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François Berthod

Professeur titulaire

François Berthod
Francois.Berthod@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche en organogenèse expérimentale
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Médecine régénératrice et médecine moléculaire
  • Neurosciences et santé mentale

Domaines de recherche

  • Médecine régénérative (y compris les cellules souches et le génie tissulaire)
  • Dermatologie
  • Physiologie sensorimotrice
  • Neurodégénérescence
  • Biologie vasculaire et endothéliale

Projets de recherche en cours

  • Urethral reconstruction using tissue engineering, final steps towards clinical translation - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2025-04-01 au 2030-03-31
  • Modélisation par génie tissulaire de la modulation de la réponse immunitaire cutanée par l’innervation sensorielle - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2025-04-01 au 2030-03-31
  • Organogenèse de muqueuse nasale autologue pour la reconstruction endoscopique endonasale en chirurgie de la base du crâne - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-10-01 au 2028-09-30
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of dermal fibroblasts in the establishment of microenvironment favouring NF1-associated skin tumor formation using personalized tissue-engineered 3D models - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-10-01 au 2028-09-30
  • A cGMP facility for personalized tissue engineering - Ministère de la Santé et des Services sociaux, Fondation Canadienne pour l'innovation (La) - Fonds d'innovation (FI), co-chercheur - 2024-12-01 au 2027-12-31
  • Modélisation par génie tissulaire du rôle du système nerveux sensoriel dans la rosacée - MITACS Inc. - Accélération Québec (MITACS et gouvernement provincial), chercheur principal - 2024-02-05 au 2027-04-04
  • Réparation des lésions des nerfs périphériques par génie tissulaire - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2021-04-01 au 2026-03-31
  • Breaking barriers in drug delivery via using viscoplastic fluids for precise control of jet evolution and penetration - Secrétariat des programmes interorganismes à l’intention des établissements - Fonds Nouvelle frontières en recherche - Volet Transformation, co-chercheur - 2024-04-01 au 2026-03-31

Financements des 2 dernières années

  • Urethral reconstruction using tissue engineering, final steps towards clinical translation - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2024-10-01 au 2025-03-31
  • Un environnement sécuritaire pour des animaux immunosupprimés - Fondation Canadienne pour l'innovation (La), Centre hospitalier universitaire de Québec - Université Laval, Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), co-chercheur - 2023-01-01 au 2024-05-24
  • Depicting disease heterogeneity in neurofibromatosis type 1 and the role of microenvironment in NF1-associated skin tumor formation through personalized tissue-engineered 3D models - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2024-02-29
  • Modélisation par génie tissulaire de la modulation de l'angiogenèse par l'innervation sensorielle - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2018-04-01 au 2023-03-31

