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Emmanuel Planel

Professeur titulaire

Emmanuel Planel
Emmanuel.Planel@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Maladie d'Alzheimer
  • Maladies neurodégénératives
  • Démences
Vieillissement
  • Nutrition et vieillissement
  • Âge et facteurs de risques

Projets de recherche

  • Microglial tau: a missing link between neuroinflammation and neurodegeneration in TDP-43 proteinopathies - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2023-03-01 au 2028-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Untangling tau contribution to cognitive impairments in Huntington’s disease. - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2019-04-01 au 2024-03-31
  • Mechanisms of neuronal and vascular impairments in ischemic retinopathies - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
  • Targeting tau pathology by modulating temperature - Société Alzheimer du Canada, chercheur principal - 2018-07-01 au 2022-09-30
  • Neurobiologie de la protéine tau: régulation et dérégulation in vivo - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2018-07-01 au 2022-06-30
  • Salaire d'un professeur sous octroi - CHU de Québec – Université Laval – CHUL, chercheur principal - 2008-11-01 au 2022-06-30
  • Regulation of tau phosphorylation and splicing during post-embryonic development. - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31

Publications

  • Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington's Disease Brain., Petry S, Nateghi B, Keraudren R, Sergeant N, Planel E, Hébert SS, St-Amour I, Neuroscience, 2022, 10.1016/j.neuroscience.2022.07.014
  • Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer's Disease., Zussy C, John R, Urgin T, Otaegui L, Claire VIGOR, Acar N, Geoffrey CANET, Vitalis M, Morin F, Planel E, OGER Camille, Durand T, Rajshree SL, Laurent Givalois, Devarajan PV, Desrumaux C, Antioxidants (Basel, Switzerland), 2022, 10.3390/antiox11050838
  • Seizure activity triggers tau hyperphosphorylation and amyloidogenic pathways., Geoffrey CANET, Zub E, Zussy C, Hernandez C, Blaquiere M, Garcia V, Vitalis M, deBock F, Moreno-Montano M, Audinat E, Desrumaux C, Planel E, Laurent Givalois, Nicola Marchi, Epilepsia, 2022, 10.1111/epi.17186
  • Sauna-like conditions or menthol treatment reduce tau phosphorylation through mild hyperthermia., Isabelle GUISLE, Geoffrey CANET, Pétry S, Fereydouni-Forouzandeh P, Françoise Morin, Kérauden R, Whittington RA, Frédéric Calon, Hébert SS, Planel E, Neurobiology of aging, 2022, 10.1016/j.neurobiolaging.2022.02.011
  • Passive immunization against phosphorylated tau improves features of Huntington's disease pathology., Melanie Alpaugh, Masnata M, Aurelie de Rus Jacquet, Eva LEPINAY, Denis HL, Saint-Pierre M, Davies P, Planel E, Francesca Cicchetti, Molecular therapy : the journal of the American Society of Gene Therapy, 2022, 10.1016/j.ymthe.2022.01.020
  • Metabolic determinants of Alzheimer's disease: A focus on thermoregulation., Tournissac M, Leclerc M, Valentin-Escalera J, Vandal M, Bosoi CR, Planel E, Calon F, Ageing research reviews, 2021, 10.1016/j.arr.2021.101462
  • Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model., Tournissac M, Vu TM, Vrabic N, Hozer C, Tremblay C, Mélançon K, Planel E, Pifferi F, Calon F, Alzheimer's research & therapy, 2021, 10.1186/s13195-021-00842-3
  • Advances and Challenges in Understanding MicroRNA Function in Tauopathies: A Case Study of miR-132/212., Boscher E, Hernandez-Rapp J, Petry S, Keraudren R, Rainone S, Loiselle A, Goupil C, Turgeon A, St-Amour I, Planel E, Hébert SS, Frontiers in neurology, 2020, 10.3389/fneur.2020.578720
  • Repurposing beta3-adrenergic receptor agonists for Alzheimer’s disease: Beneficial effects on recognition memory and amyloid pathology in a mouse model, Tournissac M, Vu T, Vrabic N, Hozer C, Tremblay C, Mélançon K, Planel E, Pifferi F, Calon F, 2020, 10.1101/2020.05.25.114454
  • Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature., Guisle I, Gratuze M, Petry S, Morin F, Keraudren R, Whittington RA, Hébert SS, Mongrain V, Planel E, Sleep, 2020, 10.1093/sleep/zsz266
