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Girish M. Shah

Professeur titulaire

Girish M. Shah
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire
Neurosciences et santé mentale
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Apoptose et cancer
  • Cancer de la peau
  • Cancer de l'appareil digestif
  • Carcinogénèse
  • Chimiothérapie
  • Diagnostic et détection du cancer
  • Environnement et cancer
  • Interaction hôte - tumeur
  • Oncogènes
  • Radiothérapie
Neurosciences, santé mentale et toxicomanies
  • Apoptose
  • Maladies neuroendocriniennes
Génomique et protéomique
  • Mécanismes biologiques et biochimiques
Organisation et fonctions biologiques

Projets de recherche

  • Roles of poly (ADP-ribose) polymerase-1 in mammalian transcription-coupled nucleotide excision repair of DNA damage - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2022-04-01 au 2027-03-31
  • Potentiation of PRRT by chemotherapy-mediated upregulation of somatostatin receptor 2 in NET cell lines-derived tumors in mice and in Lung NET patient-derived tumor explants - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2022-04-01 au 2024-12-31
  • Chemotherapy-induced upregulation of somatostatin receptors for enhancing therapeutic efficacy of, and eligibility to PRRT of neuroendocrine tumors - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2020-07-01 au 2022-12-31
  • Multiple roles of poly (ADP-ribose) polymerase-1 in mammalian nucleotide excision repair. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31
  • Role of Poly(ADP-ribose) Polymerase-1 (PARP1) in Hypoxia-induced Thrombosis - Institut indo-canadien Shastri (Canada) - Shastri Institutional Collaborative Research Grant (SICRG) 2018-2019, Jamia Millia Islamia, co-chercheur - 2018-10-01 au 2021-03-15

