Guy Boivin

Médecin clinicien enseignant titulaire

guy.boivin@fmed.ulaval.ca

Site personnel

Département de pédiatrie

Centre de recherche en infectiologie

Centre de recherche du CHU de Québec - Université Laval

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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Maladies infectieuses et immunitaires

Virus
Infections virales
Antiviraux
Développement de vaccins
Anticorps
Santé internationale et pathologies émergentes
Immunothérapie

Projets de recherche

Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
Évaluation des interactions entre des virus respiratoires - CHU de Québec – Université Laval – CHUL - Développement de la recherche (FC), chercheur principal - 2022-02-01 au 2025-01-31
A research program on the pathogenesis, treatment and prevention of respiratory and herpes viruses - Instituts de recherche en santé du Canada - Subventions Fondation, chercheur principal - 2016-07-01 au 2023-06-30
COVIGRO : Impact de la COVID-19 et du vaccin contre SARS-CoV-2 sur le développement placentaire et foetal - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, co-chercheur - 2021-12-01 au 2022-11-30
How to better manage infectious diseases in ER by triage with molecular mini-panels for the rapid detection of highly transmissible pathogens - Consortium québécois sur la découverte du médicament, co-chercheur - 2018-10-01 au 2022-09-30
Hospital-based surveillance of influenza and routine monitoring of seasonal influenza vaccine effectiveness (VE) - Services publics et Approvisionnement Canada, Dalhousie University, co-chercheur - 2020-11-01 au 2022-09-30
Évaluation du potentiel thérapeutique de la protectine DX et d'analogues contre la COVID-19 - Ministère de l'Économie et de l'Innovation, OmegaChem Inc. - Programme de soutien aux organismes de recherche et d’innovation (PSO) - Recherche-innovation - Volet 2a, co-chercheur - 2020-06-01 au 2022-03-31
Projet du Groupe québécois de recherche sur l'infection périnatale à COVID-19 (Banque de données des grossesses COVID-19) - Fonds de recherche du Québec - Santé, Ministère de la Santé et des Services sociaux - Initiatives dans le cadre de la pandémie COVID-19, Université de Montréal, co-chercheur - 2020-04-01 au 2022-03-31
Manufacturing of antigens and adjuvants for development of vaccines (MAAV) - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux, Fondation du CHU de Québec - Fonds d'innovation (FI), co-chercheur - 2020-11-01 au 2022-03-31
Évaluation de l'efficacité des probiotiques sur les affections post-COVID-19. - Instituts de recherche en santé du Canada - Subvention de fonctionnement:Nouveaux besoins prioritaires en recherche sur la COVID-19, Université de Sherbrooke, co-chercheur - 2021-06-01 au 2022-03-31
Plateforme de laboratoire de niveau de confinement 3 respiratoire - Ministère de l'Économie et de l'Innovation - Programme de soutien aux organismes de recherche et d’innovation (PSO) - Recherche-innovation - Volet 2a, chercheur principal - 2020-03-25 au 2022-03-27
Innovative therapeutic approaches for the 2019-novel coronavirus - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), chercheur principal - 2021-03-01 au 2022-02-28
Canadian Immunization Research Network - Instituts de recherche en santé du Canada - Réseau canadien de recherche sur l’immunisation, Dalhousie University, co-chercheur - 2014-06-01 au 2021-12-31
Seeking for innovative approaches in prevention and cure to COVID-19 disease - Affinité instruments, Fondation Canadienne pour l'innovation (La), Ministère de l'Économie et de l'Innovation - Fonds des occasions exceptionnelles (FOE) – COVID-19, co-chercheur - 2020-11-01 au 2021-08-30
Sentinel surveillance, viral shedding, clinical characteristics and outcomes of confirmed and suspected hospitalized cases of COVID-19/SARS-CoV-2 infection in the Canadian Immunization Research Network (CIRN) - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19, Dalhousie University, co-chercheur - 2020-04-01 au 2021-06-30
COVID-19 household study to assess secondary attack rates and the proportion asymptomatic, including children - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19, Université de Montréal, co-chercheur - 2020-06-01 au 2021-05-31
Sex as a Biological Variable Supplement - Innovative therapeutic approaches for the 2019-novel coronavirus - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Financement supplémentaire pour l’intégration du sexe comme variable biologique dans l’intervention de recherche rapide contre la COVID-19, chercheur principal - 2020-05-01 au 2021-03-31
REinfection in COVid-19 Estimation of Risk (RECOVER) - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19, Université de Montréal, co-chercheur - 2020-06-01 au 2020-09-30
Chaire de recherche du Canada sur les virus en émergence et la résistance aux antiviraux - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2013-07-01 au 2020-06-30

