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Frédéric Bretzner

Professeur titulaire

Frédéric Bretzner
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Médecine régénératrice et moléculaire
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
Neurosciences, santé mentale et toxicomanies
  • Maladies neurologiques
  • Traumatismes crânio-encéphaliques et de la moelle épinière
  • Maladies de la moelle épinière
  • Maladie de Parkinson
  • Hémiplégie et paraplégie
  • Activité nerveuse et synaptique
  • Développement du système nerveux
  • Fonctions exécutives
  • Système moteur
  • Système somato-sensoriel
  • Système visuel
Organisation et fonctions biologiques

Projets de recherche

  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Salaire d'un professeur - CHU de Québec – Université Laval – CHUL, chercheur principal - 2010-01-01 au 2024-06-30
  • Plasticité et développement du contrôle moteur - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2020-07-01 au 2024-06-30
  • Plasticity of midbrain nuclei after spinal cord injury - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
  • Deep brain photometry of spatially distinct brain areas using a single optical fiber - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2022-03-31 au 2024-03-30
  • Role of DSCAM in the development of motor circuits - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31
  • Plasticity of Reticulospinal Pathways to Promote Functional Locomotor Recovery Spinal Cord Injury - Wings for Life Spinal Cord Research Foundation, chercheur principal - 2022-02-01 au 2023-01-31
  • Plasticity Of Reticulospinal Pathways Following Spinal Cord Injury - Craig H. Neilsen Foundation, chercheur principal - 2019-07-31 au 2022-07-31
  • Optogenetic stimulation of glutamatergic neurons of the medullary reticular formation to promote the recovery of voluntary locomotor functions following a hemilesion of the spinal cord in mice - Wings for Life Spinal Cord Research Foundation, chercheur principal - 2019-09-01 au 2021-06-30
  • Plasticité et développement du contrôle moteur. - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2016-07-01 au 2020-06-30