Publications

  • Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates, , Nature communications, 2022, 10.1038/s41467-022-30376-7
  • Suppression of oxidative-stress induced melanocyte death: Role of poly(ADP-ribose) polymerase in vitiligo pathogenesis, , Indian journal of dermatology, venereology and leprology, 2022, 10.25259/IJDVL_290_2021
  • Chemotherapy-Induced Upregulation of Somatostatin Receptor-2 Increases the Uptake and Efficacy of Lu-DOTA-Octreotate in Neuroendocrine Tumor Cells, , Cancers, 2021, 10.3390/cancers13020232
  • Poly (ADP-ribose) polymerase (PARP) inhibition in cancer: Potential impact in cancer stem cells and therapeutic implications, , European journal of pharmacology, 2021, 10.1016/j.ejphar.2021.174546
  • Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair, , Journal of cell science, 2021, 10.1242/jcs.247809
  • A panel of criteria for comprehensive assessment of severity of ultraviolet B radiation-induced non-melanoma skin cancers in SKH-1 mice, , Journal of photochemistry and photobiology. B, Biology, 2020, 10.1016/j.jphotobiol.2020.111847
  • Combination treatments to enhance peptide receptor radionuclide therapy of neuroendocrine tumours, , European journal of nuclear medicine and molecular imaging, 2020, 10.1007/s00259-019-04499-x
  • Enhanced Dark-Field Hyperspectral Imaging and Spectral Angle Mapping for Nanomaterial Detection in Consumer Care Products and in Skin Following Dermal Exposure, , Chemical research in toxicology, 2020, 10.1021/acs.chemrestox.0c00090
  • Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome, , The Journal of experimental medicine, 2020, 10.1084/jem.20191688
  • Methods to Study Intracellular Movement and Localization of the Nucleotide Excision Repair Proteins at the DNA Lesions in Mammalian Cells, , Frontiers in cell and developmental biology, 2020, 10.3389/fcell.2020.590242
  • Potentiation of Lu-octreotate peptide receptor radionuclide therapy of human neuroendocrine tumor cells by PARP inhibitor, , Oncotarget, 2018, 10.18632/oncotarget.25266
  • Comprehensive measurement of UVB-induced non-melanoma skin cancer burden in mice using photographic images as a substitute for the caliper method, , PloS one, 2017, 10.1371/journal.pone.0171875
  • Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair, , Proceedings of the National Academy of Sciences of the United States of America, 2017, 10.1073/pnas.1706981114
  • Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro, , Scientific reports, 2016, 10.1038/srep19020
  • PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining, , Molecular cell, 2016, 10.1016/j.molcel.2016.01.019
  • Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study, , PloS one, 2015, 10.1371/journal.pone.0128244
  • PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets, , Frontiers in oncology, 2013, 10.3389/fonc.2013.00279
  • Resistance to PARP-Inhibitors in Cancer Therapy, , Frontiers in pharmacology, 2013, 10.3389/fphar.2013.00018
  • Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair, , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1209507110
  • Approaches to detect PARP-1 activation in vivo, in situ, and in vitro, , Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61779-270-0_1
  • Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1, , Mutation research, 2011, 10.1016/j.mrfmmm.2011.04.006
  • Persistence of different forms of transient RNAi during apoptosis in mammalian cells, , PloS one, 2010, 10.1371/journal.pone.0012263
  • Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent, , Current cancer drug targets, 2010, 10.2174/156800910791208571
  • Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1, , Cell death and differentiation, 2009, 10.1038/cdd.2009.15
  • Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells, , Mutation research, 2009, 10.1016/j.mrfmmm.2009.02.005
  • Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis, , The international journal of biochemistry & cell biology, 2009, 10.1016/j.biocel.2008.09.026
  • Depletion of poly(ADP-ribose) polymerase-1 reduces host cell reactivation of a UV-damaged adenovirus-encoded reporter gene in human dermal fibroblasts, , DNA repair, 2008, 10.1016/j.dnarep.2008.01.001
  • Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity, , European journal of cancer (Oxford, England : 1990), 2008, 10.1016/j.ejca.2008.03.019
  • Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome, , The Journal of biological chemistry, 2007, 10.1074/jbc.M610502200
  • Biochemical assessment of niacin deficiency among carcinoid cancer patients, , The American journal of gastroenterology, 2005, 10.1111/j.1572-0241.2005.00268.x
  • DNA vector-based RNAi approach for stable depletion of poly(ADP-ribose) polymerase-1, , Biochemical and biophysical research communications, 2005, 10.1016/j.bbrc.2005.03.135
  • Mechanism of early biphasic activation of poly(ADP-ribose) polymerase-1 in response to ultraviolet B radiation, , Journal of cell science, 2005, 10.1242/jcs.01636
  • Defective control of mitotic and post-mitotic checkpoints in poly(ADP-ribose) polymerase-1(-/-) fibroblasts after mitotic spindle disruption, , Cell cycle (Georgetown, Tex.), 2004
  • Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats, , The Journal of nutrition, 2002, 10.1093/jn/132.1.108
  • Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats, , The Journal of nutrition, 2002, 10.1093/jn/132.1.115
  • Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage, , Proceedings of the National Academy of Sciences of the United States of America, 2002, 10.1073/pnas.012460399
  • Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia, , The Journal of nutrition, 2000, 10.1093/jn/130.5.1102
  • Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment, , Molecular and cellular biochemistry, 1999
  • Survival and proliferation of cells expressing caspase-uncleavable Poly(ADP-ribose) polymerase in response to death-inducing DNA damage by an alkylating agent, , The Journal of biological chemistry, 1999, 10.1074/jbc.274.52.37097
  • 6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin, , Clinical cancer research : an official journal of the American Association for Cancer Research, 1998
  • Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase, , Biochemical and biophysical research communications, 1998, 10.1006/bbrc.1998.8257
  • SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis, , The Journal of cell biology, 1998, 10.1083/jcb.143.5.1361
  • Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase, , Biochimica et biophysica acta, 1997, 10.1016/s0304-4165(96)00077-3
  • Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death, , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • Specific cleavage of the large subunit of replication factor C in apoptosis is mediated by CPP32-like protease, , Biochemical and biophysical research communications, 1997, 10.1006/bbrc.1997.6456
  • Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H10T1/2 cells from oxidative stress, , Biochimica et biophysica acta, 1996, 10.1016/0167-4889(96)00004-3
  • Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells, , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1889
  • Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment, , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1565
  • New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis, , The Journal of biological chemistry, 1996, 10.1074/jbc.271.46.29073
  • Biochemical properties and function of poly(ADP-ribose) glycohydrolase, , Biochimie, 1995, 10.1016/0300-9084(96)88156-9
  • Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique, , Analytical biochemistry, 1995, 10.1006/abio.1995.0016
  • Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo, , Analytical biochemistry, 1995, 10.1006/abio.1995.1245
  • Rapid removal of nonspecific background in silver-stained polyacrylamide gel, , Analytical biochemistry, 1995, 10.1006/abio.1995.9947
  • Erasable blot of poly(ADP-ribose) polymerase, , Analytical biochemistry, 1994, 10.1006/abio.1994.1212
  • Mode of action of poly(ADP-ribose) glycohydrolase, , Biochimica et biophysica acta, 1994, 10.1016/0167-4781(94)90058-2
  • Poly(ADP-ribose) catabolism in mammalian cells, , Molecular and cellular biochemistry, 1994, 10.1007/BF00928442
  • Purification of poly(ADP-ribose) glycohydrolase and detection of its isoforms by a zymogram following one- or two-dimensional electrophoresis, , Analytical biochemistry, 1994, 10.1006/abio.1994.1177
  • Inhibition of rat hepatic nuclear RNA synthesis in vivo and in vitro by benzo a pyrene, , Polycyclic aromatic compounds, 1993
  • Mechanism of induction of c-fos by ultraviolet B (290-320 nm) in mouse JB6 epidermal cells, , Cancer research, 1993
  • Action of some retinol derivatives and their provitamins on microsome-catalyzed formation of benzo a pyrene-DNA adduct, , Journal of biochemical toxicology, 1992, 10.1002/jbt.2570070307
  • Modulation of transcription in rat liver nuclei in vitro by a diol epoxide of benzo a pyrene, , Journal of biochemical toxicology, 1992, 10.1002/jbt.2570070104
  • Oxidant carcinogenesis and antioxidant defense, , Annals of the New York Academy of Sciences, 1992, 10.1111/j.1749-6632.1992.tb38659.x
  • The effect of some new platinum (II) and palladium (II) coordination complexes on rat hepatic nuclear transcription in vitro, , Life sciences, 1992, 10.1016/0024-3205(92)90183-p
  • The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress, , Biochemistry, 1991, 10.1021/bi00102a024
  • Mechanisms of oxidant carcinogenesis, , Progress in clinical and biological research, 1990
  • Alteration in hepatic nuclear RNA polymerase activity following benzo a pyrene administration in rat, , In vivo (Athens, Greece), 1989
  • Modulation of transcription in rat liver by benzo a pyrene, , Cancer letters, 1987, 10.1016/0304-3835(87)90044-9
  • Modulation by plant flavonoids and related phenolics of microsome catalyzed adduct formation between benzo a pyrene and DNA, , Chemico-biological interactions, 1986, 10.1016/s0009-2797(86)80051-5
  • In vivo effect of L-ascorbic acid on benzo(α)pyrene metabolite-DNA adduct formation in rat liver, , Journal of biosciences, 1982, 10.1007/BF02702737
  • Inhibition of L-ascorbate of binding to DNA of benzo(a)pyrene & its metabolites, , Indian journal of biochemistry & biophysics, 1980

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Marc Bazin - Maitrîse avec mémoire - En cours
  • Marine Merlin - Doctorat - En cours
  • Nancy Petitclerc - Maitrîse avec mémoire - 2012/05
  • Mihaela Robu - Doctorat - 2017/05
  • Nupur Purohit - Doctorat - 2020/05
  • Samuel Adant - Maitrîse avec mémoire - 2021/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine, local 4645
Québec (Québec) G1V 0A6
Canada

Renseignements - Secrétariat
418 656-2690
vdres@fmed.ulaval.ca

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

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