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Darren Edward Richard

Professeur titulaire

Darren Edward Richard
darren-edward.richard@fmed.ulaval.ca
Centre de recherche sur le cancer
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Oncologie
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Cancer
Santé circulatoire et respiratoire
  • Anémies
  • Angiogénèse
  • Hypertension artérielle
  • Maladies cardiovasculaires
  • Signalisation cellulaire

Projets de recherche

  • Hydrochlorothiazide and accelerated CKD-related vascular calcification - Fondation canadienne du rein - Subventions de recherche en santé des reins, co-chercheur - 2023-07-01 au 2025-06-30
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Targeting extracellular hydroxyapatite to deliver nucleic acids to surrounding cells - CHU de Québec – Université Laval – CHUL - Subvention de fonctionnement de centre, co-chercheur - 2022-09-21 au 2023-03-31
  • Use of nanoparticles to understand and treat vascular calcification in chronic kidney disease - Fondation canadienne du rein, co-chercheur - 2020-10-01 au 2022-09-30
  • Novel Interactions and Functions for Hypoxia-Inducible Factor-1 (HIF-1) during Vascular Responses - Fondation de l'Université Laval, chercheur principal - 2016-04-01 au 2022-03-31

Publications

  • Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification, Richard, D.E., Agharazii, M., Cornfield, D.N., Gobeil, S., Lamalice, L., Larivière, R., Mokas, S., Kidney International, 2016, 10.1016/j.kint.2016.05.020
  • Erratum: Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1α and is not induced by hypoxia or HIF (Journal of Biological Chemistry (2005) 280 (31132-31140)), Trottier, E., Richard, D.E., Pouysségur, J., Mazure, N., Hattab, M., Déry, M.-A., Brahimi-Horn, M.C., Bilton, R., Journal of Biological Chemistry, 2006
  • Identification of alternative spliced variants of human hypoxia- inducible factor-1α, Pouysségur, J., Pagès, G., Berra, E., Richard, D.E., Gothié, E., Journal of Biological Chemistry, 2000, 10.1074/jbc.275.10.6922
  • Angiogenesis and G-protein-coupled receptors: Signals that bridge the gap, Pouysségur, J., Vouret-Craviari, V., Richard, D.E., Oncogene, 2001, 10.1038/sj.onc.1204193
  • Signaling angiogenesis via p42/p44 MAP kinase and hypoxia, Pouysségur, J., Pagès, G., Roux, D., Gothié, E., Viñals, F., Le Gall, M., Richard, D.E., Milanini, J., Berra, E., Biochemical Pharmacology, 2000, 10.1016/S0006-2952(00)00423-8
  • The Werner syndrome gene product (WRN): A repressor of hypoxia-inducible factor-1 activity, Richard, D.E., Lebel, M., Lamalice, L., Garand, C., Robitaille, G.A., Patten, D.A., Lafleur, V.N., Labbé, A., Experimental Cell Research, 2012, 10.1016/j.yexcr.2012.04.010
  • Selective interaction of chemical dyes with inositol 1,4,5-trisphosphate recognition sites, Richard, D.E., Guillemette, G., Boulay, G., Bernier, S., Canadian Journal of Physiology and Pharmacology, 1994
  • The high affinity state of inositol 1,4,5-trisphosphate receptor is a functional state, Servant, M., Richard, D.E., Poitras, M., Guillemette, G., Boulay, G., Bernier, S., Journal of Biological Chemistry, 1993
  • Hypoxia-inducible factor 1: Regulation by hypoxic and non-hypoxic activators, Richard, D.E., Michaud, M.D., Déry, M.-A.C., International Journal of Biochemistry and Cell Biology, 2005, 10.1016/j.biocel.2004.08.012
