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Girish M. Shah

Professeur titulaire

Girish M. Shah
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale
Oncologie

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
  • Apoptose et cancer
  • Cancer de la peau
  • Cancer de l'appareil digestif
  • Carcinogénèse
  • Chimiothérapie
  • Diagnostic et détection du cancer
  • Environnement et cancer
  • Interaction hôte - tumeur
  • Oncogènes
  • Radiothérapie
Neurosciences, santé mentale et toxicomanies
  • Apoptose
  • Maladies neuroendocriniennes
Génomique et protéomique
  • Mécanismes biologiques et biochimiques
Organisation et fonctions biologiques

Projets de recherche

  • Roles of poly (ADP-ribose) polymerase-1 in mammalian transcription-coupled nucleotide excision repair of DNA damage - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2022-04-01 au 2027-03-31
  • Screening of gastroenteropancreatic neuroendocrine tumors from patients for temozolomide-induced upregulation of SSTR2: Towards improved PRRT - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2023-04-01 au 2025-12-31
  • Potentiation of PRRT by chemotherapy-mediated upregulation of somatostatin receptor 2 in NET cell lines-derived tumors in mice and in Lung NET patient-derived tumor explants - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2022-04-01 au 2024-12-31
  • Équipement de laboratoire radiopharmaceutique pour la théranostique et l'imagerie moléculaire innovantes - Ministère de la Santé et des Services sociaux, Fondation du CHU de Québec, Fondation Canadienne pour l'innovation (La) - Fonds des leaders John-R.-Evans (FLJR), co-chercheur - 2022-07-01 au 2023-12-15
  • Chemotherapy-induced upregulation of somatostatin receptors for enhancing therapeutic efficacy of, and eligibility to PRRT of neuroendocrine tumors - Société des tumeurs Carcinoïdes-NeuroEndocrines du Canada, chercheur principal - 2020-07-01 au 2022-12-31

