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Frédéric Bretzner
Professeur titulaire
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Médecine régénératrice et moléculaire
Neurosciences et santé mentale
Domaines et intérêts de recherche du (de la) professeur(e) :
Appareil locomoteur et arthrite
Neurosciences, santé mentale et toxicomanies
- Maladies neurologiques
- Traumatismes crânio-encéphaliques et de la moelle épinière
- Maladies de la moelle épinière
- Maladie de Parkinson
- Hémiplégie et paraplégie
- Activité nerveuse et synaptique
- Développement du système nerveux
- Fonctions exécutives
- Système moteur
- Système somato-sensoriel
- Système visuel
Organisation et fonctions biologiques
Projets de recherche
- Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
- Plasticité et développement du contrôle moteur - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2020-07-01 au 2024-06-30
- Salaire d'un professeur - CHU de Québec – Université Laval – CHUL, chercheur principal - 2010-01-01 au 2024-06-30
- Plasticity of midbrain nuclei after spinal cord injury - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
- Deep brain photometry of spatially distinct brain areas using a single optical fiber - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2022-03-31 au 2024-03-30
- Role of DSCAM in the development of motor circuits - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31
- Optimisation du site de stimulation profonde dans la région mésencéphalique - Fondation du CHU de Québec, co-chercheur - 2022-03-30 au 2023-03-29
- Plasticity of Reticulospinal Pathways to Promote Functional Locomotor Recovery Spinal Cord Injury - Wings for Life Spinal Cord Research Foundation, chercheur principal - 2022-02-01 au 2023-01-31
- Plasticity Of Reticulospinal Pathways Following Spinal Cord Injury - Craig H. Neilsen Foundation, chercheur principal - 2019-07-31 au 2022-07-31
- Optogenetic stimulation of glutamatergic neurons of the medullary reticular formation to promote the recovery of voluntary locomotor functions following a hemilesion of the spinal cord in mice - Wings for Life Spinal Cord Research Foundation, chercheur principal - 2019-09-01 au 2021-06-30
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Publications
- Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype., Thiry L, Lemaire C, Rastqar A, Lemieux M, Peng J, Julien Ferent, Marie Roussel, Beaumont E, Fawcett JP, Robert Brownstone, Frederic Charron, Frederic Bretzner, eNeuro, 2022, 10.1523/eneuro.0216-18.2021
- Role of DSCAM in the Development of Neural Control of Movement and Locomotion. , Lemieux M, Thiry L, Olivier D. Laflamme, Frederic Bretzner, International journal of molecular sciences, 2021, 10.3390/ijms22168511
- Focus-tunable microscope for imaging small neuronal processes in freely moving animals, Bagramyan, A., Tabourin, L., Rastqar, A., Karimi, N., Bretzner, F., Galstian, T., Photonics Research, 2021, 10.1364/PRJ.418154
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Impact of ovariectomy and CO
2 inhalation on microglia morphology in select brainstem and hypothalamic areas regulating breathing in female rats, Marques, D.A., Gargaglioni, L.H., Joseph, V., Bretzner, F., Bícego, K.C., Fournier, S., Kinkead, R., Brain Research, 2021, 10.1016/j.brainres.2021.147276 -
Disruption of estradiol regulation of orexin neurons: a novel mechanism in excessive ventilatory response to CO
2 inhalation in a female rat model of panic disorder, Tenorio-Lopes, L., Fournier, S., Henry, M.S., Bretzner, F., Kinkead, R., Translational Psychiatry, 2020, 10.1038/s41398-020-01076-x - Focus-tunable microscope for imaging small neuronal processes in freely moving animals, Bagramyan, A., Tabourin, L., Rastqar, A., Karimi, N., Bretzner, F., Galstian, T., bioRxiv, 2020, 10.1101/2020.10.31.363507
- Using mouse genetics to investigate supraspinal pathways of the brain important to locomotion, Marie Roussel, Maxime Lemieux, Frederic Bretzner, The Neural Control of Movement, 2020, 10.1016/b978-0-12-816477-8.00012-0
