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Ayman El Ali

Professeur agrégé

Ayman El Ali
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Accidents cérébrovasculaires
  • Greffes neuronales et cellules souches
  • Maladies neurodégénératives
  • Plasticité/régénération neuronale
  • Maladie d'Alzheimer

Projets de recherche

  • Canada Research Chair in molecular and cellular neurovascular interactions - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30
  • Mechanisms regulating contribution of pericytes to brain repair after stroke - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Bourse de soutien aux nouveaux détenteurs de Chaire de recherche du Canada - Université Laval - Fonds internes - Fonds de soutien aux professeurs-chercheurs bénéficiant d’une Chaire de recherche du Canada, chercheur principal - 2020-07-01 au 2022-06-30
  • Role of canonical Wnt pathway in regulating the structural and functional integrity of the blood-brain barrier in the normal adult brain - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31
  • The role of apolipoprotein E4-canonical Wnt pathway crosstalk at the blood-brain barrier in Alzheimer’s disease - Scottish Rite Charitable Foundation of Canada - Subvention de recherche, chercheur principal - 2017-10-30 au 2021-12-31
  • Laboratory of inter-cellular dynamics within the neurovascular unit in cerebrovascular diseases - Fondation Canadienne pour l'innovation (La), Ministère de la Santé et des Services sociaux - Fonds des leaders John-R.-Evans (FLJR), chercheur principal - 2018-01-01 au 2021-07-31
  • Neurovascular Restoration in Stroke: Role of Dickkopf-Related Protein-1 (DKK1) - Fondation des maladies du coeur et de l'AVC du Canada - Subventions de recherche, chercheur principal - 2018-07-01 au 2021-06-30
  • Salaire d'un professeur - CHU de Québec – Université Laval – CHUL, chercheur principal - 2015-07-01 au 2020-06-30
  • Signalisation de l’unité neurovasculaire suite aux maladies cérébrovasculaires: Implications pathobiologiques et thérapeutiques - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2017-07-01 au 2020-06-30
  • Signalisation de l’unité neurovasculaire suite aux maladies cérébrovasculaires: Implications pathobiologiques et thérapeutiques - Fonds de recherche du Québec - Santé - Établissement de jeunes chercheurs - Juniors 1, chercheur principal - 2017-07-01 au 2020-06-30

Publications

  • Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression, Mohammed A. Al-Onaizi, Peter Thériault, Sarah Lecordier, Paul Prefontaine, Serge Rivest, Ayman ElAli, Brain, Behavior, and Immunity, 2022, 10.1016/j.bbi.2021.07.016
  • SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection, Rayan Khaddaj-Mallat, Natija Aldib, Anne-Sophie Paquette, Aymeric Ferreira, Sarah Lecordier, Maxime Bernard, Armen Saghatelyan, Ayman ElAli, 2021, 10.1101/2021.04.30.442194
  • Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease, Romain Menet, Philippe Bourassa, Frédéric Calon, Ayman ElAli, Neurochemistry International, 2020, 10.1016/j.neuint.2020.104881
  • Role of Microglia in Modulating Adult Neurogenesis in Health and Neurodegeneration., , International journal of molecular sciences, 2020, 10.3390/ijms21186875
  • Wnt Pathway: An Emerging Player in Vascular and Traumatic Mediated Brain Injuries., , Frontiers in physiology, 2020, 10.3389/fphys.2020.565667
  • Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy, Noëmie Jean LeBlanc, Romain Menet, Katherine Picard, Geneviève Parent, Marie-Ève Tremblay, Ayman ElAli, Molecular Neurobiology, 2019, 10.1007/s12035-019-1539-9
  • Hyperlipidemia in Stroke Pathobiology and Therapy: Insights and Perspectives., , Frontiers in physiology, 2018, 10.3389/fphys.2018.00488
  • Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer's disease., , Neuro-oncology, 2017, 10.1093/neuonc/nox058
  • Vascular Endothelial Growth Factor Isoform-B Stimulates Neurovascular Repair After Ischemic Stroke by Promoting the Function of Pericytes via Vascular Endothelial Growth Factor Receptor-1., , Molecular neurobiology, 2017, 10.1007/s12035-017-0478-6
  • Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions., , International journal of molecular sciences, 2017, 10.3390/ijms18030496
  • High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice., , Oncotarget, 2016, 10.18632/oncotarget.12179
  • Microglia Ontology and Signaling., , Frontiers in cell and developmental biology, 2016, 10.3389/fcell.2016.00072
  • Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner., , Oncotarget, 2016, 10.18632/oncotarget.9652
  • The implication of neurovascular unit signaling in controlling the subtle balance between injury and repair following ischemic stroke., , Neural regeneration research, 2016, 10.4103/1673-5374.184485
  • Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice., , Oncotarget, 2016, 10.18632/oncotarget.7689
  • The Role of Monocytes in Ischemic Stroke Pathobiology: New Avenues to Explore., , Frontiers in aging neuroscience, 2016, 10.3389/fnagi.2016.00029
  • Erratum to: Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain., , Acta neuropathologica, 2015, 10.1007/s00401-015-1472-6
  • Tissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice., , Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, 10.1038/npp.2015.279
  • Microglia in Alzheimer's disease: A multifaceted relationship., , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.07.021
  • The dynamics of monocytes and microglia in Alzheimer's disease., , Alzheimer's research & therapy, 2015, 10.1186/s13195-015-0125-2
  • Neurovascular Unit Dysfunction in Dementia: A Brief Summary., , Austin Alzheimer’s J Parkinsons Dis, 2014
  • The role of pericytes in neurovascular unit remodeling in brain disorders., , International journal of molecular sciences, 2014, 10.3390/ijms15046453
  • Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation., , Acta neuropathologica communications, 2013, 10.1186/2051-5960-1-75
  • Vascular endothelial growth factor promotes pericyte coverage of brain capillaries, improves cerebral blood flow during subsequent focal cerebral ischemia, and preserves the metabolic penumbra., , Stroke, 2013, 10.1161/strokeaha.111.000240
  • Hyperlipidemia attenuates vascular endothelial growth factor-induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells., , Arteriosclerosis, thrombosis, and vascular biology, 2013, 10.1161/atvbaha.112.300749
  • Innate immunity in the CNS: redefining the relationship between the CNS and Its environment., , Neuron, 2013, 10.1016/j.neuron.2013.04.005
  • The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease., , Frontiers in physiology, 2013, 10.3389/fphys.2013.00045
  • A study on the effect of JNK inhibitor, SP600125, on the disruption of blood-brain barrier induced by methamphetamine., , Neurobiology of disease, 2012, 10.1016/j.nbd.2012.10.006
  • The abluminal endothelial membrane in neurovascular remodeling in health and disease., , Science signaling, 2012, 10.1126/scisignal.2002886
  • Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation., , Stem cells (Dayton, Ohio), 2012, 10.1002/stem.1098
  • Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication., , Stroke, 2012, 10.1161/strokeaha.111.648923
  • Reelin depletion is an early phenomenon of Alzheimer's pathology., , Journal of Alzheimer's disease : JAD, 2012, 10.3233/jad-2012-112069
  • Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions., , Neurobiology of disease, 2011, 10.1016/j.nbd.2011.12.026
  • Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain., , Acta neuropathologica, 2011, 10.1007/s00401-011-0914-z
  • Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells., , Brain pathology (Zurich, Switzerland), 2011, 10.1111/j.1750-3639.2011.00517.x
  • Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation., , Stroke, 2011, 10.1161/strokeaha.111.615559
  • Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia., , Acta neuropathologica, 2011, 10.1007/s00401-011-0856-5
  • ATP-binding cassette transporters and their roles in protecting the brain., , The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2011, 10.1177/1073858410391270
  • Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity., , Brain : a journal of neurology, 2011, 10.1093/brain/awq344
  • Acute hepatocyte growth factor treatment induces long-term neuroprotection and stroke recovery via mechanisms involving neural precursor cell proliferation and differentiation., , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, 10.1038/jcbfm.2010.211
  • Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain., , Science signaling, 2010, 10.1126/scisignal.2001213
  • Combination of tissue-plasminogen activator with erythropoietin induces blood-brain barrier permeability, extracellular matrix disaggregation, and DNA fragmentation after focal cerebral ischemia in mice., , Stroke, 2010, 10.1161/strokeaha.109.574418
  • Role of Nogo-A in neuronal survival in the reperfused ischemic brain., , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, 10.1038/jcbfm.2009.268
  • Differential motility of p190bcr-abl- and p210bcr-abl-expressing cells: respective roles of Vav and Bcr-Abl GEFs., , Oncogene, 2007, 10.1038/sj.onc.1210933

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Revathy Guruswamy - Doctorat - En cours
  • Rayan Khaddaj Mallat - Post-doctorat - En cours
  • Sarah Claire Marie Lecordier - Doctorat - En cours
  • Maxime Bernard - Doctorat - En cours
  • Daniel Manrique Castano - Post-doctorat - En cours
  • Romain Menet - Doctorat - En cours
  • Yara El Moghrabi - Doctorat - En cours
  • Natija Aldib - Doctorat - En cours
  • Leila Nasrallah - Doctorat - En cours
  • Aliabbas Zia - Doctorat - En cours
  • Noémie Jean-Leblanc - Maitrîse avec mémoire - 2018/09

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.

Direction et personnes-ressources

Vice-décanat à la recherche et aux études supérieures
Pavillon Ferdinand-Vandry
Université Laval
1050, avenue de la Médecine,  local 4645
Québec, Québec G1V 0A6
Canada

Renseignements - Secrétariat :
vdres@fmed.ulaval.ca
Téléphone 418 656-2690

Jacques Simard
Vice-doyen à la recherche et aux études supérieures
vice-doyen.recherche-et-etudes-superieures@fmed.ulaval.ca

Louise Laperrière
Adjointe au vice-doyen à la recherche et aux études supérieures
louise.laperriere@fmed.ulaval.ca 

Volet recherche
Gestion financière
Volet études aux cycles supérieurs