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Publications

Predictive risk factors for hospitalization and response to colchicine in patients with COVID-19, Jean-Claude Tardif, Mariève Cossette, Marie-Claude Guertin, Nadia Bouabdallaoui, Marie-Pierre Dubé, Guy Boivin, International Journal of Infectious Diseases, 2022, 10.1016/j.ijid.2022.01.020
Influenza A(H1N1)pdm09 Virus but Not Respiratory Syncytial Virus Interferes with SARS-CoV-2 Replication during Sequential Infections in Human Nasal Epithelial Cells, Clément Fage, Mathilde Hénaut, Julie Carbonneau, Jocelyne Piret, Guy Boivin, Viruses, 2022, 10.3390/v14020395
In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance, Liva Checkmahomed, Venice Du Pont, Nicholas C. Riola, Jason K. Perry, Jiani Li, Danielle P. Porter, Guy Boivin, 2022, 10.1101/2022.02.07.479493
The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers, Étienne Racine, Guy Boivin, Yves Longtin, Deirde McCormack, Hélène Decaluwe, Patrice Savard, Matthew P. Cheng, Marie-Ève Hamelin, Fazia Tadount, Kelsey Adams, Benoîte Bourdin, Sabryna Nantel, Vladimir Gilca, Jacques Corbeil, Gaston De Serres, Caroline Quach, 2022, 10.1101/2022.02.10.22269967
Duration of isolation and contagiousness in COVID-19 patients receiving tocilizumab and dexamethasone: a case series, Florence Côté, Guy Boivin, Vilayvong Loungnarath, Annie Ruest, Julie Bestman-Smith, Julie Carbonneau, Marie-Ève Hamelin, Marie-Claude Roy, Infection Control & Hospital Epidemiology, 2022, 10.1017/ice.2022.14
Viral Interference between Respiratory Viruses., Piret J, Boivin G, Emerging infectious diseases, 2022, 10.3201/eid2802.211727
Microglia are involved in phagocytosis and extracellular digestion during Zika virus encephalitis in young adult immunodeficient mice, William Enlow, Maude Bordeleau, Jocelyne Piret, Fernando González Ibáñez, Olus Uyar, Marie-Christine Venable, Nathalie Goyette, Julie Carbonneau, Marie-Eve Tremblay, Guy Boivin, Journal of Neuroinflammation, 2021, 10.1186/s12974-021-02221-z
Antiviral Drugs Against Herpesviruses, Jocelyne Piret, Guy Boivin, Antiviral Drug Discovery and Development, 2021, 10.1007/978-981-16-0267-2_1
Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial., Tardif JC, Bouabdallaoui N, L'Allier PL, Gaudet D, Shah B, Pillinger MH, Lopez-Sendon J, da Luz P, Verret L, Audet S, Dupuis J, Denault A, COLCORONA Investigators, The Lancet. Respiratory medicine, 2021, 10.1016/s2213-2600(21)00222-8
Older Age and Frailty Are Associated With Higher Mortality but Lower Intensive Care Unit Admission Among Adults Admitted to Canadian Hospitals With COVID-19: A Report From the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance Network, Andrew M, Godin J, LeBlanc J, Boivin G, Valiquette L, McElhaney JE, Hatchette TF, ElSherif M, MacKinnon-Cameron D, Ambrose A, Trottier S, Loeb M, McNeil S, 2021, 10.2139/ssrn.3844895
Impact of Amino Acid Substitutions in Region II and Helix K of HSV-1 and HCMV DNA Polymerases on Resistance to Foscarnet., Zarrouk K, Zhu X, Pham VD, Goyette N, Piret J, Shi R, Boivin G, Antimicrobial agents and chemotherapy, 2021, 10.1128/aac.00390-21
Seroprevalence of anti-SARS-CoV-2 antibodies among school and daycare children and personnel: Protocol for a cohort study in Montreal, Canada, Zinszer K, McKinnon B, Bourque N, Zahreddine M, Charland K, Papenburg J, Fortin G, Hamelin M, Saucier A, Apostolatos A, Pierce L, Savard-Lamothe A, Quach C, 2021, 10.1101/2021.04.14.21255499
Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases, Zarrouk, K., Zhu, X., Goyette, N., Piret, J., Shi, R., Boivin, G., Antiviral Research, 2021, 10.1016/j.antiviral.2021.105046
DNA polymerases of herpesviruses and their inhibitors, Jocelyne Piret, Guy Boivin, Viral Replication Enzymes and their Inhibitors Part B, 2021, 10.1016/bs.enz.2021.07.003
Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19, Tardif J, Bouabdallaoui N, L’Allier PL, Gaudet D, Shah B, Pillinger MH, Lopez-Sendon J, da Luz P, Verret L, Audet S, Dupuis J, Denault A, for the COLCORONA Investigators, 2021, 10.1101/2021.01.26.21250494
Fitness of influenza A and B viruses with reduced susceptibility to baloxavir: A mini-review, Abed, Y., Saim-Mamoun, A., Boivin, G., Reviews in Medical Virology, 2021, 10.1002/rmv.2175
Genetics of symptom remission in outpatients with COVID-19, Dubé, M.-P., Lemaçon, A., Barhdadi, A., Lemieux Perreault, L.-P., Oussaïd, E., Asselin, G., Provost, S., Sun, M., Sandoval, J., Legault, M.-A., Mongrain, I., Dubois, A., Valois, D., Dedelis, E., Lousky, J., Choi, J., Goulet, E., Savard, C., Chicoine, L.-M., Cossette, M., Chabot-Blanchet, M., Guertin, M.-C., de Denus, S., Bouabdallaoui, N., Marchand, R., Bassevitch, Z., Nozza, A., Gaudet, D., L’Allier, P.L., Hussin, J., Boivin, G., Busseuil, D., Tardif, J.-C., Scientific Reports, 2021, 10.1038/s41598-021-90365-6
Human Respiratory Syncytial Virus-Induced Immune Signature of Infection Revealed by Transcriptome Analysis of Clinical Pediatric Nasopharyngeal Swab Samples, Nicolas De Lamballerie, C., Pizzorno, A., Dubois, J., Padey, B., Julien, T., Traversier, A., Carbonneau, J., Orcel, E., Lina, B., Hamelin, M.-E., Roche, M., Textoris, J., Boivin, G., Legras-Lachuer, C., Terrier, O., Rosa-Calatrava, M., Journal of Infectious Diseases, 2021, 10.1093/infdis/jiaa468
Pandemics Throughout History, Piret, J., Boivin, G., Frontiers in Microbiology, 2021, 10.3389/fmicb.2020.631736
RSV and HMPV Infections in 3D Tissue Cultures: Mechanisms Involved in Virus-Host and Virus-Virus Interactions, Geiser, J., Boivin, G., Huang, S., Constant, S., Kaiser, L., Tapparel, C., Essaidi-Laziosi, M., Viruses, 2021, 10.3390/v13010139
Zika virus and impact on male fertility, Jocelyne Piret, Guy Boivin, Zika Virus Biology, Transmission, and Pathology, 2021, 10.1016/b978-0-12-820268-5.00026-2
Age-stratified burden of pneumococcal community acquired pneumonia in hospitalised Canadian adults from 2010 to 2015, Leblanc, J., Elsherif, M., Ye, L., Mackinnon-Cameron, D., Ambrose, A., Hatchette, T.F., Lang, A.L.S., Gillis, H.D., Martin, I., Demczuk, W.H., Laferriere, C., Andrew, M.K., Boivin, G., Bowie, W., Green, K., Johnstone, J., Loeb, M., McCarthy, A., McGeer, A., Semret, M., Trottier, S., Valiquette, L., Webster, D., McNeil, S.A., BMJ Open Respiratory Research, 2020, 10.1136/bmjresp-2019-000550
An Early Microglial Response Is Needed to Efficiently Control Herpes Simplex Virus Encephalitis, Uyar, O., Laflamme, N., Piret, J., Venable, M.-C., Carbonneau, J., Zarrouk, K., Rivest, S., Boivin, G., Journal of Virology, 2020, 10.1128/JVI.01428-20
Characterization of contemporary influenza B recombinant viruses harboring mutations of reduced susceptibility to baloxavir marboxil, in vitro and in mice, Abed, Y., Fage, C., Checkmahomed, L., Venable, M.-C., Boivin, G., Antiviral Research, 2020, 10.1016/j.antiviral.2020.104807
Cytomegalovirus seropositivity is associated with increased microbial translocation in people living with human immunodeficiency virus and uninfected controls, Ramendra, R., Isnard, S., Lin, J., Fombuena, B., Ouyang, J., Mehraj, V., Zhang, Y., Finkelman, M., Costiniuk, C., Lebouché, B., Chartrand-Lefebvre, C., Durand, M., Tremblay, C., Ancuta, P., Boivin, G., Routy, J.-P., Clinical Infectious Diseases, 2020, 10.1093/cid/ciz1001
Droplet Digital PCR and Immunohistochemistry Techniques to Detect Zika Virus in the Central Nervous System of Mice, Enlow, W., Piret, J., Boivin, G., Methods in Molecular Biology, 2020, 10.1007/978-1-0716-0581-3_4
Effects of different drug combinations in immunodeficient mice infected with an influenza a/h3n2 virus, Mhamdi, Z., Fausther-Bovendo, H., Uyar, O., Carbonneau, J., Venable, M.-C., Abed, Y., Kobinger, G., Boivin, G., Baz, M., Microorganisms, 2020, 10.3390/microorganisms8121968
Engineering of live chimeric vaccines against human metapneumovirus, Makowska, D.O., Hamelin, M.-È., Boivin, G., Pathogens, 2020, 10.3390/pathogens9020135
Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice, Pilaev, M., Shen, Y., Carbonneau, J., Venable, M.-C., Rhéaume, C., Lavigne, S., Couture, C., Guarné, A., Hamelin, M.-È., Boivin, G., Vaccine, 2020, 10.1016/j.vaccine.2020.01.047
Frailty hinders recovery from influenza and acute respiratory illness in older adults, Lees, C., Godin, J., McElhaney, J.E., McNeil, S.A., Loeb, M., Hatchette, T.F., LeBlanc, J., Bowie, W., Boivin, G., McGeer, A., Poirier, A., Powis, J., Semret, M., Webster, D., Andrew, M.K., Journal of Infectious Diseases, 2020, 10.1093/infdis/jiaa092
Hypersusceptibility of human cytomegalovirus to foscarnet induced by mutations in helices K and P of the viral DNA polymerase, Zarrouk, K., Pham, V.D., Piret, J., Shi, R., Boivin, G., Antimicrobial Agents and Chemotherapy, 2020, 10.1128/AAC.01910-19
Immunomodulatory strategies in herpes simplex virus encephalitis, Piret, J., Boivin, G., Clinical Microbiology Reviews, 2020, 10.1128/CMR.00105-19
Impact of the Baloxavir-Resistant Polymerase Acid I38T Substitution on the Fitness of Contemporary Influenza A(H1N1)pdm09 and A(H3N2) Strains, Checkmahomed, L., M'hamdi, Z., Carbonneau, J., Venable, M.-C., Baz, M., Abed, Y., Boivin, G., The Journal of infectious diseases, 2020, 10.1093/infdis/jiz418
In vitro combinations of baloxavir acid and other inhibitors against seasonal influenza a viruses, Checkmahomed, L., Padey, B., Pizzorno, A., Terrier, O., Rosa-Calatrava, M., Abed, Y., Baz, M., Boivin, G., Viruses, 2020, 10.3390/v12101139
Infectivity of healthcare workers diagnosed with SARS-CoV-2 infection approximately 2 weeks after onset of symptoms: A cross-sectional study, Longtin, Y., Charest, H., Quach, C., Savard, P., Baz, M., Boivin, G., Farfard, J., Villeneuve, J., Roger, M., de Serres, G., Infection Control and Hospital Epidemiology, 2020, 10.1017/ice.2020.1420
Modified cyclodextrins as broad-spectrum antivirals, Jones, S.T., Cagno, V., Janeček, M., Ortiz, D., Gasilova, N., Piret, J., Gasbarri, M., Constant, D.A., Han, Y., Vuković, L., Král, P., Kaiser, L., Huang, S., Constant, S., Kirkegaard, K., Boivin, G., Stellacci, F., Tapparel, C., Science Advances, 2020, 10.1126/sciadv.aax9318
Molecular pathway of influenza pan-neuraminidase inhibitor resistance in an immunocompromised patient, Abed, Y., Schibler, M., Checkmahomed, L., Carbonneau, J., Venable, M.-C., Fage, C., Giannotti, F., Goncalves, A.R., Kaiser, L., Boivin, G., Antiviral Therapy, 2020, 10.3851/imp3344
Novel calixarene-based surfactant enables low dose split inactivated vaccine protection against influenza infection, Mandon, E.D., Pizzorno, A., Traversier, A., Champagne, A., Hamelin, M.E., Lina, B., Boivin, G., Dejean, E., Rosa-Calatrava, M., Jawhari, A., Vaccine, 2020, 10.1016/j.vaccine.2019.10.018
Validation of the Seegene RV15 multiplex PCR for the detection of influenza A subtypes and influenza B lineages during national influenza surveillance in hospitalized adults, LeBlanc, J.J., ElSherif, M., Mulpuru, S., Warhuus, M., Ambrose, A., Andrew, M., Boivin, G., Bowie, W., Chit, A., Dos Santos, G., Green, K., Halperin, S.A., Hatchette, T.F., Ibarguchi, B., Johnstone, J., Katz, K., Langley, J.M., Lagacé-Wiens, P., Loeb, M., Lund, A., MacKinnon-Cameron, D., McCarthy, A., McElhaney, J.E., McGeer, A., Poirier, A., Powis, J., Richardson, D., Semret, M., Shinde, V., Smyth, D., Trottier, S., Valiquette, L., Webster, D., Ye, L., McNeil, S.A., Journal of Medical Microbiology, 2020, 10.1099/jmm.0.001032
Antiviral agents in development for zika virus infections, Baz, M., Boivin, G., Pharmaceuticals, 2019, 10.3390/ph12030101
Characterization of cellular transcriptomic signatures induced by different respiratory viruses in human reconstituted airway epithelia, Nicolas de Lamballerie, C., Pizzorno, A., Dubois, J., Julien, T., Padey, B., Bouveret, M., Traversier, A., Legras-Lachuer, C., Lina, B., Boivin, G., Terrier, O., Rosa-Calatrava, M., Scientific Reports, 2019, 10.1038/s41598-019-48013-7
Clinical development of letermovir and maribavir: Overview of human cytomegalovirus drug resistance, Piret, J., Boivin, G., Antiviral Research, 2019, 10.1016/j.antiviral.2019.01.011
Compartmentalization of a Multidrug-Resistant Cytomegalovirus UL54 Mutant in a Stem Cell Transplant Recipient with Encephalitis, Piret, J., Schibler, M., Pham, V.D., Hantz, S., Giannotti, F., Masouridi-Levrat, S., Kaiser, L., Goyette, N., Alain, S., Shi, R., Boivin, G., Journal of Infectious Diseases, 2019, 10.1093/infdis/jiz298
Design and validation with influenza a virus of an aerosol transmission chamber for ferrets, Turgeon, N., Hamelin, M.-È., Verreault, D., Lévesque, A., Rhéaume, C., Carbonneau, J., Checkmahomed, L., Girard, M., Boivin, G., Duchaine, C., International Journal of Environmental Research and Public Health, 2019, 10.3390/ijerph16040609
Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD, Mulpuru, S., Li, L., Ye, L., Hatchette, T., Andrew, M.K., Ambrose, A., Boivin, G., Bowie, W., Chit, A., Dos Santos, G., ElSherif, M., Green, K., Haguinet, F., Halperin, S.A., Ibarguchi, B., Johnstone, J., Katz, K., Langley, J.M., LeBlanc, J., Loeb, M., MacKinnon-Cameron, D., McCarthy, A., McElhaney, J.E., McGeer, A., Powis, J., Richardson, D., Semret, M., Shinde, V., Smyth, D., Trottier, S., Valiquette, L., Webster, D., McNeil, S.A., Lagace-Wiens, P., Light, B., Poirier, A., Smith, S., Taylor, G., Chest, 2019, 10.1016/j.chest.2018.10.044
Herpes simplex encephalitis in adult patients with MASP-2 deficiency, Bibert, S., Piret, J., Quinodoz, M., Collinet, E., Zoete, V., Michielin, O., Menasria, R., Meylan, P., Bihl, T., Erard, V., Fellmann, F., Rivolta, C., Boivin, G., Bochud, P.-Y., PLoS Pathogens, 2019, 10.1371/journal.ppat.1008168
Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its smallhydrophobic protein which plays adetrimental role during infection in mice, Le, V.B., Dubois, J., Couture, C., Cavanagh, M.H., Uyar, O., Pizzorno, A., Rosa-Calatrava, M., Hamelin, M.E., Boivin, G., PLoS Pathogens, 2019, 10.1371/journal.ppat.1007689
Human parainfluenza 2 related illness and a death in a group of captive western lowland gorillas (gorilla gorilla gorilla), Couture, É.L., Ferrell, S.T., Desmarchelier, M., Hamelin, M.-E., Sánchez Mendoza, L.J., Carbonneau, J., Abrahamyan, L., Boivin, G., Lair, S., Journal of Zoo and Wildlife Medicine, 2019, 10.1638/2018-0237
In vitro properties and virulence of contemporary recombinant influenza b viruses harboring mutations of cross-resistance to neuraminidase inhibitors, Fage, C., Abed, Y., Checkmahomed, L., Venable, M.-C., Boivin, G., Viruses, 2019, 10.3390/v11010006
Influenza virus epidemiology: A permanent vaccine challenge,Épidémiologie des virus influenza: Le défi vaccinal permanent, Boivin, G., Lina, B., Virologie, 2019, 10.1684/vir.2019.0788
Molecular and epidemiologic investigation of a rhinovirus outbreak in a neonatal intensive care unit, El Idrissi, K.R., Isabel, S., Carbonneau, J., Lafond, M., Quach, C., Caya, C., Fontela, P.S., Beltempo, M., Boivin, G., Lefebvre, M.-A., Papenburg, J., Infection Control and Hospital Epidemiology, 2019, 10.1017/ice.2018.311
Novel antiviral compounds and combination therapy for influenza viruses,Nouveaux composés antiviraux et thérapie combinée contre les virus influenza, Boivin, G., Rosa-Calatrava, M., Lina, B., Virologie, 2019, 10.1684/vir.2019.0803
