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Chantelle Sephton

Professeure agrégée

Chantelle Sephton
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
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Contribution à la recherche

Projets de recherche

  • Investigating mechanisms of altered lipid droplet dynamics in ALS - Société canadienne de la sclérose latérale amyotrophique - Programme de bourses de découverte de la Société canadienne de la SLA et de la Fondation Brain Canada, chercheur principal - 2024-01-01 au 2025-12-31
  • Mechanistic studies of RNA-binding proteins regulating local RNA translation at synapses - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2020-04-01 au 2025-03-31
  • Mechanistic studies of RNA-binding proteins regulating local RNA translation at synapses - Conseil de recherches en sciences naturelles et génie Canada - Supplément Tremplin vers la découverte, chercheur principal - 2020-04-01 au 2025-03-31
  • Research tools for studying local RNA translation at synapses - Conseil de recherches en sciences naturelles et génie Canada - Subventions d'outils et d'instruments de recherche (OIR), chercheur principal - 2023-04-01 au 2024-03-31
  • Investigating mechanisms that cause mitochondrial dysfunction and synaptic loss - Brain Canada Foundation, The Azrieli Foundation - Futurs leaders canadiens de la recherche sur le cerveau 2020, chercheur principal - 2021-07-01 au 2023-06-30
  • Flashes of light: discovering rare brain events by combining astronomy and microscopy image analysis - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, co-chercheur - 2021-03-31 au 2023-03-30
  • Salaire d'un professeur - CIUSSS - CN - CERVO, chercheur principal - 2014-07-01 au 2022-06-30
  • Fonds institutionnel d'exploitation des infrastructures pour l'IUSMQ (CERVO) - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2013-04-01 au 2022-03-31
  • Enhancing the efficacy of heat shock protein inducers by cotreatment with a histone deacetylase inhibitor - A therapeutic strategy for ALS - Société canadienne de la sclérose latérale amyotrophique - 2017 ALS Canada-Brain Canada Hudson Translational Team Grant, McGill University, co-chercheur - 2017-12-01 au 2021-12-31

