , Biochimie, 2000, 10.1016/s0300-9084(00)01194-9
Sources of nitrate exposure in residents of rural areas in Quebec, Canada., , Journal of exposure analysis and environmental epidemiology, 2000, 10.1038/sj.jea.7500079
Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid., , Experimental cell research, 1999, 10.1006/excr.1998.4350
Binding capacity of various fibre to pesticide residues under simulated gastrointestinal conditions., , Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1999, 10.1016/s0278-6915(99)00110-6
Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.7.4335
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7., , The Journal of biological chemistry, 1999, 10.1074/jbc.274.40.28379
Cytochrome P450 CYP1A1 enzyme activity and DNA adducts in placenta of women environmentally exposed to organochlorines., , Environmental research, 1999, 10.1006/enrs.1998.3920
Fanconi anemia C protein acts at a switch between apoptosis and necrosis in mitomycin C-induced cell death., , Experimental cell research, 1999, 10.1006/excr.1998.4316
Immunological determination and size characterization of poly(ADP-ribose) synthesized in vitro and in vivo., , Biochimica et biophysica acta, 1999, 10.1016/s0304-4165(99)00054-9
Liver poly(ADP-ribose)polymerase is resistant to cleavage by caspases., , Biochemical and biophysical research communications, 1999, 10.1006/bbrc.1999.0313
Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment., , Molecular and cellular biochemistry, 1999
Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110-kDa protein., , Experimental cell research, 1999, 10.1006/excr.1998.4321
Poly(ADP-ribose) turnover in quail myoblast cells: relation between the polymer level and its catabolism by glycohydrolase., , Molecular and cellular biochemistry, 1999
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions., , The Biochemical journal, 1999
Poly(ADP-ribosylation) and apoptosis., , Molecular and cellular biochemistry, 1999, 10.1023/a:1006962716377
Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions., , Biochimica et biophysica acta, 1999, 10.1016/s0167-4838(98)00278-7
6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin., , Clinical cancer research : an official journal of the American Association for Cancer Research, 1998
Activation of cysteine proteases in cowpea plants during the hypersensitive response--a form of programmed cell death., , Experimental cell research, 1998, 10.1006/excr.1998.4256
Apparent cleavage of poly(ADP-ribose) polymerase in non-apoptotic mouse LTA cells: an artifact of cross-reactive secondary antibody., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006808001462
Immunodot blot method for the detection of poly(ADP-ribose) synthesized in vitro and in vivo., , Analytical biochemistry, 1998, 10.1006/abio.1998.2664
Isolation, purification and partial characterization of chloragocytes from the earthworm species Lumbricus terrestris., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006882207581
Overexpression of bcl-2 or bcl-XL fails to inhibit apoptosis mediated by a novel retinoid., , Oncology research, 1998
Proteolysis of poly(ADP-ribose) polymerase by caspase 3: kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates., , Radiation research, 1998
Rapid detection of poly(ADP-ribose) polymerase by enzyme-linked immunosorbent assay during its purification and improvement of its purification., , Molecular and cellular biochemistry, 1998, 10.1023/a:1006861015142
Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis., , European journal of biochemistry, 1998, 10.1046/j.1432-1327.1998.2510295.x
A microassay for the detection of low levels of cytochrome P450 O-deethylation activities with alkoxyresorufin substrates., , Molecular and cellular biochemistry, 1997, 10.1023/a:1006835712436
A nuclear factor other than Sp1 binds the GC-rich promoter of the gene encoding rat poly(ADP-ribose) polymerase in vitro., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
Alteration in methyl-methanesulfonate-induced poly(ADP-ribosyl)ation by 2-butoxyethanol in Syrian hamster embryo cells., , Carcinogenesis, 1997, 10.1093/carcin/18.12.2333
Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells., , Biochimica et biophysica acta, 1997, 10.1016/s0167-4838(96)00188-4
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase., , The EMBO journal, 1997, 10.1093/emboj/16.19.6018
