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Claude Rouillard

Professeur invité

Claude.Rouillard@fmed.ulaval.ca
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Maladie de Parkinson
  • Toxicomanies
  • Schizophrénie
  • Récepteurs et transporteurs
  • Maladies neurologiques
  • Maladies neurodégénératives

Projets de recherche

  • Optimisation du site de stimulation profonde dans la région mésencéphalique - Fondation du CHU de Québec, chercheur principal - 2022-03-30 au 2023-03-29

Publications

  • Contribution of spinal 5-HT1A and 5-HT7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord-transected mice, Guertin, P.A., Hedlund, P.B., Levesque, D., Rouillard, C., Lapointe, N.P., Landry, E.S., European Journal of Neuroscience, 2006, 10.1111/j.1460-9568.2006.04917.x
  • ELECTROPHYSIOLOGICAL CHARACTERISTICS AND PHARMACOLOGICAL RESPONSIVENESS OF MIDBRAIN DOPAMINERGIC-NEURONS OF THE AGED RAT, CHIODO, LA, ROUILLARD, C, KELLAND, MD, FREEMAN, AS, Journal of Pharmacology and Experimental Therapeutics, 1989
  • Retinoid receptors and Nur77, new putative pharmacological targets for neurodegenerative and neuropsychiatric disorders, Rouillard, C., Maheux, J., Bourhis, E., Levesque, D., The International Journal of Neuropsychopharmacology, 2006
  • Naltrexone in the short-term decreases antiparkinsonian response to L-Dopa and in the long-term increases dyskinesias in drug-naïve parkinsonian monkeys, Bédard, P.J., Rouillard, C., Di Paolo, T., Tahar, A.H., Grégoire, L., Samadi, P., Neuropharmacology, 2005, 10.1016/j.neuropharm.2005.02.009
  • Nur77 mRNA levels and L-Dopa-induced dyskinesias in MPTP monkeys treated with docosahexaenoic acid, Lévesque, D., Di Paolo, T., Rouillard, C., Grégoire, L., Morissette, M., Ouattara, B., Gilbert, F., Samadi, P., Mahmoudi, S., Neurobiology of Disease, 2009, 10.1016/j.nbd.2009.07.017
  • Clozapine and Dopamine D3 Receptor Antisense Reduce Cocaine- and Amphetamine-Regulated Transcript Expression in the Rat Nucleus Accumbens Shell, Lévesque, D., Rouillard, C., Zekki, H., Beaudry, G., Synapse, 2004, 10.1002/syn.10302
  • Modulation of haloperidol-induced patterns of the transcription factor Nur77 and Nor-1 expression by serotonergic and adrenergic drugs in the mouse brain, Lévesque, D., Rouillard, C., Mahfouz, M., Vuillier, L., Maheux, J., International Journal of Neuropsychopharmacology, 2012, 10.1017/S1461145711000630
  • Functional neurochemistry of the basal ganglia, Di Paolo, T., Bédard, P.J., Rouillard, C., Samadi, P., Handbook of Clinical Neurology, 2007, 10.1016/S0072-9752(07)83002-8
  • Brain morphometry in adults with gambling disorder, Shirley Fecteau, Jean Leblond, Claude Rouillard, Francine Ferland, Christophe Lenglos, Emmanuelle Renauld, Maya Dickler, Amy E. Bouchard, Journal of Psychiatric Research, 2021, 10.1016/j.jpsychires.2021.06.032
  • Dopamine and serotonin interactions in the modulation of the expression of the immediate-early transcription factor, nerve growth factor-inducible B, in the striatum, Rouillard, C., Richard, D., Soghomonian, J.-J., Gervais, J., Neuroscience, 1999, 10.1016/S0306-4522(98)00688-5
  • Effects of chronic treatment of MPTP monkeys with bromocriptine alone or in combination with SKF 38393, Di Paolo, T., Bedard, P.J., Rouillard, C., European Journal of Pharmacology, 1990, 10.1016/0014-2999(90)90642-J