Novel antiviral compounds and combination therapy for influenza viruses,Nouveaux composés antiviraux et thérapie combinée contre les virus influenza, Boivin, G., Rosa-Calatrava, M., Lina, B., Virologie, 2019, 10.1684/vir.2019.0802
OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes, Del Campo, J., Pizzorno, A., Djebali, S., Bouley, J., Haller, M., Pérez-Vargas, J., Lina, B., Boivin, G., Hamelin, M.-E., Nicolas, F., Le Vert, A., Leverrier, Y., Rosa-Calatrava, M., Marvel, J., Hill, F., npj Vaccines, 2019, 10.1038/s41541-019-0098-4
Reduced susceptibility to neuraminidase inhibitors in influenza b isolate, Canada, Abed, Y., Fage, C., Lagüe, P., Carbonneau, J., Papenburg, J., Vinh, D.C., Boivin, G., Emerging Infectious Diseases, 2019, 10.3201/EID2504.181554
Repurposing of drugs as novel influenza inhibitors from clinical gene expression infection signatures, Pizzorno, A., Terrier, O., de Lamballerie, C.N., Julien, T., Padey, B., Traversier, A., Roche, M., Hamelin, M.-E., Rhéaume, C., Croze, S., Escuret, V., Poissy, J., Lina, B., Legras-Lachuer, C., Textoris, J., Boivin, G., Rosa-Calatrava, M., Frontiers in Immunology, 2019, 10.3389/fimmu.2019.00060
Strain-dependent impact of G and SH deletions provide new insights for live-attenuated HMPV vaccine development, Dubois, J., Pizzorno, A., Cavanagh, M.-H., Padey, B., De Lamballerie, C.N., Uyar, O., Venable, M.-C., Carbonneau, J., Traversier, A., Julien, T., Lavigne, S., Couture, C., Lina, B., Hamelin, M.-È., Terrier, O., Rosa-Calatrava, M., Boivin, G., Vaccines, 2019, 10.3390/vaccines7040164
Streptococcus pneumoniae serotype 3 is masking PCV13-mediated herd immunity in Canadian adults hospitalized with community acquired pneumonia: A study from the Serious Outcomes Surveillance (SOS) Network of the Canadian immunization research Network (CIRN), LeBlanc, J.J., ElSherif, M., Ye, L., MacKinnon-Cameron, D., Ambrose, A., Hatchette, T.F., Lang, A.L.S., Gillis, H.D., Martin, I., Demczuk, W., Andrew, M.K., Boivin, G., Bowie, W., Green, K., Johnstone, J., Loeb, M., McCarthy, A.E., McGeer, A., Semret, M., Trottier, S., Valiquette, L., Webster, D., McNeil, S.A., Vaccine, 2019, 10.1016/j.vaccine.2019.05.003
Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus, Baz, M., M’hamdi, Z., Carbonneau, J., Lavigne, S., Couture, C., Abed, Y., Boivin, G., Scientific Reports, 2019, 10.1038/s41598-019-51877-4
The impact of prior season vaccination on subsequent influenza vaccine effectiveness to prevent influenza-related hospitalizations over 4 influenza seasons in Canada, Nichols, M.K., Andrew, M.K., Ye, L., Hatchette, T.F., Ambrose, A., Boivin, G., Bowie, W., Dos Santos, G., Elsherif, M., Green, K., Haguinet, F., Katz, K., Leblanc, J., Loeb, M., Mackinnon-Cameron, D., McCarthy, A., McElhaney, J.E., McGeer, A., Powis, J., Richardson, D., Semret, M., Sharma, R., Shinde, V., Smyth, D., Trottier, S., Valiquette, L., Webster, D., McNeil, S.A., Clinical Infectious Diseases, 2019, 10.1093/cid/ciy1009
The nonstructural NS1 protein of influenza viruses modulates TP53 splicing through host factor CPSF4, Dubois, J., Traversier, A., Julien, T., Padey, B., Lina, B., Bourdon, J.-C., Marcel, V., Boivin, G., Rosa-Calatrava, M., Terrier, O., Journal of Virology, 2019, 10.1128/JVI.02168-18
The recruitment of peripheral blood leukocytes to the brain is delayed in susceptible BALB/c compared to resistant C57BL/6 mice during herpes simplex virus encephalitis, Canivet, C., Uyar, O., Rhéaume, C., Piret, J., Boivin, G., Journal of NeuroVirology, 2019, 10.1007/s13365-019-00730-5
The Val430Ile neuraminidase (NA) substitution, identified in influenza B virus isolates, impacts the catalytic 116Arg residue causing reduced susceptibility to NA inhibitors, Abed, Y., Fage, C., Checkmahomed, L., Begin, G., Carbonneau, J., Lague, P., Boivin, G., Antiviral Research, 2019, 10.1016/j.antiviral.2019.104561
Zika-Induced Male Infertility in Mice Is Potentially Reversible and Preventable by Deoxyribonucleic Acid Immunization, De La Vega, M.-A., Piret, J., Griffin, B.D., Rhéaume, C., Venable, M.-C., Carbonneau, J., Couture, C., Das Neves Almeida, R., Tremblay, R.R., Magalhães, K.G., Park, Y.K., Roberts, C.C., Maslow, J.N., Sardesai, N.Y., Kim, J.J., Muthumani, K., Weiner, D.B., Kobinger, G.P., Boivin, G., Journal of Infectious Diseases, 2019, 10.1093/infdis/jiy336
Resistance of Herpesviruses to Antiviral Agents, William L. Drew, Jocelyne Piret, Guy Boivin, Antimicrobial Resistance in the 21st Century, 2018, 10.1007/978-3-319-78538-7_8
The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation., Kotton CN, Kumar D, Caliendo AM, Huprikar S, Chou S, Danziger-Isakov L, Humar A, The Transplantation Society International CMV Consensus Group, Transplantation, 2018, 10.1097/tp.0000000000002191
Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis, Canivet, C., Rhéaume, C., Lebel, M., Piret, J., Gosselin, J., Boivin, G., Journal of NeuroVirology, 2018, 10.1007/s13365-018-0666-9
Combination therapy with oseltamivir and favipiravir delays mortality but does not prevent oseltamivir resistance in immunodeficient mice infected with pandemic A(H1N1) influenza virus, Baz, M., Carbonneau, J., Rhéaume, C., Cavanagh, M.-H., Boivin, G., Viruses, 2018, 10.3390/v10110610
Comparison of early and recent influenza A(H1N1)pdm09 isolates harboring or not the H275Y neuraminidase mutation, in vitro and in animal models, Abed, Y., Tu, V., Carbonneau, J., Checkmahomed, L., Venable, M.-C., Fage, C., Marie-Ève-Hamelin, Dufresne, S.F., Kobinger, G., Boivin, G., Antiviral Research, 2018, 10.1016/j.antiviral.2018.09.007
Evaluation of anticoagulant agents for the treatment of human metapneumovirus infection in mice, Lê, B.V., Jandrot-Perrus, M., Couture, C., Checkmahomed, L., Venable, M.-C., Hamelin, M.-È., Boivin, G., Journal of General Virology, 2018, 10.1099/jgv.0.001135
Impact of R152K and R368K neuraminidase catalytic substitutions on in vitro properties and virulence of recombinant A(H1N1)pdm09 viruses, Tu, V., Abed, Y., Fage, C., Baz, M., Boivin, G., Antiviral Research, 2018, 10.1016/j.antiviral.2018.04.009
Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network), Nichols, M.K., Andrew, M.K., Hatchette, T.F., Ambrose, A., Boivin, G., Bowie, W., Chit, A., Dos Santos, G., ElSherif, M., Green, K., Haguinet, F., Halperin, S.A., Ibarguchi, B., Johnstone, J., Katz, K., Lagacé-Wiens, P., Langley, J.M., LeBlanc, J., Loeb, M., MacKinnon-Cameron, D., McCarthy, A., McElhaney, J.E., McGeer, A., Poirier, A., Powis, J., Richardson, D., Schuind, A., Semret, M., Shinde, V., Smith, S., Smyth, D., Stiver, G., Taylor, G., Trottier, S., Valiquette, L., Webster, D., Ye, L., McNeil, S.A., Vaccine, 2018, 10.1016/j.vaccine.2018.02.093
Predominant role of IPS-1 over TRIF adaptor proteins in early innate immune response against Zika virus in mice, Piret, J., Carbonneau, J., Rhéaume, C., Baz, M., Boivin, G., Journal of General Virology, 2018, 10.1099/jgv.0.000992
Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections, Lê, V.B., Riteau, B., Alessi, M.-C., Couture, C., Jandrot-Perrus, M., Rhéaume, C., Hamelin, M.-È., Boivin, G., British Journal of Pharmacology, 2018, 10.1111/bph.14084
Resource utilization and cost of influenza requiring hospitalization in Canadian adults: A study from the serious outcomes surveillance network of the Canadian Immunization Research Network, Ng, C., Ye, L., Noorduyn, S.G., Hux, M., Thommes, E., Goeree, R., Ambrose, A., Andrew, M.K., Hatchette, T., Boivin, G., Bowie, W., ElSherif, M., Green, K., Johnstone, J., Katz, K., Leblanc, J., Loeb, M., MacKinnon-Cameron, D., McCarthy, A., McElhaney, J., McGeer, A., Poirier, A., Powis, J., Richardson, D., Sharma, R., Semret, M., Smith, S., Smyth, D., Stiver, G., Trottier, S., Valiquette, L., Webster, D., McNeil, S.A., Influenza and other Respiratory Viruses, 2018, 10.1111/irv.12521
The quest for a nanoparticle-based vaccine inducing broad protection to influenza viruses, Bolduc, M., Baz, M., Laliberté-Gagné, M.-È., Carignan, D., Garneau, C., Russel, A., Boivin, G., Savard, P., Leclerc, D., Nanomedicine: Nanotechnology, Biology, and Medicine, 2018, 10.1016/j.nano.2018.08.010
Herpesvirus Resistance to Antiviral Drugs, Jocelyne Piret, Guy Boivin, Antimicrobial Drug Resistance, 2017, 10.1007/978-3-319-47266-9_24
A Review of Clinical Influenza A and B Infections With Reduced Susceptibility to Both Oseltamivir and Zanamivir., Abed Y, Boivin G, Open forum infectious diseases, 2017, 10.1093/ofid/ofx105
Antiviral drug resistance in herpesviruses, Piret, J., Drouot, E., Boivin, G., Handbook of Antimicrobial Resistance, 2017, 10.1007/978-1-4939-0694-9_7
Assessing the diagnostic accuracy of PCR-based detection of Streptococcus pneumoniae from nasopharyngeal swabs collected for viral studies in Canadian adults hospitalised with community-acquired pneumonia: A Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research (CIRN) study, Gillis, H.D., Lang, A.L.S., Elsherif, M., Martin, I., Hatchette, T.F., McNeil, S.A., LeBlanc, J.J., Andrew, M., Webster, D., Trottier, S., Boivin, G., Valiquette, L., Semret, M., McCarthy, A., McGeer, A., Loeb, M., Johnstone, J., Bowie, W., Stiver, G., BMJ Open, 2017, 10.1136/bmjopen-2016-015008
Burden of vaccine-preventable pneumococcal disease in hospitalized adults: A Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS) network study, LeBlanc, J.J., ElSherif, M., Ye, L., MacKinnon-Cameron, D., Li, L., Ambrose, A., Hatchette, T.F., Lang, A.L., Gillis, H., Martin, I., Andrew, M.K., Boivin, G., Bowie, W., Green, K., Johnstone, J., Loeb, M., McCarthy, A., McGeer, A., Moraca, S., Semret, M., Stiver, G., Trottier, S., Valiquette, L., Webster, D., McNeil, S.A., Vaccine, 2017, 10.1016/j.vaccine.2017.05.049
Cell culture systems to study human herpesvirus 6A/B chromosomal integration, Gravel, A., Dubuc, I., Wallaschek, N., Gilbert-Girard, S., Collin, V., Hall-Sedlak, R., Jerome, K.R., Mori, Y., Carbonneau, J., Boivin, G., Kaufer, B.B., Flamand, L., Journal of Virology, 2017, 10.1128/JVI.00437-17
DNA vaccination protects mice against Zika virus-induced damage to the testes, Griffin, B.D., Muthumani, K., Warner, B.M., Majer, A., Hagan, M., Audet, J., Stein, D.R., Ranadheera, C., Racine, T., De La Vega, M.-A., Piret, J., Kucas, S., Tran, K.N., Frost, K.L., De Graff, C., Soule, G., Scharikow, L., Scott, J., McTavish, G., Smid, V., Park, Y.K., Maslow, J.N., Sardesai, N.Y., Kim, J.J., Yao, X.-J., Bello, A., Lindsay, R., Boivin, G., Booth, S.A., Kobasa, D., Embury-Hyatt, C., Safronetz, D., Weiner, D.B., Kobinger, G.P., Nature Communications, 2017, 10.1038/ncomms15743
Droplet digital PCR to investigate quasi-species at codons 119 and 275 of the A(H1N1)pdm09 neuraminidase during zanamivir and oseltamivir therapies, Abed, Y., Carbonneau, J., L'Huillier, A.G., Kaiser, L., Boivin, G., Journal of Medical Virology, 2017, 10.1002/jmv.24680
Drug susceptibility and replicative capacity of multidrug-resistant recombinant human cytomegalovirus harboring mutations in UL56 and UL54 genes, Piret, J., Goyette, N., Boivin, G., Antimicrobial Agents and Chemotherapy, 2017, 10.1128/AAC.01044-17
Herpesvirus DNA polymerases: Structures, functions and inhibitors, Zarrouk, K., Piret, J., Boivin, G., Virus Research, 2017, 10.1016/j.virusres.2017.01.019
In vitro and in vivo evidence of a potential A(H1N1)pdm09 antigenic drift mediated by escape mutations in the haemagglutinin Sa antigenic site, Retama, M., Abed, Y., Rhéaume, C., Baz, M., Boivin, G., Journal of General Virology, 2017, 10.1099/jgv.0.000800
In vitro susceptibility of geographically and temporally distinct Zika viruses to favipiravir and ribavirin, Baz, M., Goyette, N., Griffin, B.D., Kobinger, G.P., Boivin, G., Antiviral Therapy, 2017, 10.3851/IMP3180
Influenza vaccine effectiveness against influenza-related hospitalization during a season with mixed outbreaks of four influenza viruses: A test-negative case-control study in adults in Canada, Andrew, M.K., Shinde, V., Hatchette, T., Ambrose, A., Boivin, G., Bowie, W., Chit, A., Dos Santos, G., ElSherif, M., Green, K., Haguinet, F., Halperin, S.A., Ibarguchi, B., Johnstone, J., Katz, K., Langley, J.M., LeBlanc, J., Loeb, M., MacKinnon-Cameron, D., McCarthy, A., McElhaney, J., McGeer, A., Nichols, M.K., Powis, J., Richardson, D., Semret, M., Stiver, G., Trottier, S., Valiquette, L., Webster, D., Ye, L., McNeil, S.A., BMC Infectious Diseases, 2017, 10.1186/s12879-017-2905-8
Mutations in the fusion protein heptad repeat domains of human metapneumovirus impact on the formation of syncytia, Dubois, J., Cavanagh, M.-H., Terrier, O., Hamelin, M.È., Lina, B., Shi, R., Rosa-Calatrava, M., Boivin, G., Journal of General Virology, 2017, 10.1099/jgv.0.000796
Peramivir susceptibilities of recombinant influenza A and B variants selected with various neuraminidase inhibitors, Fage, C., Tu, V., Carbonneau, J., Abed, Y., Boivin, G., Antiviral Therapy, 2017, 10.3851/IMP3158
Protective role of CX3CR1 signalling in resident cells of the central nervous system during experimental herpes simplex virus encephalitis, Menasria, R., Canivet, C., Piret, J., Gosselin, J., Boivin, G., Journal of General Virology, 2017, 10.1099/jgv.0.000667
The combination of oseltamivir with azithromycin does not show additional benefits over oseltamivir monotherapy in mice infected with influenza A(H1N1)pdm2009 virus, Fage, C., Pizzorno, A., Rhéaume, C., Abed, Y., Boivin, G., Journal of Medical Virology, 2017, 10.1002/jmv.24911
The I427T neuraminidase (NA) substitution, located outside the NA active site of an influenza A(H1N1)pdm09 variant with reduced susceptibility to NA inhibitors, alters NA properties and impairs viral fitness, Tu, V., Abed, Y., Barbeau, X., Carbonneau, J., Fage, C., Lagüe, P., Boivin, G., Antiviral Research, 2017, 10.1016/j.antiviral.2016.11.007
The importance of frailty in the assessment of influenza vaccine effectiveness against influenza-related hospitalization in elderly people, Andrew, M.K., Shinde, V., Ye, L., Hatchette, T., Haguinet, F., Santos, G.D., Mcelhaney, B.J.E., Ambrose, A., Boivin, G., Bowie, W., Chit, A., Elsherif, M., Green, K., Halperin, S., Ibarguchi, B., Johnstone, J., Katz, K., Langley, J., Leblanc, J., Loeb, M., Mackinnon-Cameron, D., McCarthy, A., Mcgeer, A., Powis, J., Richardson, D., Semret, M., Stiver, G., Trottier, S., Valiquette, L., Webster, D., McNeil, S.A., Journal of Infectious Diseases, 2017, 10.1093/infdis/jix282
A collaborative study to establish the 1st WHO International Standard for human cytomegalovirus for nucleic acid amplification technology., Fryer JF, Heath AB, Minor PD, Collaborative Study Group, Biologicals : journal of the International Association of Biological Standardization, 2016, 10.1016/j.biologicals.2016.04.005
A Cluster of Three Cases of Hantavirus Pulmonary Syndrome among Canadian Military Personnel., Parkes LO, Nguyen TT, Longtin J, Beaudoin MC, Bestman-Smith J, Vinh DC, Boivin G, Loo VG, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2016, 10.1155/2016/2757969
Artesunate demonstrates in vitro synergism with several antiviral agents against human cytomegalovirus., Drouot E, Piret J, Boivin G, Antiviral therapy, 2016, 10.3851/imp3028
Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: Diagnosis and management, Piret, J., Boivin, G., Current Opinion in Infectious Diseases, 2016, 10.1097/QCO.0000000000000288