Bcl-2 acts upstream of the PARP protease and prevents its activation., , Cell death and differentiation, 1997, 10.1038/sj.cdd.4400200
Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase., , Biochimica et biophysica acta, 1997, 10.1016/s0304-4165(96)00077-3
Characterization of antibodies specific for the caspase cleavage site on poly(ADP-ribose) polymerase: specific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997
Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway., , The Journal of experimental medicine, 1997, 10.1084/jem.185.3.481
Determination of genotoxicity of the metabolites of the pesticides Guthion, Sencor, Lorox, Reglone, Daconil and Admire by 32P-postlabeling., , Molecular and cellular biochemistry, 1997, 10.1023/a:1006861621031
Extrusion of earthworm coelomocytes: comparison of the cell populations recovered from the species Lumbricus terrestris, Eisenia fetida and Octolasion tyrtaeum., , Laboratory animals, 1997, 10.1258/002367797780596068
Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms., , The American journal of pathology, 1997
Glycol ethers induce death and necrosis in human leukemia cells., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres., , Current biology : CB, 1997, 10.1016/s0960-9822(06)00382-4
Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide., , Experimental cell research, 1997, 10.1006/excr.1996.3459
Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks., , Radiation research, 1997
Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis., , Proceedings of the National Academy of Sciences of the United States of America, 1997, 10.1073/pnas.94.10.5073
Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular sensitization to gamma irradiation., , European journal of biochemistry, 1997, 10.1111/j.1432-1033.1997.00015.x
Purification of the death substrate poly(ADP-ribose) polymerase., , Analytical biochemistry, 1997, 10.1006/abio.1997.2153
Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway., , Blood, 1997
Specific cleavage of the large subunit of replication factor C in apoptosis is mediated by CPP32-like protease., , Biochemical and biophysical research communications, 1997, 10.1006/bbrc.1997.6456
Transcriptional regulation of the rat poly(ADP-ribose) polymerase gene by Sp1., , European journal of biochemistry, 1997, 10.1111/j.1432-1033.1997.0342a.x
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis., , The Journal of biological chemistry, 1997, 10.1074/jbc.272.30.18530
Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors., , Experimental cell research, 1996, 10.1006/excr.1996.0259
Association of poly(ADP-ribose) polymerase with nuclear subfractions catalyzed with sodium tetrathionate and hydrogene peroxide crosslinks., , Molecular and cellular biochemistry, 1996, 10.1007/BF00420918
Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase., , Oncogene, 1996
Bcl-2 overexpression blocks activation of the death protease CPP32/Yama/apopain., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.0597
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis., , Proceedings of the National Academy of Sciences of the United States of America, 1996, 10.1073/pnas.93.16.8395
Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H10T1/2 cells from oxidative stress., , Biochimica et biophysica acta, 1996, 10.1016/0167-4889(96)00004-3
CrmA/SPI-2 inhibition of an endogenous ICE-related protease responsible for lamin A cleavage and apoptotic nuclear fragmentation., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.51.32487
Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3., , Current biology : CB, 1996, 10.1016/s0960-9822(02)00614-0
Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1889
Ethoxyresorufin O-deethylase (EROD) activity in placental tissue from Inuit women exposed to organochlorines through the arctic food chain, , Organohalogen Compounds, 1996
Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1565
High Performance Electrophoresis Chromatography, , The protein protocols handbook, 1996
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.28.16720
Identification of a 116 kDa protein able to bind 1,3-bis(2-chloroethyl)-1-nitrosourea-damaged DNA as poly(ADP-ribose) polymerase., , Mutation research, 1996, 10.1016/0921-8777(95)00030-5
Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases., , The Journal of biological chemistry, 1996, 10.1074/jbc.271.9.4573
prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2., , The Biochemical journal, 1996, 10.1042/bj3160025