  • The highly selective mGlu(2) receptor positive allosteric modulator LY-487,379 alleviates l-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease, Huot, Philippe, Parent, Martin, Parent, Andre, Rouillard, Claude, Wallman, Marie-Josee, Gagnon, Dave, Bedard, Dominique, Nafade, Vaidehi, Frouni, Imane, Kwan, Cynthia, Sid-Otmane, Lamia, Hamadjida, Adjia, European Journal of Neuroscience, 2020, 10.1111/EJN.14679
  • Fenfluramine-induced activation of the immediate-early gene c-fos in the striatum: Possible interaction between serotonin and dopamine, Richard, D., Gervais, J., Bovetto, S., Rouillard, C., Molecular Brain Research, 1996, 10.1016/0169-328X(95)00284-Y
  • Modifications occurring in motor programs during learning of a complex task in man, Tremblay, L.E., Rouillard, C.A., Lagasse, P.P., Normand, M.C., Brain Research, 1982, 10.1016/0006-8993(82)91231-8
  • Dopamine D2 antagonist-induced striatal gene expression requires activation of mGlu5 receptors by cortical afferents, Rompre, P. -P., Rouillard, C., Maheux, J., Tirrota, E., Borrelli, E., Levesque, D., The International Journal of Neuropsychopharmacology, 2012
  • Modulation of Nur77 expression by dopaminergic drug is altered by a MEK pathway inhibitor in vivo, Levesque, D, Rouillard, C, Bourhis, E, Maheux, J, The FASEB Journal, 2006
  • Effects of cocaine on c-Fos and NGFI-B mRNA expression in transgenic mice underexpressing glucocorticoid receptors, Rouillard, C., Barden, N., Lévesque, D., Tremblay, P.-O., St-Hilaire, M., Neuropsychopharmacology, 2003, 10.1038/sj.npp.1300067
  • DOES CHRONIC TREATMENT WITH SKF-38393 POTENTIATE THE ACTION OF BROMOCRIPTINE IN PARKINSONIAN MPTP-TREATED MONKEYS, DIPAOLO, T, BOUCHER, R, BEDARD, PJ, ROUILLARD, C, Canadian Journal of Neurological Sciences, 1988
  • Profile of immediate early gene expression in the lumbar spinal cord of low-thoracic paraplegic mice, Guertin, P.A., Levesque, D., Rouillard, C., Landry, E.S., Behavioral Neuroscience, 2006, 10.1037/0735-7044.120.6.1384
  • NR4A orphan nuclear receptors in glucose homeostasis: A minireview, Buteau, J., Rouillard, C., Close, A.F., Diabetes and Metabolism, 2013, 10.1016/j.diabet.2013.07.005
  • Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons, Perlmann, T., Ichinose, H., Björklund, A., Olson, L., Larsson, N.-G., Lindqvist, E., Chambon, P., Metzger, D., Nomura, T., Sumi-Ichinose, C., Muramatsu, S.-I., Carta, M., Rouillard, C., Mattsson, B., Joodmardi, E., Ito, T., Kadkhodaei, B., Journal of Neuroscience, 2009, 10.1523/JNEUROSCI.3910-09.2009
  • 17β-estradiol at a physiological dose acutely increases dopamine turnover in rat brain, Bedard, P., Rouillard, C., Di Paolo, T., European Journal of Pharmacology, 1985
  • Role of the transcription factor NUR77 in haloperidol-induced hyperprolactinemia, Rouillard, C., Giner, X., Levesque, D., The International Journal of Neuropsychopharmacology, 2012
  • Electrophysiological characteristics and pharmacological responsiveness of midbrain dopaminergic neurons of the aged rat, Chiodo, L.A., Rouillard, C., Kelland, M.D., Freeman, A.S., Journal of Pharmacology and Experimental Therapeutics, 1989