Publications

  • Rapid removal of nonspecific background in silver-stained polyacrylamide gel, , Analytical biochemistry, 1995, 10.1006/abio.1995.9947
  • Methods to Study Intracellular Movement and Localization of the Nucleotide Excision Repair Proteins at the DNA Lesions in Mammalian Cells, , Frontiers in cell and developmental biology, 2020, 10.3389/fcell.2020.590242
  • XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair, Martijn Luijsterburg, Andreas Ladurner, Haico van Attikum, Hannes Lans, Sheera Adar, Girish Shah, Alfred C. O. Vertegaal, Orlando D. Schärer, Hyun-Suk Kim, Angela Kragten, Jin Cai, Daphne E. C. Boer, Tia Tyrsett Kuo, Rashmi G. Shah, Avital Parnas, Adi Yifrach, Román González-Prieto, Melanie van der Woude, Magdalena B. Rother, Claudia Gonzalez-Leal, Diana van den Heuvel, Katja Apelt, Charlotte Blessing, Nature Communications, 2022, 10.1038/s41467-022-31820-4
  • Mechanisms of oxidant carcinogenesis, , Progress in clinical and biological research, 1990
  • Biochemical assessment of niacin deficiency among carcinoid cancer patients, , The American journal of gastroenterology, 2005, 10.1111/j.1572-0241.2005.00268.x
  • Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent, , Current cancer drug targets, 2010, 10.2174/156800910791208571
  • Alteration in hepatic nuclear RNA polymerase activity following benzo a pyrene administration in rat, , In vivo (Athens, Greece), 1989
  • Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair, , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1209507110
  • Characterization of the interactions of PARP-1 with UV-damaged DNA in vivo and in vitro, , Scientific reports, 2016, 10.1038/srep19020
  • Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo, , Analytical biochemistry, 1995, 10.1006/abio.1995.1245
  • Suppression of oxidative-stress induced melanocyte death: Role of poly(ADP-ribose) polymerase in vitiligo pathogenesis, , Indian journal of dermatology, venereology and leprology, 2022, 10.25259/IJDVL_290_2021
  • DNA vector-based RNAi approach for stable depletion of poly(ADP-ribose) polymerase-1, , Biochemical and biophysical research communications, 2005, 10.1016/j.bbrc.2005.03.135
  • Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death, , Biochemistry and cell biology = Biochimie et biologie cellulaire, 1997
  • Abrogation of DNA vector-based RNAi during apoptosis in mammalian cells due to caspase-mediated cleavage and inactivation of Dicer-1, , Cell death and differentiation, 2009, 10.1038/cdd.2009.15
  • The effect of some new platinum (II) and palladium (II) coordination complexes on rat hepatic nuclear transcription in vitro, , Life sciences, 1992, 10.1016/0024-3205(92)90183-p
  • New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis, , The Journal of biological chemistry, 1996, 10.1074/jbc.271.46.29073
  • Comprehensive measurement of UVB-induced non-melanoma skin cancer burden in mice using photographic images as a substitute for the caliper method, , PloS one, 2017, 10.1371/journal.pone.0171875
  • Approaches to detect PARP-1 activation in vivo, in situ, and in vitro, , Methods in molecular biology (Clifton, N.J.), 2011, 10.1007/978-1-61779-270-0_1
  • Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study, , PloS one, 2015, 10.1371/journal.pone.0128244
  • Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment, , Molecular and cellular biochemistry, 1999
  • Purification of poly(ADP-ribose) glycohydrolase and detection of its isoforms by a zymogram following one- or two-dimensional electrophoresis, , Analytical biochemistry, 1994, 10.1006/abio.1994.1177
  • Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1, , Mutation research, 2011, 10.1016/j.mrfmmm.2011.04.006
  • Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair, , Proceedings of the National Academy of Sciences of the United States of America, 2017, 10.1073/pnas.1706981114
  • Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia, , The Journal of nutrition, 2000, 10.1093/jn/130.5.1102
  • Specific cleavage of the large subunit of replication factor C in apoptosis is mediated by CPP32-like protease, , Biochemical and biophysical research communications, 1997, 10.1006/bbrc.1997.6456
  • Modulation of transcription in rat liver by benzo a pyrene, , Cancer letters, 1987, 10.1016/0304-3835(87)90044-9
  • Persistence of different forms of transient RNAi during apoptosis in mammalian cells, , PloS one, 2010, 10.1371/journal.pone.0012263
  • Mode of action of poly(ADP-ribose) glycohydrolase, , Biochimica et biophysica acta, 1994, 10.1016/0167-4781(94)90058-2
  • Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase, , Biochemical and biophysical research communications, 1998, 10.1006/bbrc.1998.8257
  • In vivo effect of L-ascorbic acid on benzo(α)pyrene metabolite-DNA adduct formation in rat liver, , Journal of biosciences, 1982, 10.1007/BF02702737
  • Depletion of poly(ADP-ribose) polymerase-1 reduces host cell reactivation of a UV-damaged adenovirus-encoded reporter gene in human dermal fibroblasts, , DNA repair, 2008, 10.1016/j.dnarep.2008.01.001
  • Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H10T1/2 cells from oxidative stress, , Biochimica et biophysica acta, 1996, 10.1016/0167-4889(96)00004-3
  • Chemotherapy-Induced Upregulation of Somatostatin Receptor-2 Increases the Uptake and Efficacy of Lu-DOTA-Octreotate in Neuroendocrine Tumor Cells, , Cancers, 2021, 10.3390/cancers13020232
  • Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity, , European journal of cancer (Oxford, England : 1990), 2008, 10.1016/j.ejca.2008.03.019
  • Action of some retinol derivatives and their provitamins on microsome-catalyzed formation of benzo a pyrene-DNA adduct, , Journal of biochemical toxicology, 1992, 10.1002/jbt.2570070307