Proteasomes play an essential role in thymocyte apoptosis., , The EMBO journal, 1996
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B., , Proceedings of the National Academy of Sciences of the United States of America, 1996, 10.1073/pnas.93.5.1972
Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells., , Journal of virology, 1996, 10.1128/JVI.70.4.2215-2220.1996
32P-postlabeling determination of DNA adducts in the earthworm Lumbricus terrestris exposed to PAH-contaminated soils., , Bulletin of environmental contamination and toxicology, 1995, 10.1007/BF00206095
Biochemical properties and function of poly(ADP-ribose) glycohydrolase., , Biochimie, 1995, 10.1016/0300-9084(96)88156-9
Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells., , Journal of cell science. Supplement, 1995, 10.1242/jcs.1995.supplement_19.6
Comparative study of DNA adducts levels in white sucker fish (Catostomus commersoni) from the basin of the St. Lawrence River (Canada)., , Molecular and cellular biochemistry, 1995, 10.1007/BF00928150
Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique., , Analytical biochemistry, 1995, 10.1006/abio.1995.0016
DNA base excision repair of 5-hydroxymethyl-2'-deoxyuridine stimulates poly(ADP-ribose) synthesis in Chinese hamster cells., , Carcinogenesis, 1995, 10.1093/carcin/16.5.1173
Equilibrium model in an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1995, 10.1016/0167-4781(95)00143-5
Isolation of genomic DNA from the earthworm species Eisenia fetida., , Molecular and cellular biochemistry, 1995, 10.1007/BF00928909
Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo., , Analytical biochemistry, 1995, 10.1006/abio.1995.1245
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks., , Trends in biochemical sciences, 1995, 10.1016/s0968-0004(00)89089-1
Rapid removal of nonspecific background in silver-stained polyacrylamide gel., , Analytical biochemistry, 1995, 10.1006/abio.1995.9947
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution., , Proceedings of the National Academy of Sciences of the United States of America, 1995, 10.1073/pnas.92.20.9042
The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis., , The Journal of biological chemistry, 1995, 10.1074/jbc.270.28.16526
The effect of niacin deficiency on diethylnitrosamine-induced hepatic poly(ADP-ribose) levels and altered hepatic foci in the Fischer-344 rat., , Nutrition and cancer, 1995, 10.1080/01635589509514399
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase., , Cell, 1995, 10.1016/0092-8674(95)90541-3
Autoantibodies reacting with poly(ADP-ribose) and with a zinc-finger functional domain of poly(ADP-ribose) polymerase involved in the recognition of damaged DNA., , Clinical immunology and immunopathology, 1994, 10.1006/clin.1994.1187
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE., , Nature, 1994, 10.1038/371346a0
Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage., , Biochemistry, 1994, 10.1021/bi00189a012
Erasable blot of poly(ADP-ribose) polymerase., , Analytical biochemistry, 1994, 10.1006/abio.1994.1212
Mode of action of poly(ADP-ribose) glycohydrolase., , Biochimica et biophysica acta, 1994, 10.1016/0167-4781(94)90058-2
One-step protein purification using micropreparative electrophoresis fully compatible with protein microsequencing., , Analytical biochemistry, 1994, 10.1006/abio.1994.1437
Poly(ADP-ribose) catabolism in mammalian cells., , Molecular and cellular biochemistry, 1994, 10.1007/BF00928442
Purification of poly(ADP-ribose) glycohydrolase and detection of its isoforms by a zymogram following one- or two-dimensional electrophoresis., , Analytical biochemistry, 1994, 10.1006/abio.1994.1177
The role of poly(ADP-ribose) metabolism in response to active oxygen cytotoxicity., , Biochimica et biophysica acta, 1994, 10.1016/0167-4889(94)90243-7
Diethylnitrosamine administration in vivo increases hepatic poly(ADP-ribose) levels in rats: results of a modified technique for poly(ADP-ribose) measurement., , Carcinogenesis, 1993, 10.1093/carcin/14.12.2513
Enzymatic mechanisms for joining DNA strand interruptions in human cells, , DNA repair mechanisms: proceedings of the Alfred Benzon Symposium 35, held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen, August 9-13, 1992, 1993
Expression in Escherichia coli of the 36 kDa domain of poly(ADP-ribose) polymerase and investigation of its DNA binding properties., , Biochimica et biophysica acta, 1993, 10.1016/0167-4838(93)90277-x