- Using mouse genetics to study the developing spinal locomotor circuit, Louise Thiry, Marie Roussel, Maxime Lemieux, Frederic Bretzner, The Neural Control of Movement, 2020, 10.1016/b978-0-12-816477-8.00011-9
- Distinct dampening effects of progesterone on the activity of nucleus tractus solitarii neurons in rat pups, Fournier, S., Boukari, R., Chamberland, S., Bretzner, F., Joseph, V., Kinkead, R., Experimental Physiology, 2019, 10.1113/EP087461
- DSCAM Mutation Impairs Motor Cortex Network Dynamic and Voluntary Motor Functions, Laflamme, O.D., Lemieux, M., Thiry, L., Bretzner, F., Cerebral Cortex, 2019, 10.1093/cercor/bhy097
- Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse, Lemieux, M., Bretzner, F., PLoS Biology, 2019, 10.1371/journal.pbio.2003880
- The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice, Gratuze, M., Josset, N., Petry, F.R., Pflieger, M., Eyoum Jong, L., Truchetti, G., Poitras, I., Julien, J., Bezeau, F., Morin, F., Samadi, P., Cicchetti, F., Bretzner, F., Planel, E., Brain Research, 2019, 10.1016/j.brainres.2019.01.016
- Age- and speed-dependent modulation of gaits in DSCAM 2J mutant mice, Thiry, L., Lemieux, M., Bretzner, F., Journal of Neurophysiology, 2018, 10.1152/jn.00471.2017
- Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse, Josset, N., Roussel, M., Lemieux, M., Lafrance-Zoubga, D., Rastqar, A., Bretzner, F., Current Biology, 2018, 10.1016/j.cub.2018.02.007
- Facilitation of locomotor spinal networks activity by buspirone after a complete spinal cord lesion in mice, Jeffrey-Gauthier, R., Josset, N., Bretzner, F., Leblond, H., Journal of Neurotrauma, 2018, 10.1089/neu.2017.5476
- Nogo-A inactivation improves visual plasticity and recovery after retinal injury, Mdzomba, J.B., Jordi, N., Rodriguez, L., Joly, S., Bretzner, F., Pernet, V., Cell Death and Disease, 2018, 10.1038/s41419-018-0780-x
- Betacellulin regulates schwann cell proliferation and myelin formation in the injured mouse peripheral nerve, Vallières, N., Barrette, B., Wang, L.X., Bélanger, E., Thiry, L., Schneider, M.R., Filali, M., Côté, D., Bretzner, F., Lacroix, S., GLIA, 2017, 10.1002/glia.23119
- Neonatal maternal separation opposes the facilitatory effect of castration on the respiratory response to hypercapnia of the adult male rat: Evidence for the involvement of the medial amygdala, Tenorio-Lopes, L., Henry, M.S., Marques, D., Tremblay, M.-È., Drolet, G., Bretzner, F., Kinkead, R., Journal of Neuroendocrinology, 2017, 10.1111/jne.12550
- Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM, Lemieux, M., Laflamme, O.D., Thiry, L., Boulanger-Piette, A., Frenette, J., Bretzner, F., Journal of Neurophysiology, 2016, 10.1152/jn.00556.2015
- Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits, Thiry, L., Lemieux, M., Laflamme, O.D., Bretzner, F., Journal of Neurophysiology, 2016, 10.1152/jn.00557.2015
- Speed-dependent modulation of the locomotor behavior in adult mice reveals attractor and transitional gaits, Lemieux, M., Josset, N., Roussel, M., Couraud, S., Bretzner, F., Frontiers in Neuroscience, 2016, 10.3389/fnins.2016.00042
- Schwann cells generated from neonatal skin-derived precursors or neonatal peripheral nerve improve functional recovery after acute transplantation into the partially injured cervical spinal cord of the rat, Sparling, J.S., Bretzner, F., Biernaskie, J., Assinck, P., Jiang, Y., Arisato, H., Plunet, W.T., Borisoff, J., Liu, J., Miller, F.D., Tetzlaff, W., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.1070-14.2015
- Respiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathing, Kinkead, R., Tenorio, L., Drolet, G., Bretzner, F., Gargaglioni, L., Respiratory Physiology and Neurobiology, 2014, 10.1016/j.resp.2014.06.013
- Lhx3-Chx10 reticulospinal neurons in locomotor circuits, Bretzner, F., Brownstone, R.M., Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.5231-12.2013