  • Sphingosine-1-phosphate: A novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells, Richard, D.E., Gratton, J.-P., Robitaille, G.A., Michaud, M.D., Arteriosclerosis, Thrombosis, and Vascular Biology, 2009, 10.1161/ATVBAHA.109.185280
  • Desensitization of AT1 receptor-mediated cellular responses requires long term receptor down-regulation in bovine adrenal glomerulosa cells, Richard, D.E., Leduc, R., Laporte, S.A., Guillemette, G., Bernier, S.G., Endocrinology, 1997, 10.1210/en.138.9.3828
  • HIF-1 activation during tumor progression: Implications and consequences | Activation de HIF1 dans le cancer: Implications et conséquences, Richard, D.E., Michaud, M.D., Lauzier, M.-C., Déry, M.-A.C., Bulletin du Cancer, 2006
  • Hypoxic gene activation by lipopolysaccharide in macrophages: Implication of hypoxia-inducible factor 1α, Richard, D.E., Soucy, G.M., Pagé, E.L., Blouin, C.C., Blood, 2004, 10.1182/blood-2003-07-2427
  • The organization of the suprachiasmatic circadian pacemaker of the rat and its regulation by neurotransmitters and modulators., Tcheng, T.K., Richard, D., Medanic, M., McArthur, A.J., Liu, C., Faiman, L.E., Gallman, E.A., Ding, J.M., DeMarco, S.J., Gillette, M.U., 1993
  • Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification, Richard, D.E., Larivière, R., Mokas, S., Ung, R.-V., Gautier-Bastien, A., St-Louis, R., Agharazii, M., American Journal of Hypertension, 2015, 10.1093/ajh/hpu225
  • Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1α and is not induced by hypoxia or HIF, Brahimi-Horn, M.C., Pouysségur, J., Richard, D.E., Déry, M.-A., Hattab, M., Trottier, E., Mazure, N., Bilton, R., Journal of Biological Chemistry, 2005, 10.1074/jbc.M504482200
  • The adenoviral protein E4orf4: a probing tool to decipher mechanical stress-induced nuclear envelope remodeling in tumor cells, Josée N. Lavoie, Darren E. Richard, Marc-Antoine Rodrigue, Kévin Jacquet, Cell Cycle, 2020, 10.1080/15384101.2020.1836441
  • Effects of TGF-β1 on endothelial factors, Lebel, M., Larivire, R., Richard, D.E., Robitaille, G.A., Midaoui, A.E., Cellier, E., Archives of Physiology and Biochemistry, 2010, 10.3109/13813451003610862
  • Endothelin type A receptor blockade reduces vascular calcification and inflammation in rats with chronic kidney disease, Agharazii, M., Richard, D.E., Mac-Way, F., St-Hilaire, J., Ung, R.-V., Gauthier-Bastien, A., Lariviere, R., Journal of Hypertension, 2017, 10.1097/HJH.0000000000001161
  • Desensitization of AT1 receptor-mediated cellular responses requires long term receptor down-regulation in bovine adrenal glomerulosa cells., Guillemette, G., Leduc, R., Bernier, S.G., Laporte, S.A., Richard, D.E., Endocrinology, 1997
  • (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors, Richard, D.E., Giaccia, A.J., Chan, D.A., Robitaille, G.A., Lauzier, M.-C., Molecular Pharmacology, 2008, 10.1124/mol.108.045690
  • Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels, Jean-François Côté, Jean-Philippe Gratton, Morag Park, Darren E. Richard, William J. Muller, Carla V. Rothlin, Hellen Kuasne, Chloé Apcher, Islam E. Elkholi, Marie-Anne Goyette, Proceedings of the National Academy of Sciences, 2021, 10.1073/pnas.2023868118
  • Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state, Richard, D.E., Guillemette, G., Chrétien, L., Boulay, G., Endocrinology, 1994, 10.1210/en.135.5.2130
  • Effect of uncoupling agents on AT1 receptor affinity for antagonist analogs of angiotensin II, Sidibé, A., Richard, D.E., Poitras, M., Guillemette, G., Chrétien, L., Receptors and Channels, 1998
  • Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation, Côté, J., Kutateladze, T.G., Yang, X.-J., Richard, D.E., Robitaille, G.A., Cayrou, C., Doyon, Y., Landry, A.-J., Glass, K.C., Paquet, E., Saksouk, N., Lalonde, M.-E., Avvakumov, N., Molecular and Cellular Biology, 2012, 10.1128/MCB.06455-11
  • The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity, Richard, D.E., Lu, K.P., Zhou, X.Z., Lamalice, L., Lafleur, V.N., Déry, M.A.C., Jalouli, M., 2014, 10.1016/j.cellsig.2014.04.005
  • Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state, Guillemettes, G., Richard, D.E., Chrétien, L., Boulay, G., Endocrinology, 1994, 10.1210/endo.135.5.7956936
  • Selective HIF-1 regulation under nonhypoxic conditions by the p42/p44 MAP kinase inhibitor PD184161, Richard, D.E., Lamalice, L., Turgeon, C.A., Mokas, S., Jalouli, M., Molecular Pharmacology, 2017, 10.1124/mol.117.108654
  • Tumor necrosis factor inhibitors as novel therapeutic tools for vascular remodeling diseases, Bonnet, S., Richard, D.E., Agharazii, M., Robitaille, G.A., Meloche, J., Roy, M., Lambert, C.M., American Journal of Physiology - Heart and Circulatory Physiology, 2010, 10.1152/ajpheart.00562.2010
  • The tyrosine within the NPXnY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization, Servant, G., Richard, D.E., Leduc, R., Laporte, S.A., Guillemette, G., Escher, E., Molecular Pharmacology, 1996
  • Angiogenesis: How a tumor adapts to hypoxia, Pouysségur, J., Berra, E., Richard, D.E., Biochemical and Biophysical Research Communications, 1999, 10.1006/bbrc.1999.1889
  • Transforming growth factor β1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression, Dubois, C.M., Richard, D.E., Grandmont, S., Charbonneau, M., McMahon, S., Journal of Biological Chemistry, 2006, 10.1074/jbc.M604507200
  • Stimulation of the angiotensin II type I receptor on bovine adrenal glomerulosa cells activates a temperature-sensitive internalization-recycling pathway, Guillemette, G., Caron, M., Chrétien, L., Richard, D.E., Molecular and Cellular Endocrinology, 1997, 10.1016/S0303-7207(97)00065-8
  • Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1, Richard, D.E., Richard, S., Lafleur, V.N., Molecular Biology of the Cell, 2014, 10.1091/mbc.E13-07-0423
  • Induction of hypoxia-inducible factor-1α by transcriptional and translational mechanisms, Richard, D.E., Pouysségur, J., Robitaille, G.A., Pagé, E.L., Journal of Biological Chemistry, 2002, 10.1074/jbc.M209114200
  • Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: Impact on the bioactivation of proproteins, Dubois, C.M., Richard, D.E., McDonald, P.P., Grondin, F., McMahon, S., Journal of Biological Chemistry, 2005, 10.1074/jbc.M413248200
  • HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation, Pouysségur, J., Gothié, E., Richard, D.E., Berra, E., FEBS Letters, 2001, 10.1016/S0014-5793(01)02159-7
  • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells, Pouyssegur, J., Berra, E., Richard, D.E., Journal of Biological Chemistry, 2000, 10.1074/jbc.M003325200
  • TGFβ-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration, Lebrun, J.-J., Richard, D.E., Laporte, S.A., Sontag, T., Mancini, J., Ho, J., Chen, H., Guo, J., Cellular Signalling, 2009, 10.1016/j.cellsig.2009.01.037
  • Bovine adrenal glomerulosa cells express such a low level of functional B2 receptors that bradykinin does not significantly increase their aldosterone production, Guillemette, G., Paitras, M., Poirier, S.N., Richard, D.E., Chrétien, L., Journal of Endocrinology, 1998, 10.1677/joe.0.1560449