Molecular and biochemical features of poly (ADP-ribose) metabolism., , Molecular and cellular biochemistry, 1993, 10.1007/BF01076101
NAD(+)-dependent repair of damaged DNA by human cell extracts., , The Journal of biological chemistry, 1993
Poly(ADP-ribose) polymerase can bind melphalan damaged DNA., , Cancer research, 1993
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis., , Cancer research, 1993
The US-1 element from the gene encoding rat poly(ADP-ribose) polymerase binds the transcription factor Sp1., , European journal of biochemistry, 1993, 10.1111/j.1432-1033.1993.tb18008.x
ADP-ribosylation Reactions, , 1992
Automodification and NADase activity of poly(ADP-ribose) polymerase, , ADP-ribosylation Reactions, 1992
DNA base excision repair stimulates poly(ADP-ribose synthesis, , ADP-ribosylation Reactions, 1992
Enzymatic properties of Poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase on chromatin, , ADP-ribosylation Reactions, 1992
Expression of poly(ADP-ribose) polymerase in differentiating HL-60 cells, , ADP-ribosylation Reactions, 1992
Molecular Cloning of the rat poly(ADP-ribose)polymerase gene and preliminary characterization of its promoter and 5'-flanking region, , ADP-ribosylation Reactions, 1992
Poly(ADP-ribosyl)ation of chromatin in an in-vitro poly(ADP-ribose)-turnover system., , Biochimica et biophysica acta, 1992, 10.1016/0167-4889(92)90199-l
Proteolytic cleavage of poly(ADP-ribose) polymerase in human leukemia cells treated with etoposide and other cytotoxic agents, , ADP-ribosylation Reactions, 1992
Proteolytic degradation of poly(ADP-ribose) polymerase by contaminating proteases in commercial preparations of DNAse I, , ADP-ribosylation Reactions, 1992
Rearrangements of the nucleosome structure in chromatin by poly(ADP-ribose)., , Biochimica et biophysica acta, 1992, 10.1016/0167-4838(92)90163-8
Resistance of ADP-ribosylated histones and HMG proteins to proteases., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1992, 10.1139/o92-172
Structural analysis of the putative regulatory region of the rat gene encoding poly(ADP-ribose) polymerase., , FEBS letters, 1992, 10.1016/0014-5793(92)80457-r
Analysis of the activation of poly(ADP-ribose) polymerase by various types of DNA., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1991, 10.1139/o91-086
Association of poly(ADP-ribose) polymerase with the nuclear matrix: the role of intermolecular disulfide bond formation, RNA retention, and cell type., , Experimental cell research, 1991, 10.1016/0014-4827(91)90072-3
Enzymological properties of poly(ADP-ribose)polymerase: characterization of automodification sites and NADase activity., , Biochimica et biophysica acta, 1991, 10.1016/0167-4838(91)99007-f
An affinity matrix for the purification of poly(ADP-ribose) glycohydrolase., , Nucleic acids research, 1990, 10.1093/nar/18.16.4691
Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase., , FEBS letters, 1990, 10.1016/0014-5793(90)80770-j
Poly(ADP-ribosyl)ation reactions and modulation of chromatin structure, , DNA repair mechanisms and their biological implications in mammalian cells, 1990
Reconstitution of an in vitro poly(ADP-ribose) turnover system., , Biochimica et biophysica acta, 1990, 10.1016/0167-4781(90)90083-e
Stimulation of poly(ADP-ribose) synthesis by free radicals in C3H10T1/2 cells: relationship with NAD metabolism and DNA breakage., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1990, 10.1139/o90-085
Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1989, 10.1139/o89-097
DNA replication and poly(ADP-ribosyl)ation of chromatin., , Cytobios, 1989
Hyperthermia and poly(ADP-ribose) metabolism, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
Localization of the zinc-binding sites in the DNA-binding domain of the bovine poly(ADP-ribose) polymerase, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
Modulation of chromatin structure by poly(ADP-ribosyl)ation, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
Monoclonal antibodies against poly(ADP- ribose) polymerase. Epitope mapping, inhibition of activity and interspecies immunoreactivity, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
Reconstitution of an in vitro poly(ADP)-ribose turnover system, , ADP-ribose transfer reactions: mechanisms and biological significance, 1989
The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin. A role of poly(ADP-ribosyl)ation on core nucleosome structure., , The Journal of biological chemistry, 1989