Publications

  • Modélisation tridimensionnelle in vitro des systèmes nerveux et immunitaire de la peau, Vincent Flacher, François Berthod, Quentin Muller, médecine/sciences, 2021, 10.1051/medsci/2020260
  • Cutaneous nociception: Role of keratinocytes, , Experimental Dermatology, 2019, 10.1111/exd.13975
  • Comparative study of bovine, porcine and avian collagens for the production of a tissue engineered dermis, François Berthod, Lucie Germain, Claude Gariépy, Simon Cliche, Robert Gauvin, Rémi Parenteau-Bareil, Acta Biomaterialia, 2011, 10.1016/j.actbio.2011.06.020
  • Repair of peripheral nerve injuries using a prevascularized cell-based tissue-engineered nerve conduit, François Berthod, Hélène T. Khuong, Chantal M. Fauvel, Todd Galbraith, Alexane Thibodeau, Biomaterials, 2022, 10.1016/j.biomaterials.2021.121269
  • Differentiation of Human Induced Pluripotent Stem Cells into Mature and Myelinating Schwann Cells, François Berthod, Rémy Pépin, Marie-Josée Beaudet, Aurélie Louit, Tissue Engineering Part C: Methods, 2023, 10.1089/ten.tec.2022.0186
  • Collagen-Based Biomaterials for Tissue Engineering Applications, François Berthod, Robert Gauvin, Rémi Parenteau-Bareil, Materials, 2010, 10.3390/ma3031863
  • Inosculation of Tissue-Engineered Capillaries with the Host's Vasculature in a Reconstructed Skin Transplanted on Mice, Francois A. Auger, Lucie Germain, Francois Berthod, Valerie Hudon, Pierre-Luc Tremblay, American Journal of Transplantation, 2005, 10.1111/j.1600-6143.2005.00790.x
  • Potential of tissue engineering and neural stem cells in the understanding and treatment of neurodegenerative diseases, Berthod, F., Auclair-Daigle, C., Stem Cell and Tissue Engineering, 2011, 10.1142/9789814317061_0016
  • Tissue-engineered human skin substitutes developed from collagen-populated hydrated gels: Clinical and fundamental applications, Germain, L., Moulin, V., Berthod, F., Goulet, F., Rouabhia, M., Auger, F.A., Medical and Biological Engineering and Computing, 1998, 10.1007/BF02518887
  • In vitro reconstruction of a tissue-engineered endothelialized bladder from a single porcine biopsy, Stéphane Bolduc, Frédéric Soucy, Marie-France Champigny, François Berthod, Martine Magnan, Journal of Pediatric Urology, 2006, 10.1016/j.jpurol.2005.11.019
  • Collagen fibril network and elastic system remodeling in a reconstructed skin transplanted on nude mice, François A. Auger, Odile Damour, Wen Xu, Hui Li, Lucie Germain, François Berthod, Matrix Biology, 2001, 10.1016/s0945-053x(01)00162-7
  • Early stages of hair follicle development: a step by step microarray identity., Berthod F, Parenteau-Bareil R, Voegel J, Rhetore S, Rosignoli C, Cadau S, European journal of dermatology : EJD, 2013, 10.1684/ejd.2013.1972
  • Sensory neurons accelerate skin reepithelialization via substance P in an innervated tissue-engineered wound healing model, Berthod, F., Cadau, S., Bellenfant, S., Germain, M.-A., Mottier, L., Blais, M., Tissue Engineering - Part A, 2014, 10.1089/ten.tea.2013.0535
  • Use of in Vitro Reconstructed Skin To Cover Skin Flap Donor Site, , Journal of Surgical Research, 1997, 10.1006/jsre.1997.5229
  • Improvement of Nerve Regeneration in Tissue-Engineered Skin Enriched with Schwann Cells, François Berthod, Myriam Grenier, Mathieu Blais, Journal of Investigative Dermatology, 2009, 10.1038/jid.2009.159
  • Tissue‐engineered in vitro modeling of the impact of Schwann cells in amyotrophic lateral sclerosis, François Berthod, François Gros‐Louis, Marie‐Josée Beaudet, Aurélie Louit, Biotechnology and Bioengineering, 2022, 10.1002/bit.28083
  • Modélisation in vitro du système nerveux par génie tissulaire, , médecine/sciences, 2009, 10.1051/medsci/2009253288
  • Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling, Saghatelyan, A., Parent, A., Barker, P.A., Götz, M., Berthod, F., Gravel, C., Ninkovic, J., Massouh, M., Blais, M., Brill, M.S., Lemasson, M., Snapyan, M., Journal of Neuroscience, 2009, 10.1523/JNEUROSCI.4956-08.2009
  • Quantitative Method to Evaluate the Functionality of the Trigeminal Nerve, François Berthod, Marie-France Champigny, Robert Paquin, Pierre-Éric Landry, René Caissie, Journal of Oral and Maxillofacial Surgery, 2007, 10.1016/j.joms.2006.09.010