  • Focus-tunable microscope for imaging small neuronal processes in freely moving animals, Bagramyan, A., Tabourin, L., Rastqar, A., Karimi, N., Bretzner, F., Galstian, T., Photonics Research, 2021, 10.1364/PRJ.418154
  • Impact of ovariectomy and CO2 inhalation on microglia morphology in select brainstem and hypothalamic areas regulating breathing in female rats, Marques, D.A., Gargaglioni, L.H., Joseph, V., Bretzner, F., Bícego, K.C., Fournier, S., Kinkead, R., Brain Research, 2021, 10.1016/j.brainres.2021.147276
  • Role of dscam in the development of neural control of movement and locomotion, Lemieux, M., Thiry, L., Laflamme, O.D., Bretzner, F., International Journal of Molecular Sciences, 2021, 10.3390/ijms22168511
  • Disruption of estradiol regulation of orexin neurons: a novel mechanism in excessive ventilatory response to CO2 inhalation in a female rat model of panic disorder, Tenorio-Lopes, L., Fournier, S., Henry, M.S., Bretzner, F., Kinkead, R., Translational Psychiatry, 2020, 10.1038/s41398-020-01076-x
  • Focus-tunable microscope for imaging small neuronal processes in freely moving animals, Bagramyan, A., Tabourin, L., Rastqar, A., Karimi, N., Bretzner, F., Galstian, T., bioRxiv, 2020, 10.1101/2020.10.31.363507
  • Using mouse genetics to investigate supraspinal pathways of the brain important to locomotion, Marie Roussel, Maxime Lemieux, Frederic Bretzner, The Neural Control of Movement, 2020, 10.1016/b978-0-12-816477-8.00012-0
  • Using mouse genetics to study the developing spinal locomotor circuit, Louise Thiry, Marie Roussel, Maxime Lemieux, Frederic Bretzner, The Neural Control of Movement, 2020, 10.1016/b978-0-12-816477-8.00011-9
  • Distinct dampening effects of progesterone on the activity of nucleus tractus solitarii neurons in rat pups, Fournier, S., Boukari, R., Chamberland, S., Bretzner, F., Joseph, V., Kinkead, R., Experimental Physiology, 2019, 10.1113/EP087461
  • DSCAM Mutation Impairs Motor Cortex Network Dynamic and Voluntary Motor Functions, Laflamme, O.D., Lemieux, M., Thiry, L., Bretzner, F., Cerebral Cortex, 2019, 10.1093/cercor/bhy097
  • Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse, Lemieux, M., Bretzner, F., PLoS Biology, 2019, 10.1371/journal.pbio.2003880
  • The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice, Gratuze, M., Josset, N., Petry, F.R., Pflieger, M., Eyoum Jong, L., Truchetti, G., Poitras, I., Julien, J., Bezeau, F., Morin, F., Samadi, P., Cicchetti, F., Bretzner, F., Planel, E., Brain Research, 2019, 10.1016/j.brainres.2019.01.016
  • Age- and speed-dependent modulation of gaits in DSCAM 2J mutant mice, Thiry, L., Lemieux, M., Bretzner, F., Journal of Neurophysiology, 2018, 10.1152/jn.00471.2017
  • Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse, Josset, N., Roussel, M., Lemieux, M., Lafrance-Zoubga, D., Rastqar, A., Bretzner, F., Current Biology, 2018, 10.1016/j.cub.2018.02.007
  • Facilitation of locomotor spinal networks activity by buspirone after a complete spinal cord lesion in mice, Jeffrey-Gauthier, R., Josset, N., Bretzner, F., Leblond, H., Journal of Neurotrauma, 2018, 10.1089/neu.2017.5476
  • Nogo-A inactivation improves visual plasticity and recovery after retinal injury, Mdzomba, J.B., Jordi, N., Rodriguez, L., Joly, S., Bretzner, F., Pernet, V., Cell Death and Disease, 2018, 10.1038/s41419-018-0780-x
  • Betacellulin regulates schwann cell proliferation and myelin formation in the injured mouse peripheral nerve, Vallières, N., Barrette, B., Wang, L.X., Bélanger, E., Thiry, L., Schneider, M.R., Filali, M., Côté, D., Bretzner, F., Lacroix, S., GLIA, 2017, 10.1002/glia.23119
  • Neonatal maternal separation opposes the facilitatory effect of castration on the respiratory response to hypercapnia of the adult male rat: Evidence for the involvement of the medial amygdala, Tenorio-Lopes, L., Henry, M.S., Marques, D., Tremblay, M.-È., Drolet, G., Bretzner, F., Kinkead, R., Journal of Neuroendocrinology, 2017, 10.1111/jne.12550
  • Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM, Lemieux, M., Laflamme, O.D., Thiry, L., Boulanger-Piette, A., Frenette, J., Bretzner, F., Journal of Neurophysiology, 2016, 10.1152/jn.00556.2015
  • Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits, Thiry, L., Lemieux, M., Laflamme, O.D., Bretzner, F., Journal of Neurophysiology, 2016, 10.1152/jn.00557.2015
  • Speed-dependent modulation of the locomotor behavior in adult mice reveals attractor and transitional gaits, Lemieux, M., Josset, N., Roussel, M., Couraud, S., Bretzner, F., Frontiers in Neuroscience, 2016, 10.3389/fnins.2016.00042
  • Schwann cells generated from neonatal skin-derived precursors or neonatal peripheral nerve improve functional recovery after acute transplantation into the partially injured cervical spinal cord of the rat, Sparling, J.S., Bretzner, F., Biernaskie, J., Assinck, P., Jiang, Y., Arisato, H., Plunet, W.T., Borisoff, J., Liu, J., Miller, F.D., Tetzlaff, W., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.1070-14.2015
  • Respiratory manifestations of panic disorder in animals and humans: A unique opportunity to understand how supramedullary structures regulate breathing, Kinkead, R., Tenorio, L., Drolet, G., Bretzner, F., Gargaglioni, L., Respiratory Physiology and Neurobiology, 2014, 10.1016/j.resp.2014.06.013
  • Lhx3-Chx10 reticulospinal neurons in locomotor circuits, Bretzner, F., Brownstone, R.M., Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.5231-12.2013
  • Target populations for first-in-human embryonic stem cell research in spinal cord injury, Bretzner, F., Gilbert, F., Baylis, F., Brownstone, R.M., Cell Stem Cell, 2011, 10.1016/j.stem.2011.04.012
  • Combination of olfactory ensheathing cells with local versus systemic cAMP treatment after a cervical rubrospinal tract injury, Bretzner, F., Plemel, J.R., Liu, J., Richter, M., Roskams, A.J., Tetzlaff, W., Journal of Neuroscience Research, 2010, 10.1002/jnr.22440
  • Functional characterization of cardiac progenitor cells and their derivatives in the embryonic heart post-chamber formation, McMullen, N.M., Zhang, F., Hotchkiss, A., Bretzner, F., Wilson, J.M., Hong, M., Wafa, K., Brownstone, R.M., Pasumarthi, K.B.S., Developmental Dynamics, 2009, 10.1002/dvdy.22112
  • Undesired effects of a combinatorial treatment for spinal cord injury - Transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus, Bretzner, F., Liu, J., Currie, E., Roskams, A.J., Tetzlaff, W., European Journal of Neuroscience, 2008, 10.1111/j.1460-9568.2008.06462.x
  • Changes in corticospinal efficacy contribute to the locomotor plasticity observed after unilateral cutaneous denervation of the hindpaw in the cat, Bretzner, F., Drew, T., Journal of Neurophysiology, 2005, 10.1152/jn.00254.2005
  • Contribution of the motor cortex to the structure and the timing of hindlimb locomotion in the cat: A microstimulation study, Bretzner, F., Drew, T., Journal of Neurophysiology, 2005, 10.1152/jn.01245.2004
  • Motor cortical modulation of cutaneous reflex responses in the hindlimb of the intact cat, Bretzner, F., Drew, T., Journal of Neurophysiology, 2005, 10.1152/jn.01247.2004
  • Effects of excitation and inactivation in area 17 on paired cells in area 18, Tan, Y.-F., Bretzner, F., Lepore, F., Itaya, S., Shumikhina, S., Molotchnikoff, S., NeuroReport, 2004, 10.1097/00001756-200410050-00006
  • Influence of NO downregulation on oscillatory evoked responses in developing rat superior colliculus, Aïtoubah, J., Itaya, S.K., Bretzner, F., Chemtob, S., Guillemot, J.-P., Tan, Y.-F., Shumikhina, S., Molotchnikoff, S., Developmental Brain Research, 2002, 10.1016/S0165-3806(02)00465-0
  • Comparative computations of spike synchronization in visual cortex of cats, Molotchnikoff, S., Aïtoubah, J., Bretzner, F., Shumikhina, S., Tan, Y.-F., Guillemot, J.-P., Brain Research Protocols, 2001, 10.1016/S1385-299X(00)00050-7
  • Modulation of the synchronization between cells in visual cortex by contextual targets, Bretzner, F., Aïtoubah, J., Shumikhina, S., Tan, Y.-F., Molotchnikoff, S., European Journal of Neuroscience, 2001, 10.1046/j.0953-816X.2001.01776.x
  • Stimuli outside the classical receptive field modulate the synchronization of action potentials between cells in visual cortex of cats, Bretzner, F., Aïtoubah, J., Shumikhina, S., Tan, Y.-F., Molotchnikoff, S., NeuroReport, 2000, 10.1097/00001756-200004270-00033

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Floriane Uyttersprot - Maitrîse avec mémoire - En cours
  • Marie Roussel - Doctorat - En cours
  • Sébastien Couraud - Doctorat - En cours
  • Yacine Haili - Maitrîse avec mémoire - En cours
  • Guillaume Clain - Maitrîse avec mémoire - En cours
  • Quentin Bruxelles - Maitrîse avec mémoire - En cours
  • Mélissa Christine Sourioux - Post-doctorat - En cours
  • Chloé Lemaire - Maitrîse avec mémoire - En cours
  • Loïc Tabourin - Doctorat - En cours
  • Nicolas Josset - Doctorat - 2018/05
  • Ali Rastqarfarajzadeh - Maitrîse avec mémoire - 2019/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine,  local 4645
Québec, Québec G1V 0A6

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Téléphone 418 656-2690

Jacques Simard
Vice-doyen à la recherche et aux études supérieures

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures

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