  • MicroRNA-138 Overexpression Alters Aβ42 Levels and Behavior in Wildtype Mice., Boscher E, Goupil C, Petry S, Keraudren R, Loiselle A, Planel E, Hébert SS, Frontiers in neuroscience, 2020, 10.3389/fnins.2020.591138
  • Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits., Muhire G, Iulita MF, Vallerand D, Youwakim J, Gratuze M, Petry FR, Planel E, Ferland G, Girouard H, Journal of the American Heart Association, 2019, 10.1161/jaha.118.011630
  • Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation., Tournissac M, Bourassa P, Martinez-Cano RD, Vu TM, Hébert SS, Planel E, Calon F, Molecular metabolism, 2019, 10.1016/j.molmet.2019.01.008
  • The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice., Gratuze M, Josset N, Petry FR, Pflieger M, Eyoum Jong L, Truchetti G, Poitras I, Julien J, Bezeau F, Morin F, Samadi P, Cicchetti F, Bretzner F, Planel E, Brain research, 2019, 10.1016/j.brainres.2019.01.016
  • Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain., Whittington RA, Virág L, Gratuze M, Lewkowitz-Shpuntoff H, Cheheltanan M, Petry F, Poitras I, Morin F, Planel E, Neurobiology of aging, 2018, 10.1016/j.neurobiolaging.2018.10.027
  • Corrigendum: Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons., Rodriguez L, Mdzomba JB, Joly S, Boudreau-Laprise M, Planel E, Pernet V, Frontiers in molecular neuroscience, 2018, 10.3389/fnmol.2018.00390
  • Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons., Rodriguez L, Mdzomba JB, Joly S, Boudreau-Laprise M, Planel E, Pernet V, Frontiers in molecular neuroscience, 2018, 10.3389/fnmol.2018.00293
  • Co-occurrence of mixed proteinopathies in late-stage Huntington's disease., St-Amour I, Turgeon A, Goupil C, Planel E, Hébert SS, Acta neuropathologica, 2017, 10.1007/s00401-017-1786-7
  • Impaired Resolution of Inflammation in Alzheimer's Disease: A Review., Whittington RA, Planel E, Terrando N, Frontiers in immunology, 2017, 10.3389/fimmu.2017.01464
  • Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease., Cisbani G, Maxan A, Kordower JH, Planel E, Freeman TB, Cicchetti F, Brain : a journal of neurology, 2017, 10.1093/brain/awx255
  • Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet., Gratuze M, Julien J, Morin F, Marette A, Planel E, Progress in neuro-psychopharmacology & biological psychiatry, 2017, 10.1016/j.pnpbp.2017.08.001
  • Regulation of brain insulin signaling: A new function for tau., Gratuze M, Planel E, The Journal of experimental medicine, 2017, 10.1084/jem.20170979
  • Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology., Gratuze M, Julien J, Petry FR, Morin F, Planel E, Scientific reports, 2017, 10.1038/srep46359
  • A Simple Method to Avoid Nonspecific Signal When Using Monoclonal Anti-Tau Antibodies in Western Blotting of Mouse Brain Proteins., Petry FR, Nicholls SB, Hébert SS, Planel E, Methods in molecular biology (Clifton, N.J.), 2017, 10.1007/978-1-4939-6598-4_15
  • Old age potentiates cold-induced tau phosphorylation: linking thermoregulatory deficit with Alzheimer's disease., Tournissac M, Vandal M, François A, Planel E, Calon F, Neurobiology of aging, 2016, 10.1016/j.neurobiolaging.2016.09.024
  • Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease., Gratuze M, El Khoury NB, Turgeon A, Julien C, Marcouiller F, Morin F, Whittington RA, Marette A, Calon F, Planel E, Neurobiology of disease, 2016, 10.1016/j.nbd.2016.10.004
  • microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer's disease triple transgenic mice., Hernandez-Rapp J, Rainone S, Goupil C, Dorval V, Smith PY, Saint-Pierre M, Vallée M, Planel E, Droit A, Calon F, Cicchetti F, Hébert SS, Scientific reports, 2016, 10.1038/srep30953
  • High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology., Gratuze M, Julien J, Morin F, Calon F, Hébert SS, Marette A, Planel E, Neurobiology of aging, 2016, 10.1016/j.neurobiolaging.2016.07.016
  • Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease., Vandal M, White PJ, Tournissac M, Tremblay C, St-Amour I, Drouin-Ouellet J, Bousquet M, Traversy MT, Planel E, Marette A, Calon F, Neurobiology of aging, 2016, 10.1016/j.neurobiolaging.2016.03.024