  • Normal Human Epithelial Cells Regulate the Size and Morphology of Tissue-Engineered Capillaries, Lucie Germain, François A. Auger, François Berthod, Kathleen Baker, Charles J. Roberge, Florence Tomasetig, Véronique Fortin, Julie Fradette, Marie-Hélène Rochon, Tissue Engineering Part A, 2010, 10.1089/ten.tea.2009.0090
  • What is new in mechanical properties of tissue-engineered organs., Germain, L., Goulet, F., Berthod, F., Auger, F.A., Current topics in pathology. Ergebnisse der Pathologie, 1999
  • Engineering human tissues for in vivo applications, Auger, F.A., Berthod, F., Moulin, V., Goulet, F., Germain, L., Annals of the New York Academy of Sciences, 2002, 10.1111/j.1749-6632.2002.tb03099.x
  • Characterization of Skin Reconstructed on a Chitosan-Cross-Linked Collagen-Glycosaminoglycan Matrix, Christian Collombel, Odile Damour, François Berthod, Lili Shahabeddin, Skin Pharmacology and Physiology, 1990, 10.1159/000210857
  • In vivo enhancement of sensory perception recovery in a tissue-engineered skin enriched with laminin, François Berthod, Marie-France Champigny, Marie Gingras, René Caissie, Biomaterials, 2006, 10.1016/j.biomaterials.2006.01.014
  • Tissue-engineered skin substitutes: From in vitro constructs to in vivo applications, Germain, L., Pouliot, R., Moulin, V., Berthod, F., Auger, F.A., Biotechnology and Applied Biochemistry, 2004
  • In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent, François A. Auger, Lucie Germain, Nicolas L'heureux, François Berthod, Annie F. Black, The FASEB Journal, 1998, 10.1096/fasebj.12.13.1331
  • Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function, , Stroke, 2022, 10.1161/strokeaha.120.032691
  • In vitro development of a tissue-engineered model of peripheral nerve regeneration to study neurite growth , FRANÇOIS BERTHOD, HEATHER D. DURHAM, JULIEN DÉRY, JULIE BERGERON, MARIE GINGRAS, The FASEB Journal, 2003, 10.1096/fj.02-1180fje
  • Early detection of structural abnormalities and cytoplasmic accumulation of TDP-43 in tissue-engineered skins derived from ALS patients, François Gros-Louis, François Berthod, Nicolas Dupré, Guy A Rouleau, Peter Gould, Jean-Pierre Bouchard, Patrick A Dion, Hélène T Khuong, François-Dominique Scott, Marie-Soleil Lamarre, Rémy Lamontagne, Lydia Touzel-Deschênes, Bastien Paré, Acta Neuropathologica Communications, 2015, 10.1186/s40478-014-0181-z
  • Development of an innervated tissue-engineered skin with human sensory neurons and Schwann cells differentiated from iPS cells, François Berthod, Vincent Flacher, Sabrina Bellenfant, Thiéry De Serres-Bérard, Marie-Josée Beaudet, Quentin Muller, Acta Biomaterialia, 2018, 10.1016/j.actbio.2018.10.011
  • Prevascularized Tissue-Engineered Human Vaginal Mucosa: In Vitro Optimization and In Vivo Validation, , Tissue Engineering Part A, 2020, 10.1089/ten.tea.2020.0036
  • Mesenchymal-epithelial interactions regulate gene expression of type VII collagen and kalinin in keratinocytes and dermal-epidermal junction formation in a skin equivalent model, Odile Damour, Christian Collombel, Francois Berthod, Keiko Nakazawa, Florent Sahuc, Wound Repair and Regeneration, 1996, 10.1046/j.1524-475x.1996.40116.x
  • In Vitro Characterization of Motor Neurons and Purkinje Cells Differentiated from Induced Pluripotent Stem Cells Generated from Patients with Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay, François Berthod, Nicolas Dupré, François Gros-Louis, Mathieu Blais, Marie-Josée Beaudet, Aurélie Louit, Stem Cells International, 2023, 10.1155/2023/1496597
  • Le génie tissulaire au service de la compréhension du vivant, François A. Auger, Lucie Germain, François Berthod, Francine Goulet, Véronique Moulin, médecine/sciences, 2003, 10.1051/medsci/200319101003
  • A Longitudinal Low Dose μCT Analysis of Bone Healing in Mice: A Pilot Study, , Advances in Orthopedics, 2014, 10.1155/2014/791539
  • Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cord, François Berthod, Heather D. Durham, Sandra Minotti, Vicky Gagnon, Marie Gingras, Journal of Neuroscience Methods, 2007, 10.1016/j.jneumeth.2007.02.024