Both cerebral and hematopoietic deficiencies in CCR2 result in uncontrolled herpes simplex virus infection of the central nervous system in Mice, Menasria, R., Canivet, C., Piret, J., Gosselin, J., Boivin, G., PLoS ONE, 2016, 10.1371/journal.pone.0168034
Diagnosis of viral infections, Boivin, G., Mazzulli, T., Petric, M., Clinical Virology, 2016, 10.1128/9781555819439.ch15
Impact of a large deletion in the neuraminidase protein identified in a laninamivir-selected influenza A/Brisbane/10/2007 (H3N2) variant on viral fitness in vitro and in ferrets, Ann, J., Abed, Y., Beaulieu, E., Bouhy, X., Joly, M.-H., Dubé, K., Carbonneau, J., Hamelin, M.-E., Mallett, C., Boivin, G., Influenza and other Respiratory Viruses, 2016, 10.1111/irv.12356
Novel method based on real-time cell analysis for drug susceptibility testing of herpes simplex virus and human cytomegalovirus, Piret, J., Goyette, N., Boivin, G., Journal of Clinical Microbiology, 2016, 10.1128/JCM.03274-15
Standardization of Hemagglutination Inhibition Assay for Influenza Serology Allows for High Reproducibility between Laboratories, Zacour, M., Ward, B.J., Brewer, A., Tang, P., Boivin, G., Li, Y., Warhuus, M., McNeil, S.A., LeBlanc, J.J., Hatchette, T.F., Clinical and Vaccine Immunology, 2016, 10.1128/CVI.00613-15
Structural Insight into NS5 of Zika Virus Leading to the Discovery of MTase Inhibitors, Stephen, P., Baz, M., Boivin, G., Lin, S.-X., Journal of the American Chemical Society, 2016, 10.1021/jacs.6b10399
The E119D neuraminidase mutation identified in a multidrug-resistant influenza A(H1N1)pdm09 isolate severely alters viral fitness in vitro and in animal models, Abed, Y., Bouhy, X., L'Huillier, A.G., Rhéaume, C., Pizzorno, A., Retamal, M., Fage, C., Dubé, K., Joly, M.-H., Beaulieu, E., Mallett, C., Kaiser, L., Boivin, G., Antiviral Research, 2016, 10.1016/j.antiviral.2016.05.006
Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility., Piret J, Goyette N, Eckenroth BE, Drouot E, Götte M, Boivin G, Journal of virology, 2015, 10.1128/jvi.03360-14
Heterosubtypic protection conferred by the human monoclonal antibody PN-SIA28 against influenza A virus lethal infections in mice., Retamal M, Abed Y, Rhéaume C, Cappelletti F, Clementi N, Mancini N, Clementi M, Burioni R, Boivin G, Antimicrobial agents and chemotherapy, 2015, 10.1128/aac.00118-15
Adjuvant effect of the human metapneumovirus (HMPV) matrix protein in HMPV subunit vaccines, Aerts, L., Aume, C.R., Carbonneau, J., Lavigne, S., Couture, C., Hamelin, M.-É.V., Boivin, G., Journal of General Virology, 2015, 10.1099/vir.0.000031
Cytomegalovirus quantification in plasma with Abbott RealTime CMV and Roche Cobas Amplicor CMV assays, Tremblay, M.-A., Rodrigue, M.-A., Deschênes, L., Boivin, G., Longtin, J., Journal of Virological Methods, 2015, 10.1016/j.jviromet.2015.08.010
E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate from a Stem-Cell Transplant Recipient, L'Huillier, A.G., Abed, Y., Petty, T.J., Cordey, S., Thomas, Y., Bouhy, X., Schibler, M., Simon, A., Chalandon, Y., Van Delden, C., Zdobnov, E., Boquete-Suter, P., Boivin, G., Kaiser, L., Journal of Infectious Diseases, 2015, 10.1093/infdis/jiv288
Effect of in vitro syncytium formation on the severity of human metapneumovirus disease in a murine model, Aerts, L., Cavanagh, M.-H., Dubois, J., Carbonneau, J., Rhéaume, C., Lavigne, S., Couture, C., Hamelin, M.-È., Boivin, G., PLoS ONE, 2015, 10.1371/journal.pone.0120283
Impact of the H275Y and I223V mutations in the neuraminidase of the 2009 pandemic influenza virus in vitro and evaluating experimental reproducibility, Paradis, E.G., Pinilla, L.T., Holder, B.P., Abed, Y., Boivin, G., Beauchemin, C.A.A., PLoS ONE, 2015, 10.1371/journal.pone.0126115
Infiltration pattern of blood monocytes into the central nervous system during experimental herpes simplex virus encephalitis, Menasria, R., Canivet, C., Piret, J., Boivin, G., PLoS ONE, 2015, 10.1371/journal.pone.0145773
Innate immune response during herpes simplex virus encephalitis and development of immunomodulatory strategies, Piret, J., Boivin, G., Reviews in Medical Virology, 2015, 10.1002/rmv.1848
Intrahost dynamics of antiviral resistance in influenza a virus reflect complex patterns of segment linkage, reassortment, and natural selection, Rogers, M.B., Song, T., Sebra, R., Greenbaum, B.D., Hamelin, M.-E., Fitch, A., Twaddle, A., Cui, L., Holmes, E.C., Boivin, G., Ghedina, E., mBio, 2015, 10.1128/mBio.02464-14
Optimization of Droplet Digital PCR from RNA and DNA extracts with direct comparison to RT-qPCR: Clinical implications for quantification of Oseltamivir-resistant subpopulations, Taylor, S.C., Carbonneau, J., Shelton, D.N., Boivin, G., Journal of Virological Methods, 2015, 10.1016/j.jviromet.2015.08.014
Permissive changes in the neuraminidase play a dominant role in improving the viral fitness of oseltamivir-resistant seasonal influenza A(H1N1) strains, Abed, Y., Pizzorno, A., Bouhy, X., Boivin, G., Antiviral Research, 2015, 10.1016/j.antiviral.2014.12.006
Targeted Proteomics of Human Metapneumovirus in Clinical Samples and Viral Cultures, Foster, M.W., Gerhardt, G., Robitaille, L., Plante, P.-L., Boivin, G., Corbeil, J., Moseley, M.A., Analytical Chemistry, 2015, 10.1021/acs.analchem.5b01544
Valacyclovir combined with artesunate or rapamycin improves the outcome of herpes simplex virus encephalitis in mice compared to antiviral therapy alone, Canivet, C., Menasria, R., Rhéaume, C., Piret, J., Boivin, G., Antiviral Research, 2015, 10.1016/j.antiviral.2015.09.007
Antiviral Drug Resistance in Herpesviruses, Jocelyne Piret, Emilien Drouot, Guy Boivin, Handbook of Antimicrobial Resistance, 2014, 10.1007/978-1-4939-0667-3_7-1
Adjuvanted inactivated influenza A(H3N2) vaccines induce stronger immunogenicity in mice and confer higher protection in ferrets than unadjuvanted inactivated vaccines, Ann, J., Samant, M., Rheaume, C., Dumas, C., Beaulieu, E., Morasse, A., Mallett, C., Hamelin, M.-E., Papadopoulou, B., Boivin, G., Vaccine, 2014, 10.1016/j.vaccine.2014.08.029
Antiviral drug resistance in herpesviruses other than cytomegalovirus, Piret, J., Boivin, G., Reviews in Medical Virology, 2014, 10.1002/rmv.1787
Characterization of drug-resistant influenza virus A(H1N1) and A(H3N2) variants selected in vitro with laninamivir, Samson, M., Abed, Y., Desrochers, F.-M., Hamilton, S., Luttick, A., Tucker, S.P., Pryor, M.J., Boivin, G., Antimicrobial Agents and Chemotherapy, 2014, 10.1128/AAC.03313-14
Characterization of multiple cytomegalovirus drug resistance mutations detected in a hematopoietic stem cell transplant recipient by recombinant phenotyping, Drouot, E., Piret, J., Lebel, M.H., Boivin, G., Journal of Clinical Microbiology, 2014, 10.1128/JCM.02205-14
Epitope mapping of the 2009 pandemic and the A/brisbane/59/2007 seasonal (H1N1) influenza virus haemagglutinins using mabs and escape mutants, Retamal, M., Abed, Y., Corbeil, J., Boivin, G., Journal of General Virology, 2014, 10.1099/vir.0.067819-0
Evolution of oseltamivir resistance mutations in influenza A(H1N1) and A(H3N2) viruses during selection in experimentally infected mice, Pizzorno, A., Abed, Y., Plante, P.-L., Carbonneau, J., Baz, M., Hamelin, M.-È., Corbeil, J., Boivin, G., Antimicrobial Agents and Chemotherapy, 2014, 10.1128/AAC.02956-14
Human metapneumovirus viral load is an important risk factor for disease severity in young children, Roussy, J.-F., Carbonneau, J., Ouakki, M., Papenburg, J., Hamelin, M.-T., De Serres, G., Boivin, G., Journal of Clinical Virology, 2014, 10.1016/j.jcv.2014.03.001
Impact of potential permissive neuraminidase mutations on viral fitness of the H275Y oseltamivir-resistant influenza A(H1N1)pdm09 virus in vitro, in mice and in ferrets, Abed, Y., Pizzorno, A., Bouhy, X., Rhéaume, C., Boivin, G., Journal of Virology, 2014, 10.1128/JVI.02681-13
Interim estimates of 2013/14 influenza clinical severity and vaccine effectiveness in the prevention of laboratory-confirmed influenza-related hospitalisation, Canada, February 2014, McNeil, S.A., Shinde, V., Andrew, M., Hatchette, T.F., Leblanc, J., Ambrose, A., Boivin, G., Bowie, W.R., Diaz-Mitoma, F., ElSherif, M., Green, K., Haguinet, F., Halperin, S., Ibarguchi, B., Katz, K., Langley, J.M., Lagacã-Wiens, P., Light, B., Loeb, M., McElhaney, J., MacKinnon-Cameron, D., McCarthy, A.E., Poirier, M., Powis, J., Richardson, D., Semret, M., Smith, S., Smyth, D., Stiver, G., Trottier, S., Valiquette, L., Webster, D., Ye, L., McGeer, A., Eurosurveillance, 2014, 10.2807/1560-7917.ES2014.19.9.20729
Oseltamivir-zanamivir combination therapy is not superior to zanamivir monotherapy in mice infected with influenza A(H3N2) and A(H1N1)pdm09 viruses, Pizzorno, A., Abed, Y., Rhéaume, C., Boivin, G., Antiviral Research, 2014, 10.1016/j.antiviral.2014.02.017
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial, Chou, S., Boivin, G., Ives, J., Elston, R., Journal of Infectious Diseases, 2014, 10.1093/infdis/jit654
Randomized controlled ferret study to assess the direct impact of 2008-09 trivalent inactivated influenza vaccine on A(H1N1)pdm09 disease risk, Skowronski, D.M., Hamelin, M.-E., De Serres, G., Janjua, N.Z., Li, G., Sabaiduc, S., Bouhy, X., Couture, C., Leung, A., Kobasa, D., Embury-Hyatt, C., De Bruin, E., Balshaw, R., Lavigne, S., Petric, M., Koopmans, M., Boivin, G., PLoS ONE, 2014, 10.1371/journal.pone.0086555
Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model., Aerts L, Hamelin MÈ, Rhéaume C, Lavigne S, Couture C, Kim W, Susan-Resiga D, Prat A, Seidah NG, Vergnolle N, Riteau B, Boivin G, PloS one, 2013, 10.1371/journal.pone.0072529
Analysis of HHV-6 mutations in solid organ transplant recipients at the onset of cytomegalovirus disease and following treatment with intravenous ganciclovir or oral valganciclovir., Bounaadja L, Piret J, Goyette N, Boivin G, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2013, 10.1016/j.jcv.2013.06.024
Novel method based on "en passant" mutagenesis coupled with a gaussia luciferase reporter assay for studying the combined effects of human cytomegalovirus mutations., Drouot E, Piret J, Boivin G, Journal of clinical microbiology, 2013, 10.1128/jcm.01275-13
Reply to "Calibration technologies for correct determination of Epstein-Barr Virus, human herpesvirus 6 (HHV-6), and HHV-8 antiviral drug susceptibilities by use of real-time-PCR-based assays"., Bounaadja L, Piret J, Goyette N, Boivin G, Journal of clinical microbiology, 2013, 10.1128/jcm.00545-13
Both TRIF and IPS-1 adaptor proteins contribute to the cerebral innate immune response against herpes simplex virus 1 infection., Menasria R, Boivin N, Lebel M, Piret J, Gosselin J, Boivin G, Journal of virology, 2013, 10.1128/jvi.00591-13
Host and viral factors affecting clinical performance of a rapid diagnostic test for respiratory syncytial virus in hospitalized children., Papenburg J, Buckeridge DL, De Serres G, Boivin G, The Journal of pediatrics, 2013, 10.1016/j.jpeds.2013.03.067
Virus-like particle vaccine induces cross-protection against human metapneumovirus infections in mice., Lévy C, Aerts L, Hamelin MÈ, Granier C, Szécsi J, Lavillette D, Boivin G, Cosset FL, Vaccine, 2013, 10.1016/j.vaccine.2013.03.051
Influenza virus resistance to neuraminidase inhibitors., Samson M, Pizzorno A, Abed Y, Boivin G, Antiviral research, 2013, 10.1016/j.antiviral.2013.03.014
Detection and management of antiviral resistance for influenza viruses, Boivin, G., Influenza and other Respiratory Viruses, 2013, 10.1111/irv.12176
Emergence of an oseltamivir-resistant influenza A/H3N2 Virus in an elderly patient receiving a suboptimal dose of antiviral prophylaxis, Roussy, J.-F., Abed, Y., Bouhy, X., Boivin, G., Journal of Clinical Microbiology, 2013, 10.1128/JCM.02659-13
Evaluation of Epstein-Barr virus, human herpesvirus 6 (HHV-6), and HHV-8 antiviral drug susceptibilities by use of real-time-PCR-based assays., Bounaadja L, Piret J, Goyette N, Boivin G, Journal of clinical microbiology, 2013, 10.1128/jcm.03234-12
Evaluation of recombinant 2009 pandemic influenza A (H1N1) viruses harboring zanamivir resistance mutations in mice and ferrets., Pizzorno A, Abed Y, Rhéaume C, Bouhy X, Boivin G, Antimicrobial agents and chemotherapy, 2013, 10.1128/aac.02269-12
Genetic diversity and molecular evolution of the major human metapneumovirus surface glycoproteins over a decade, Papenburg, J., Carbonneau, J., Isabel, S., Bergeron, M.G., Williams, J.V., De Serres, G., Hamelin, M.-T., Boivin, G., Journal of Clinical Virology, 2013, 10.1016/j.jcv.2013.08.029
The combination of valacyclovir with an anti-TNF alpha antibody increases survival rate compared to antiviral therapy alone in a murine model of herpes simplex virus encephalitis, Boivin, N., Menasria, R., Piret, J., Rivest, S., Boivin, G., Antiviral Research, 2013, 10.1016/j.antiviral.2013.10.007
Modulation of TLR9 response in a mouse model of herpes simplex virus encephalitis., Boivin N, Menasria R, Piret J, Boivin G, Antiviral research, 2012, 10.1016/j.antiviral.2012.09.022
Presence of oseltamivir-resistant pandemic A/H1N1 minor variants before drug therapy with subsequent selection and transmission., Ghedin E, Holmes EC, DePasse JV, Pinilla LT, Fitch A, Hamelin ME, Papenburg J, Boivin G, The Journal of infectious diseases, 2012, 10.1093/infdis/jis571
Cross-reactive and vaccine-induced antibody to an emerging swine-origin variant of influenza A virus subtype H3N2 (H3N2v)., Skowronski DM, Janjua NZ, De Serres G, Purych D, Gilca V, Scheifele DW, Dionne M, Sabaiduc S, Gardy JL, Li G, Bastien N, Petric M, Boivin G, Li Y, The Journal of infectious diseases, 2012, 10.1093/infdis/jis500
Treatment with a novel topical nanoemulsion (NB-001) speeds time to healing of recurrent cold sores., Kircik L, Jones TM, Jarratt M, Flack MR, Ijzerman M, Ciotti S, Sutcliffe J, Boivin G, Stanberry LR, Baker JR, NB-001 Study Group, Journal of drugs in dermatology : JDD, 2012
Seroconversion to seasonal influenza viruses after A(H1N1)pdm09 virus infection, Quebec, Canada., Baz M, Papenburg J, Hamelin ME, Ouakki M, Skowronski DM, De Serres G, Boivin G, Emerging infectious diseases, 2012, 10.3201/eid1807.111680
The H275Y neuraminidase mutation of the pandemic A/H1N1 influenza virus lengthens the eclipse phase and reduces viral output of infected cells, potentially compromising fitness in ferrets., Pinilla LT, Holder BP, Abed Y, Boivin G, Beauchemin CA, Journal of virology, 2012, 10.1128/jvi.07244-11
Cross-lineage influenza B and heterologous influenza A antibody responses in vaccinated mice: immunologic interactions and B/Yamagata dominance., Skowronski DM, Hamelin ME, Janjua NZ, De Serres G, Gardy JL, Rhéaume C, Bouhy X, Boivin G, PloS one, 2012, 10.1371/journal.pone.0038929
Therapeutic activity of intramuscular peramivir in mice infected with a recombinant influenza A/WSN/33 (H1N1) virus containing the H275Y neuraminidase mutation., Abed Y, Pizzorno A, Boivin G, Antimicrobial agents and chemotherapy, 2012, 10.1128/aac.00753-12
Comparison of risk factors for human metapneumovirus and respiratory syncytial virus disease severity in young children., Papenburg J, Hamelin MÈ, Ouhoummane N, Carbonneau J, Ouakki M, Raymond F, Robitaille L, Corbeil J, Caouette G, Frenette L, De Serres G, Boivin G, The Journal of infectious diseases, 2012, 10.1093/infdis/jis333
Recent developments with live-attenuated recombinant paramyxovirus vaccines., Le Bayon JC, Lina B, Rosa-Calatrava M, Boivin G, Reviews in medical virology, 2012, 10.1002/rmv.1717
Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis., Boivin N, Menasria R, Gosselin D, Rivest S, Boivin G, The Journal of general virology, 2012, 10.1099/vir.0.041046-0
Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010., Skowronski DM, De Serres G, Janjua NZ, Gardy JL, Gilca V, Dionne M, Hamelin ME, Rhéaume C, Boivin G, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2012, 10.2807/ese.17.04.20066-en
Effects of different adjuvants in the context of intramuscular and intranasal routes on humoral and cellular immune responses induced by detergent-split A/H3N2 influenza vaccines in mice, Baz, M., Samant, M., Zekki, H., Tribout-Jover, P., Plante, M., Lanteigne, A.-M., Hamelin, M.-E., Mallett, C., Papadopoulou, B., Boivin, G., Clinical and Vaccine Immunology, 2012, 10.1128/CVI.05441-11
Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus, Pizzorno, A., Abed, Y., Bouhy, X., Beaulieu, É., Mallett, C., Russell, R., Boivin, G., Antimicrobial Agents and Chemotherapy, 2012, 10.1128/AAC.05994-11
Incidence of cytomegalovirus UL97 and UL54 amino acid substitutions detected after 100 or 200 days of valganciclovir prophylaxis., Boivin G, Goyette N, Farhan M, Ives J, Elston R, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2012, 10.1016/j.jcv.2011.12.019
Molecular and antigenic evolution of human influenza A/H3N2 viruses in Quebec, Canada, 2009-2011, Ann, J., Papenburg, J., Bouhy, X., Rhéaume, C., Hamelin, M.-T., Boivin, G., Journal of Clinical Virology, 2012, 10.1016/j.jcv.2011.09.016
Molecular evolution of respiratory syncytial virus fusion gene, Canada, 2006-2010., Papenburg J, Carbonneau J, Hamelin MÈ, Isabel S, Bouhy X, Ohoumanne N, Déry P, Paes BA, Corbeil J, Bergeron MG, De Serres G, Boivin G, Emerging infectious diseases, 2012, 10.3201/eid1801.110515
Ten years of human metapneumovirus research, Feuillet, F., Lina, B., Rosa-Calatrava, M., Boivin, G., Journal of Clinical Virology, 2012, 10.1016/j.jcv.2011.10.002
Treatment with a novel topical nanoemulsion (NB-001) speeds time to healing of recurrent cold sores, Kircik, L., Jones, T.M., Jarratt, M., Flack, M.R., Ijzerman, M., Ciotti, S., Sutcliffe, J., Boivin, G., Stanberry, L.R., Baker, J.R., Journal of Drugs in Dermatology, 2012
The cost-effectiveness and value of information of three influenza vaccination dosing strategies for individuals with human immunodeficiency virus., Nosyk B, Sharif B, Sun H, Cooper C, Anis AH, CIHR Canadian HIV Trials Network Influenza Vaccine Research Group, PloS one, 2011, 10.1371/journal.pone.0027059
Comparison of pandemic and seasonal influenza in the pediatric emergency department., Aguirre E, Papenburg J, Ouakki M, Fontela PS, Guimont C, De Serres G, Boivin G, The Pediatric infectious disease journal, 2011, 10.1097/inf.0b013e3182103d54
Influenza drug resistance., Pizzorno A, Abed Y, Boivin G, Seminars in respiratory and critical care medicine, 2011, 10.1055/s-0031-1283281
Influenza vaccine oculorespiratory syndrome incidence is reduced in HIV., Cooper C, Thorne A, Canadian Institutes of Health Research-Canadian HIV Trials Network (CTN) Influenza Vaccine Research Group, Vaccine, 2011, 10.1016/j.vaccine.2011.08.066
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet., Gilbert C, Azzi A, Goyette N, Lin SX, Boivin G, Antimicrobial agents and chemotherapy, 2011, 10.1128/aac.00334-11
Low systemic ganciclovir exposure and preemptive treatment failure of cytomegalovirus reactivation in a transplanted child., Autmizguine J, Théôret Y, Launay E, Duval M, Rousseau C, Tapiéro B, Boivin G, Ovetchkine P, Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique, 2011
Systematic review of influenza resistance to the neuraminidase inhibitors., Thorlund K, Awad T, Boivin G, Thabane L, BMC infectious diseases, 2011, 10.1186/1471-2334-11-134
Assessing the in vitro fitness of an oseltamivir-resistant seasonal A/H1N1 influenza strain using a mathematical model., Holder BP, Simon P, Liao LE, Abed Y, Bouhy X, Beauchemin CA, Boivin G, PloS one, 2011, 10.1371/journal.pone.0014767
Immunogenicity is not improved by increased antigen dose or booster dosing of seasonal influenza vaccine in a randomized trial of HIV infected adults., Cooper C, Thorne A, Klein M, Conway B, Boivin G, Haase D, Shafran S, Zubyk W, Singer J, Halperin S, Walmsley S, CIHR Canadian HIV Trials Network Influenza Vaccine Research Group, PloS one, 2011, 10.1371/journal.pone.0017758
A nasally administered trivalent inactivated influenza vaccine is well tolerated, stimulates both mucosal and systemic immunity, and potentially protects against influenza illness., Langley JM, Aoki F, Ward BJ, McGeer A, Angel JB, Stiver G, Gorfinkel I, Shu D, White L, Lasko B, Dzongowski P, Papp K, Alexander M, Boivin G, Fries L, Vaccine, 2011, 10.1016/j.vaccine.2010.12.100
Antibody persistence and response to 2010-2011 trivalent influenza vaccine one year after a single dose of 2009 AS03-adjuvanted pandemic H1N1 vaccine in children, Gilca, V., De Serres, G., Hamelin, M.-E., Boivin, G., Ouakki, M., Boulianne, N., Sauvageau, C., Dionne, M., Gilca, R., Skowronski, D., Vaccine, 2011, 10.1016/j.vaccine.2011.10.062
Design considerations in building in silico equivalents of common experimental influenza virus assays., Holder BP, Liao LE, Simon P, Boivin G, Beauchemin CA, Autoimmunity, 2011, 10.3109/08916934.2011.523267
Evaluation of serological diagnostic methods for the 2009 pandemic influenza A (H1N1) virus., Papenburg J, Baz M, Hamelin MÈ, Rhéaume C, Carbonneau J, Ouakki M, Rouleau I, De Serres G, Boivin G, Clinical and vaccine immunology : CVI, 2011, 10.1128/cvi.00449-10
Generation and characterization of recombinant pandemic influenza A(H1N1) viruses resistant to neuraminidase inhibitors., Pizzorno A, Bouhy X, Abed Y, Boivin G, The Journal of infectious diseases, 2011, 10.1093/infdis/jiq010
Human metapneumovirus, the point ten years after its discovery. Genomic characteristics, virological and therapeutic advances,Le métapneumovirus humain, le point dix années après sa découverte. Caractéristiques génomiques, virologiques et avancées thérapeutiques, Feuillet, F., Rosa-Calatrava, M., Boivin, G., Virologie, 2011, 10.1684/vir.2011.0411
Long-term impairment of Streptococcus pneumoniae lung clearance is observed after initial infection with influenza A virus but not human metapneumovirus in mice, Ludewick, H.P., Aerts, L., Hamelin, M.E., Boivin, G., Journal of General Virology, 2011, 10.1099/vir.0.030825-0
Neuraminidase-inhibitor resistance testing for pandemic influenza A (H1N1) 2009 in Ontario, Canada., Longtin J, Patel S, Eshaghi A, Lombos E, Higgins R, Alexander D, Olsha R, Doyle J, Tran D, Sarabia A, Lee C, Bastien N, Li Y, Low D, Boivin G, Gubbay J, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2011, 10.1016/j.jcv.2010.12.007
Parenteral peramivir treatment for oseltamivir-resistant 2009 pandemic influenza a H1N1 viruses, Abed, Y., Boivin, G., Yoshida, R., Kodama, M., Hernandez, J.E., Journal of Infectious Diseases, 2011, 10.1093/infdis/jir610
Reduced airborne transmission of oseltamivir-resistant pandemic A/H1N1 virus in ferrets., Hamelin ME, Baz M, Bouhy X, Beaulieu E, Dubé K, Mallett C, Boivin G, Antiviral therapy, 2011, 10.3851/imp1794
Risk factors for hospitalization and severe outcomes of 2009 pandemic H1N1 influenza in Quebec, Canada, Gilca, R., de Serres, G., Boulianne, N., Ouhoummane, N., Papenburg, J., Douville-Fradet, M., Fortin, E., Dionne, M., Boivin, G., Skowronski, D.M., Influenza and other Respiratory Viruses, 2011, 10.1111/j.1750-2659.2011.00204.x
Role of permissive neuraminidase mutations in influenza A/Brisbane/59/2007-like (H1N1) viruses, Abed, Y., Pizzorno, A., Bouhy, X., Boivin, G., PLoS Pathogens, 2011, 10.1371/journal.ppat.1002431
The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferrets, Abed, Y., Pizzorno, A., Hamelin, M.-E., Leung, A., Joubert, P., Couture, C., Kobasa, D., Boivin, G., Journal of Infectious Diseases, 2011, 10.1093/infdis/jir483
Immunogenicity and tolerability of an inactivated and adjuvanted pandemic H1N1 influenza vaccine, in HIV-1-infected patients., Tremblay CL, Rouleau D, Fortin C, Toma E, Sylla M, Cyr L, Cote S, Baz M, Sampalis J, Trautman L, Sékaly RP, Boivin G, Vaccine, 2010, 10.1016/j.vaccine.2010.12.023
Recombinant phenotyping of cytomegalovirus sequence variants detected after 200 or 100 days of valganciclovir prophylaxis., Chou S, Marousek G, Boivin G, Goyette N, Farhan M, Ives JA, Elston R, Transplantation, 2010, 10.1097/tp.0b013e3181fdd9d2
Household transmission of the 2009 pandemic A/H1N1 influenza virus: elevated laboratory‐confirmed secondary attack rates and evidence of asymptomatic infections., Papenburg J, Baz M, Hamelin MÈ, Rhéaume C, Carbonneau J, Ouakki M, Rouleau I, Hardy I, Skowronski D, Roger M, Charest H, De Serres G, Boivin G, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010, 10.1086/656582
Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management., Piret J, Boivin G, Antimicrobial agents and chemotherapy, 2010, 10.1128/aac.00615-10
The I222V neuraminidase mutation has a compensatory role in replication of an oseltamivir-resistant influenza virus A/H3N2 E119V mutant., Simon P, Holder BP, Bouhy X, Abed Y, Beauchemin CA, Boivin G, Journal of clinical microbiology, 2010, 10.1128/jcm.01732-10
Contrasting effects on ganciclovir susceptibility and replicative capacity of two mutations at codon 466 of the human cytomegalovirus UL97 gene., Martin M, Goyette N, Boivin G, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2010, 10.1016/j.jcv.2010.08.008
Oseltamivir-resistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferrets., Hamelin ME, Baz M, Abed Y, Couture C, Joubert P, Beaulieu E, Bellerose N, Plante M, Mallett C, Schumer G, Kobinger GP, Boivin G, PLoS pathogens, 2010, 10.1371/journal.ppat.1001015
Prophylactic and therapeutic benefits of a monoclonal antibody against the fusion protein of human metapneumovirus in a mouse model., Hamelin ME, Gagnon C, Prince GA, Kiener P, Suzich J, Ulbrandt N, Boivin G, Antiviral research, 2010, 10.1016/j.antiviral.2010.07.001
The distinguishing features of human metapneumovirus and respiratory syncytial virus., Papenburg J, Boivin G, Reviews in medical virology, 2010, 10.1002/rmv.651
Contagious period for pandemic (H1N1) 2009., De Serres G, Rouleau I, Hamelin ME, Quach C, Skowronski D, Flamand L, Boulianne N, Li Y, Carbonneau J, Bourgault A, Couillard M, Charest H, Boivin G, Emerging infectious diseases, 2010, 10.3201/eid1605.091894
Neurovirulence and latency of drug-resistant clinical herpes simplex viruses in animal models., Dambrosi S, Martin M, Yim K, Miles B, Canas J, Sergerie Y, Boivin G, Journal of medical virology, 2010, 10.1002/jmv.21773
Comparison of Automated Microarray Detection with Real-Time PCR Assays for Detection of Respiratory Viruses in Specimens Obtained from Children, Raymond F, Carbonneau J, Boucher N, Robitaille L, Boisvert S, Wu W, De Serres G, Boivin G, Corbeil J, Journal of clinical microbiology, 2010
International consensus guidelines on the management of cytomegalovirus in solid organ transplantation., Kotton CN, Kumar D, Caliendo AM, Asberg A, Chou S, Snydman DR, Allen U, Humar A, Transplantation Society International CMV Consensus Group, Transplantation, 2010, 10.1097/tp.0b013e3181cee42f
Prophylactic activity of intramuscular peramivir in mice infected with a recombinant influenza A/WSN/33 (H1N1) virus containing the H274Y neuraminidase mutation., Abed Y, Simon P, Boivin G, Antimicrobial agents and chemotherapy, 2010, 10.1128/aac.01681-09
Effect of the neuraminidase mutation H274Y conferring resistance to oseltamivir on the replicative capacity and virulence of old and recent human influenza A(H1N1) viruses., Baz M, Abed Y, Simon P, Hamelin ME, Boivin G, The Journal of infectious diseases, 2010, 10.1086/650464
Whole-genome characterization and genotyping of global WU polyomavirus strains., Bialasiewicz S, Rockett R, Whiley DW, Abed Y, Allander T, Binks M, Boivin G, Cheng AC, Chung JY, Ferguson PE, Gilroy NM, Leach AJ, Lindau C, Sloots TP, Journal of virology, 2010, 10.1128/jvi.02658-09
Incidence and characterization of cytomegalovirus resistance mutations among pediatric solid organ transplant patients who received valganciclovir prophylaxis., Martin M, Goyette N, Ives J, Boivin G, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2010, 10.1016/j.jcv.2010.01.009
Management and prevention of herpes zoster: A Canadian perspective., Boivin G, Jovey R, Elliott CT, Patrick DM, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2010, 10.1155/2010/178036
Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity., Martin M, Azzi A, Lin SX, Boivin G, Antiviral therapy, 2010, 10.3851/imp1565
Viral pathogens including human metapneumovirus are the primary cause of febrile respiratory illness in HIV-infected adults receiving antiretroviral therapy., Klein MB, Yang H, DelBalso L, Carbonneau J, Frost E, Boivin G, The Journal of infectious diseases, 2010, 10.1086/649587
Emergence of oseltamivir-resistant pandemic H1N1 virus during prophylaxis., Baz M, Abed Y, Papenburg J, Bouhy X, Hamelin ME, Boivin G, The New England journal of medicine, 2009, 10.1056/nejmc0910060
Importance of viral and bacterial infections in chronic obstructive pulmonary disease exacerbations., De Serres G, Lampron N, La Forge J, Rouleau I, Bourbeau J, Weiss K, Barret B, Boivin G, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2009, 10.1016/j.jcv.2009.07.010
The need for validation of statistical methods for estimating respiratory virus-attributable hospitalization., Gilca R, De Serres G, Skowronski D, Boivin G, Buckeridge DL, American journal of epidemiology, 2009, 10.1093/aje/kwp195
Molecular characterization of viruses from clinical respiratory samples producing unidentified cytopathic effects in cell culture., Abed Y, Boivin G, Viruses, 2009, 10.3390/v1020084
Épidémiologie et impact clinique des nouveaux virus respiratoires., Hamelin ME, Boivin G, Revue des maladies respiratoires actualites, 2009, 10.1016/s1877-1203(09)75275-9
Influenza virus shedding: excretion patterns and effects of antiviral treatment., Aoki FY, Boivin G, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2009, 10.1016/j.jcv.2009.01.010
A novel neuraminidase deletion mutation conferring resistance to oseltamivir in clinical influenza A/H3N2 virus., Abed Y, Baz M, Boivin G, The Journal of infectious diseases, 2009, 10.1086/595736
Comparison of automated microarray detection with real-time PCR assays for detection of respiratory viruses in specimens obtained from children., Raymond F, Carbonneau J, Boucher N, Robitaille L, Boisvert S, Wu WK, De Serres G, Boivin G, Corbeil J, Journal of clinical microbiology, 2009, 10.1128/jcm.01297-08
Cytomegalovirus resistance in solid organ transplant recipients treated with intravenous ganciclovir or oral valganciclovir., Boivin G, Goyette N, Rollag H, Jardine AG, Pescovitz MD, Asberg A, Ives J, Hartmann A, Humar A, Antiviral therapy, 2009
Diagnosis of Viral Infections*, , Clinical Virology, Third Edition, 2009, 10.1128/9781555815981.ch13
Disseminated herpes simplex virus type 1 primary infection in a healthy individual., Boivin G, Malette B, Goyette N, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2009, 10.1155/2009/482407