  • The effects of the phencyclidine analogs BTCP and TCP on nigrostriatal dopamine neuronal activity, Freeman, A.S., Chiodo, L.A., Rouillard, C., European Journal of Pharmacology, 1990, 10.1016/0014-2999(90)90281-A
  • Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra, , 1911, 10.1002/(SICI)1098-2396(20000315)35:4<281::AID-SYN6>3.0.CO;2-A
  • Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents, Lévesque, D., Rompré, P.-P., Rouillard, C., Borrelli, E., Tirotta, E., Voyer, D., St-Hilaire, M., Maheux, J., Frontiers in Pharmacology, 2012, 10.3389/fphar.2012.00153
  • Endocrine and neurochemical actions of cocaine, Bedard, J.P., Levesque, D., Morissette, M., Rouillard, C., Di Paolo, T., Canadian Journal of Physiology and Pharmacology, 1989
  • Effects of electrical stimulation of the central nucleus of the amygdala on the in vivo electrophysiological activity of rat nigral dopaminergic neurons, , 1911, 10.1002/syn.890210410
  • Contrasting patterns and cellular specificity of transcriptional regulation of the nuclear receptor nerve growth factor-inducible B by haloperidol and clozapine in the rat forebrain, Lévesque, D., Rouillard, C., Weppe, I., Langlois, M.-C., Beaudry, G., Journal of Neurochemistry, 2000, 10.1046/j.1471-4159.2000.0751694.x
  • Retinoid x receptor and NUR77 modulate amphetamine-induced locomotor activity, Levesque, D, Rouillard, C, Shudo, K, Kagechika, H, Cicchetti, F, Paquet, B, Maheux, J, Bourhis, E, The FASEB Journal, 2006
  • BEHAVIORAL AND BIOCHEMICAL-COMPARISON OF REPEATED ADMINISTRATION OF BROMOCRIPTINE AND L-DOPA IN 6-OHDA LESIONED RATS AND IN MPTP-TREATED PARKINSONIAN MONKEYS, FALARDEAU, P, DIPAOLO, T, BOUCHER, R, BEDARD, PJ, ROUILLARD, C, Canadian Journal of Neurological Sciences, 1985
  • Opioids and motor complications in Parkinson's disease, , 1911, 10.1016/j.tips.2006.08.002
  • The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell mass, Jean Buteau, Claude Rouillard, Bárbara Scoralick Villela, Nidheesh Dadheech, Anne-Françoise Close, Journal of Biological Chemistry, 2019, 10.1074/jbc.RA118.005135
  • Repeated stimulation of D-1 dopamine receptors increases the circling response to bromocriptine in rats with a 6-OHDA lesion, Di Paolo, T., Falardeau, P., Bedard, P., Rouillard, C., European Journal of Pharmacology, 1988
  • Extracellular signal-regulated kinases (ERK) and protein kinase C (PKC) activities are involved in the modulation ofNur77andNor-1 expression by dopaminergic drugs, , 1911, 10.1111/j.1471-4159.2008.05455.x
  • Specific D1 and D2 dopamine agonists have synergistic effects in the 6-hydroxydopamine circling model in the rat, Bédard, P.J., Rouillard, C., Neuropharmacology, 1988, 10.1016/0028-3908(88)90028-7
  • Denervation and repeated L-DOPA induce complex regulatory changes in neurochemical phenotypes of striatal neurons: Implication of a dopamine D 1-dependent mechanism, Rouillard, C., Lévesque, D., Landry, E., St-Hilaire, M., Neurobiology of Disease, 2005, 10.1016/j.nbd.2005.04.001
  • Membrane cholesterol removal and replenishment affect rat and monkey brain monoamine transporters, Di Paolo, T., Rouillard, C., Morin, N., Morissette, M., Neuropharmacology, 2018, 10.1016/j.neuropharm.2018.01.039
  • Endocrine and neurochemical actions of cocaine, , 1911, 10.1139/y89-187
  • Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys, , 1911, 10.1002/ana.20738
