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François Berthod
Professeur titulaire
Centre thématique de recherche en neurosciences
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Médecine régénératrice et moléculaire
Neurosciences et santé mentale
Domaines et intérêts de recherche du (de la) professeur(e) :
Appareil locomoteur et arthrite
- Peau
- Affections cutanées
- Maladies des tissus conjonctifs
- Maladies musculaires
- Tissu conjonctif
Maladies infectieuses et immunitaires
- Brûlure et infection
- Maladies auto-immunes
Neurosciences, santé mentale et toxicomanies
- Greffes neuronales et cellules souches
- Maladies du système nerveux périphérique
- Maladies neurodégénératives
- Maladies de la moelle épinière
- Maladies neuromusculaires
- Système moteur
- Système somato-sensoriel
- Ataxies
Projets de recherche
- Réparation des lésions des nerfs périphériques par génie tissulaire - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-04-01 au 2026-03-31
- Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
- Un environnement sécuritaire pour des animaux immunosupprimés - Fondation Canadienne pour l'innovation (La), Centre hospitalier universitaire de Québec - Université Laval, Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), co-chercheur - 2023-01-01 au 2024-05-24
- Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
- Conversion directe de fibroblastes en cellules de Schwann pour stimuler la réparation des nerfs périphériques - Fonds de recherche du Québec - Santé - Réseaux thématiques de recherche, Université de Montréal, co-chercheur - 2022-04-01 au 2023-03-31
- Étude de l'impact de l'innervation cutanée dans le Psoriasis - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2018-04-01 au 2023-03-31
- Modélisation par génie tissulaire de la modulation de l'angiogenèse par l'innervation sensorielle - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31
- Rôle du système nerveux sensitif sur la régénération de tissus vascularisés - Conseil régional d'Aquitaine, Université de Limoges, co-chercheur - 2021-04-01 au 2022-03-31
- Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2017-04-01 au 2022-03-31
- Stratégies de réparation des transsections des nerfs périphériques par génie tissulaire - Instituts de recherche en santé du Canada - Volet Projet: Concours pilotes, chercheur principal - 2016-07-01 au 2021-06-30
- such terms being hereinafter referred to as a "SOW" - Ananda Deviees, chercheur principal - 2019-12-09 au 2021-03-31
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Publications
- In Vitro 3D Modeling of Neurodegenerative Diseases, Aurélie Louit, Todd Galbraith, François Berthod, Bioengineering, 2023, 10.3390/bioengineering10010093
- Tissue‐engineered in vitro modeling of the impact of Schwann cells in amyotrophic lateral sclerosis, Aurélie Louit, Marie‐Josée Beaudet, François Gros‐Louis, François Berthod, Biotechnology and Bioengineering, 2022, 10.1002/bit.28083
- Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function, , Stroke, 2022, 10.1161/strokeaha.120.032691
- Repair of peripheral nerve injuries using a prevascularized cell-based tissue-engineered nerve conduit, Alexane Thibodeau, Todd Galbraith, Chantal M. Fauvel, Hélène T. Khuong, François Berthod, Biomaterials, 2022, 10.1016/j.biomaterials.2021.121269
- Modélisation tridimensionnelle in vitro des systèmes nerveux et immunitaire de la peau, Quentin Muller, François Berthod, Vincent Flacher, médecine/sciences, 2021, 10.1051/medsci/2020260
- Neuropeptide Substance P Released from a Nonswellable Laponite-Based Hydrogel Enhances Wound Healing in a Tissue-Engineered Skin In Vitro, Thiéry De Serres-Bérard, Tiago B. Becher, Carolyne B. Braga, Catia Ornelas, François Berthod, ACS Applied Polymer Materials, 2020, 10.1021/acsapm.0c01034
- Prevascularized Tissue-Engineered Human Vaginal Mucosa: In Vitro Optimization and In Vivo Validation, , Tissue Engineering Part A, 2020, 10.1089/ten.tea.2020.0036
- Lifting the veil on the keratinocyte contribution to cutaneous nociception, , Protein & Cell, 2020, 10.1007/s13238-019-00683-9
- Cutaneous nociception: Role of keratinocytes, , Experimental Dermatology, 2019, 10.1111/exd.13975
- Development of an innervated tissue-engineered skin with human sensory neurons and Schwann cells differentiated from iPS cells, Quentin Muller, Marie-Josée Beaudet, Thiéry De Serres-Bérard, Sabrina Bellenfant, Vincent Flacher, François Berthod, Acta Biomaterialia, 2018, 10.1016/j.actbio.2018.10.011
- Biotechnological Management of Skin Burn Injuries: Challenges and Perspectives in Wound Healing and Sensory Recovery, Girard, D., Laverdet, B., Buhé, V., Trouillas, M., Ghazi, K., Alexaline, M.M., Egles, C., Misery, L., Coulomb, B., Lataillade, J.-J., Berthod, F., Desmoulière, A., Tissue Engineering - Part B: Reviews, 2017, 10.1089/ten.teb.2016.0195
- Potential of tissue engineering and neural stem cells in the understanding and treatment of neurodegenerative diseases, Auclair-Daigle, C., Berthod, F., Engineering Stem Cells For Tissue Regeneration, 2017, 10.1142/10228
- High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord, Marie-Josée Beaudet, Qiurui Yang, Sébastien Cadau, Mathieu Blais, Sabrina Bellenfant, François Gros-Louis, François Berthod, Scientific Reports, 2015, 10.1038/srep16763
- In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules, Sébastien Cadau, Sabrina Leoty-Okombi, Sabine Pain, Nicolas Bechetoille, Valérie André-Frei, François Berthod, Biomaterials, 2015, 10.1016/j.biomaterials.2015.01.066
- Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients, Bastien Paré, Lydia Touzel-Deschênes, Rémy Lamontagne, Marie-Soleil Lamarre, François-Dominique Scott, Hélène T Khuong, Patrick A Dion, Jean-Pierre Bouchard, Peter Gould, Guy A Rouleau, Nicolas Dupré, François Berthod, François Gros-Louis, Acta Neuropathologica Communications, 2015, 10.1186/s40478-014-0181-z
- The Relation between ALS and the Skin: A Novel Human In Vitro Model to Identify New Biomarkers, Bastien Pare, Francois Berthod, Francois Gros Louis, Journal of Molecular Biomarkers & Diagnosis, 2015, 10.4172/2155-9929.1000e121
- A Longitudinal Low Dose μCT Analysis of Bone Healing in Mice: A Pilot Study, , Advances in Orthopedics, 2014, 10.1155/2014/791539
- Sensory neurons accelerate skin reepithelialization via substance P in an innervated tissue-engineered wound healing model, Blais, M., Mottier, L., Germain, M.-A., Bellenfant, S., Cadau, S., Berthod, F., Tissue Engineering - Part A, 2014, 10.1089/ten.tea.2013.0535
- Nerve Growth Factor, Brain-Derived Neurotrophic Factor, Neurotrophin-3 and Glial-Derived Neurotrophic Factor Enhance Angiogenesis in a Tissue-Engineered In Vitro Model, Mathieu Blais, Philippe Lévesque, Sabrina Bellenfant, François Berthod, Tissue Engineering Part A, 2013, 10.1089/ten.tea.2012.0745
- Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment, Mathieu Blais, Rémi Parenteau-Bareil, Sébastien Cadau, François Berthod, STEM CELLS Translational Medicine, 2013, 10.5966/sctm.2012-0181
- Fibroblasts and endothelial cells: The basic angiogenic unit, Berthod, F., Angiogenesis: Insights from a Systematic Overview, 2013
- Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro, François Berthod, Julie Symes, Nathalie Tremblay, Jeffrey A. Medin, François A. Auger, Journal of Cellular Physiology, 2012, 10.1002/jcp.22943
- Comparative study of bovine, porcine and avian collagens for the production of a tissue engineered dermis, Rémi Parenteau-Bareil, Robert Gauvin, Simon Cliche, Claude Gariépy, Lucie Germain, François Berthod, Acta Biomaterialia, 2011, 10.1016/j.actbio.2011.06.020
- Hair Follicles Guide Nerve Migration In Vitro and In Vivo in Tissue-Engineered Skin, Vicky Gagnon, Danielle Larouche, Rémi Parenteau-Bareil, Marie Gingras, Lucie Germain, François Berthod, Journal of Investigative Dermatology, 2011, 10.1038/jid.2011.34
- Potential of tissue engineering and neural stem cells in the understanding and treatment of neurodegenerative diseases, Auclair-Daigle, C., Berthod, F., Stem Cell and Tissue Engineering, 2011, 10.1142/9789814317061_0016
- Normal Human Epithelial Cells Regulate the Size and Morphology of Tissue-Engineered Capillaries, Marie-Hélène Rochon, Julie Fradette, Véronique Fortin, Florence Tomasetig, Charles J. Roberge, Kathleen Baker, François Berthod, François A. Auger, Lucie Germain, Tissue Engineering Part A, 2010, 10.1089/ten.tea.2009.0090
- Collagen-Based Biomaterials for Tissue Engineering Applications, Rémi Parenteau-Bareil, Robert Gauvin, François Berthod, Materials, 2010, 10.3390/ma3031863
- Modélisation in vitro du système nerveux par génie tissulaire, , médecine/sciences, 2009, 10.1051/medsci/2009253288
- Improvement of Nerve Regeneration in Tissue-Engineered Skin Enriched with Schwann Cells, Mathieu Blais, Myriam Grenier, François Berthod, Journal of Investigative Dermatology, 2009, 10.1038/jid.2009.159
- Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling, Snapyan, M., Lemasson, M., Brill, M.S., Blais, M., Massouh, M., Ninkovic, J., Gravel, C., Berthod, F., Götz, M., Barker, P.A., Parent, A., Saghatelyan, A., Journal of Neuroscience, 2009, 10.1523/JNEUROSCI.4956-08.2009
- Cutaneous Myiasis: Diagnosis, Treatment, and Prevention, René Caissie, Frédéric Beaulieu, Marjolaine Giroux, François Berthod, Pierre-Éric Landry, Journal of Oral and Maxillofacial Surgery, 2008, 10.1016/j.joms.2007.09.005
- Quantitative Method to Evaluate the Functionality of the Trigeminal Nerve, René Caissie, Pierre-Éric Landry, Robert Paquin, Marie-France Champigny, François Berthod, Journal of Oral and Maxillofacial Surgery, 2007, 10.1016/j.joms.2006.09.010
- Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cord, Marie Gingras, Vicky Gagnon, Sandra Minotti, Heather D. Durham, François Berthod, Journal of Neuroscience Methods, 2007, 10.1016/j.jneumeth.2007.02.024
- In vitro study of axonal migration and myelination of motor neurons in a three-dimensional tissue-engineered model, Marie Gingras, Marie-Michèle Beaulieu, Vicky Gagnon, Heather D. Durham, François Berthod, Glia, 2007, 10.1002/glia.20617
- Tissue-engineered skin and the treatment of burns: Skin doctor, Berthod, F., Biochemist, 2007
- In vitro reconstruction of a tissue-engineered endothelialized bladder from a single porcine biopsy, Martine Magnan, François Berthod, Marie-France Champigny, Frédéric Soucy, Stéphane Bolduc, Journal of Pediatric Urology, 2006, 10.1016/j.jpurol.2005.11.019
- In vivo enhancement of sensory perception recovery in a tissue-engineered skin enriched with laminin, René Caissie, Marie Gingras, Marie-France Champigny, François Berthod, Biomaterials, 2006, 10.1016/j.biomaterials.2006.01.014
- Differentiation of human adult skin-derived neuronal precursors into mature neurons, Marie Gingras, Marie-France Champigny, François Berthod, Journal of Cellular Physiology, 2006, 10.1002/jcp.20889
- Extracellular matrix deposition by fibroblasts is necessary to promote capillary-like tube formation in vitro, François Berthod, Lucie Germain, Nathalie Tremblay, François A. Auger, Journal of Cellular Physiology, 2006, 10.1002/jcp.20584
- Inosculation of Tissue-Engineered Capillaries with the Host's Vasculature in a Reconstructed Skin Transplanted on Mice, Pierre-Luc Tremblay, Valerie Hudon, Francois Berthod, Lucie Germain, Francois A. Auger, American Journal of Transplantation, 2005, 10.1111/j.1600-6143.2005.00790.x
- In vitro evaluation of the angiostatic potential of drugs using an endothelialized tissue-engineered connective tissue, Tremblay, P.-L., Berthod, F., Germain, L., Auger, F.A., Journal of Pharmacology and Experimental Therapeutics, 2005, 10.1124/jpet.105.089524
- Tissue-engineered skin substitutes: From in vitro constructs to in vivo applications, Auger, F.A., Berthod, F., Moulin, V., Pouliot, R., Germain, L., Biotechnology and Applied Biochemistry, 2004
- Principles of Living Organ Reconstruction by Tissue Engineering, Lucie Germain, François Berthod, Véronique Moulin, Francine Goulet, Franc¸ois Auger, Tissue Engineering And Novel Delivery Systems, 2003, 10.1201/9780203913338.ch10
- In vitro development of a tissue-engineered model of peripheral nerve regeneration to study neurite growth , MARIE GINGRAS, JULIE BERGERON, JULIEN DÉRY, HEATHER D. DURHAM, FRANÇOIS BERTHOD, The FASEB Journal, 2003, 10.1096/fj.02-1180fje
- Le génie tissulaire au service de la compréhension du vivant, Véronique Moulin, Francine Goulet, François Berthod, Lucie Germain, François A. Auger, médecine/sciences, 2003, 10.1051/medsci/200319101003
- Nerve regeneration in a collagen–chitosan tissue-engineered skin transplanted on nude mice, Marie Gingras, Isabelle Paradis, François Berthod, Biomaterials, 2003, 10.1016/s0142-9612(02)00572-0
- A tissue-engineered endothelialized dermis to study the modulation of angiogenic and angiostatic molecules on capillary-like tube formation in vitro, Hudon, V., Berthod, F., Black, A.F., Damour, O., Germain, L., Auger, F.A., British Journal of Dermatology, 2003, 10.1046/j.1365-2133.2003.05298.x
- Engineering human tissues for in vivo applications, Germain, L., Goulet, F., Moulin, V., Berthod, F., Auger, F.A., Annals of the New York Academy of Sciences, 2002, 10.1111/j.1749-6632.2002.tb03099.x
- Collagen fibril network and elastic system remodeling in a reconstructed skin transplanted on nude mice, François Berthod, Lucie Germain, Hui Li, Wen Xu, Odile Damour, François A. Auger, Matrix Biology, 2001, 10.1016/s0945-053x(01)00162-7
- What is new in mechanical properties of tissue-engineered organs., Auger, F.A., Berthod, F., Goulet, F., Germain, L., Current topics in pathology. Ergebnisse der Pathologie, 1999
- In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent, Annie F. Black, François Berthod, Nicolas L'heureux, Lucie Germain, François A. Auger, The FASEB Journal, 1998, 10.1096/fasebj.12.13.1331
- Tissue-engineered human skin substitutes developed from collagen-populated hydrated gels: Clinical and fundamental applications, Auger, F.A., Rouabhia, M., Goulet, F., Berthod, F., Moulin, V., Germain, L., Medical and Biological Engineering and Computing, 1998, 10.1007/BF02518887