Herpesvirus Resistance, G. Boivin, W.L. Drew, Antimicrobial Drug Resistance, 2009, 10.1007/978-1-60327-595-8_24
A review of influenza vaccine immunogenicity and efficacy in HIV-infected adults., Cooper C, Hutton B, Fergusson D, Mills E, Klein MB, Boivin G, Halperin S, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2008, 10.1155/2008/419710
Activity of the oral neuraminidase inhibitor A-322278 against the oseltamivir-resistant H274Y (A/H1N1) influenza virus mutant in mice., Baz M, Abed Y, Nehmé B, Boivin G, Antimicrobial agents and chemotherapy, 2008, 10.1128/aac.01276-08
Detection of human metapneumovirus antigens in nasopharyngeal aspirates using an enzyme immunoassay., Kukavica-Ibrulj I, Boivin G, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2008, 10.1016/j.jcv.2008.09.011
Infection with human metapneumovirus predisposes mice to severe pneumococcal pneumonia., Kukavica-Ibrulj I, Hamelin ME, Prince GA, Gagnon C, Bergeron Y, Bergeron MG, Boivin G, Journal of virology, 2008, 10.1128/jvi.01123-08
Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis., Boivin N, Sergerie Y, Rivest S, Boivin G, The Journal of infectious diseases, 2008, 10.1086/590671
Human parechovirus causes encephalitis with white matter injury in neonates., Verboon-Maciolek MA, Groenendaal F, Hahn CD, Hellmann J, van Loon AM, Boivin G, de Vries LS, Annals of neurology, 2008, 10.1002/ana.21445
Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo., Bernstein DI, Goyette N, Cardin R, Kern ER, Boivin G, Ireland J, Juteau JM, Vaillant A, Antimicrobial agents and chemotherapy, 2008, 10.1128/aac.00279-08
Development of a universal influenza A vaccine based on the M2e peptide fused to the papaya mosaic virus (PapMV) vaccine platform., Denis J, Acosta-Ramirez E, Zhao Y, Hamelin ME, Koukavica I, Baz M, Abed Y, Savard C, Pare C, Lopez Macias C, Lopez Macias C, Boivin G, Leclerc D, Vaccine, 2008, 10.1016/j.vaccine.2008.04.052
Human metapneumovirus infection in immunocompromised child., Abed Y, Boivin G, Emerging infectious diseases, 2008, 10.3201/eid1405.071459
New Saffold cardioviruses in 3 children, Canada., Abed Y, Boivin G, Emerging infectious diseases, 2008, 10.3201/eid1405.071675
Human bocavirus infections in hospitalized children and adults., Longtin J, Bastien M, Gilca R, Leblanc E, de Serres G, Bergeron MG, Boivin G, Emerging infectious diseases, 2008, 10.3201/eid1402.070851
Human respiratory syncytial virus and other viral infections in infants receiving palivizumab., Boivin G, Caouette G, Frenette L, Carbonneau J, Ouakki M, De Serres G, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2008, 10.1016/j.jcv.2007.11.012
Inhibition of human metapneumovirus replication by small interfering RNA., Deffrasnes C, Cavanagh MH, Goyette N, Cui K, Ge Q, Seth S, Templin MV, Quay SC, Johnson PH, Boivin G, Antiviral therapy, 2008
The prophylactic administration of a monoclonal antibody against human metapneumovirus attenuates viral disease and airways hyperresponsiveness in mice., Hamelin ME, Couture C, Sackett M, Kiener P, Suzich J, Ulbrandt N, Boivin G, Antiviral therapy, 2008
Enhanced lung disease and Th2 response following human metapneumovirus infection in mice immunized with the inactivated virus., Hamelin MÈ, Couture C, Sackett MK, Boivin G, The Journal of general virology, 2007, 10.1099/vir.0.83250-0
WU polyomavirus in children, Canada., Abed Y, Wang D, Boivin G, Emerging infectious diseases, 2007, 10.3201/eid1312.070909
Identification and evaluation of a highly effective fusion inhibitor for human metapneumovirus., Deffrasnes C, Hamelin ME, Prince GA, Boivin G, Antimicrobial agents and chemotherapy, 2007, 10.1128/aac.00793-07
Activity of the neuraminidase inhibitor A-315675 against oseltamivir-resistant influenza neuraminidases of N1 and N2 subtypes., Abed Y, Nehmé B, Baz M, Boivin G, Antiviral research, 2007, 10.1016/j.antiviral.2007.08.008
Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes., Sergerie Y, Boivin G, Antiviral research, 2007, 10.1016/j.antiviral.2007.08.009
Mapping and characterization of the primary and anamnestic H-2(d)-restricted cytotoxic T-lymphocyte response in mice against human metapneumovirus., Melendi GA, Zavala F, Buchholz UJ, Boivin G, Collins PL, Kleeberger SR, Polack FP, Journal of virology, 2007, 10.1128/jvi.02423-06
Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis., Sergerie Y, Rivest S, Boivin G, The Journal of infectious diseases, 2007, 10.1086/520094
Influenzavirus infection is a primary cause of febrile respiratory illness in HIV-infected adults, despite vaccination., Klein MB, Lu Y, DelBalso L, Coté S, Boivin G, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, 10.1086/518986
Antibiotic use in children is not influenced by the result of rapid antigen detection test for the respiratory syncytial virus., Thibeault R, Gilca R, Côté S, De Serres G, Boivin G, Déry P, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007, 10.1016/j.jcv.2007.04.013
Human metapneumovirus: enhanced pulmonary disease in cotton rats immunized with formalin-inactivated virus vaccine and challenged., Yim KC, Cragin RP, Boukhvalova MS, Blanco JC, Hamlin ME, Boivin G, Porter DD, Prince GA, Vaccine, 2007, 10.1016/j.vaccine.2007.04.075
Development of a serological assay based on a synthetic peptide selected from the VP0 capsid protein for detection of human parechoviruses., Abed Y, Wolf D, Dagan R, Boivin G, Journal of clinical microbiology, 2007, 10.1128/jcm.02432-06
Human metapneumovirus., Deffrasnes C, Hamelin ME, Boivin G, Seminars in respiratory and critical care medicine, 2007, 10.1055/s-2007-976493
An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility., Boivin G, De Serres G, Hamelin ME, Côté S, Argouin M, Tremblay G, Maranda-Aubut R, Sauvageau C, Ouakki M, Boulianne N, Couture C, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, 10.1086/513204
Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice., Sergerie Y, Boivin G, Gosselin D, Rivest S, The Journal of infectious diseases, 2007, 10.1086/511987
Amphipathic DNA polymers are candidate vaginal microbicides and block herpes simplex virus binding, entry and viral gene expression., Guzman EM, Cheshenko N, Shende V, Keller MJ, Goyette N, Juteau JM, Boivin G, Vaillant A, Herold BC, Antiviral therapy, 2007
Influenza virus susceptibility and resistance to oseltamivir., Aoki FY, Boivin G, Roberts N, Antiviral therapy, 2007
Longitudinal evaluation of herpes simplex virus DNA load during episodes of herpes labialis., Boivin G, Goyette N, Sergerie Y, Keays S, Booth T, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2006, 10.1016/j.jcv.2006.09.006
Characterization of drug-resistant recombinant influenza A/H1N1 viruses selected in vitro with peramivir and zanamivir., Baz M, Abed Y, Boivin G, Antiviral research, 2006, 10.1016/j.antiviral.2006.10.012
Characterization of multidrug-resistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child., Baz M, Abed Y, McDonald J, Boivin G, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, 10.1086/508777
Human parainfluenza type 4 infections, Canada., Vachon ML, Dionne N, Leblanc E, Moisan D, Bergeron MG, Boivin G, Emerging infectious diseases, 2006, 10.3201/eid1211.060196
Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses., Sergerie Y, Boivin G, Antimicrobial agents and chemotherapy, 2006, 10.1128/aac.00889-06
Three-dimensional modeling of cytomegalovirus DNA polymerase and preliminary analysis of drug resistance., Shi R, Azzi A, Gilbert C, Boivin G, Lin SX, Proteins, 2006, 10.1002/prot.21005
Characterization of human cytomegalovirus (HCMV) UL97 mutations found in a valganciclovir/oral ganciclovir prophylactic trial by use of a bacterial artificial chromosome containing the HCMV genome., Martin M, Gilbert C, Covington E, Boivin G, The Journal of infectious diseases, 2006, 10.1086/505882
Human parechovirus types 1, 2 and 3 infections in Canada., Abed Y, Boivin G, Emerging infectious diseases, 2006, 10.3201/eid1206.051675
Pathogenicity and response to topical antiviral therapy in a murine model of acyclovir-sensitive and acyclovir-resistant herpes simplex viruses isolated from the same patient., Lebel A, Boivin G, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2006, 10.1016/j.jcv.2006.05.003
Human metapneumovirus infection induces long-term pulmonary inflammation associated with airway obstruction and hyperresponsiveness in mice., Hamelin ME, Prince GA, Gomez AM, Kinkead R, Boivin G, The Journal of infectious diseases, 2006, 10.1086/504262
Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection., Hamelin ME, Prince GA, Boivin G, Antimicrobial agents and chemotherapy, 2006, 10.1128/aac.50.2.774-777.2006
Human metapneumovirus, Peru., Gray GC, Capuano AW, Setterquist SF, Sanchez JL, Neville JS, Olson J, Lebeck MG, McCarthy T, Abed Y, Boivin G, Emerging infectious diseases, 2006, 10.3201/eid1202.051133
Role of helix P of the human cytomegalovirus DNA polymerase in resistance and hypersusceptibility to the antiviral drug foscarnet., Tchesnokov EP, Gilbert C, Boivin G, Götte M, Journal of virology, 2006, 10.1128/jvi.80.3.1440-1450.2006
Treatment of respiratory virus infections., Abed Y, Boivin G, Antiviral research, 2006, 10.1016/j.antiviral.2006.01.006
Cytomegalovirus ventriculoencephalitis in a peripheral blood stem cell transplant recipient., Miller GG, Boivin G, Dummer JS, McConnell T, Becher MW, Kassim A, Tang YW, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006, 10.1086/499366
Impact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds., Abed Y, Baz M, Boivin G, Antiviral therapy, 2006
Respiratory Syncytial Virus, Human Metapneumovirus, and the Parainfluenza Viruses, , Manual of Molecular and Clinical Laboratory Immunology, 7th Edition, 2006, 10.1128/9781555815905.ch79
Infections by human coronavirus-NL in hospitalized children., Boivin G, Baz M, Côté S, Gilca R, Deffrasnes C, Leblanc E, Bergeron MG, Déry P, De Serres G, The Pediatric infectious disease journal, 2005, 10.1097/01.inf.0000183743.68569.c7
Molecular characterization of a Canadian human parechovirus (HPeV)-3 isolate and its relationship to other HPeVs., Abed Y, Boivin G, Journal of medical virology, 2005, 10.1002/jmv.20493
New reporter cell line to evaluate the sequential emergence of multiple human cytomegalovirus mutations during in vitro drug exposure., Gilbert C, Boivin G, Antimicrobial agents and chemotherapy, 2005, 10.1128/aac.49.12.4860-4866.2005
Analysis of cytomegalovirus DNA polymerase (UL54) mutations in solid organ transplant patients receiving valganciclovir or ganciclovir prophylaxis., Boivin G, Goyette N, Gilbert C, Covington E, Journal of medical virology, 2005, 10.1002/jmv.20471
Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons., Gilca R, De Serres G, Tremblay M, Vachon ML, Leblanc E, Bergeron MG, Dery P, Boivin G, The Journal of infectious diseases, 2005, 10.1086/498526
Human metapneumovirus: a ubiquitous and long-standing respiratory pathogen., Hamelin ME, Boivin G, The Pediatric infectious disease journal, 2005, 10.1097/01.inf.0000188158.27840.7c
Clinical impact of ganciclovir-resistant cytomegalovirus infections in solid organ transplant patients., Boivin G, Goyette N, Gilbert C, Humar A, Covington E, Transplant infectious disease : an official journal of the Transplantation Society, 2005, 10.1111/j.1399-3062.2005.00112.x
Human metapneumovirus genetic variability, South Africa., Ludewick HP, Abed Y, van Niekerk N, Boivin G, Klugman KP, Madhi SA, Emerging infectious diseases, 2005, 10.3201/eid1107.050050
Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease., Hamelin ME, Côté S, Laforge J, Lampron N, Bourbeau J, Weiss K, Gilca R, DeSerres G, Boivin G, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, 10.1086/431981
Pathogenesis of human metapneumovirus lung infection in BALB/c mice and cotton rats., Hamelin ME, Yim K, Kuhn KH, Cragin RP, Boukhvalova M, Blanco JC, Prince GA, Boivin G, Journal of virology, 2005, 10.1128/jvi.79.14.8894-8903.2005
A trial of valganciclovir prophylaxis for cytomegalovirus prevention in lung transplant recipients., Humar A, Kumar D, Preiksaitis J, Boivin G, Siegal D, Fenton J, Jackson K, Nia S, Lien D, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2005, 10.1111/j.1600-6143.2005.00866.x
Human cytomegalovirus resistance to antiviral drugs., Gilbert C, Boivin G, Antimicrobial agents and chemotherapy, 2005, 10.1128/aac.49.3.873-883.2005
Development and validation of an enzyme-linked immunosorbent assay for human metapneumovirus serology based on a recombinant viral protein., Hamelin ME, Boivin G, Clinical and diagnostic laboratory immunology, 2005, 10.1128/cdli.12.2.249-253.2005
Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations., Abed Y, Goyette N, Boivin G, Antimicrobial agents and chemotherapy, 2005, 10.1128/aac.49.2.556-559.2005
Influenza virus activates human immunodeficiency virus type-1 gene expression in human CD4-expressing T cells through an NF-kappaB-dependent pathway., Sun J, Bergeron M, Barbeau B, Boivin G, Tremblay MJ, Clinical immunology (Orlando, Fla.), 2005, 10.1016/j.clim.2004.10.002
Analysis of replication kinetics of the human metapneumovirus in different cell lines by real-time PCR., Deffrasnes C, Côté S, Boivin G, Journal of clinical microbiology, 2005, 10.1128/jcm.43.1.488-490.2005
Human parechovirus 3 and neonatal infections., Boivin G, Abed Y, Boucher FD, Emerging infectious diseases, 2005, 10.3201/eid1101.040606
Canadian consensus guidelines for the management of cytomegalovirus disease in HIV/AIDS., Lalonde RG, Boivin G, Deschênes J, Hodge WG, Hopkins JJ, Klein AH, Lindley JI, Phillips P, Shafran SD, Walmsley S, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2004, 10.1155/2004/369390
A reverse genetics study of resistance to neuraminidase inhibitors in an influenza A/H1N1 virus., Abed Y, Goyette N, Boivin G, Antiviral therapy, 2004
Comparative evaluation of three serological methods for detection of human herpesvirus 8-specific antibodies in Canadian allogeneic stem cell transplant recipients., Sergerie Y, Abed Y, Roy J, Boivin G, Journal of clinical microbiology, 2004, 10.1128/jcm.42.6.2663-2667.2004
Diagnosis of herpesvirus infections of the central nervous system., Boivin G, Herpes : the journal of the IHMF, 2004
Global genetic diversity of human metapneumovirus fusion gene., Boivin G, Mackay I, Sloots TP, Madhi S, Freymuth F, Wolf D, Shemer-Avni Y, Ludewick H, Gray GC, LeBlanc E, Emerging infectious diseases, 2004, 10.3201/eid1006.031097
Absence of cytomegalovirus-resistance mutations after valganciclovir prophylaxis, in a prospective multicenter study of solid-organ transplant recipients., Boivin G, Goyette N, Gilbert C, Roberts N, Macey K, Paya C, Pescovitz MD, Humar A, Dominguez E, Washburn K, Blumberg E, Alexander B, Freeman R, Covington E, The Journal of infectious diseases, 2004, 10.1086/382753
Fluorescent polymeric transducer for the rapid, simple, and specific detection of nucleic acids at the zeptomole level., Doré K, Dubus S, Ho HA, Lévesque I, Brunette M, Corbeil G, Boissinot M, Boivin G, Bergeron MG, Boudreau D, Leclerc M, Journal of the American Chemical Society, 2004, 10.1021/ja038900d
Human metapneumovirus: a new player among respiratory viruses., Hamelin ME, Abed Y, Boivin G, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, 10.1086/382536