  • Desensitization of AT1receptor-mediated cellular responses requires long term receptor down-regulation in bovine adrenal glomerulosa cells, Guillemette, G., Leduc, R., Bernier, S.G., Laporte, S.A., Richard, D.E., Endocrinology, 1997, 10.1210/endo.138.9.5409
  • Hypoxia-inducible factor-1α stabilization in nonhypoxic conditions: Role of oxidation and intracellular ascorbate depletion, Richard, D.E., Levine, M., Giaccia, A.J., Chan, D.A., Page, E.L., Molecular Biology of the Cell, 2008, 10.1091/mbc.E07-06-0612
  • Signaling angiogenesis via p42/p44 MAP kinase cascade, Viñals, F., Richard, D.E., Pouysségur, J., Pagès, G., Milanini, J., Gothié, E., Berra, E., Annals of the New York Academy of Sciences, 2000
  • Hypoxia-inducible factor-1 activation in nonhypoxic conditions: The essential role of mitochondrial-derived reactive oxygen species, Richard, D.E., Giaccia, A.J., Chan, D.A., Robitaille, G.A., Lafleur, V.N., Patten, D.A., Molecular Biology of the Cell, 2010, 10.1091/mbc.E10-01-0025
  • Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death, Josée N. Lavoie, Marc-Étienne Huot, François Bordeleau, Darren E. Richard, Patrick Laprise, Herman Lambert, Margit Fuchs, Jonathan Bergeman, Marie-Chloé Boulanger, Kévin Jacquet, Alexia Caillier, Marc-Antoine Rodrigue, Claire Dziengelewski, Journal of Cell Biology, 2020, 10.1083/jcb.201805122
  • HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism, Bonnet, S., Richard, D.E., Robitaille, G.A., Roy, M., Lambert, C.M., Cardiovascular Research, 2010, 10.1093/cvr/cvq152
  • p42/p44 mitogen-activated protein kinases phosphorylate hypoxia- reducible factor (HIF-1α) and enhance the transcriptional activity of HIF-1, Pouysségur, J., Roux, D., Gothié, E., Berra, E., Richard, D.E., Journal of Biological Chemistry, 1999, 10.1074/jbc.274.46.32631
  • Novel cyclic analogs of angiotensin II with cyclization between positions 5 and 7: Conformational and biological implications, Marshall, G.R., Escher, E., Richard, D.E., Pérodin, J., Nikiforovich, G.V., Zhang, W.-J., Journal of Medicinal Chemistry, 1996, 10.1021/jm9507744
  • Hypoxia-inducible factor-1α (HIF-1 escapes O2-driven proteasomal degradation irrespective of its subcellular localization: Nucleus or cytoplasm, Pouysségur, J., Richard, D.E., Roux, D., Berra, E., EMBO Reports, 2001, 10.1093/embo-reports/kve130
  • HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism, Bonnet, S., Richard, D.E., Robitaille, G.A., Roy, M., Lambert, C.M., Continuing Education in Anaesthesia, Critical Care and Pain, 2010
  • Differential regulation of hypoxia-inducible factor-1 through receptor tyrosine kinase transactivation in vascular smooth muscle cells, Richard, D.E., Michaud, M.D., Pagé, E.L., Lauzier, M.-C., Endocrinology, 2007, 10.1210/en.2007-0285
  • A role for hypoxia-inducible factor-1 (HIF-1) in phosphate-induced vascular smooth muscle cell calcification, , Kidney International (In Press), 2016

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Rémi Riga - Maîtrise avec mémoire - En cours
  • Arianne Gervais - Maîtrise avec mémoire - En cours
  • Veronique Lafleur - Maîtrise avec mémoire - 2011/05
  • Maroua Jalouli - Doctorat - 2018/05
  • Catherine Turgeon - Maîtrise avec mémoire - 2019/05
  • Hadrien Benk-Fortin - Maîtrise avec mémoire - 2022/05

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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