Cell cycle regulation of poly(ADP-ribose) synthetase in FR3T3 cells., , Biochimica et biophysica acta, 1988, 10.1016/0167-4889(88)90018-3
Effect of hyperthermia on poly(adenosine diphosphate-ribose) glycohydrolase., , Cancer research, 1988
Immunoelectron microscopical distribution of poly(ADP-ribose)polymerase in the mammalian cell nucleus., , Experimental cell research, 1988, 10.1016/0014-4827(88)90289-3
Les réactions de poly(ADP-ribosyl)ation, , Regards sur la biochimie, 1988
Modulation of chromatin structure by poly(ADP-ribosyl)ation., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1988, 10.1139/o88-072
Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study., , Biochimica et biophysica acta, 1988, 10.1016/0167-4781(88)90007-3
Rapid assay of poly(ADP-ribose) glycohydrolase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1987, 10.1139/o87-088
Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation., , The Journal of biological chemistry, 1986
Poly(ADP-ribose) accessibility to poly(ADP-ribose) glycohydrolase activity on poly(ADP-ribosyl)ated nucleosomal proteins., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1986, 10.1139/o86-023
Possible role of ADP-ribosylation of adenovirus core proteins in virus infection., , Virus research, 1986, 10.1016/0168-1702(86)90078-x
Production and characterization of monoclonal antibodies specific for the functional domains of poly(ADP-ribose) polymerase., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1986, 10.1139/o86-051
Visualization of poly(ADP-ribose) synthetase associated with polynucleosomes by immunoelectron microscopy., , Biochimica et biophysica acta, 1986, 10.1016/0167-4889(86)90239-9
Modulation of rat pancreatic muscarinic cholinergic receptors by caerulein., , Biochemical pharmacology, 1985, 10.1016/0006-2952(85)90609-4
Muscarinic cholinergic receptors in pancreatic acinar carcinoma of rat., , International journal of cancer, 1985, 10.1002/ijc.2910350412
Non-histone chromosomal protein acceptors for poly(ADP)-ribose in phorbol-12-myristate-13-acetate treated mouse embryo fibroblasts (C3H10T1/2)., , Carcinogenesis, 1985, 10.1093/carcin/6.10.1489
Poly ADP-ribosylation and DNA strand breakage in SV40 minichromosomes., , Carcinogenesis, 1985, 10.1093/carcin/6.2.283
Poly(ADP-ribosyl)ation of chromatin: kinetics of relaxation and its effect on chromatin solubility., , Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 1985, 10.1139/o85-096
Sequential ADP-ribosylation pattern of nucleosomal histones. ADP-ribosylation of nucleosomal histones., , European journal of biochemistry, 1985, 10.1111/j.1432-1033.1985.tb08650.x
Tumor promoter phorbol-12-myristate-13-acetate induces poly ADP-ribosylation in human monocytes., , Biochemical and biophysical research communications, 1985, 10.1016/0006-291x(85)90314-6
Tumor promoter phorbol-12-myristate-13-acetate induces poly(ADP)-ribosylation in fibroblasts., , The EMBO journal, 1985
Changes in acetylcholinesterase and cholinesterase activities in rat pancreas during postnatal development. Lack of relation with muscarinic receptor maturation., , Pharmacology, 1984, 10.1159/000137990
Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation., , The EMBO journal, 1983
Modulation of rat pancreatic amylase secretion and muscarinic receptor populations by chronic bethanechol treatment., , European journal of pharmacology, 1983, 10.1016/0014-2999(83)90637-4
Nucleosomal poly(ADP-ribose) polymerase: properties and relaxation of the chromatin structure., , Princess Takamatsu symposia., 1983
Adenosine diphosphate ribosylation of chicken-erythrocyte histones H1, H5 and high-mobility-group proteins by purified calf-thymus poly(adenosinediphosphate-ribose) polymerase., , European journal of biochemistry, 1982, 10.1111/j.1432-1033.1982.tb06891.x
Chromosomal protein poly(ADP-ribosyl)ation in pancreatic nucleosomes., , Canadian journal of biochemistry, 1982, 10.1139/o82-036
Hyper(ADP-ribosyl)ation of histone H1., , Canadian journal of biochemistry, 1982, 10.1139/o82-139
Modulation of pancreatic muscarinic receptors by weaning., , Life sciences, 1982, 10.1016/0024-3205(82)90506-9
Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure., , Proceedings of the National Academy of Sciences of the United States of America, 1982, 10.1073/pnas.79.11.3423
Distribution of muscarinic receptors in the digestive tract organs., , Pharmacology, 1981, 10.1159/000137489