Sequence polymorphism of the predicted human metapneumovirus G glycoprotein., Peret TCT, Abed Y, Anderson LJ, Erdman DD, Boivin G, The Journal of general virology, 2004, 10.1099/vir.0.19504-0
Multiplex real-time PCR assay for detection of influenza and human respiratory syncytial viruses., Boivin G, Côté S, Déry P, De Serres G, Bergeron MG, Journal of clinical microbiology, 2004, 10.1128/jcm.42.1.45-51.2004
Human metapneumovirus-associated lower respiratory tract infections among hospitalized human immunodeficiency virus type 1 (HIV-1)-infected and HIV-1-uninfected African infants., Madhi SA, Ludewick H, Abed Y, Klugman KP, Boivin G, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, 10.1086/379771
Evolution of surface and nonstructural-1 genes of influenza B viruses isolated in the Province of Québec, Canada, during the 1998-2001 period., Abed Y, Coulthart MB, Li Y, Boivin G, Virus genes, 2003, 10.1023/a:1025768308631
Genetic diversity between human metapneumovirus subgroups., Biacchesi S, Skiadopoulos MH, Boivin G, Hanson CT, Murphy BR, Collins PL, Buchholz UJ, Virology, 2003, 10.1016/s0042-6822(03)00528-2
Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro., Wyde PR, Chetty SN, Jewell AM, Boivin G, Piedra PA, Antiviral research, 2003, 10.1016/s0166-3542(03)00153-0
Comparative evaluation of real-time PCR assays for detection of the human metapneumovirus., Côté S, Abed Y, Boivin G, Journal of clinical microbiology, 2003, 10.1128/jcm.41.8.3631-3635.2003
Evaluation of susceptibility of human herpesvirus 8 to antiviral drugs by quantitative real-time PCR., Sergerie Y, Boivin G, Journal of clinical microbiology, 2003, 10.1128/jcm.41.8.3897-3900.2003
Quantification of the influenza virus load by real-time polymerase chain reaction in nasopharyngeal swabs of patients treated with oseltamivir., Boivin G, Coulombe Z, Wat C, The Journal of infectious diseases, 2003, 10.1086/377046
Cytomegalovirus (CMV) glycoprotein B genotypes and response to antiviral therapy, in solid-organ-transplant recipients with CMV disease., Humar A, Kumar D, Gilbert C, Boivin G, The Journal of infectious diseases, 2003, 10.1086/377002
Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids., Bestman-Smith J, Boivin G, Journal of virology, 2003, 10.1128/jvi.77.14.7820-7829.2003
Human metapneumovirus infections in hospitalized children., Boivin G, De Serres G, Côté S, Gilca R, Abed Y, Rochette L, Bergeron MG, Déry P, Emerging infectious diseases, 2003, 10.3201/eid0906.030017
Sequence analysis of the N, P, M and F genes of Canadian human metapneumovirus strains., Bastien N, Normand S, Taylor T, Ward D, Peret TC, Boivin G, Anderson LJ, Li Y, Virus research, 2003, 10.1016/s0168-1702(03)00065-0
Discordant phenotypes and genotypes of cytomegalovirus (CMV) in patients with AIDS and relapsing CMV retinitis., Gilbert C, Boivin G, AIDS (London, England), 2003, 10.1097/00002030-200302140-00007
Quantification of human herpesvirus 8 by real-time PCR in blood fractions of AIDS patients with Kaposi's sarcoma and multicentric Castleman's disease., Boivin G, Côté S, Cloutier N, Abed Y, Maguigad M, Routy JP, Journal of medical virology, 2002, 10.1002/jmv.10217
Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups., Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Côté S, Peret TC, Erdman DD, Anderson LJ, The Journal of infectious diseases, 2002, 10.1086/344319
Characterization of 2 influenza A(H3N2) clinical isolates with reduced susceptibility to neuraminidase inhibitors due to mutations in the hemagglutinin gene., Abed Y, Bourgault AM, Fenton RJ, Morley PJ, Gower D, Owens IJ, Tisdale M, Boivin G, The Journal of infectious diseases, 2002, 10.1086/344237
Respiratory tract reinfections by the new human Metapneumovirus in an immunocompromised child., Pelletier G, Déry P, Abed Y, Boivin G, Emerging infectious diseases, 2002, 10.3201/eid0809.020238
Cytomegalovirus (CMV) virus load kinetics to predict recurrent disease in solid-organ transplant patients with CMV disease., Humar A, Kumar D, Boivin G, Caliendo AM, The Journal of infectious diseases, 2002, 10.1086/342601
Divergent evolution of hemagglutinin and neuraminidase genes in recent influenza A:H3N2 viruses isolated in Canada., Abed Y, Hardy I, Li Y, Boivin G, Journal of medical virology, 2002, 10.1002/jmv.10143
Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain., Boivin G, Coulombe Z, Rivest S, The European journal of neuroscience, 2002, 10.1046/j.1460-9568.2002.02057.x
Susceptibility of recent Canadian influenza A and B virus isolates to different neuraminidase inhibitors., Boivin G, Goyette N, Antiviral research, 2002, 10.1016/s0166-3542(01)00219-4
Characterization of human metapneumoviruses isolated from patients in North America., Peret TC, Boivin G, Li Y, Couillard M, Humphrey C, Osterhaus AD, Erdman DD, Anderson LJ, The Journal of infectious diseases, 2002, 10.1086/340518
Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy., Bestman-Smith J, Boivin G, Journal of medical virology, 2002, 10.1002/jmv.2195
Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms., Gilbert C, Bestman-Smith J, Boivin G, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 2002, 10.1016/s1368-7646(02)00021-3
Role of picornaviruses in flu-like illnesses of adults enrolled in an oseltamivir treatment study who had no evidence of influenza virus infection., Boivin G, Osterhaus AD, Gaudreau A, Jackson HC, Groen J, Ward P, Journal of clinical microbiology, 2002, 10.1128/jcm.40.2.330-334.2002
Prolonged excretion of amantadine-resistant influenza a virus quasi species after cessation of antiviral therapy in an immunocompromised patient., Boivin G, Goyette N, Bernatchez H, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, 10.1086/338870
Syncytium formation and HIV-1 replication are both accentuated by purified influenza and virus-associated neuraminidase., Sun J, Barbeau B, Sato S, Boivin G, Goyette N, Tremblay MJ, The Journal of biological chemistry, 2002, 10.1074/jbc.m110764200
Lack of emergence of cytomegalovirus UL97 mutations conferring ganciclovir (GCV) resistance following preemptive GCV therapy in allogeneic stem cell transplant recipients., Gilbert C, Roy J, Belanger R, Delage R, Beliveau C, Demers C, Boivin G, Antimicrobial agents and chemotherapy, 2001, 10.1128/aac.45.12.3669-3671.2001
Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as induction and maintenance therapy for CMV retinitis., Boivin G, Gilbert C, Gaudreau A, Greenfield I, Sudlow R, Roberts NA, The Journal of infectious diseases, 2001, 10.1086/324672
Case study: rapid emergence of a cytomegalovirus UL97 mutant in a heart-transplant recipient on pre-emptive ganciclovir therapy., Gilbert C, LeBlanc MH, Boivin G, Herpes : the journal of the IHMF, 2001
Molecular evolution of influenza A/H3N2 viruses in the province of Québec (Canada) during the 1997-2000 period., Hardy I, Li Y, Coulthart MB, Goyette N, Boivin G, Virus research, 2001, 10.1016/s0168-1702(01)00269-6
Highly reliable heterologous system for evaluating resistance of clinical herpes simplex virus isolates to nucleoside analogues., Bestman-Smith J, Schmit I, Papadopoulou B, Boivin G, Journal of virology, 2001, 10.1128/jvi.75.7.3105-3110.2001
Evaluation of a rapid optical immunoassay for influenza viruses (FLU OIA test) in comparison with cell culture and reverse transcription-PCR., Boivin G, Hardy I, Kress A, Journal of clinical microbiology, 2001, 10.1128/jcm.39.2.730-732.2001
Quantitative analysis of cytomegalovirus (CMV) viremia using the pp65 antigenemia assay and the COBAS AMPLICOR CMV MONITOR PCR test after blood and marrow allogeneic transplantation., Boivin G, Bélanger R, Delage R, Béliveau C, Demers C, Goyette N, Roy J, Journal of clinical microbiology, 2000, 10.1128/jcm.38.12.4356-4360.2000
Predicting influenza infections during epidemics with use of a clinical case definition., Boivin G, Hardy I, Tellier G, Maziade J, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000, 10.1086/317425
Evaluation of the human herpesvirus 8 DNA load in blood and Kaposi's sarcoma skin lesions from AIDS patients on highly active antiretroviral therapy., Boivin G, Gaudreau A, Routy JP, AIDS (London, England), 2000, 10.1097/00002030-200009080-00004
Recent advances in management of genital herpes., Tétrault I, Boivin G, Canadian family physician Medecin de famille canadien, 2000
Reply, Boivin G, The Journal of infectious diseases, 2000, 10.1086/315668
Human herpesvirus 8 infection of the genital tract of HIV-seropositive and HIV-seronegative women at risk of sexually transmitted diseases. Canadian Women's HIV Study Group., Boivin G, Hankins C, Lapointe N, Walmsley S, Gaudreau A, Forest P, Coutlée F, AIDS (London, England), 2000, 10.1097/00002030-200005260-00028
Rapid antiviral effect of inhaled zanamivir in the treatment of naturally occurring influenza in otherwise healthy adults., Boivin G, Goyette N, Hardy I, Aoki F, Wagner A, Trottier S, The Journal of infectious diseases, 2000, 10.1086/315392
Clearance of cytomegalovirus viremia after initiation of highly active antiretroviral therapy., Boivin G, LeBlanc RP, The Journal of infectious diseases, 2000, 10.1086/315358
Human cytomegalovirus glycoprotein B genotypes in blood of AIDS patients: lack of association with either the viral DNA load in leukocytes or presence of retinitis., Gilbert C, Handfield J, Toma E, Lalonde R, Bergeron MG, Boivin G, Journal of medical virology, 1999, 10.1002/(sici)1096-9071(199909)59:1<98::aid-jmv16>3.0.co;2-a
Characterization of the DNA polymerase and thymidine kinase genesof herpes simplex virus isolates from AIDS patients in whom acyclovirand foscarnet therapy sequentially failed., Schmit I, Boivin G, The Journal of infectious diseases, 1999, 10.1086/314900
Expression of the late cytomegalovirus (CMV) pp150 transcript in leukocytes of AIDS patients is associated with a high viral DNA load in leukocytes and presence of CMV DNA in plasma., Boivin G, Handfield J, Toma E, Lalonde R, Bergeron MG, The Journal of infectious diseases, 1999, 10.1086/314721
Human herpesvirus 8 DNA load in leukocytes of human immunodeficiency virus-infected subjects: correlation with the presence of Kaposi's sarcoma and response to anticytomegalovirus therapy., Boivin G, Gaudreau A, Toma E, Lalonde R, Routy JP, Murray G, Handfield J, Bergeron MG, Antimicrobial agents and chemotherapy, 1999, 10.1128/aac.43.2.377
Reply , Boivin G, The Journal of infectious diseases, 1998, 10.1086/314472
Evaluation of the AMPLICOR cytomegalovirus test with specimens from human immunodeficiency virus-infected subjects., Boivin G, Handfield J, Toma E, Murray G, Lalonde R, Tevere VJ, Sun R, Bergeron MG, Journal of clinical microbiology, 1998, 10.1128/jcm.36.9.2509-2513.1998
Drug-resistant herpesviruses: should we look for them?, Boivin G, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1998, 10.1007/bf01708615
Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients., Gaudreau A, Hill E, Balfour HH, Erice A, Boivin G, The Journal of infectious diseases, 1998, 10.1086/515626
Quantitation of cytomegalovirus: methodologic aspects and clinical applications., Boeckh M, Boivin G, Clinical microbiology reviews, 1998, 10.1128/cmr.11.3.533
Comparative evaluation of the cytomegalovirus DNA load in polymorphonuclear leukocytes and plasma of human immunodeficiency virus-infected subjects., Boivin G, Handfield J, Toma E, Murray G, Lalonde R, Bergeron MG, The Journal of infectious diseases, 1998, 10.1086/514190
Emergence and prevalence of cytomegalovirus UL97 mutations associated with ganciclovir resistance in AIDS patients., Gilbert C, Handfield J, Toma E, Lalonde R, Bergeron MG, Boivin G, AIDS (London, England), 1998, 10.1097/00002030-199802000-00001
A case of ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with AIDS: longitudinal molecular analysis of the CMV viral load and viral mutations in blood compartments., Boivin G, Gilbert C, Morissette M, Handfield J, Goyette N, Bergeron MG, AIDS (London, England), 1997, 10.1097/00002030-199707000-00005
Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients., Erice A, Gil-Roda C, Pérez JL, Balfour HH, Sannerud KJ, Hanson MN, Boivin G, Chou S, The Journal of infectious diseases, 1997, 10.1086/516446
Early effects of ganciclovir therapy on the quantity of cytomegalovirus DNA in leukocytes of immunocompromised patients., Boivin G, Quirk MR, Kringstad BA, Germain M, Jordan MC, Antimicrobial agents and chemotherapy, 1997, 10.1128/aac.41.4.860
Quantitation of cytomegalovirus (CMV) DNA in leukocytes of human immunodeficiency virus-infected subjects with and without CMV disease by using PCR and the SHARP Signal Detection System., Boivin G, Handfield J, Murray G, Toma E, Lalonde R, Lazar JG, Bergeron MG, Journal of clinical microbiology, 1997, 10.1128/jcm.35.2.525-526.1997
Effect of foscarnet on quantities of cytomegalovirus and human immunodeficiency virus in blood of persons with AIDS., Balfour HH, Fletcher CV, Erice A, Henry WK, Acosta EP, Smith SA, Holm MA, Boivin G, Shepp DH, Crumpacker CS, Eaton CA, Martin-Munley SS, Antimicrobial agents and chemotherapy, 1996, 10.1128/aac.40.12.2721
Quantitation of cytomegalovirus DNA and characterization of viral gene expression in bronchoalveolar cells of infected patients with and without pneumonitis., Boivin G, Olson CA, Quirk MR, Kringstad B, Hertz MI, Jordan MC, The Journal of infectious diseases, 1996, 10.1093/infdis/173.6.1304
Detection of ganciclovir resistance mutations quantitation of cytomegalovirus (CMV) DNA in leukocytes of patients with fatal disseminated CMV disease., Boivin G, Chou S, Quirk MR, Erice A, Jordan MC, The Journal of infectious diseases, 1996, 10.1093/infdis/173.3.523
Quantitation of human cytomegalovirus glycoprotein H gene in cells using competitive PCR and a rapid fluorescence-based detection system., Boivin G, Olson CA, Quirk MR, St-Cyr SM, Jordan MC, Journal of virological methods, 1995, 10.1016/0166-0934(94)00128-4
Phenotypic and genotypic characterization of acyclovir-resistant varicella-zoster viruses isolated from persons with AIDS., Boivin G, Edelman CK, Pedneault L, Talarico CL, Biron KK, Balfour HH, The Journal of infectious diseases, 1994, 10.1093/infdis/170.1.68
Intravenous ciprofloxacin disposition in obesity., Allard S, Kinzig M, Boivin G, Sörgel F, LeBel M, Clinical pharmacology and therapeutics, 1993, 10.1038/clpt.1993.162
Ganciclovir susceptibilities of cytomegalovirus (CMV) isolates from solid organ transplant recipients with CMV viremia after antiviral prophylaxis., Boivin G, Erice A, Crane DD, Dunn DL, Balfour HH, The Journal of infectious diseases, 1993, 10.1093/infdis/168.2.332
Acyclovir susceptibilities of herpes simplex virus strains isolated from solid organ transplant recipients after acyclovir or ganciclovir prophylaxis., Boivin G, Erice A, Crane DD, Dunn DL, Balfour HH, Antimicrobial agents and chemotherapy, 1993, 10.1128/aac.37.2.357
[The emergence of viruses resistant to antiviral agents: a new challenge]., Boivin G, L'union medicale du Canada, 1993
Norwalk-like gastroenteritis epidemic in a teaching hospital--Quebec., Boivin G, Murray G, Courtinat Y, Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada, 1990
Resistance of Herpesviruses to Antiviral Agents, G. Boivin, W. L. Drew, Antimicrobial Resistance and Implications for the Twenty-First Century, 1911, 10.1007/978-0-387-72418-8_8