Publications

  • Metabolic Networks Influencing Skeletal Muscle Fiber Composition, Paul A. Dutchak, Chantelle F. Sephton, Isabelle Bourdeau Julien, Frontiers in Cell and Developmental Biology, 2018, 10.3389/fcell.2018.00125
  • Activity-dependent FUS dysregulation disrupts synaptic homeostasis, Gang Yu, Joachim Herz, Eric J. Huang, Kimberly M. Huber, Carla B. Green, Michael Q. Zhang, Yun Liu, Jeremy J. Stubblefield, Mieu Brooks, James West, Ashwinikumar Kulkarni, Amy A. Tang, Chantelle F. Sephton, Proceedings of the National Academy of Sciences, 2014, 10.1073/pnas.1406162111
  • TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development, Gang Yu, Joachim Herz, Paul Mayer, Colleen M. Dewey, Stan Atkin, Shannon K. Good, Chantelle F. Sephton, Journal of Biological Chemistry, 2010, 10.1074/jbc.m109.061846
  • Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes, Gang Yu, Melissa J. Moore, Junmin Peng, Joachim Herz, Frederick P. Roth, Colleen M. Dewey, YuHong Han, Basar Cenik, Eric B. Dammer, Alper Kucukural, Can Cenik, Chantelle F. Sephton, Journal of Biological Chemistry, 2011, 10.1074/jbc.m110.190884
  • Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS, Heather D. Durham, Josephine N. Nalbantoglu, M. Vera, Chantelle F. Sephton, Richard Robitaille, Nancy Larochelle, Javeria Rizwan, Suleima Jacob-Tomas, Sandra Minotti, Mario Fernández Comaduran, 2023, 10.1101/2023.12.13.571549
  • The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1, D.D. Mousseau, M.P. Scheid, P.R. Pennington, T.M. Lehmann, D. Zhang, C.F. Sephton, Cellular Signalling, 2009, 10.1016/j.cellsig.2009.06.010
  • NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis, Paul A. Dutchak, Chantelle F. Sephton, Christophe D. Proulx, Mohamed Chahine, Quentin Plumereau, Janani Priya Venkatasubramani, Myriam Sévigny, Mari Carmen Pelaez, Jose Cesar Hernandez Silva, Jeremy B. Hui, eneuro, 2022, 10.1523/eneuro.0317-21.2022
  • Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD, Li Gan, Ari Green, Robert V. Farese, Timothy W. Kraft, Erik D. Roberson, Andrew E. Arrant, Anthony J. Filiano, Joachim Herz, Gang Yu, William W. Seeley, Lauren Herl Martens, John Boscardin, Sakura Minami, Jeffrey M. Gelfand, Chantelle F. Sephton, Robert Chen, Bruce L. Miller, Alice Taubes, Michael E. Ward, Journal of Experimental Medicine, 2014, 10.1084/jem.20140214
  • Chronic Stress Induces Sex-Specific Functional and Morphological Alterations in Corticoaccumbal and Corticotegmental Pathways, Benoit Labonté, Christophe D. Proulx, Chantelle Sephton, Igor Timofeev, Josée Seigneur, Yoan Cherasse, Eric Arsenault, Léa-Jeanne Blanchette, Daphnée Morency, Francis Quessy, Andrée-Anne Lavigne, Jose Cesar Hernandez Silva, MariCarmen Pelaez, Thibault P. Bittar, Biological Psychiatry, 2021, 10.1016/j.biopsych.2021.02.014
  • FUS contributes to mTOR-dependent inhibition of translation, Chantelle F. Sephton, Paul A. Dutchak, Jeremy B. Hui, Janani Priya Venkatasubramani, Isabelle Bourdeau Julien, Myriam Sévigny, Journal of Biological Chemistry, 2020, 10.1074/jbc.RA120.013801
  • Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease, Chantelle F. Sephton, Paul A. Dutchak, Pauline A. Gelon, Frontiers in Molecular Neuroscience, 2022, 10.3389/fnmol.2022.1000183
  • The function of RNA-binding proteins at the synapse: implications for neurodegeneration, Gang Yu, Chantelle F. Sephton, Cellular and Molecular Life Sciences, 2015, 10.1007/s00018-015-1943-x
  • TDP-43 aggregation in neurodegeneration: Are stress granules the key?, Gang Yu, Joachim Herz, Brett A. Johnson, Chantelle F. Sephton, Basar Cenik, Colleen M. Dewey, Brain Research, 2012, 10.1016/j.brainres.2012.02.032
  • Dephosphorylation of Akt in C6 cells grown in serum‐free conditions corresponds with redistribution of p85/PI3K to the nucleus, D. D. Mousseau, C. F. Sephton, Journal of Neuroscience Research, 2008, 10.1002/jnr.21516
  • GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1, Paul A. Dutchak, Chantelle F. Sephton, Conghao Zhang, Imane Hadj-Aissa, Jasmine Bélanger, Maéline Muller, International Journal of Molecular Sciences, 2024, 10.3390/ijms25042068
  • Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration, Gang Yu, Joachim Herz, Bercin Kutluk Cenik, Chantelle F. Sephton, Basar Cenik, Journal of Biological Chemistry, 2012, 10.1074/jbc.r112.399170
  • γ-Secretase-regulated Proteolysis of the Notch Receptor by Mitochondrial Intermediate Peptidase, Gang Yu, Jin Jiang, Sanjiv Shah, Yun Wang, Colleen M. Dewey, Cong Yu, Bing Wang, Daniel R. Dries, Chantelle F. Sephton, Bhooma Srinivasan, Sheu-Fen Lee, Journal of Biological Chemistry, 2011, 10.1074/jbc.m111.243154
  • hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated, Christine Vande Velde, Chantelle F. Sephton, Richard Robitaille, Sarah Peyrard, Gurleen Litt, Alicia Dubinski, Danielle Arbour, Yousri Benchaar, Hadjara Sidibé, Jade-Emmanuelle Deshaies, Myriam Gagné, Frontiers in Neuroscience, 2021, 10.3389/fnins.2021.724307
  • Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription, Joachim Herz, Gang Yu, Bruce A. Posner, Robert V. Farese, Bruce L. Miller, Fen-Biao Gao, Daniel H. Geschwind, Sandra Almeida, Daniel R. Dries, Suzee E. Lee, Sarah E. Coughlin, Giovanni Coppola, Wenze Niu, Kimberley Yu, Shuguang Wei, Xunde Xian, Colleen M. Dewey, Chantelle F. Sephton, Basar Cenik, Journal of Biological Chemistry, 2011, 10.1074/jbc.m110.193433
  • A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics, Chantelle Sephton, Anne Rovelet-Lecrux, Annie Laquerrière, Flavie Lavoie-Cardinal, David Wallon, Paul A. Dutchak, Dominique Campion, John C. Van Swieten, Jeroen G. J. Van Rooij, Tsz H. Wong, Ito Kawakami, Masato Hasegawa, Haruhiko Akiyama, Ellen Gelpi, Jordi Clarimon Echavarria, Vincent Meyer, Jean-François Deleuze, Anne Boland, Charles Duyckaerts, Vincent Deramecourt, Kévin Cassinari, Anne-Claire Richard, Stéphane Rousseau, Magalie Lecourtois, Anaïs Audebrand, Sébastien Feuillette, Maria Carment del Pelaez, Andréanne Deschênes, Florent Marguet, François Lecoquierre, Myriam Sévigny, Gael Nicolas, Acta Neuropathologica Communications, 2022, 10.1186/s40478-022-01314-x
  • TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration, Gang Yu, Joachim Herz, Bercin Kutluk Cenik, Basar Cenik, Chantelle F. Sephton, bchm, 2012, 10.1515/hsz-2012-0115
  • TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor, Gang Yu, Joachim Herz, Brett A. Johnson, Shannon K. Good, Paul Mayer, Daniel R. Dries, Chantelle F. Sephton, Basar Cenik, Colleen M. Dewey, Molecular and Cellular Biology, 2011, 10.1128/mcb.01279-10

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Pauline Gelon - Maîtrise avec mémoire - En cours
  • Maria Del Carmen Pelaez Brenes - Doctorat - En cours
  • Jean-Michel Bellavance - Maîtrise avec mémoire - En cours
  • Maéline Muller - Doctorat - En cours
  • Antoine Desmeules - Maîtrise avec mémoire - En cours
  • Bastien Glasson - Doctorat - En cours
  • Isabelle Bourdeau-Julien - Maîtrise avec mémoire - 2020/01
  • Jasmine Bélanger - Maîtrise avec mémoire - 2021/09
  • Yousri Embarek Benchaar - Maîtrise avec mémoire - 2023/05
  • Gloria Nwamaka Edozie - Maîtrise avec mémoire - 2023/09
*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.