Maturation of muscarinic agonist receptors in rat developing pancreas and its relation to maximal enzyme secretion., , Life sciences, 1981, 10.1016/0024-3205(81)90537-3
Muscarinic receptor of rat pancreatic acini: [3H]QNB binding and amylase., , European journal of pharmacology, 1981, 10.1016/0014-2999(81)90508-2
Parallel maturation of the pancreatic secretory response to cholinergic stimulation and the muscarinic receptor population., , British journal of pharmacology, 1981, 10.1111/j.1476-5381.1981.tb10428.x
Poly(adenosine diphosphoribose) polymerase activity and adenosine diphosphate ribosylation of proteins during pancreatic degeneration and regeneration., , Cancer research, 1981
Poly(ADP-ribose) polymerase activity in mouse cells which exhibit temperature-sensitive DNA synthesis., , Biochimica et biophysica acta, 1981, 10.1016/0005-2787(81)90162-3
Separation of poly(ADP-ribosylated) nuclear proteins by polyacrylamide gel electrophoresis at acidic pH and low temperature., , Analytical biochemistry, 1981, 10.1016/0003-2697(81)90489-9
Adenosine diphosphate ribosylation of proteins in rat pancreas [proceedings]., , Biochemical Society transactions, 1980, 10.1042/bst0080192
ADP-ribosylation of pancreatic histone H1 and of other histones., , Canadian journal of biochemistry, 1980, 10.1139/o80-069
ADP-ribosylation of rye histones., , Canadian journal of biochemistry, 1980, 10.1139/o80-097
Characterization and purification of a calcium-sensitive ATP diphosphohydrolase from pig pancreas., , The Journal of biological chemistry, 1980
Muscarinic receptors of the pancreas: a correlation between displacement of (3 H)-quinuclidinyl benzilate binding and amylase secretion., , Pharmacology, 1979, 10.1159/000137262
A convenient method for the ATPase assay., , Analytical biochemistry, 1978, 10.1016/0003-2697(78)90277-4
Delayed weaning and denial of solid food nibbling upon pancreatic acinar cell responsiveness to urecholine in neonatal rats., , Digestion, 1978, 10.1159/000198188
Effect of early weaning of the neonatal rat on pancreatic acinar cell responsiveness to urecholine., , Digestion, 1978, 10.1159/000198126
Properties of poly(ADP-ribose) synthetase from rat pancreas and poly(ADP-ribosylation) of basic nuclear proteins., , Canadian journal of biochemistry, 1978, 10.1139/o78-119
Adenosine diphosphoribosylation of certain basic chromosomal proteins in isolated trout testis nuclei., , European journal of biochemistry, 1977, 10.1111/j.1432-1033.1977.tb11635.x
Comparative inhibitory effects of 3-quinuclidinyl benzilate (QNB) and atropine on amylase release from rat pancreas., , British journal of pharmacology, 1977, 10.1111/j.1476-5381.1977.tb09745.x
Purification of plasma membranes from rat pancreas: a rapid method., , Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1977, 10.3181/00379727-155-39799
Polypeptide receptor mechanisms in anterior pituitary gland, , Anatomical neuroendocrinology: based on the International Conference on Neurobiology of CNS-Hormone Interactions, Chapel Hill, N. C., May 14-16, 1974, 1975
Hypophysiotropic hormones, cyclic AMP and adenohypophyseal protein synthesis and release, , Hormones and brain function. [Proceedings of the second congress of the International Society of Psychoneuroendocrinology held in Budapest (Hungary) from July 1 to 3, 1971] Edited by K. Lissâak, 1973
Stimulation of adenohypophyseal adenylate cyclase activity by synthetic luteinizing hormone-releasing hormone (LHRH) and purified growth hormone (GH-RH), , Hypothalamic hypophysiotropic hormones; physiological and clinical studies. Proceedings of the conference held at Acapulco, Gro., Mexico, June 29-July 1, 1972, 1973
Stimulation of adenosine 3',5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by purified growth hormone-releasing hormone., , Transactions of the Association of American Physicians, 1973
Adenohypophyseal secretory granules. I. Their phosphorylation and association with protein kinase., , The Journal of biological chemistry, 1971
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009
Olivia Gavard - Doctorat - En cours
Louis Marie Paul Michel Nonfoux - Doctorat - En cours
Charu Kothari - Post-doctorat - En cours
Maria Tedim Ferreira - Doctorat - 2018/09
Julia O'Sullivan - Doctorat - 2021/09
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec (Québec) G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail