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Thématiques de recherche de la Faculté de
médecine :
Immunologie-infectiologie
Neurosciences et santé mentale
Santé cardiovasculaire, respiratoire et métabolisme
Santé des populations et pratiques optimales en santé
Transfert des connaissances
Domaines et intérêts de recherche du (de la)
professeur(e) :
Neurosciences, santé mentale et toxicomanies
Accidents cérébrovasculaires
Apprentissage et mémoire
Dépression
Motivations et émotions
Stress
Troubles affectifs (de l'humeur)
Santé différentielle des sexes
Projets de recherche
Union Neurosciences et Intelligence Artificielle - Québec (UNIQUE)- Université Laval - Fonds internes, Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2022-04-01 au 2028-03-31
La santé neurovasculaire, un déterminant de la réponse au stress et le développement des troubles de l'humeur- Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2022-07-01 au 2026-06-30
Neurovascular adaptations driving stress-induced depression vs resilience- Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
The Canadian Brain Research Strategy (International Brain Initiative Canadian Secretariat)- Instituts de recherche en santé du Canada - Subventions Catalyseur de réseaux, co-chercheur - 2020-04-01 au 2025-03-31
Extreme zooming on intestinal permeability and the western-style diet: Unravelling the role of dietary antigens on the prevalence of cardiometabolic and mental health diseases in the North- Secrétariat des programmes interorganismes à l’intention des établissements - Sentinelle Nord - Deuxième appel à projets majeurs, co-chercheur - 2020-11-01 au 2024-12-31
Northern biological signatures of stress responses and potentiality of a diet enriched in n-3 fatty acids to promote resilience when facing adversity- Secrétariat des programmes interorganismes à l’intention des établissements - Sentinelle Nord - Deuxième appel à projets majeurs, chercheur principal - 2020-11-01 au 2024-12-31
Modulation of memory encoding by the bloodbrain- Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
Chaire de recherche sur la neurobiologie du stress et de la résilience- Secrétariat des programmes interorganismes à l’intention des établissements - Fonds d'excellence en recherche Apogée Canada, chercheur principal - 2018-02-05 au 2023-02-04
A central role for neurovascular health in emotional memory encoding and stress responses- Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2020-01-01 au 2022-12-31
The endocannabinoid system: a master regulator of brain and gut health in mood disorders- Brain Canada Foundation, chercheur principal - 2020-11-01 au 2022-10-31
Effet du stress chronique sur la santé neurovasculaire, le développement de la dépression et la maladie d’Alzheimer- Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2018-07-01 au 2022-06-30
Effet du stress chronique sur la santé neurovasculaire, le développement de la dépression et la maladie d’Alzheimer- Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2018-07-01 au 2022-06-30
Développement d'un nanomatériau peptidique naturel comme thérapie novatrice capable d'influer positivement sur les pathologies liées au syndrome métabolique et aux troubles de l'humeur- Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, co-chercheur - 2019-03-29 au 2022-03-28
Programme de soutien aux nouveaux chercheurs- Université Laval - Fonds internes - Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, chercheur principal - 2019-01-01 au 2021-12-31
Fonds de démarrage - Fondation CERVO Caroline Ménard- Fondation CERVO, chercheur principal - 2018-04-01 au 2021-03-31
...
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Publications
Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue, , Nature Communications, 2022, 10.1038/s41467-021-27604-x
Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders, Ellen Doney, Alice Cadoret, Laurence Dion‐Albert, Manon Lebel, Caroline Menard, European Journal of Neuroscience, 2022, 10.1111/ejn.15239
Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression, , Molecular Psychiatry, 2022, 10.1038/s41380-021-01110-4
Sex differences in the blood–brain barrier: Implications for mental health, , Frontiers in Neuroendocrinology, 2022, 10.1016/j.yfrne.2022.100989
The Canadian Brain Research Strategy: A Focus on Early Career Researchers, Caroline Menard, Tabrez J. Siddiqui, Derya Sargin, Ashley Lawson, Yves De Koninck, Judy Illes, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2022, 10.1017/cjn.2021.81
An Indigenous Lens on Priorities for the Canadian Brain Research Strategy, Melissa L. Perreault, Malcolm King, Chelsea Gabel, Christopher J. Mushquash, Yves De Koninck, Ashley Lawson, Caterina Marra, Caroline Menard, Jennie Z. Young, Judy Illes, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2021, 10.1017/cjn.2021.501