  • Optimization of thickness, pore size and mechanical properties of a biomaterial designed for deep burn coverage, Damour, O., Collombel, C., Hayek, D., Chretien, F., Saintigny, G., Berthod, F., Clinical Materials, 1994, 10.1016/0267-6605(94)90055-8
  • Tissue-engineered skin and the treatment of burns: Skin doctor, Berthod, F., Biochemist, 2007
  • Collagen synthesis by fibroblasts cultured within a collagen sponge, Christian Collombel, Odile Damour, Dany Hayek, François Berthod, Biomaterials, 1993, 10.1016/0142-9612(93)90039-5
  • Sensory neurons increase keratinocyte proliferation through CGRP release in a tissue engineered in vitro model of innervation in psoriasis, François Berthod, Roxane Pouliot, Hélène Veillette, Todd Galbraith, Sabrina Bellenfant, Marie-Josée Beaudet, Julien Ringuet, Rémy Pépin, Acta Biomaterialia, 2024, 10.1016/j.actbio.2024.05.021
  • Differentiation of human adult skin-derived neuronal precursors into mature neurons, François Berthod, Marie-France Champigny, Marie Gingras, Journal of Cellular Physiology, 2006, 10.1002/jcp.20889
  • Biotechnological Management of Skin Burn Injuries: Challenges and Perspectives in Wound Healing and Sensory Recovery, Desmoulière, A., Berthod, F., Lataillade, J.-J., Coulomb, B., Misery, L., Egles, C., Alexaline, M.M., Ghazi, K., Trouillas, M., Buhé, V., Laverdet, B., Girard, D., Tissue Engineering - Part B: Reviews, 2017, 10.1089/ten.teb.2016.0195
  • Reconstructed skin from co-cultured human keratinocytes and fibroblasts on a chitosane cross-linked collagen-GAG matrix, Collombel, C., Saintigny, G., Rousselle, P., Berthod, F., Damour, O., Shahabeddin, L., Journal of Materials Science: Materials in Medicine, 1991, 10.1007/BF00703375
  • Deposition of collagen fibril bundles by long-term culture of fibroblasts in a collagen sponge, Collombel, C., Damour, O., Hayek, D., Sahuc, F., Berthod, F., Journal of Biomedical Materials Research, 1996, 10.1002/(SICI)1097-4636(199609)32:1<87::AID-JBM10>3.0.CO;2-F
  • In vitro evaluation of the angiostatic potential of drugs using an endothelialized tissue-engineered connective tissue, Auger, F.A., Germain, L., Berthod, F., Tremblay, P.-L., Journal of Pharmacology and Experimental Therapeutics, 2005, 10.1124/jpet.105.089524
  • Tridimensional cell culture of dermal fibroblasts promotes exosome-mediated secretion of extracellular matrix proteins, François Gros-Louis, Stéphane Bolduc, François Berthod, Lydia Touzel Deschênes, Cassandra R. Goulet, Bastien Paré, Vincent Roy, Vincent Clément, Scientific Reports, 2022, 10.1038/s41598-022-23433-0
  • In vitro reconstructed skin models for wound coverage in deep burns, Damour, O., Berthod, F., British Journal of Dermatology, 1997, 10.1111/j.1365-2133.1997.tb03917.x
  • Nerve regeneration in a collagen–chitosan tissue-engineered skin transplanted on nude mice, François Berthod, Isabelle Paradis, Marie Gingras, Biomaterials, 2003, 10.1016/s0142-9612(02)00572-0
  • A tissue-engineered endothelialized dermis to study the modulation of angiogenic and angiostatic molecules on capillary-like tube formation in vitro, Auger, F.A., Germain, L., Damour, O., Black, A.F., Berthod, F., Hudon, V., British Journal of Dermatology, 2003, 10.1046/j.1365-2133.2003.05298.x
  • In Vitro 3D Modeling of Neurodegenerative Diseases, François Berthod, Todd Galbraith, Aurélie Louit, Bioengineering, 2023, 10.3390/bioengineering10010093
  • Fibroblasts and endothelial cells: The basic angiogenic unit, Berthod, F., Angiogenesis: Insights from a Systematic Overview, 2013
  • Hair Follicles Guide Nerve Migration In Vitro and In Vivo in Tissue-Engineered Skin, François Berthod, Lucie Germain, Marie Gingras, Rémi Parenteau-Bareil, Danielle Larouche, Vicky Gagnon, Journal of Investigative Dermatology, 2011, 10.1038/jid.2011.34
  • Neuropeptide Substance P Released from a Nonswellable Laponite-Based Hydrogel Enhances Wound Healing in a Tissue-Engineered Skin In Vitro, François Berthod, Catia Ornelas, Carolyne B. Braga, Tiago B. Becher, Thiéry De Serres-Bérard, ACS Applied Polymer Materials, 2020, 10.1021/acsapm.0c01034
  • Lifting the veil on the keratinocyte contribution to cutaneous nociception, , Protein & Cell, 2020, 10.1007/s13238-019-00683-9