  • 6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin, , Clinical cancer research : an official journal of the American Association for Cancer Research, 1998
  • Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair, , Journal of cell science, 2021, 10.1242/jcs.247809
  • Poly(ADP-ribose) catabolism in mammalian cells, , Molecular and cellular biochemistry, 1994, 10.1007/BF00928442
  • Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly (ADP-ribose) polymerase, , Biochimica et biophysica acta, 1997, 10.1016/s0304-4165(96)00077-3
  • Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis, , The international journal of biochemistry & cell biology, 2009, 10.1016/j.biocel.2008.09.026
  • Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells, , Mutation research, 2009, 10.1016/j.mrfmmm.2009.02.005
  • Erasable blot of poly(ADP-ribose) polymerase, , Analytical biochemistry, 1994, 10.1006/abio.1994.1212
  • Inhibition of rat hepatic nuclear RNA synthesis in vivo and in vitro by benzo a pyrene, , Polycyclic aromatic compounds, 1993
  • Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment, , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1565
  • Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats, , The Journal of nutrition, 2002, 10.1093/jn/132.1.115
  • Modulation of transcription in rat liver nuclei in vitro by a diol epoxide of benzo a pyrene, , Journal of biochemical toxicology, 1992, 10.1002/jbt.2570070104
  • Modulation by plant flavonoids and related phenolics of microsome catalyzed adduct formation between benzo a pyrene and DNA, , Chemico-biological interactions, 1986, 10.1016/s0009-2797(86)80051-5
  • Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage, , Proceedings of the National Academy of Sciences of the United States of America, 2002, 10.1073/pnas.012460399
  • Combination treatments to enhance peptide receptor radionuclide therapy of neuroendocrine tumours, , European journal of nuclear medicine and molecular imaging, 2020, 10.1007/s00259-019-04499-x
  • Survival and proliferation of cells expressing caspase-uncleavable Poly(ADP-ribose) polymerase in response to death-inducing DNA damage by an alkylating agent, , The Journal of biological chemistry, 1999, 10.1074/jbc.274.52.37097
  • Resistance to PARP-Inhibitors in Cancer Therapy, , Frontiers in pharmacology, 2013, 10.3389/fphar.2013.00018
  • Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats, , The Journal of nutrition, 2002, 10.1093/jn/132.1.108
  • Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome, , The Journal of experimental medicine, 2020, 10.1084/jem.20191688
  • Mechanism of induction of c-fos by ultraviolet B (290-320 nm) in mouse JB6 epidermal cells, , Cancer research, 1993
  • Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome, , The Journal of biological chemistry, 2007, 10.1074/jbc.M610502200
  • The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress, , Biochemistry, 1991, 10.1021/bi00102a024
  • Mechanism of early biphasic activation of poly(ADP-ribose) polymerase-1 in response to ultraviolet B radiation, , Journal of cell science, 2005, 10.1242/jcs.01636
  • PARP Inhibitors in Cancer Therapy: Magic Bullets but Moving Targets, , Frontiers in oncology, 2013, 10.3389/fonc.2013.00279
  • Detection of poly(ADP-ribose) polymerase and its apoptosis-specific fragment by a nonisotopic activity-western blot technique, , Analytical biochemistry, 1995, 10.1006/abio.1995.0016
  • SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis, , The Journal of cell biology, 1998, 10.1083/jcb.143.5.1361
  • Enhanced Dark-Field Hyperspectral Imaging and Spectral Angle Mapping for Nanomaterial Detection in Consumer Care Products and in Skin Following Dermal Exposure, , Chemical research in toxicology, 2020, 10.1021/acs.chemrestox.0c00090
  • Oxidant carcinogenesis and antioxidant defense, , Annals of the New York Academy of Sciences, 1992, 10.1111/j.1749-6632.1992.tb38659.x
  • Potentiation of Lu-octreotate peptide receptor radionuclide therapy of human neuroendocrine tumor cells by PARP inhibitor, , Oncotarget, 2018, 10.18632/oncotarget.25266
  • PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining, , Molecular cell, 2016, 10.1016/j.molcel.2016.01.019
  • Poly (ADP-ribose) polymerase (PARP) inhibition in cancer: Potential impact in cancer stem cells and therapeutic implications, , European journal of pharmacology, 2021, 10.1016/j.ejphar.2021.174546
  • Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells, , Biochemical and biophysical research communications, 1996, 10.1006/bbrc.1996.1889
  • Biochemical properties and function of poly(ADP-ribose) glycohydrolase, , Biochimie, 1995, 10.1016/0300-9084(96)88156-9
  • Inhibition of L-ascorbate of binding to DNA of benzo(a)pyrene & its metabolites, , Indian journal of biochemistry & biophysics, 1980
  • Defective control of mitotic and post-mitotic checkpoints in poly(ADP-ribose) polymerase-1(-/-) fibroblasts after mitotic spindle disruption, , Cell cycle (Georgetown, Tex.), 2004
  • A panel of criteria for comprehensive assessment of severity of ultraviolet B radiation-induced non-melanoma skin cancers in SKH-1 mice, , Journal of photochemistry and photobiology. B, Biology, 2020, 10.1016/j.jphotobiol.2020.111847
  • Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates, , Nature communications, 2022, 10.1038/s41467-022-30376-7

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Marine Merlin - Doctorat - En cours
  • Nancy Petitclerc - Maîtrise avec mémoire - 2012/05
  • Mihaela Robu - Doctorat - 2017/05
  • Nupur Purohit - Doctorat - 2020/05
  • Samuel Adant - Maîtrise avec mémoire - 2021/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.