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Caroline Ménard

Professeure sous octroi agrégée

Caroline Ménard
Caroline.Menard@cervo.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie
Neurosciences et santé mentale
Santé cardiovasculaire, respiratoire et métabolisme
Santé des populations et pratiques optimales en santé
Transfert des connaissances

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Accidents cérébrovasculaires
  • Apprentissage et mémoire
  • Dépression
  • Motivations et émotions
  • Stress
  • Troubles affectifs (de l'humeur)
Santé différentielle des sexes

Projets de recherche

  • Union Neurosciences et Intelligence Artificielle - Québec (UNIQUE) - Université Laval - Fonds internes, Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2022-04-01 au 2028-03-31
  • La santé neurovasculaire, un déterminant de la réponse au stress et le développement des troubles de l'humeur - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2022-07-01 au 2026-06-30
  • Neurovascular adaptations driving stress-induced depression vs resilience - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • The Canadian Brain Research Strategy (International Brain Initiative Canadian Secretariat) - Instituts de recherche en santé du Canada - Subventions Catalyseur de réseaux, co-chercheur - 2020-04-01 au 2025-03-31
  • Extreme zooming on intestinal permeability and the western-style diet: Unravelling the role of dietary antigens on the prevalence of cardiometabolic and mental health diseases in the North - Secrétariat des programmes interorganismes à l’intention des établissements - Sentinelle Nord - Deuxième appel à projets majeurs, co-chercheur - 2020-11-01 au 2024-12-31
  • Northern biological signatures of stress responses and potentiality of a diet enriched in n-3 fatty acids to promote resilience when facing adversity - Secrétariat des programmes interorganismes à l’intention des établissements - Sentinelle Nord - Deuxième appel à projets majeurs, chercheur principal - 2020-11-01 au 2024-12-31
  • Modulation of memory encoding by the bloodbrain - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2019-04-01 au 2024-03-31
  • Chaire de recherche sur la neurobiologie du stress et de la résilience - Secrétariat des programmes interorganismes à l’intention des établissements - Fonds d'excellence en recherche Apogée Canada, chercheur principal - 2018-02-05 au 2023-02-04
  • A central role for neurovascular health in emotional memory encoding and stress responses - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2020-01-01 au 2022-12-31
  • The endocannabinoid system: a master regulator of brain and gut health in mood disorders - Brain Canada Foundation, chercheur principal - 2020-11-01 au 2022-10-31
  • Effet du stress chronique sur la santé neurovasculaire, le développement de la dépression et la maladie d’Alzheimer - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2018-07-01 au 2022-06-30
  • Effet du stress chronique sur la santé neurovasculaire, le développement de la dépression et la maladie d’Alzheimer - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2018-07-01 au 2022-06-30
  • Développement d'un nanomatériau peptidique naturel comme thérapie novatrice capable d'influer positivement sur les pathologies liées au syndrome métabolique et aux troubles de l'humeur - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, co-chercheur - 2019-03-29 au 2022-03-28
  • Programme de soutien aux nouveaux chercheurs - Université Laval - Fonds internes - Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, chercheur principal - 2019-01-01 au 2021-12-31