Depression and Social Defeat Stress Are Associated with Inhibitory Synaptic Changes in the Nucleus Accumbens, Mitra Heshmati, Daniel J. Christoffel, Katherine LeClair, Flurin Cathomas, Sam A. Golden, Hossein Aleyasin, Gustavo Turecki, Allyson K. Friedman, Ming-Hu Han, Caroline Menard, Scott J. Russo, The Journal of Neuroscience, 2020, 10.1523/JNEUROSCI.2568-19.2020
LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress, Christopher A. Guevara, Bridget A. Matikainen-Ankney, Nebojsa Kezunovic, Katherine LeClair, Alexander P. Conway, Caroline Menard, Meghan E. Flanigan, Madeline Pfau, Scott J. Russo, Deanna L. Benson, George W. Huntley, Journal of Neurophysiology, 2020, 10.1152/jn.00137.2020
LRRK2 mutation alters behavioral, synaptic and non-synaptic adaptations to acute social stress, Christopher A. Guevara, Bridget A. Matikainen-Ankney, Nebojsa Kezunovic, Katherine LeClair, Alexander P. Conway, Caroline Menard, Meghan E. Flanigan, Madeline Pfau, Scott J. Russo, Deanna L. Benson, George W. Huntley, 2020, 10.1101/2020.02.25.965194
Role of Monocyte-Derived MicroRNA106b∼25 in Resilience to Social Stress, Madeline L. Pfau, Caroline Menard, Flurin Cathomas, Fiona Desland, Veronika Kana, Kenny L. Chan, Yusuke Shimo, Katherine LeClair, Meghan E. Flanigan, Hossein Aleyasin, Deena M. Walker, Sylvain Bouchard, Matthias Mack, Georgia E. Hodes, Miriam M. Merad, Scott J. Russo, Biological Psychiatry, 2019, 10.1016/j.biopsych.2019.02.023
Neurobiology of resilience in depression: immune and vascular insights from human and animal studies, , European Journal of Neuroscience, 2019, 10.1111/ejn.14547
Multidimensional Predictors of Susceptibility and Resilience to Social Defeat Stress, , Biological Psychiatry, 2019, 10.1016/j.biopsych.2019.06.030
Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice, Jun Wang, Georgia E. Hodes, Hongxing Zhang, Song Zhang, Wei Zhao, Sam A. Golden, Weina Bi, Caroline Menard, Veronika Kana, Marylene Leboeuf, Marc Xie, Dana Bregman, Madeline L. Pfau, Meghan E. Flanigan, Adelaida Esteban-Fernández, Shrishailam Yemul, Ali Sharma, Lap Ho, Richard Dixon, Miriam Merad, Ming-Hu Han, Scott J. Russo, Giulio M. Pasinetti, Nature Communications, 2018, 10.1038/s41467-017-02794-5
Inflamed Astrocytes: A Path to Depression Led by Menin, , Neuron, 2018, 10.1016/j.neuron.2018.10.039
Parkinson's Disease-linked LRRK2-G2019S mutation alters synaptic plasticity and promotes resilience to chronic social stress in young adulthood, , The Journal of Neuroscience, 2018, 10.1523/JNEUROSCI.1457-18.2018
Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression, Hossein Aleyasin, Meghan E. Flanigan, Sam A. Golden, Aki Takahashi, Caroline Menard, Madeline L. Pfau, Jacob Multer, Jacqueline Pina, Kathryn A. McCabe, Naemal Bhatti, Georgia E. Hodes, Mitra Heshmati, Rachael L. Neve, Eric J. Nestler, Elizabeth A. Heller, Scott J. Russo, The Journal of Neuroscience, 2018, 10.1523/JNEUROSCI.0296-18.2018
The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline, , Current Biology, 2018, 10.1016/j.cub.2018.02.047
Inflammatory Mediators in Mood Disorders: Therapeutic Opportunities., , Annual Review of Pharmacology and Toxicology, 2018, 10.1146/annurev-pharmtox-010617-052823
Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility, Mitra Heshmati, Hossein Aleyasin, Caroline Menard, Daniel J. Christoffel, Meghan E. Flanigan, Madeline L. Pfau, Georgia E. Hodes, Ashley E. Lepack, Lucy K. Bicks, Aki Takahashi, Ramesh Chandra, Gustavo Turecki, Mary Kay Lobo, Ian Maze, Sam A. Golden, Scott J. Russo, Proceedings of the National Academy of Sciences, 2018, 10.1073/pnas.1719014115
Establishment of a repeated social defeat stress model in female mice, Aki Takahashi, Jia-Ru Chung, Song Zhang, Hongxing Zhang, Yael Grossman, Hossein Aleyasin, Meghan E. Flanigan, Madeline L. Pfau, Caroline Menard, Dani Dumitriu, Georgia E. Hodes, Bruce S. McEwen, Eric J. Nestler, Ming-Hu Han, Scott J. Russo, Scientific Reports, 2017, 10.1038/s41598-017-12811-8
Social stress induces neurovascular pathology promoting depression, Caroline Menard, Madeline L. Pfau, Georgia E. Hodes, Veronika Kana, Victoria X. Wang, Sylvain Bouchard, Aki Takahashi, Meghan E. Flanigan, Hossein Aleyasin, Katherine B. LeClair, William G. Janssen, Benoit Labonté, Eric M. Parise, Zachary S. Lorsch, Sam A. Golden, Mitra Heshmati, Carol Tamminga, Gustavo Turecki, Matthew Campbell, Zahi A. Fayad, Cheuk Ying Tang, Miriam Merad, Scott J. Russo, Nature Neuroscience, 2017, 10.1038/s41593-017-0010-3
VGF function in depression and antidepressant efficacy, C Jiang, W-J Lin, M Sadahiro, B Labonté, C Menard, M L Pfau, C A Tamminga, G Turecki, E J Nestler, S J Russo, S R Salton, Molecular Psychiatry, 2017, 10.1038/mp.2017.233
Sex-specific transcriptional signatures in human depression, , Nature Medicine, 2017, 10.1038/nm.4386
Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens., , Neuroscience, 2017, 10.1016/j.neuroscience.2017.03.014
Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience., , Neuropsychopharmacology, 2017, 10.1038/npp.2016.90
Integrative analysis of sex-specific microRNA networks following stress in mouse nucleus accumbens, , Frontiers in Molecular Neuroscience, 2016, 10.3389/fnmol.2016.00144
Integrating Interleukin-6 into depression diagnosis and treatment, Georgia E. Hodes, Caroline Ménard, Scott J. Russo, Neurobiology of Stress, 2016, 10.1016/j.ynstr.2016.03.003
Basal forebrain projections to the lateral habenula modulate aggression reward, , Nature, 2016, 10.1038/nature18601
Pathogenesis of depression: Insights from human and rodent studies., , Neuroscience, 2016
Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress., , The Journal of Neuroscience, 2015
Neuroimmune mechanisms of depression, Georgia E Hodes, Veronika Kana, Caroline Menard, Miriam Merad, Scott J Russo, Nature Neuroscience, 2015, 10.1038/nn.4113
Neuroprotective action of resveratrol, , BBA - Molecular Basis of Disease, 2015
Signaling pathways relevant to cognition-enhancing drug targets., , Handbook of Experimental Pharmacology - Cognitive Enhancement, 2015
Glutamate presynaptic vesicular transporter and postsynaptic receptor levels correlate with spatial memory status in aging rat models, , Neurobiology of Aging, 2015
Le rat LOU: un modèle unique pour l’identification de nouvelles cibles impliquées dans la préservation de la mémoire, , Vieillissement et démences : Un défi médical, scientifique et socio-économique, 2014
Glutamatergic signaling and low prodynorphin expression are associated with intact memory and reduced anxiety in rat models of healthy aging, , Frontiers in Aging Neuroscience, 2014
Possible Role of Dynorphins in Alzheimer's Disease and Age-Related Cognitive Deficits., , Neurodegenerative Diseases, 2014
Une association surprenante entre la consommation de sodium, l'exercice physique et la mémoire des personnes âgées, , Médecine Sciences Amérique, 2013
Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma, , Frontiers in Cellular Neuroscience, 2013
Immune marker CD68 correlates with cognitive impairment in normally aged rats., , Neurobiology of Aging, 2013
Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging., , The Journal of Neuroscience, 2013
Impaired structural hippocampal plasticity is associated with emotional and memory deficits in the olfactory bulbectomized rat., , Neuroscience, 2013
Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain., , Frontiers in Pharmacology , 2012
Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways., , PLoS One, 2012
Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory., , Trends in Pharmacological Sciences, 2011
AMPA receptor-mediated cell death is reduced by docosahexaenoic acid but not by eicosapentaenoic acid in area CA1 of hippocampal slice cultures., , Journal of Neuroscience Research, 2009
Calcium-independent phospholipase A2 activities in the brain: Functional and pathological perspectives, , Current Topics in Pharmacology, 2009
Calcium-independent phospholipase A(2) influences AMPA-mediated toxicity of hippocampal slices by regulating the GluR1 subunit in synaptic membranes., , Hippocampus, 2007
A novel role for calcium-independent phospholipase A in alpha-amino-3-hydroxy-5-methylisoxazole-propionate receptor regulation during long-term potentiation., , European Journal of Neuroscience, 2006
Phosphorylation of AMPA receptor subunits is differentially regulated by phospholipase A2 inhibitors., , Neuroscience Letters, 2005
AMPA receptor phosphorylation is selectively regulated by constitutive phospholipase A(2) and 5-lipoxygenase activities., , Hippocampus, 2005
Strain-related variations of AMPA receptor modulation by calcium-dependent mechanisms in the hippocampus: contribution of lipoxygenase metabolites of arachidonic acid., , Brain Research, 2004
*Les supervisions d’étudiant(e)s de 1er cycle en
stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées
ultérieurement.
Vice-décanat à la recherche et aux études supérieures Pavillon Ferdinand-Vandry Université Laval 1050, avenue de la Médecine, local 4645 Québec (Québec) G1V 0A6 Canada
Catherine Comtois Agente de gestion des études etudes.sup2@fmed.ulaval.ca Biostatistique Épidémiologie Évaluation économique des technologies de la santé Santé publique
Marianne Rivest et Claudia Gonzalez Agentes de gestion des études etudes.sup1@fmed.ulaval.ca Biologie cellulaire et moléculaire Génomique fonctionnelle Médecine moléculaire Microbiologie-immunologie Neurosciences
Isabelle Tremblay Agente de gestion des études etudes.sup3@fmed.ulaval.ca Pédagogie universitaire en sciences de la santé Sciences cliniques et biomédicales Sciences de la réadaptation Prévention et gestion de la santé et de la sécurité au travail