  • Is Huntington's disease a tauopathy?, Gratuze M, Cisbani G, Cicchetti F, Planel E, Brain : a journal of neurology, 2016, 10.1093/brain/aww021
  • Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma., Winston CN, Noël A, Neustadtl A, Parsadanian M, Barton DJ, Chellappa D, Wilkins TE, Alikhani AD, Zapple DN, Villapol S, Planel E, Burns MP, The American journal of pathology, 2016, 10.1016/j.ajpath.2015.11.006
  • Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice., El Khoury NB, Gratuze M, Petry F, Papon MA, Julien C, Marcouiller F, Morin F, Nicholls SB, Calon F, Hébert SS, Marette A, Planel E, Neurobiology of disease, 2016, 10.1016/j.nbd.2016.01.005
  • miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo., Smith PY, Hernandez-Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, Dorval V, Parsi S, Morin F, Planel E, Bennett DA, Fernandez-Gomez FJ, Hébert SS, Human molecular genetics, 2015, 10.1093/hmg/ddv377
  • Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease., Vandal M, White PJ, Chevrier G, Tremblay C, St-Amour I, Planel E, Marette A, Calon F, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, 10.1096/fj.14-268482
  • Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro., Whittington RA, Virág L, Gratuze M, Petry FR, Noël A, Poitras I, Truchetti G, Marcouiller F, Papon MA, El Khoury N, Wong K, Bretteville A, Morin F, Planel E, Neurobiology of aging, 2015, 10.1016/j.neurobiolaging.2015.05.002
  • Memory formation and retention are affected in adult miR-132/212 knockout mice., Hernandez-Rapp J, Smith PY, Filali M, Goupil C, Planel E, Magill ST, Goodman RH, Hébert SS, Behavioural brain research, 2015, 10.1016/j.bbr.2015.03.032
  • ERK (MAPK) does not phosphorylate tau under physiological conditions in vivo or in vitro., Noël A, Poitras I, Julien J, Petry FR, Morin F, Charron J, Planel E, Neurobiology of aging, 2014, 10.1016/j.neurobiolaging.2014.11.005
  • Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease., Gratuze M, Noël A, Julien C, Cisbani G, Milot-Rousseau P, Morin F, Dickler M, Goupil C, Bezeau F, Poitras I, Bissonnette S, Whittington RA, Planel E, Human molecular genetics, 2014, 10.1093/hmg/ddu456
  • Insulin reverses the high-fat diet-induced increase in brain Aβ and improves memory in an animal model of Alzheimer disease., Vandal M, White PJ, Tremblay C, St-Amour I, Chevrier G, Emond V, Lefrançois D, Virgili J, Planel E, Giguere Y, Marette A, Calon F, Diabetes, 2014, 10.2337/db14-0375
  • Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons., Mohamed NV, Plouffe V, Rémillard-Labrosse G, Planel E, Leclerc N, Scientific reports, 2014, 10.1038/srep05715
  • Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions., Petry FR, Pelletier J, Bretteville A, Morin F, Calon F, Hébert SS, Whittington RA, Planel E, PloS one, 2014, 10.1371/journal.pone.0094251
  • Insulin dysfunction and Tau pathology., El Khoury NB, Gratuze M, Papon MA, Bretteville A, Planel E, Frontiers in cellular neuroscience, 2014, 10.3389/fncel.2014.00022
  • Anesthesia, surgery and neurodegeneration. Preface., Eckenhoff RG, Planel E, Progress in neuro-psychopharmacology & biological psychiatry, 2013, 10.1016/j.pnpbp.2013.10.012
  • Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar., Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Hemmings HC, British journal of anaesthesia, 2013, 10.1093/bja/aet177
  • Anesthesia and tau pathology., Whittington RA, Bretteville A, Dickler MF, Planel E, Progress in neuro-psychopharmacology & biological psychiatry, 2013, 10.1016/j.pnpbp.2013.03.004
  • Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation., Whittington RA, Bretteville A, Virág L, Emala CW, Maurin TO, Marcouiller F, Julien C, Petry FR, El-Khoury NB, Morin F, Charron J, Planel E, Scientific reports, 2013, 10.1038/srep01388
  • Insulin resistance and obesity: how do they affect tau pathology?, Gratuze M, El Khoury N, DicklerI M, Papon M, Julien C, Marcouiller F, Morin F, Planel E, Molecular neurodegeneration, 2013, 10.1186/1750-1326-8-s1-p67
