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Girish M. Shah

Professeur titulaire

Girish M. Shah
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire
Neurosciences et santé mentale
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Apoptose et cancer
  • Cancer de la peau
  • Cancer de l'appareil digestif
  • Carcinogénèse
  • Chimiothérapie
  • Diagnostic et détection du cancer
  • Environnement et cancer
  • Interaction hôte - tumeur
  • Oncogènes
  • Radiothérapie
Neurosciences, santé mentale et toxicomanies
  • Apoptose
  • Maladies neuroendocriniennes
Génomique et protéomique
  • Mécanismes biologiques et biochimiques
Organisation et fonctions biologiques

Projets de recherche

  • Potentiation of PRRT by chemotherapy-mediated upregulation of somatostatin receptor 2 in NET cell lines-derived tumors in mice and in Lung NET patient-derived tumor explants - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2022-04-01 au 2024-12-31
  • Chemotherapy-induced upregulation of somatostatin receptors for enhancing therapeutic efficacy of, and eligibility to PRRT of neuroendocrine tumors - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2020-07-01 au 2022-12-31
  • Multiple roles of poly (ADP-ribose) polymerase-1 in mammalian nucleotide excision repair. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31
  • Role of Poly(ADP-ribose) Polymerase-1 (PARP1) in Hypoxia-induced Thrombosis - Institut indo-canadien Shastri (Canada) - Shastri Institutional Collaborative Research Grant (SICRG) 2018-2019, Jamia Millia Islamia, co-chercheur - 2018-10-01 au 2021-03-15

Publications

  • Chemotherapy-Induced Upregulation of Somatostatin Receptor-2 Increases the Uptake and Efficacy of 177Lu-DOTA-Octreotate in Neuroendocrine Tumor Cells, Rashmi G. Shah, Marine A. Merlin, Samuel Adant, Fayçal Zine-Eddine, Jean-Mathieu Beauregard, Girish M. Shah, Cancers, 2021, 10.3390/cancers13020232
  • Methods to Study Intracellular Movement and Localization of the Nucleotide Excision Repair Proteins at the DNA Lesions in Mammalian Cells, , Frontiers in Cell and Developmental Biology, 2020, 10.3389/fcell.2020.590242
  • Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome, , Journal of Experimental Medicine, 2020, 10.1084/jem.20191688
  • Enhanced Dark-Field Hyperspectral Imaging and Spectral Angle Mapping for Nanomaterial Detection in Consumer Care Products and in Skin Following Dermal Exposure, , Chemical Research in Toxicology, 2020, 10.1021/acs.chemrestox.0c00090
  • A panel of criteria for comprehensive assessment of severity of ultraviolet B radiation-induced non-melanoma skin cancers in SKH-1 mice, , Journal of Photochemistry and Photobiology B: Biology, 2020, 10.1016/j.jphotobiol.2020.111847
  • Combination treatments to enhance peptide receptor radionuclide therapy of neuroendocrine tumours, , European Journal of Nuclear Medicine and Molecular Imaging, 2020, 10.1007/s00259-019-04499-x
  • Potentiation of 177Lu-octreotate peptide receptor radionuclide therapy of human neuroendocrine tumor cells by PARP inhibitor, , Oncotarget, 2018, 10.18632/oncotarget.25266
  • Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair, , Proceedings of the National Academy of Sciences, 2017, 10.1073/pnas.1706981114
  • Comprehensive measurement of UVB-induced non-melanoma skin cancer burden in mice using photographic images as a substitute for the caliper method, , PLOS ONE, 2017, 10.1371/journal.pone.0171875
  • Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro, , Scientific Reports, 2016, 10.1038/srep19020
  • PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining, , Molecular Cell, 2016, 10.1016/j.molcel.2016.01.019
  • Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study, , PLOS ONE, 2015, 10.1371/journal.pone.0128244
  • Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair, , Proceedings of the National Academy of Sciences, 2013, 10.1073/pnas.1209507110
  • PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets, , Frontiers in Oncology, 2013, 10.3389/fonc.2013.00279
  • Resistance to PARP-Inhibitors in Cancer Therapy, , Frontiers in Pharmacology, 2013, 10.3389/fphar.2013.00018
  • Approaches to Detect PARP-1 Activation In Vivo, In Situ, and In Vitro, , Methods in Molecular Biology, 2011, 10.1007/978-1-61779-270-0_1
  • Persistence of Different Forms of Transient RNAi during Apoptosis in Mammalian Cells, , PLoS ONE, 2010, 10.1371/journal.pone.0012263
  • Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1, , Cell Death & Differentiation, 2009, 10.1038/cdd.2009.15
  • Depletion of poly(ADP-ribose) polymerase-1 reduces host cell reactivation of a UV-damaged adenovirus-encoded reporter gene in human dermal fibroblasts, , DNA Repair, 2008, 10.1016/j.dnarep.2008.01.001
  • Biochemical Assessment of Niacin Deficiency Among Carcinoid Cancer Patients, , The American Journal of Gastroenterology, 2005, 10.1111/j.1572-0241.2005.00268.x
  • DNA vector-based RNAi approach for stable depletion of poly(ADP-ribose) polymerase-1, , Biochemical and Biophysical Research Communications, 2005, 10.1016/j.bbrc.2005.03.135
  • Mechanism of early biphasic activation of poly(ADP-ribose) polymerase-1 in response to ultraviolet B radiation, , Journal of Cell Science, 2005, 10.1242/jcs.01636
  • Defective control of mitotic and post-mitotic checkpoints in poly(ADP-ribose) polymerase-1(-/-) fibroblasts after mitotic spindle disruption., , Cell cycle (Georgetown, Tex.), 2004
  • Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage, , Proceedings of the National Academy of Sciences, 2002, 10.1073/pnas.012460399
  • Survival and Proliferation of Cells Expressing Caspase-uncleavable Poly(ADP-ribose) Polymerase in Response to Death-inducing DNA Damage by an Alkylating Agent, , Journal of Biological Chemistry, 1999, 10.1074/jbc.274.52.37097
  • SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis, , Journal of Cell Biology, 1998, 10.1083/jcb.143.5.1361
  • Cellular Responses to DNA Damage in the Absence of Poly(ADP-ribose) Polymerase, , Biochemical and Biophysical Research Communications, 1998, 10.1006/bbrc.1998.8257
  • Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death., , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997, 10.1139/bcb-75-4-337
  • Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells., , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1889
  • Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique., , Analytical biochemistry, 1995, 10.1006/abio.1995.0016
  • Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo., , Analytical biochemistry, 1995, 10.1006/abio.1995.1245

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Marc Bazin - Maitrîse avec mémoire - En cours
  • Marine Merlin - Doctorat - En cours
  • Nancy Petitclerc - Maitrîse avec mémoire - 2012/05
  • Mihaela Robu - Doctorat - 2017/05
  • Nupur Purohit - Doctorat - 2020/05
  • Samuel Adant - Maitrîse avec mémoire - 2021/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine,  local 4645
Québec, Québec G1V 0A6
Canada

Renseignements - Secrétariat :
vdres@fmed.ulaval.ca
Téléphone 418 656-2690

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

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