- Target populations for first-in-human embryonic stem cell research in spinal cord injury, Bretzner, F., Gilbert, F., Baylis, F., Brownstone, R.M., Cell Stem Cell, 2011, 10.1016/j.stem.2011.04.012
- Combination of olfactory ensheathing cells with local versus systemic cAMP treatment after a cervical rubrospinal tract injury, Bretzner, F., Plemel, J.R., Liu, J., Richter, M., Roskams, A.J., Tetzlaff, W., Journal of Neuroscience Research, 2010, 10.1002/jnr.22440
- Functional characterization of cardiac progenitor cells and their derivatives in the embryonic heart post-chamber formation, McMullen, N.M., Zhang, F., Hotchkiss, A., Bretzner, F., Wilson, J.M., Hong, M., Wafa, K., Brownstone, R.M., Pasumarthi, K.B.S., Developmental Dynamics, 2009, 10.1002/dvdy.22112
- Undesired effects of a combinatorial treatment for spinal cord injury - Transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus, Bretzner, F., Liu, J., Currie, E., Roskams, A.J., Tetzlaff, W., European Journal of Neuroscience, 2008, 10.1111/j.1460-9568.2008.06462.x
- Changes in corticospinal efficacy contribute to the locomotor plasticity observed after unilateral cutaneous denervation of the hindpaw in the cat, Bretzner, F., Drew, T., Journal of Neurophysiology, 2005, 10.1152/jn.00254.2005
- Contribution of the motor cortex to the structure and the timing of hindlimb locomotion in the cat: A microstimulation study, Bretzner, F., Drew, T., Journal of Neurophysiology, 2005, 10.1152/jn.01245.2004
- Motor cortical modulation of cutaneous reflex responses in the hindlimb of the intact cat, Bretzner, F., Drew, T., Journal of Neurophysiology, 2005, 10.1152/jn.01247.2004
- Effects of excitation and inactivation in area 17 on paired cells in area 18, Tan, Y.-F., Bretzner, F., Lepore, F., Itaya, S., Shumikhina, S., Molotchnikoff, S., NeuroReport, 2004, 10.1097/00001756-200410050-00006
- Influence of NO downregulation on oscillatory evoked responses in developing rat superior colliculus, Aïtoubah, J., Itaya, S.K., Bretzner, F., Chemtob, S., Guillemot, J.-P., Tan, Y.-F., Shumikhina, S., Molotchnikoff, S., Developmental Brain Research, 2002, 10.1016/S0165-3806(02)00465-0
- Comparative computations of spike synchronization in visual cortex of cats, Molotchnikoff, S., Aïtoubah, J., Bretzner, F., Shumikhina, S., Tan, Y.-F., Guillemot, J.-P., Brain Research Protocols, 2001, 10.1016/S1385-299X(00)00050-7
- Modulation of the synchronization between cells in visual cortex by contextual targets, Bretzner, F., Aïtoubah, J., Shumikhina, S., Tan, Y.-F., Molotchnikoff, S., European Journal of Neuroscience, 2001, 10.1046/j.0953-816X.2001.01776.x
- Stimuli outside the classical receptive field modulate the synchronization of action potentials between cells in visual cortex of cats, Bretzner, F., Aïtoubah, J., Shumikhina, S., Tan, Y.-F., Molotchnikoff, S., NeuroReport, 2000, 10.1097/00001756-200004270-00033
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Marie-Claude Carrier - Maîtrise avec mémoire - En cours
- Yacine Haili - Maîtrise avec mémoire - En cours
- Guillaume Clain - Maîtrise avec mémoire - En cours
- Maryam Abrishamdar - Doctorat - En cours
- Marie Roussel - Doctorat - En cours
- Gilles-Philippe Morin - Maîtrise avec mémoire - En cours
- Abigaïl Chubwa Ndiku - Maîtrise avec mémoire - En cours
- Chloé Lemaire - Maîtrise avec mémoire - En cours
- Mélissa Christine Sourioux - Post-doctorat - En cours
- Abderraouf Redjem - Maîtrise avec mémoire - En cours
- Loïc Tabourin - Doctorat - En cours
- Olivier D. Laflamme - Maîtrise avec mémoire - 2016/01
- Louise Thiry - Doctorat - 2018/01
- Ali Rastqarfarajzadeh - Maîtrise avec mémoire - 2019/09
Encadrement d'étudiant(e)s pour les programmes suivants :
Disponibilité d'encadrement d'étudiant(e)s
Ce (cette) professeur(e) est présentement à la recherche d'étudiant(e)s.
Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.