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Emmanuel Planel

Professeur titulaire

Emmanuel Planel
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Démences
Vieillissement
  • Nutrition et vieillissement
  • Âge et facteurs de risques

Projets de recherche

  • Physiological regulation of tau protein - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
  • Microglial tau: a missing link between neuroinflammation and neurodegeneration in TDP-43 proteinopathies - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-04-01 au 2028-03-31
  • Microglial tau: a missing link between neuroinflammation and neurodegeneration in TDP-43 proteinopathies - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2028-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Mechanisms of neuronal and vascular impairments in ischemic retinopathies - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
  • Untangling tau contribution to cognitive impairments in Huntington’s disease. - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-04-01 au 2024-03-31
  • Targeting tau pathology by modulating temperature - Société Alzheimer du Canada, chercheur principal - 2018-07-01 au 2022-09-30
  • Neurobiologie de la protéine tau: régulation et dérégulation in vivo - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2018-07-01 au 2022-06-30
  • Salaire d'un professeur sous octroi - CHU de Québec – Université Laval – CHUL, chercheur principal - 2008-11-01 au 2022-06-30
  • Regulation of tau phosphorylation and splicing during post-embryonic development. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31

Publications

  • Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors., Planel E, Hébert SS, Lévesque G, Mouginot D, Poitras I, Petry FR, El Khoury NB, Julien C, Marcouiller F, Bretteville A, Scientific reports, 2012, 10.1038/srep00480
  • Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse., Ishiguro K, Fujita SC, Yasutake K, Planel E, The Journal of biological chemistry, 2001, 10.1074/jbc.m102780200
  • Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau., Takashima A, Hashikawa T, Sato S, Planel E, Ishiguro K, Murayama M, Tanemura K, Fujiwara M, Iwasaki K, Mishima K, Akagi T, Chui DH, Miyasaka T, Tatebayashi Y, Proceedings of the National Academy of Sciences of the United States of America, 2002, 10.1073/pnas.202205599
  • Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma., Burns MP, Planel E, Villapol S, Zapple DN, Alikhani AD, Wilkins TE, Chellappa D, Barton DJ, Parsadanian M, Neustadtl A, Noël A, Winston CN, The American journal of pathology, 2016, 10.1016/j.ajpath.2015.11.006
  • Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer's Disease., Desrumaux C, Devarajan PV, Laurent Givalois, Rajshree SL, Durand T, OGER Camille, Planel E, Morin F, Vitalis M, Geoffrey CANET, Acar N, Claire VIGOR, Otaegui L, Urgin T, John R, Zussy C, Antioxidants (Basel, Switzerland), 2022, 10.3390/antiox11050838
  • High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology., Planel E, Marette A, Hébert SS, Calon F, Morin F, Julien J, Gratuze M, Neurobiology of aging, 2016, 10.1016/j.neurobiolaging.2016.07.016
  • Postoperative cognitive decline: where art tau?, Planel E, Eckenhoff RG, Anesthesiology, 2012, 10.1097/aln.0b013e31824be8e1
  • Impaired Resolution of Inflammation in Alzheimer's Disease: A Review., Terrando N, Planel E, Whittington RA, Frontiers in immunology, 2017, 10.3389/fimmu.2017.01464
  • Repurposing beta3-adrenergic receptor agonists for Alzheimer’s disease: Beneficial effects on recognition memory and amyloid pathology in a mouse model, Calon F, Pifferi F, Planel E, Mélançon K, Tremblay C, Hozer C, Vu T, Vrabic N, Tournissac M, 2020, 10.1101/2020.05.25.114454
  • Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature., Planel E, Mongrain V, Hébert SS, Whittington RA, Keraudren R, Morin F, Petry S, Gratuze M, Guisle I, Sleep, 2020, 10.1093/sleep/zsz266
  • A Simple Method to Avoid Nonspecific Signal When Using Monoclonal Anti-Tau Antibodies in Western Blotting of Mouse Brain Proteins., Planel E, Hébert SS, Nicholls SB, Petry FR, Methods in molecular biology (Clifton, N.J.), 2017, 10.1007/978-1-4939-6598-4_15
  • Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease., First International Workshop on Anesthetics and Alzheimer's Disease, Planel E, Perouansky M, Palotás A, Jevtovic-Todorovic V, Hogan KJ, Eckenhoff RG, Eckenhoff MF, Culley DJ, Crosby GJ, Bickler PE, Baranov D, Anesthesia and analgesia, 2009, 10.1213/ane.0b013e318199dc72
  • Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice., Planel E, Marette A, Hébert SS, Calon F, Nicholls SB, Morin F, Marcouiller F, Julien C, Papon MA, Petry F, El Khoury NB, Gratuze M, Neurobiology of disease, 2016, 10.1016/j.nbd.2016.01.005
  • Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease., Calon F, Marette A, Planel E, Traversy MT, Bousquet M, Drouin-Ouellet J, St-Amour I, Tremblay C, Tournissac M, White PJ, Vandal M, Neurobiology of aging, 2016, 10.1016/j.neurobiolaging.2016.03.024
  • Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington's Disease Brain., St-Amour I, Hébert SS, Planel E, Sergeant N, Keraudren R, Nateghi B, Petry S, Neuroscience, 2022, 10.1016/j.neuroscience.2022.07.014
  • U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy., Takashima A, Nakayama KI, Takahashi R, Planel E, Chui DH, Murayama M, Kamura T, Matsumoto M, Hatakeyama S, Journal of neurochemistry, 2004, 10.1111/j.1471-4159.2004.02713.x
  • Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease., Planel E, Whittington RA, Bissonnette S, Poitras I, Bezeau F, Goupil C, Dickler M, Morin F, Milot-Rousseau P, Cisbani G, Julien C, Noël A, Gratuze M, Human molecular genetics, 2014, 10.1093/hmg/ddu456
  • Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein., Duff KE, Clark LN, Cookson MR, Planel E, Wang L, Figueroa HY, Dorado B, Yu WH, The American journal of pathology, 2009, 10.2353/ajpath.2009.080928
  • Is Huntington's disease a tauopathy?, Planel E, Cicchetti F, Cisbani G, Gratuze M, Brain : a journal of neurology, 2016, 10.1093/brain/aww021
  • Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet., Planel E, Marette A, Morin F, Julien J, Gratuze M, Progress in neuro-psychopharmacology & biological psychiatry, 2017, 10.1016/j.pnpbp.2017.08.001
  • Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation., Planel E, Hébert SS, Baillargeon J, El Khoury NB, Bretteville A, Marcouiller F, Julien C, PloS one, 2012, 10.1371/journal.pone.0040020
  • Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions., Planel E, Whittington RA, Hébert SS, Calon F, Morin F, Bretteville A, Pelletier J, Petry FR, PloS one, 2014, 10.1371/journal.pone.0094251
  • MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy., Hébert SS, Buée L, Sergeant N, Planel E, Papon MA, Girard J, Delay C, Smith PY, Human molecular genetics, 2011, 10.1093/hmg/ddr330
  • Memory formation and retention are affected in adult miR-132/212 knockout mice., Hébert SS, Goodman RH, Magill ST, Planel E, Filali M, Goupil C, Smith PY, Hernandez-Rapp J, Behavioural brain research, 2015, 10.1016/j.bbr.2015.03.032
  • Passive immunization against phosphorylated tau improves features of Huntington's disease pathology., Francesca Cicchetti, Planel E, Davies P, Denis HL, Saint-Pierre M, Eva LEPINAY, Aurelie de Rus Jacquet, Masnata M, Melanie Alpaugh, Molecular therapy : the journal of the American Society of Gene Therapy, 2022, 10.1016/j.ymthe.2022.01.020
  • Co-occurrence of mixed proteinopathies in late-stage Huntington's disease., Hébert SS, Planel E, Goupil C, Turgeon A, St-Amour I, Acta neuropathologica, 2017, 10.1007/s00401-017-1786-7
  • Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model., Calon F, Pifferi F, Planel E, Mélançon K, Tremblay C, Hozer C, Vrabic N, Vu TM, Tournissac M, Alzheimer's research & therapy, 2021, 10.1186/s13195-021-00842-3
  • Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation., Small SA, Arancio O, Duff K, Ganetzky B, Honig LS, Kreber R, Ho L, Herman M, Planel E, Yu R, Staniszewski A, Zhang H, Flores I, Muhammad A, Proceedings of the National Academy of Sciences of the United States of America, 2008, 10.1073/pnas.0802545105
  • Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons., Leclerc N, Planel E, Rémillard-Labrosse G, Plouffe V, Mohamed NV, Scientific reports, 2014, 10.1038/srep05715
  • Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing., Duff KE, Yu WH, Lau LF, Liu L, Wang L, Figueroa HY, Herman M, Planel E, Wen Y, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/jneurosci.5245-07.2008
  • Anesthesia and tau pathology., Planel E, Dickler MF, Bretteville A, Whittington RA, Progress in neuro-psychopharmacology & biological psychiatry, 2013, 10.1016/j.pnpbp.2013.03.004
  • Metabolic determinants of Alzheimer's disease: A focus on thermoregulation., Calon F, Planel E, Bosoi CR, Vandal M, Valentin-Escalera J, Leclerc M, Tournissac M, Ageing research reviews, 2021, 10.1016/j.arr.2021.101462
  • Hypothermia and Alzheimer's disease neuropathogenic pathways., Planel E, Chouinard F, Papon MA, Whittington RA, Current Alzheimer research, 2010, 10.2174/156720510793611646
  • Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration., De Strooper B, Buée L, Sergeant N, Silahtaroglu AN, Planel E, Galas MC, Papadopoulou AS, Smith P, Hébert SS, Human molecular genetics, 2010, 10.1093/hmg/ddq311
  • Untangling memory deficits., Planel E, Duff K, Nature medicine, 2005, 10.1038/nm0805-826
  • The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice., Planel E, Bretzner F, Cicchetti F, Samadi P, Morin F, Bezeau F, Julien J, Poitras I, Truchetti G, Eyoum Jong L, Pflieger M, Petry FR, Josset N, Gratuze M, Brain research, 2019, 10.1016/j.brainres.2019.01.016
  • Corrigendum: Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons., Pernet V, Planel E, Boudreau-Laprise M, Joly S, Mdzomba JB, Rodriguez L, Frontiers in molecular neuroscience, 2018, 10.3389/fnmol.2018.00390
  • Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice., Planel E, Hébert SS, Mathews PM, Amrani A, Gaudreau S, Petry FR, Bretteville A, Morin F, Julien C, Marcouiller F, El Khoury NB, Papon MA, Diabetes, 2012, 10.2337/db12-0187
  • Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia., Duff KE, Whittington RA, Dickson DW, Yu WH, Du AL, Virag L, Liu L, Bretteville A, Planel E, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, 10.1096/fj.08-122424
  • Anesthesia, surgery and neurodegeneration. Preface., Planel E, Eckenhoff RG, Progress in neuro-psychopharmacology & biological psychiatry, 2013, 10.1016/j.pnpbp.2013.10.012
  • Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation., Planel E, Charron J, Morin F, El-Khoury NB, Petry FR, Julien C, Marcouiller F, Maurin TO, Emala CW, Virág L, Bretteville A, Whittington RA, Scientific reports, 2013, 10.1038/srep01388
  • Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways., Nicola Marchi, Laurent Givalois, Planel E, Desrumaux C, Audinat E, Moreno-Montano M, deBock F, Vitalis M, Garcia V, Blaquiere M, Hernandez C, Zussy C, Zub E, Geoffrey CANET, Epilepsia, 2022, 10.1111/epi.17186
  • Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia., Planel E, Hébert SS, Frédéric Calon, Whittington RA, Kérauden R, Françoise Morin, Fereydouni-Forouzandeh P, Pétry S, Geoffrey CANET, Isabelle GUISLE, Neurobiology of aging, 2022, 10.1016/j.neurobiolaging.2022.02.011
  • Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease., Calon F, Marette A, Planel E, St-Amour I, Tremblay C, Chevrier G, White PJ, Vandal M, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, 10.1096/fj.14-268482
  • Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212., Hébert SS, Planel E, St-Amour I, Turgeon A, Goupil C, Loiselle A, Rainone S, Keraudren R, Petry S, Hernandez-Rapp J, Boscher E, Frontiers in neurology, 2020, 10.3389/fneur.2020.578720
  • Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain., Planel E, Morin F, Poitras I, Petry F, Cheheltanan M, Lewkowitz-Shpuntoff H, Gratuze M, Virág L, Whittington RA, Neurobiology of aging, 2018, 10.1016/j.neurobiolaging.2018.10.027
  • Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells., Takashima A, Ishiguro K, Yoshioka K, Hashikawa T, Sun X, Tanemura K, Planel E, Miyasaka T, Murayama M, Chui DH, Akagi T, Tatebayashi Y, Sato S, The Journal of biological chemistry, 2002, 10.1074/jbc.m202241200
  • Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation., Calon F, Planel E, Hébert SS, Vu TM, Martinez-Cano RD, Bourassa P, Tournissac M, Molecular metabolism, 2019, 10.1016/j.molmet.2019.01.008
  • ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro., Planel E, Charron J, Morin F, Petry FR, Julien J, Poitras I, Noël A, Neurobiology of aging, 2014, 10.1016/j.neurobiolaging.2014.11.005
  • Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)., Planel E, Calon F, Julien C, Theriault P, Lalonde R, Filali M, Behavioural brain research, 2012, 10.1016/j.bbr.2012.07.004
  • Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease., Fujita SC, Ishiguro K, Planel E, Yanagisawa M, FEBS letters, 1999, 10.1016/s0014-5793(99)01480-5
  • c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis., Takashima A, Rivka R, Yoshioka K, Kikuchi N, Murayama M, Sahara N, Miyasaka T, Sato S, Chui DH, Planel E, Tatebayashi Y, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, 10.1096/fj.05-4362fje
  • Tau aggregates: toxic, inert, or protective species?, Planel E, Bretteville A, Journal of Alzheimer's disease : JAD, 2008, 10.3233/jad-2008-14411
  • In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice., Mathews PM, Planel E, Matsuoka Y, Levy E, Choi JH, Diaz NS, Berger JD, Mazzella MJ, Morales-Corraliza J, PloS one, 2009, 10.1371/journal.pone.0007134
  • Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo., Duff KE, Nixon RA, Takashima A, Davies P, Whittington RA, Yu WH, Figueroa HY, Bretteville A, Kumar A, Herman M, Liu L, Miyasaka T, Krishnamurthy P, Planel E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/jneurosci.4101-08.2008
  • Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease., Cicchetti F, Freeman TB, Planel E, Kordower JH, Maxan A, Cisbani G, Brain : a journal of neurology, 2017, 10.1093/brain/awx255
  • Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar., Hemmings HC, Planel E, Orser BA, Ma D, Loepke AW, Herold KF, Giffard RG, Fiskum G, Culley DJ, Crosby G, Brambrink A, Blomgren K, Absalom AR, Jevtovic-Todorovic V, British journal of anaesthesia, 2013, 10.1093/bja/aet177
  • Regulation of brain insulin signaling: A new function for tau., Planel E, Gratuze M, The Journal of experimental medicine, 2017, 10.1084/jem.20170979
  • Propofol directly increases tau phosphorylation., Planel E, Emala CW, Morin F, Julien C, El Khoury NB, Papon MA, Marcouiller F, Virág L, Whittington RA, PloS one, 2011, 10.1371/journal.pone.0016648
  • microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice., Hébert SS, Cicchetti F, Calon F, Droit A, Planel E, Vallée M, Saint-Pierre M, Smith PY, Dorval V, Goupil C, Rainone S, Hernandez-Rapp J, Scientific reports, 2016, 10.1038/srep30953
  • Alzheimer's disease and anesthesia., Planel E, El-Khoury NB, Whittington RA, Papon MA, Frontiers in neuroscience, 2011, 10.3389/fnins.2010.00272
  • Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits., Girouard H, Ferland G, Planel E, Petry FR, Gratuze M, Youwakim J, Vallerand D, Iulita MF, Muhire G, Journal of the American Heart Association, 2019, 10.1161/jaha.118.011630
  • Old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with Alzheimer's disease., Calon F, Planel E, François A, Vandal M, Tournissac M, Neurobiology of aging, 2016, 10.1016/j.neurobiolaging.2016.09.024
  • Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons., Pernet V, Planel E, Boudreau-Laprise M, Joly S, Mdzomba JB, Rodriguez L, Frontiers in molecular neuroscience, 2018, 10.3389/fnmol.2018.00293
  • A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment., Duff K, Arancio O, Yu WH, Figueroa H, Herman M, Wang L, Krishnamurthy P, Bretteville A, Wen Y, Planel E, Orozco IJ, Liu L, Neurobiology of disease, 2008, 10.1016/j.nbd.2008.03.005
  • Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease., Takashima A, Tatebayashi Y, Ishiguro K, Murayama O, Sato S, Tanemura K, Chui DH, Launey T, Miyasaka T, Planel E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/jneurosci.5561-03.2004
  • Biochemical isolation of insoluble tau in transgenic mouse models of tauopathies., Planel E, Bretteville A, Julien C, Methods in molecular biology (Clifton, N.J.), 2012, 10.1007/978-1-61779-551-0_32
  • Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing., Duff K, Lahiri DK, Lau LF, Planel E, Liu L, Krishnamurthy P, Herman M, Figueroa H, Wang L, Maurin T, Marié I, Ma J, Bailey J, Maloney B, Yu WH, Wen Y, Neuron, 2008, 10.1016/j.neuron.2008.02.024
  • MicroRNA-138 Overexpression Alters Aβ42 Levels and Behavior in Wildtype Mice., Hébert SS, Planel E, Loiselle A, Keraudren R, Petry S, Goupil C, Boscher E, Frontiers in neuroscience, 2020, 10.3389/fnins.2020.591138
  • Insulin dysfunction and Tau pathology., Planel E, Bretteville A, Papon MA, Gratuze M, El Khoury NB, Frontiers in cellular neuroscience, 2014, 10.3389/fncel.2014.00022
  • miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo., Hébert SS, Fernandez-Gomez FJ, Bennett DA, Planel E, Morin F, Parsi S, Dorval V, Goupil C, Bisht K, Lecours C, Jolivette F, Hernandez-Rapp J, Smith PY, Human molecular genetics, 2015, 10.1093/hmg/ddv377
  • Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo., Duff K, Bhat R, Wen Y, Krishnamurthy P, Burns M, Feinstein B, LaFrancois J, Wang L, Gaynor K, Suleman F, Meyerson J, Olm V, Zehr C, Planel E, Noble W, Proceedings of the National Academy of Sciences of the United States of America, 2005, 10.1073/pnas.0500466102
  • Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro., Planel E, Morin F, Bretteville A, Wong K, El Khoury N, Papon MA, Marcouiller F, Truchetti G, Poitras I, Noël A, Petry FR, Gratuze M, Virág L, Whittington RA, Neurobiology of aging, 2015, 10.1016/j.neurobiolaging.2015.05.002
  • Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease., Calon F, Marette A, Giguere Y, Planel E, Virgili J, Lefrançois D, Emond V, Chevrier G, St-Amour I, Tremblay C, White PJ, Vandal M, Diabetes, 2014, 10.2337/db14-0375
  • A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease., Aisen PS, Gozes I, Arancio O, Planel E, Walker BR, Lecanu L, Feng L, Li HF, Hirata-Fukae C, Ma L, Gray AJ, Jouroukhin Y, Matsuoka Y, The Journal of pharmacology and experimental therapeutics, 2008, 10.1124/jpet.107.130526
  • Insulin resistance and obesity: how do they affect tau pathology?, Planel E, Morin F, Marcouiller F, Julien C, Papon M, DicklerI M, El Khoury N, Gratuze M, Molecular neurodegeneration, 2013, 10.1186/1750-1326-8-s1-p67
  • Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease., Planel E, Calon F, Marette A, Whittington RA, Morin F, Marcouiller F, Julien C, Turgeon A, El Khoury NB, Gratuze M, Neurobiology of disease, 2016, 10.1016/j.nbd.2016.10.004
  • Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons., Hébert SS, Buée L, Zommer N, Planel E, Calvo E, Delay C, Smith PY, Dorval V, PloS one, 2012, 10.1371/journal.pone.0044060
  • Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia., Duff KE, Lau LF, Nelson RB, Schachter JB, Wang L, Herman M, Krishnamurthy P, Wen Y, Liu L, Finley JE, Nolan CE, Richter KE, Planel E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/jneurosci.4854-06.2007
  • Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology., Planel E, Morin F, Petry FR, Julien J, Gratuze M, Scientific reports, 2017, 10.1038/srep46359
  • Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms., Takashima A, Duff KE, Wadzinski B, Luchsinger JA, Yu WH, Herman M, Wang L, Liu L, Miyasaka T, Tatebayashi Y, Planel E, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/jneurosci.3949-07.2007

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Sofía Diego Díaz - Maîtrise avec mémoire - En cours
  • Geoffrey Canet - Post-doctorat - En cours
  • Emma Rocaboy - Maîtrise avec mémoire - En cours
  • François Marcouiller - Maîtrise avec mémoire - 2011/05
  • Noura El Khoury - Doctorat - 2013/05
  • Serena Petry - Doctorat - 2017/01
  • Maud Gratuze - Doctorat - 2017/05
  • Andréanne Turgeon - Maîtrise avec mémoire - 2018/05
  • Laura Eyoum Jong - Maîtrise avec mémoire - 2018/05
  • Ophélie Lerdu - Maîtrise avec mémoire - 2019/05
  • Isabelle Guisle - Doctorat - 2020/01
  • Julius Baya Mdzomba - Doctorat - 2021/01
  • Eva Lepinay - Maîtrise avec mémoire - 2023/01
  • Parissa Fereydouni-Forouzandeh - Maîtrise avec mémoire - 2023/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.