...

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009

France Feuillet - Doctorat - En cours
Olus Uyar - Doctorat - En cours
Marie-Josée Toulouse - Doctorat - En cours
Shella Gilbert-Girard - Post-doctorat - En cours
Amel Saim Mamoun - Doctorat - En cours
Daniela Alicja Ogonczyk-Makowska - Doctorat - En cours
Lina Lapeyre - Doctorat - En cours
Philippe Simon - Maitrîse avec mémoire - 2010/09
Mario Andres Pizzorno - Maitrîse avec mémoire - 2011/05
Lady Tatiana Pinilla - Maitrîse avec mémoire - 2012/09
Rafik Menasria - Maitrîse avec mémoire - 2013/05
Julie Ann - Doctorat - 2015/01
Emilien Drouot - Doctorat - 2015/09
Miguel Retamal - Doctorat - 2016/09
Véronique Tu - Maitrîse avec mémoire - 2017/09
Julia Dubois - Doctorat - 2018/01
Martin Pilaev - Maitrîse avec mémoire - 2018/09
Coraline Canivet - Doctorat - 2019/09
Karima Zarrouk - Doctorat - 2021/05
William Enlow - Maitrîse avec mémoire - 2021/09
Zeineb M'hamdi - Doctorat - 2021/09

Encadrement d'étudiant(e)s pour les programmes suivants :

Microbiologie-immunologie

Disponibilité d'encadrement d'étudiant(e)s

Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

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