  • Deregulation of protein phosphatase 2A and hyperphosphorylation of τ protein following onset of diabetes in NOD mice., Papon MA, El Khoury NB, Marcouiller F, Julien C, Morin F, Bretteville A, Petry FR, Gaudreau S, Amrani A, Mathews PM, Hébert SS, Planel E, Diabetes, 2012, 10.2337/db12-0187
  • Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons., Dorval V, Smith PY, Delay C, Calvo E, Planel E, Zommer N, Buée L, Hébert SS, PloS one, 2012, 10.1371/journal.pone.0044060
  • Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)., Filali M, Lalonde R, Theriault P, Julien C, Calon F, Planel E, Behavioural brain research, 2012, 10.1016/j.bbr.2012.07.004
  • Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation., Julien C, Marcouiller F, Bretteville A, El Khoury NB, Baillargeon J, Hébert SS, Planel E, PloS one, 2012, 10.1371/journal.pone.0040020
  • Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors., Bretteville A, Marcouiller F, Julien C, El Khoury NB, Petry FR, Poitras I, Mouginot D, Lévesque G, Hébert SS, Planel E, Scientific reports, 2012, 10.1038/srep00480
  • Postoperative cognitive decline: where art tau?, Eckenhoff RG, Planel E, Anesthesiology, 2012, 10.1097/aln.0b013e31824be8e1
  • Biochemical isolation of insoluble tau in transgenic mouse models of tauopathies., Julien C, Bretteville A, Planel E, Methods in molecular biology (Clifton, N.J.), 2012, 10.1007/978-1-61779-551-0_32
  • MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy., Smith PY, Delay C, Girard J, Papon MA, Planel E, Sergeant N, Buée L, Hébert SS, Human molecular genetics, 2011, 10.1093/hmg/ddr330
  • Alzheimer's disease and anesthesia., Papon MA, Whittington RA, El-Khoury NB, Planel E, Frontiers in neuroscience, 2011, 10.3389/fnins.2010.00272
  • Propofol directly increases tau phosphorylation., Whittington RA, Virág L, Marcouiller F, Papon MA, El Khoury NB, Julien C, Morin F, Emala CW, Planel E, PloS one, 2011, 10.1371/journal.pone.0016648
  • Hypothermia and Alzheimer's disease neuropathogenic pathways., Whittington RA, Papon MA, Chouinard F, Planel E, Current Alzheimer research, 2010, 10.2174/156720510793611646
  • Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration., Hébert SS, Papadopoulou AS, Smith P, Galas MC, Planel E, Silahtaroglu AN, Sergeant N, Buée L, De Strooper B, Human molecular genetics, 2010, 10.1093/hmg/ddq311
  • In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice., Morales-Corraliza J, Mazzella MJ, Berger JD, Diaz NS, Choi JH, Levy E, Matsuoka Y, Planel E, Mathews PM, PloS one, 2009, 10.1371/journal.pone.0007134
  • Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein., Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE, The American journal of pathology, 2009, 10.2353/ajpath.2009.080928
  • Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease., Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotás A, Perouansky M, Planel E, First International Workshop on Anesthetics and Alzheimer's Disease, Anesthesia and analgesia, 2009, 10.1213/ane.0b013e318199dc72
  • Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia., Planel E, Bretteville A, Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009, 10.1096/fj.08-122424
  • Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo., Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/jneurosci.4101-08.2008
  • Tau aggregates: toxic, inert, or protective species?, Bretteville A, Planel E, Journal of Alzheimer's disease : JAD, 2008, 10.3233/jad-2008-14411
  • Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation., Muhammad A, Flores I, Zhang H, Yu R, Staniszewski A, Planel E, Herman M, Ho L, Kreber R, Honig LS, Ganetzky B, Duff K, Arancio O, Small SA, Proceedings of the National Academy of Sciences of the United States of America, 2008, 10.1073/pnas.0802545105
  • A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment., Liu L, Orozco IJ, Planel E, Wen Y, Bretteville A, Krishnamurthy P, Wang L, Herman M, Figueroa H, Yu WH, Arancio O, Duff K, Neurobiology of disease, 2008, 10.1016/j.nbd.2008.03.005
  • Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing., Wen Y, Planel E, Herman M, Figueroa HY, Wang L, Liu L, Lau LF, Yu WH, Duff KE, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, 10.1523/jneurosci.5245-07.2008
  • Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing., Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marié I, Maurin T, Wang L, Figueroa H, Herman M, Krishnamurthy P, Liu L, Planel E, Lau LF, Lahiri DK, Duff K, Neuron, 2008, 10.1016/j.neuron.2008.02.024
  • A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease., Matsuoka Y, Jouroukhin Y, Gray AJ, Ma L, Hirata-Fukae C, Li HF, Feng L, Lecanu L, Walker BR, Planel E, Arancio O, Gozes I, Aisen PS, The Journal of pharmacology and experimental therapeutics, 2008, 10.1124/jpet.107.130526
  • Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms., Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, Yu WH, Luchsinger JA, Wadzinski B, Duff KE, Takashima A, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/jneurosci.3949-07.2007
  • Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia., Planel E, Richter KE, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, Nelson RB, Lau LF, Duff KE, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/jneurosci.4854-06.2007
  • c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis., Tatebayashi Y, Planel E, Chui DH, Sato S, Miyasaka T, Sahara N, Murayama M, Kikuchi N, Yoshioka K, Rivka R, Takashima A, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, 10.1096/fj.05-4362fje
  • Untangling memory deficits., Duff K, Planel E, Nature medicine, 2005, 10.1038/nm0805-826
  • Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo., Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, Gaynor K, Wang L, LaFrancois J, Feinstein B, Burns M, Krishnamurthy P, Wen Y, Bhat R, Duff K, Proceedings of the National Academy of Sciences of the United States of America, 2005, 10.1073/pnas.0500466102
  • U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy., Hatakeyama S, Matsumoto M, Kamura T, Murayama M, Chui DH, Planel E, Takahashi R, Nakayama KI, Takashima A, Journal of neurochemistry, 2004, 10.1111/j.1471-4159.2004.02713.x
  • Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease., Planel E, Miyasaka T, Launey T, Chui DH, Tanemura K, Sato S, Murayama O, Ishiguro K, Tatebayashi Y, Takashima A, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, 10.1523/jneurosci.5561-03.2004
  • Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau., Tatebayashi Y, Miyasaka T, Chui DH, Akagi T, Mishima K, Iwasaki K, Fujiwara M, Tanemura K, Murayama M, Ishiguro K, Planel E, Sato S, Hashikawa T, Takashima A, Proceedings of the National Academy of Sciences of the United States of America, 2002, 10.1073/pnas.202205599
  • Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells., Sato S, Tatebayashi Y, Akagi T, Chui DH, Murayama M, Miyasaka T, Planel E, Tanemura K, Sun X, Hashikawa T, Yoshioka K, Ishiguro K, Takashima A, The Journal of biological chemistry, 2002, 10.1074/jbc.m202241200
  • Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse., Planel E, Yasutake K, Fujita SC, Ishiguro K, The Journal of biological chemistry, 2001, 10.1074/jbc.m102780200
  • Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease., Yanagisawa M, Planel E, Ishiguro K, Fujita SC, FEBS letters, 1999, 10.1016/s0014-5793(99)01480-5

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Juliette Cheng - Maîtrise avec mémoire - En cours
  • Geoffrey Canet - Post-doctorat - En cours
  • Emilie Wong Chong - Doctorat - En cours
  • Yacine Tensaouti - Maîtrise avec mémoire - En cours
  • Eva Lepinay - Maîtrise avec mémoire - En cours
  • Sofía Diego Díaz - Maîtrise avec mémoire - En cours
  • Parissa Fereydouni-Forouzandeh - Maîtrise avec mémoire - En cours
  • Amy Bouchard - Doctorat - En cours
  • François Marcouiller - Maîtrise avec mémoire - 2011/05
  • Noura El Khoury - Doctorat - 2013/05
  • Serena Petry - Doctorat - 2017/01
  • Maud Gratuze - Doctorat - 2017/05
  • Laura Eyoum Jong - Maîtrise avec mémoire - 2018/05
  • Andréanne Turgeon - Maîtrise avec mémoire - 2018/05
  • Isabelle Guisle - Doctorat - 2020/01
  • Julius Baya Mdzomba - Doctorat - 2021/01

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