  • Role of CRH in the effects of 5-HT-receptor agonists on food intake and metabolic rate, Richard, D., Rouillard, C., Bovetto, S., American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 1996
  • Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection, Guertin, P.A., Rouillard, C., Lapointe, N.P., Rouleau, P., Landry, E.S., Ung, R.-V., European Journal of Neuroscience, 2008, 10.1111/j.1460-9568.2008.06508.x
  • The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex, Margarita Arango-Lievano, Stephen D. Ginsberg, David A. Lewis, Ronald S. Duman, Tina C. Franklin, Vanja Duric, Marie-Pierre Moisan, Yann Dromard, Daniel Levesque, Claude Rouillard, Carlie J.M. De Vries, Mariska Vos, Christian Barrère, Freddy Jeanneteau, The Journal of Neuroscience, 2018, 10.1523/JNEUROSCI.2793-17.2017
  • Cystamine metabolism and brain transport properties: Clinical implications for neurodegenerative diseases, Cicchetti, F., Calon, F., Rouillard, C., Ouellet, M., Gibrat, C., Bousquet, M., Journal of Neurochemistry, 2010, 10.1111/j.1471-4159.2010.06874.x
  • The Transcription Factor NGFI-B (Nur77) and Retinoids Play a Critical Role in Acute Neuroleptic-Induced Extrapyramidal Effect and Striatal Neuropeptide Gene Expression, Lévesque, D., Rouillard, C., Milbrandt, J., St-Hilaire, M., Beaudry, G., Éthier, I., Neuropsychopharmacology, 2004, 10.1038/sj.npp.1300318
  • Behavioral and biochemical evidence for a different effect of repeated administration of l-DOPA and bromocriptine on denervated versus non-denervated striatal dopamine receptors, Dipaolo, T., Falardeau, P., Bédard, P.J., Rouillard, C., Neuropharmacology, 1987, 10.1016/0028-3908(87)90008-6
  • Dyskinesias occur in response to saline and naltrexone alone after priming with combination of dopaminergic agents and naltrexone in the MPTP parkinsonian monkeys, Bédard, P.J., Rouillard, C., Grégoire, L., Samadi, P., Neurobiology of Disease, 2005, 10.1016/j.nbd.2005.01.006
  • The highly-selective mGluR2 positive allosteric modulator LY-487,379 alleviates L-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease, Huot, P., Adjia, H., Rouillard, C., Parent, A., Parent, M., Sid-Otmane, L., Wallman, M-J., Gagnon, D., Nafade, V., Frouni, I., Kwan, C., Movement Disorders, 2017
  • Docosahexaenoic acid reduces haloperidol-induced dyskinesias in mice: Involvement of Nur77 and retinoid receptors, Lévesque, D., Rouillard, C., Shudo, K., Kagechika, H., Éthier, I., Biological Psychiatry, 2004, 10.1016/j.biopsych.2004.06.036
  • Nur77 and retinoid X receptors: crucial factors in dopamine-related neuroadaptation, Rouillard, C., Lévesque, D., Trends in Neurosciences, 2007, 10.1016/j.tins.2006.11.006
  • Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and L-Dopa-induced dyskinesia in experimental Parkinson's disease, Lévesque, D., Majeur, S., Darlix, N., Lévesque, C., Maheux, J., St-Hilaire, M., Paquet, B., Baillargeon, J., Rouillard, C., Experimental Neurology, 2018, 10.1016/j.expneurol.2018.03.008
  • Estrogen receptors and lesion-induced response of striatal dopamine receptors, Di Paolo, T., Rouillard, C., Morissette, M., Al Sweidi, S., Neuroscience, 2013, 10.1016/j.neuroscience.2012.12.058