- Differential Expression of Collagens XII and XIV in Human Skin and in Reconstructed Skin, François Berthod, Lucie Germain, Rina Guignard, Claire Lethias, Robert Garrone, Odile Damour, Michel van der Rest, François A. Auger, Journal of Investigative Dermatology, 1997, 10.1111/1523-1747.ep12292122
- In vitro reconstructed skin models for wound coverage in deep burns, Berthod, F., Damour, O., British Journal of Dermatology, 1997, 10.1111/j.1365-2133.1997.tb03917.x
- Use of in Vitro Reconstructed Skin To Cover Skin Flap Donor Site, , Journal of Surgical Research, 1997, 10.1006/jsre.1997.5229
- Deposition of collagen fibril bundles by long-term culture of fibroblasts in a collagen sponge, Berthod, F., Sahuc, F., Hayek, D., Damour, O., Collombel, C., Journal of Biomedical Materials Research, 1996, 10.1002/(SICI)1097-4636(199609)32:1<87::AID-JBM10>3.0.CO;2-F
- Mesenchymal-epithelial interactions regulate gene expression of type VII collagen and kalinin in keratinocytes and dermal-epidermal junction formation in a skin equivalent model, Florent Sahuc, Keiko Nakazawa, Francois Berthod, Christian Collombel, Odile Damour, Wound Repair and Regeneration, 1996, 10.1046/j.1524-475x.1996.40116.x
- A dermal substrate made of collagen-GA-chitosan for deep burn coverage: First clinical uses, Damour, O., Gueugniaud, P.Y., Berthin-Maghit, M., Rousselle, P., Berthod, F., Sahuc, F., Collombel, C., Clinical Materials, 1994, 10.1016/0267-6605(94)90057-4
- Optimization of thickness, pore size and mechanical properties of a biomaterial designed for deep burn coverage, Berthod, F., Saintigny, G., Chretien, F., Hayek, D., Collombel, C., Damour, O., Clinical Materials, 1994, 10.1016/0267-6605(94)90055-8
- Collagen synthesis by fibroblasts cultured within a collagen sponge, François Berthod, Dany Hayek, Odile Damour, Christian Collombel, Biomaterials, 1993, 10.1016/0142-9612(93)90039-5
- Reconstructed skin from co-cultured human keratinocytes and fibroblasts on a chitosane cross-linked collagen-GAG matrix, Shahabeddin, L., Damour, O., Berthod, F., Rousselle, P., Saintigny, G., Collombel, C., Journal of Materials Science: Materials in Medicine, 1991, 10.1007/BF00703375
- Characterization of Skin Reconstructed on a Chitosan-Cross-Linked Collagen-Glycosaminoglycan Matrix, Lili Shahabeddin, François Berthod, Odile Damour, Christian Collombel, Skin Pharmacology and Physiology, 1990, 10.1159/000210857
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Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Catherine Gaudet - Maîtrise avec mémoire - En cours
- Alexane Thibodeau - Doctorat - En cours
- Abir Attia - Maîtrise avec mémoire - En cours
- Rémy Pépin - Doctorat - En cours
- Oumayma Hayouni - Doctorat - En cours
- Mathias Lemarchand - Doctorat - En cours
- Rémi Parenteau-Bareil - Doctorat - En cours
- Qiurui Yang - Maîtrise avec mémoire - En cours
- Bastien Paré - Maîtrise avec mémoire - En cours
- Josy Baldaheani Naud - Doctorat - En cours
- Marie-Anne Germain - Maîtrise avec mémoire - En cours
- Lorène Mottier - Maîtrise avec mémoire - 2014/09
- Audrey Labarre - Maîtrise avec mémoire - 2014/09
- Kiefer Thouin - Maîtrise avec mémoire - 2017/01
- Thiéry De Serres-Bérard - Maîtrise avec mémoire - 2019/01
- Aurélie Louit - Doctorat - 2021/09
Encadrement d'étudiant(e)s pour les programmes suivants :
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Envoyer un courriel*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.