Publications

  • Environmental conditions of recognition memory testing induce neurovascular changes in the hippocampus in a sex-specific manner in mice, Alice Cadoret, Laurence Dion-Albert, Sara Amrani, Laurianne Caron, Mathilde Théberge, Audrey Turmel, Manon Lebel, Caroline Menard, Behavioural Brain Research, 2023, 10.1016/j.bbr.2023.114443
  • Glutamate shall not pass: a mechanistic role for astrocytic O-GlcNAc transferase in stress and depression, Sam E.J. Paton, Caroline Menard, Journal of Clinical Investigation, 2023, 10.1172/JCI168662
  • Neurovascular adaptations modulating cognition, mood, and stress responses, Laurence Dion-Albert, Katarzyna A. Dudek, Scott J. Russo, Matthew Campbell, Caroline Menard, Trends in Neurosciences, 2023, 10.1016/j.tins.2023.01.005
  • An Indigenous Lens on Priorities for the Canadian Brain Research Strategy, Melissa L. Perreault, Malcolm King, Chelsea Gabel, Christopher J. Mushquash, Yves De Koninck, Ashley Lawson, Caterina Marra, Caroline Ménard, Jennie Z. Young, Judy Illes, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2023, 10.1017/cjn.2021.501
  • Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue, , Nature Communications, 2022, 10.1038/s41467-021-27604-x
  • Environmental conditions of recognition memory testing induce neurovascular changes in the hippocampus in a sex-specific manner in mice, Alice Cadoret, Laurence Dion-Albert, Sara Amrani, Laurianne Caron, Mathilde Théberge, Audrey Turmel, Manon Lebel, Caroline Menard, 2022, 10.1101/2022.09.29.510187
  • Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders, Ellen Doney, Alice Cadoret, Laurence Dion‐Albert, Manon Lebel, Caroline Menard, European Journal of Neuroscience, 2022, 10.1111/ejn.15239
  • Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression, , Molecular Psychiatry, 2022, 10.1038/s41380-021-01110-4
  • Sex differences in the blood–brain barrier: Implications for mental health, , Frontiers in Neuroendocrinology, 2022, 10.1016/j.yfrne.2022.100989
  • The Canadian Brain Research Strategy: A Focus on Early Career Researchers, Caroline Menard, Tabrez J. Siddiqui, Derya Sargin, Ashley Lawson, Yves De Koninck, Judy Illes, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2022, 10.1017/cjn.2021.81
  • Chronic stress exposure alters the gut barrier: sex-specific effects on microbiota and jejunum tight junctions, Doney, E., Dion-Albert, L., Coulombe-Rozon, F., Osborne, N., Bernatchez, R., Paton, S.E.J., Kaufmann, F.N., Agomma, R.O., Solano, J.L., Gaumond, R., Dudek, K.A., Szyszkowicz, J.K., Consortium, S., Lebel, M., Doyen, A., Durand, A., Lavoie-Cardinal, F., Audet, M.-C., Menard, C., bioRxiv, 2022, 10.1101/2022.09.13.507821
  • Central and peripheral stress-induced epigenetic mechanisms of resilience, Dudek, K.A., Kaufmann, F.N., Lavoie, O., Menard, C., Current Opinion in Psychiatry, 2021, 10.1097/YCO.0000000000000664
  • Depression and Social Defeat Stress Are Associated with Inhibitory Synaptic Changes in the Nucleus Accumbens, Mitra Heshmati, Daniel J. Christoffel, Katherine LeClair, Flurin Cathomas, Sam A. Golden, Hossein Aleyasin, Gustavo Turecki, Allyson K. Friedman, Ming-Hu Han, Caroline Menard, Scott J. Russo, The Journal of Neuroscience, 2020, 10.1523/JNEUROSCI.2568-19.2020
  • LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress, Christopher A. Guevara, Bridget A. Matikainen-Ankney, Nebojsa Kezunovic, Katherine LeClair, Alexander P. Conway, Caroline Menard, Meghan E. Flanigan, Madeline Pfau, Scott J. Russo, Deanna L. Benson, George W. Huntley, Journal of Neurophysiology, 2020, 10.1152/jn.00137.2020
  • LRRK2 mutation alters behavioral, synaptic and non-synaptic adaptations to acute social stress, Christopher A. Guevara, Bridget A. Matikainen-Ankney, Nebojsa Kezunovic, Katherine LeClair, Alexander P. Conway, Caroline Menard, Meghan E. Flanigan, Madeline Pfau, Scott J. Russo, Deanna L. Benson, George W. Huntley, 2020, 10.1101/2020.02.25.965194