  • Cutaneous Myiasis: Diagnosis, Treatment, and Prevention, Pierre-Éric Landry, François Berthod, Marjolaine Giroux, Frédéric Beaulieu, René Caissie, Journal of Oral and Maxillofacial Surgery, 2008, 10.1016/j.joms.2007.09.005
  • High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord, François Berthod, François Gros-Louis, Sabrina Bellenfant, Mathieu Blais, Sébastien Cadau, Qiurui Yang, Marie-Josée Beaudet, Scientific Reports, 2015, 10.1038/srep16763
  • Bioengineering Human Upper Respiratory Mucosa: A Systematic Review of the State of the Art of Cell Culture Techniques, Pierre-Olivier Champagne, François Gros-Louis, François Berthod, Célina Maguemoun, Thibault Maurand, Lydia Touzel Deschênes, Clémence Tanguay Boivin, Davaine Joel Ndongo Sonfack, Bioengineering, 2024, 10.3390/bioengineering11080826
  • The Relation between ALS and the Skin: A Novel Human In Vitro Model to Identify New Biomarkers, Francois Gros Louis, Francois Berthod, Bastien Pare, Journal of Molecular Biomarkers & Diagnosis, 2015, 10.4172/2155-9929.1000e121
  • Extracellular matrix deposition by fibroblasts is necessary to promote capillary-like tube formation in vitro, François A. Auger, Nathalie Tremblay, Lucie Germain, François Berthod, Journal of Cellular Physiology, 2006, 10.1002/jcp.20584
  • Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment, François Berthod, Sébastien Cadau, Rémi Parenteau-Bareil, Mathieu Blais, STEM CELLS Translational Medicine, 2013, 10.5966/sctm.2012-0181
  • In vitro glycation of a tissue‐engineered wound healing model to mimic diabetic ulcers, François Berthod, Sébastien Cadau, Sabrina Bellenfant, Thiéry De Serres‐Bérard, Kiefer Thouin, Mathias Lemarchand, Biotechnology and Bioengineering, 2023, 10.1002/bit.28359
  • Nerve Growth Factor, Brain-Derived Neurotrophic Factor, Neurotrophin-3 and Glial-Derived Neurotrophic Factor Enhance Angiogenesis in a Tissue-Engineered In Vitro Model, François Berthod, Sabrina Bellenfant, Philippe Lévesque, Mathieu Blais, Tissue Engineering Part A, 2013, 10.1089/ten.tea.2012.0745
  • A dermal substrate made of collagen-GA-chitosan for deep burn coverage: First clinical uses, Collombel, C., Sahuc, F., Berthod, F., Rousselle, P., Berthin-Maghit, M., Gueugniaud, P.Y., Damour, O., Clinical Materials, 1994, 10.1016/0267-6605(94)90057-4
  • In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules, François Berthod, Valérie André-Frei, Nicolas Bechetoille, Sabine Pain, Sabrina Leoty-Okombi, Sébastien Cadau, Biomaterials, 2015, 10.1016/j.biomaterials.2015.01.066
  • Principles of Living Organ Reconstruction by Tissue Engineering, Franc¸ois Auger, Francine Goulet, Véronique Moulin, François Berthod, Lucie Germain, Tissue Engineering And Novel Delivery Systems, 2003, 10.1201/9780203913338.ch10
  • Potential of tissue engineering and neural stem cells in the understanding and treatment of neurodegenerative diseases, Berthod, F., Auclair-Daigle, C., Engineering Stem Cells For Tissue Regeneration, 2017, 10.1142/10228
  • Differential Expression of Collagens XII and XIV in Human Skin and in Reconstructed Skin, François A. Auger, Michel van der Rest, Odile Damour, Robert Garrone, Claire Lethias, Rina Guignard, Lucie Germain, François Berthod, Journal of Investigative Dermatology, 1997, 10.1111/1523-1747.ep12292122
  • In vitro study of axonal migration and myelination of motor neurons in a three-dimensional tissue-engineered model, François Berthod, Heather D. Durham, Vicky Gagnon, Marie-Michèle Beaulieu, Marie Gingras, Glia, 2007, 10.1002/glia.20617
  • Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro, François A. Auger, Jeffrey A. Medin, Nathalie Tremblay, Julie Symes, François Berthod, Journal of Cellular Physiology, 2012, 10.1002/jcp.22943

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/05
  • Emilie Genin - Doctorat - En cours
  • Gérald Guillebaud - Doctorat - En cours
  • Oumayma Hayouni - Doctorat - En cours
  • Alexane Thibodeau - Maîtrise avec mémoire - 2020/09
  • Aurélie Louit - Doctorat - 2021/09
  • Rémy Pépin - Doctorat - 2024/05
  • Mathias Lemarchand - Doctorat - 2024/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Sciences cliniques et biomédicales

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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