  • The impact of brain morphometry on tDCS effects on GABA levels, Fecteau, Shirley, Leblond, Jean, Rouillard, Claude, Edden, Richard A., Ferland, Francine, Lenglos, Christophe, Renauld, Emmanuelle, Dickler, Maya, Bouchard, Amy E., Brain Stimulation, 2020, 10.1016/J.BRS.2019.10.013
  • Nur77 Gene Knockout Alters Dopamine Neuron Biochemical Activity and Dopamine Turnover, Lévesque, D., Di Paolo, T., Rouillard, C., Paquet, B., St-Hilaire, M., Morissette, M., Gilbert, F., Biological Psychiatry, 2006, 10.1016/j.biopsych.2006.04.023
  • The antisense strategy applied to the study of dopamine D3 receptor functions in rat forebrain, Lévesque, D., Rouillard, C., Tremblay, M., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1998, 10.1016/S0278-5846(98)00045-1
  • DIFFERENTIAL EFFECT OF APOMORPHINE TREATMENT REPEATED AT 2 AND 12 HOURS INTERVALS ON 6-HYDROXYDOPAMINE LESIONED RAT STRIATAL DOPAMINE-RECEPTORS FUNCTION, DIPAOLO, T, BEDARD, PJ, ROUILLARD, C, FALARDEAU, P, Clinical and Investigative Medicine, 1986
  • Dopamine D3 receptor antisense reduces neuropeptide mRNA levels in rat nucleus accumbens, , 1911, 10.1097/00001756-199712220-00012
  • Cognitive and clinical correlates of resting-state fMRI in adults with gambling disorder, Shirley Fecteau, Jean Leblond, Claude Rouillard, Francine Ferland, Christophe Lenglos, Emmanuelle Renauld, Maya Dickler, Amy E. Bouchard, European Neuropsychopharmacology, 2023, 10.1016/j.euroneuro.2022.12.007
  • Rotenone induces non-specific central nervous system and systemic toxicity., Cicchetti, F., Rouillard, C., Gould, P., Blanchet, J., Martinoli, M.G., St-Hilaire, M., Lapointe, N., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004
  • The nuclear receptor Nor1/Nr4a3, a novel regulator of beta-cell mass, Buteau, J., Rouillard, C., Villela, B., Close, A. -F., The FEBS Journal, 2014
  • 17β-Estradiol delays 6-OHDA-induced apoptosis by acting on Nur77 translocation from the nucleus to the cytoplasm, Martinoli, M.-G., Rouillard, C., Bournival, J., Chiasson, K., Renaud, J., Neurotoxicity Research, 2014, 10.1007/s12640-013-9442-z
  • Dopamine D3 receptor antisense administration reduces basal c-fos and NGFI-B mRNA levels in the rat forebrain, Lévesque, D., Rouillard, C., Tremblay, M., Synapse, 1999, 10.1002/(SICI)1098-2396(199904)32:1<51::AID-SYN7>3.0.CO;2-E
  • The highly-selective metabotropic glutamate receptor 2 positive allosteric modulator LY-487,379 alleviates psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset, Huot, P., Gourdon, J., Panisset, M., Rouillard, C., Veyres, N., Hamadjida, A., Nuara, S., Sid-Otmane, L., Movement Disorders, 2017
  • The transcription factors Nur77 and retinoid X receptors participate in amphetamine-induced locomotor activities, Lévesque, D., Rouillard, C., Rompré, P.-P., Shudo, K., Kagechika, H., Paquet, B., Maheux, J., Bourhis, E., Psychopharmacology, 2009, 10.1007/s00213-008-1343-0
  • Impact of antipsychotic drug administration on the expression of nuclear receptors in the neocortex and striatum of the rat brain, Lévesque, D., Rouillard, C., Zekki, H., Beaudry, G., Langlois, M.-C., Neuroscience, 2001, 10.1016/S0306-4522(01)00248-2
  • Research in addiction (psychiatry in progress, vol. 2), , 1911, 10.1016/0278-5846(96)00045-0
  • Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: Common implication of striatal neuropeptides, Di Paolo, T., Rouillard, C., Lévesque, D., Ouattara, B., Grégoire, L., Morissette, M., Samadi, P., Tamim, M.K., Neuropharmacology, 2010, 10.1016/j.neuropharm.2009.06.030
  • Effect of chronic l-DOPA treatment on 5-HT1A receptors in parkinsonian monkey brain, Paolo, T.D., Parent, M., Samadi, P., Rouillard, C., Lévesque, D., Morissette, M., Riahi, G., Neurochemistry International, 2012, 10.1016/j.neuint.2012.08.009
  • Docosahexaenoic acid reduces 6-OHDA- and MPP plus -induced translocation of Nur77 to the cytoplasm: A possible mechanism of neuroprotection, Martinoli, M. -G., Rouillard, C., Tremblay, C., Movement Disorders, 2008
  • Neuroprotective mechanisms of cystamine in a murine model of Parkinson's disease, Cicchetti, F., Rouillard, C., Calon, F., Levesque, D., Saint-Pierre, M., Bousquet, M., Gibrat, C., Parkinsonism and Related Disorders, 2009, 10.1016/S1353-8020(09)70481-X
  • Role of Nur77 and retinoids in animal models of Parkinson's disease and drug abuse, Levesque, D., St-Hilaire, M., Samadi, R., Rouillard, C., The International Journal of Neuropsychopharmacology, 2006
  • Neuroprotective effects of cystamine in aged parkinsonian mice, Cicchetti, F., Rouillard, C., Lévesque, D., Bourhis, E., Saint-Pierre, M., Tremblay, M.-E., Neurobiology of Aging, 2006, 10.1016/j.neurobiolaging.2005.04.004
  • Differences between subacute and chronic MPTP mice models: Investigation of dopaminergic neuronal degeneration and α-synuclein inclusions, Cicchetti, F., Rouillard, C., Lévesque, D., Bousquet, M., Saint-Pierre, M., Gibrat, C., Journal of Neurochemistry, 2009, 10.1111/j.1471-4159.2009.06072.x
  • Docosahexaenoic acid (DHA) reduces haloperidol-induced oro-facial dyskinesias: Involvement of Nur77 (NGFI-B) and retinoids, Levesque, D, Ethier, I, Rouillard, C, The International Journal of Neuropsychopharmacology, 2004
  • Impaired behavioural and molecular adaptations to dopamine denervation and repeated L-DOPA treatment in Nur77-knockout mice, Rouillard, C., Lévesque, D., Bourhis, E., St-Hilaire, M., European Journal of Neuroscience, 2006, 10.1111/j.1460-9568.2006.04954.x
  • Cystamine prevents MPTP-induced toxicity in young adult mice via the up-regulation of the brain-derived neurotrophic factor, Cicchetti, F., Rouillard, C., Calon, F., Lévesque, D., Saint-Pierre, M., Bousquet, M., Gibrat, C., Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010, 10.1016/j.pnpbp.2009.11.005
  • Induction patterns of transcription factors of the Nur family (Nurr1, Nur77, and Nor-1) by typical and atypical antipsychotics in the mouse brain: Implication for their mechanism of action, Lévesque, D., Rouillard, C., Éthier, I., Maheux, J., Journal of Pharmacology and Experimental Therapeutics, 2005, 10.1124/jpet.104.080184
  • Denervation and repeated L-DOPA induce a coordinate expression of the transcription factor NGFI-B in striatal projection pathways in hemi-parkinsonian rats, Rouillard, C., Lévesque, D., Landry, E., St-Hilaire, M., Neurobiology of Disease, 2003, 10.1016/S0969-9961(03)00081-0

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Antoine Hone-Blanchet - Maîtrise avec mémoire - 2012/01
  • Amy Bouchard - Doctorat - 2022/05

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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