  • Molecular adaptations of the blood–brain barrier promote stress resilience vs. Depression, Dudek, K.A., Dion-Albert, L., Lebel, M., LeClair, K., Labrecque, S., Tuck, E., Perez, C.F., Golden, S.A., Tamminga, C., Turecki, G., Mechawar, N., Russo, S.J., Menard, C., Proceedings of the National Academy of Sciences of the United States of America, 2020, 10.1073/pnas.1914655117
  • Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice, Flanigan, M.E., Aleyasin, H., Li, L., Burnett, C.J., Chan, K.L., LeClair, K.B., Lucas, E.K., Matikainen-Ankney, B., Durand-de Cuttoli, R., Takahashi, A., Menard, C., Pfau, M.L., Golden, S.A., Bouchard, S., Calipari, E.S., Nestler, E.J., DiLeone, R.J., Yamanaka, A., Huntley, G.W., Clem, R.L., Russo, S.J., Nature Neuroscience, 2020, 10.1038/s41593-020-0617-7
  • Role of Monocyte-Derived MicroRNA106b∼25 in Resilience to Social Stress, Madeline L. Pfau, Caroline Menard, Flurin Cathomas, Fiona Desland, Veronika Kana, Kenny L. Chan, Yusuke Shimo, Katherine LeClair, Meghan E. Flanigan, Hossein Aleyasin, Deena M. Walker, Sylvain Bouchard, Matthias Mack, Georgia E. Hodes, Miriam M. Merad, Scott J. Russo, Biological Psychiatry, 2019, 10.1016/j.biopsych.2019.02.023
  • Neurobiology of resilience in depression: immune and vascular insights from human and animal studies, , European Journal of Neuroscience, 2019, 10.1111/ejn.14547
  • Multidimensional Predictors of Susceptibility and Resilience to Social Defeat Stress, , Biological Psychiatry, 2019, 10.1016/j.biopsych.2019.06.030
  • Inflamed Astrocytes: A Path to Depression Led by Menin, , Neuron, 2018, 10.1016/j.neuron.2018.10.039
  • Parkinson's Disease-linked LRRK2-G2019S mutation alters synaptic plasticity and promotes resilience to chronic social stress in young adulthood, , The Journal of Neuroscience, 2018, 10.1523/JNEUROSCI.1457-18.2018
  • Non-invasive chemogenetics, , Nature Biomedical Engineering, 2018, 10.1038/s41551-018-0269-z
  • Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression, Hossein Aleyasin, Meghan E. Flanigan, Sam A. Golden, Aki Takahashi, Caroline Menard, Madeline L. Pfau, Jacob Multer, Jacqueline Pina, Kathryn A. McCabe, Naemal Bhatti, Georgia E. Hodes, Mitra Heshmati, Rachael L. Neve, Eric J. Nestler, Elizabeth A. Heller, Scott J. Russo, The Journal of Neuroscience, 2018, 10.1523/JNEUROSCI.0296-18.2018
  • The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline, , Current Biology, 2018, 10.1016/j.cub.2018.02.047
  • Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice, Jun Wang, Georgia E. Hodes, Hongxing Zhang, Song Zhang, Wei Zhao, Sam A. Golden, Weina Bi, Caroline Menard, Veronika Kana, Marylene Leboeuf, Marc Xie, Dana Bregman, Madeline L. Pfau, Meghan E. Flanigan, Adelaida Esteban-Fernández, Shrishailam Yemul, Ali Sharma, Lap Ho, Richard Dixon, Miriam Merad, Ming-Hu Han, Scott J. Russo, Giulio M. Pasinetti, Nature Communications, 2018, 10.1038/s41467-017-02794-5
  • Inflammatory Mediators in Mood Disorders: Therapeutic Opportunities., , Annual Review of Pharmacology and Toxicology, 2018, 10.1146/annurev-pharmtox-010617-052823
  • Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility, Mitra Heshmati, Hossein Aleyasin, Caroline Menard, Daniel J. Christoffel, Meghan E. Flanigan, Madeline L. Pfau, Georgia E. Hodes, Ashley E. Lepack, Lucy K. Bicks, Aki Takahashi, Ramesh Chandra, Gustavo Turecki, Mary Kay Lobo, Ian Maze, Sam A. Golden, Scott J. Russo, Proceedings of the National Academy of Sciences, 2018, 10.1073/pnas.1719014115
  • Social stress induces neurovascular pathology promoting depression, Caroline Menard, Madeline L. Pfau, Georgia E. Hodes, Veronika Kana, Victoria X. Wang, Sylvain Bouchard, Aki Takahashi, Meghan E. Flanigan, Hossein Aleyasin, Katherine B. LeClair, William G. Janssen, Benoit Labonté, Eric M. Parise, Zachary S. Lorsch, Sam A. Golden, Mitra Heshmati, Carol Tamminga, Gustavo Turecki, Matthew Campbell, Zahi A. Fayad, Cheuk Ying Tang, Miriam Merad, Scott J. Russo, Nature Neuroscience, 2017, 10.1038/s41593-017-0010-3
  • VGF function in depression and antidepressant efficacy, C Jiang, W-J Lin, M Sadahiro, B Labonté, C Menard, M L Pfau, C A Tamminga, G Turecki, E J Nestler, S J Russo, S R Salton, Molecular Psychiatry, 2017, 10.1038/mp.2017.233
  • Establishment of a repeated social defeat stress model in female mice, Aki Takahashi, Jia-Ru Chung, Song Zhang, Hongxing Zhang, Yael Grossman, Hossein Aleyasin, Meghan E. Flanigan, Madeline L. Pfau, Caroline Menard, Dani Dumitriu, Georgia E. Hodes, Bruce S. McEwen, Eric J. Nestler, Ming-Hu Han, Scott J. Russo, Scientific Reports, 2017, 10.1038/s41598-017-12811-8
  • Sex-specific transcriptional signatures in human depression, , Nature Medicine, 2017, 10.1038/nm.4386
  • Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens., , Neuroscience, 2017, 10.1016/j.neuroscience.2017.03.014
  • Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience., , Neuropsychopharmacology, 2017, 10.1038/npp.2016.90
  • Integrative analysis of sex-specific microRNA networks following stress in mouse nucleus accumbens, , Frontiers in Molecular Neuroscience, 2016, 10.3389/fnmol.2016.00144
  • Integrating Interleukin-6 into depression diagnosis and treatment, Georgia E. Hodes, Caroline Ménard, Scott J. Russo, Neurobiology of Stress, 2016, 10.1016/j.ynstr.2016.03.003
  • Basal forebrain projections to the lateral habenula modulate aggression reward, , Nature, 2016, 10.1038/nature18601
  • Pathogenesis of depression: Insights from human and rodent studies, Ménard, C., Hodes, G.E., Russo, S.J., Neuroscience, 2016, 10.1016/j.neuroscience.2015.05.053
  • Neuroimmune mechanisms of depression, Georgia E Hodes, Veronika Kana, Caroline Menard, Miriam Merad, Scott J Russo, Nature Neuroscience, 2015, 10.1038/nn.4113
  • Glutamate presynaptic vesicular transporter and postsynaptic receptor levels correlate with spatial memory status in aging rat models, Ménard, C., Quirion, R., Vigneault, E., Bouchard, S., Ferland, G., El Mestikawy, S., Gaudreau, P., Neurobiology of Aging, 2015, 10.1016/j.neurobiolaging.2014.11.013
  • Neuroprotective action of resveratrol, Bastianetto, S., Ménard, C., Quirion, R., Biochimica et Biophysica Acta - Molecular Basis of Disease, 2015, 10.1016/j.bbadis.2014.09.011
  • Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress, Hodes, G.E., Pfau, M.L., Purushothaman, I., Francisca Ahn, H., Golden, S.A., Christoffel, D.J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M.E., Ménard, C., Aleyasin, H., Koo, J.W., Lorsch, Z.S., Feng, J., Heshmati, M., Wang, M., Turecki, G., Neve, R., Zhang, B., Shen, L., Nestler, E.J., Russo, S.J., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.1392-15.2015
  • Signaling pathways relevant to cognition- enhancing drug targets, Ménard, C., Gaudreau, P., Quirion, R., Handbook of Experimental Pharmacology, 2015, 10.1007/978-3-319-16522-6_3
  • Le rat LOU: un modèle unique pour l’identification de nouvelles cibles impliquées dans la préservation de la mémoire, , Vieillissement et démences : Un défi médical, scientifique et socio-économique, 2014
  • Glutamatergic signaling and low prodynorphin expression are associated with intact memory and reduced anxiety in rat models of healthy aging, Ménard, C., Quirion, R., Bouchard, S., Ferland, G., Gaudreau, P., Frontiers in Aging Neuroscience, 2014, 10.3389/fnagi.2014.00081
  • Possible role of dynorphins in alzheimer's disease and age-related cognitive deficits, Ménard, C., Herzog, H., Schwarzer, C., Quirion, R., Neurodegenerative Diseases, 2014, 10.1159/000353848
  • Une association surprenante entre la consommation de sodium, l'exercice physique et la mémoire des personnes âgées, , Médecine Sciences Amérique, 2013
  • Impaired structural hippocampal plasticity is associated with emotional and memory deficits in the olfactory bulbectomized rat, Morales-Medina, J.C., Juarez, I., Venancio-García, E., Cabrera, S.N., Menard, C., Yu, W., Flores, G., Mechawar, N., Quirion, R., Neuroscience, 2013, 10.1016/j.neuroscience.2013.01.037
  • Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging, Ménard, C., Tse, Y.C., Cavanagh, C., Chabot, J.-G., Herzog, H., Schwarzer, C., Wong, T.P., Quirion, R., Journal of Neuroscience, 2013, 10.1523/JNEUROSCI.0290-13.2013
  • Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma, Menard, C., Bastianetto, S., Quirion, R., Frontiers in Cellular Neuroscience, 2013, 10.3389/fncel.2013.00281
  • The immune marker CD68 correlates with cognitive impairment in normally aged rats, Farso, M., Ménard, C., Colby-Milley, J., Quirion, R., Neurobiology of Aging, 2013, 10.1016/j.neurobiolaging.2013.02.008
  • Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain, Ménard, C., Quirion, R., Frontiers in Pharmacology, 2012, 10.3389/fphar.2012.00182
  • Successful cognitive aging in rats: A role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways, Ménard, C., Quirion, R., PLoS ONE, 2012, 10.1371/journal.pone.0028666
  • Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory, Benoit, C.-E., Rowe, W.B., Menard, C., Sarret, P., Quirion, R., Trends in Pharmacological Sciences, 2011, 10.1016/j.tips.2010.10.002
  • AMPA receptor-mediated cell death is reduced by docosahexaenoic acid but not by eicosapentaenoic acid in area CA1 of hippocampal slice cultures, Ménard, C., Patenaude, C., Gagné, A.-M., Massicotte, G., Journal of Neuroscience Research, 2009, 10.1002/jnr.21916
  • Calcium-independent phospholipase A2 activities in the brain: Functional and pathological perspectives, Massicotte, G., Ménard, C., Patenaude, C., Current Topics in Pharmacology, 2009
  • Calcium-independent phospholipase A2 influences AMPA-mediated toxicity of hippocampal slices by regulating the GluR1 subunit in synaptic membranes, Ménard, C., Chartier, É., Patenaude, C., Robinson, P., Cyr, M., Baudry, M., Massicotte, G., Hippocampus, 2007, 10.1002/hipo.20343
  • A novel role for calcium-independent phospholipase A2 in α-amino-3-hydroxy-5-methylisoxazole-propionate receptor regulation during long-term potentiation, Martel, M.-A., Patenaude, C., Ménard, C., Alaux, S., Cummings, B.S., Massicotte, G., European Journal of Neuroscience, 2006, 10.1111/j.1460-9568.2005.04565.x
  • AMPA receptor phosphorylation is selectively regulated by constitutive phospholipase A2 and 5-lipoxygenase activities, Ménard, C., Valastro, B., Martel, M.-A., Chartier, É., Marineau, A., Baudry, M., Massicotte, G., Hippocampus, 2005, 10.1002/hipo.20061
  • Phosphorylation of AMPA receptor subunits is differentially regulated by phospholipase A2 inhibitors, Ménard, C., Patenaude, C., Massicotte, G., Neuroscience Letters, 2005, 10.1016/j.neulet.2005.07.012
  • Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission, St-Gelais, F., Ménard, C., Congar, P., Trudeau, L.-E., Massicotte, G., Hippocampus, 2004, 10.1002/hipo.10176
  • Strain-related variations of AMPA receptor modulation by calcium-dependent mechanisms in the hippocampus: Contribution of lipoxygenase metabolites of arachidonic acid, Ménard, C., Valastro, B., Martel, M.-A., Martinoli, M.-G., Massicotte, G., Brain Research, 2004, 10.1016/j.brainres.2004.03.012

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Laurence Dion-Albert - Doctorat - En cours
  • Fernanda Neutzling Kaufmann - Post-doctorat - En cours
  • Giada Giorgini - Doctorat - En cours
  • Adeline Collignon - Doctorat - En cours
  • Samuel Paton - Maîtrise avec mémoire - En cours
  • José Luis Solano Lopez - Doctorat - En cours
  • Béatrice Daigle - Maîtrise avec mémoire - En cours
  • Laura Menegatti Bevilacqua - Doctorat - En cours
  • Katarzyna Anna Dudek - Doctorat - En cours
  • Alice Cadoret - Doctorat - En cours
  • Luisa Bandeira Binder - Doctorat - En cours
  • Jonathan Bouchard - Maîtrise avec mémoire - 2022/01
  • François Coulombe-Rozon - Maîtrise avec mémoire - 2022/09

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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