Découvrez nos professeurs et professeures!
Ayman El Ali
Professeur agrégé

Contribution à la recherche
Axe de recherche de l'Université Laval :
Santé et bien-être durables
Thématiques de recherche de la Faculté de médecine :
Neurosciences et santé mentale
Domaines et intérêts de recherche du (de la) professeur(e) :
Neurosciences, santé mentale et toxicomanies
- Accidents cérébrovasculaires
- Greffes neuronales et cellules souches
- Maladies neurodégénératives
- Plasticité/régénération neuronale
- Maladie d'Alzheimer
Projets de recherche
- Investigate the mechanisms regulating the fibrotic reaction mediated by perivascular cells in cerebrovascular disorders - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-04-01 au 2028-03-31
- Elucidate the role of KLF4 in regulating mural cell contribution to tissue repair after stroke - Fondation des maladies du coeur et de l'AVC du Canada - Subventions de recherche, chercheur principal - 2023-07-01 au 2026-06-30
- Canada Research Chair in molecular and cellular neurovascular interactions - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30
- Mechanisms regulating contribution of pericytes to brain repair after stroke - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
- Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
- Bourse de soutien aux nouveaux détenteurs de Chaire de recherche du Canada - Université Laval - Fonds internes - Fonds de soutien aux professeurs-chercheurs bénéficiant d’une Chaire de recherche du Canada, chercheur principal - 2020-07-01 au 2022-06-30
- Role of canonical Wnt pathway in regulating the structural and functional integrity of the blood-brain barrier in the normal adult brain - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31
- The role of apolipoprotein E4-canonical Wnt pathway crosstalk at the blood-brain barrier in Alzheimer’s disease - Scottish Rite Charitable Foundation of Canada - Subvention de recherche, chercheur principal - 2017-10-30 au 2021-12-31
Publications
- PDGF-D is de novo expressed after stroke and contributes to neurovascular protection by rescuing the function of pericytes, Maxime Bernard, Romain Menet, Sarah Lecordier, Ayman ElAli, 2023, 10.21203/rs.3.rs-3059240/v1
- Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression, Mohammed A. Al-Onaizi, Peter Thériault, Sarah Lecordier, Paul Prefontaine, Serge Rivest, Ayman ElAli, Brain, Behavior, and Immunity, 2022, 10.1016/j.bbi.2021.07.016
- SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection, Rayan Khaddaj-Mallat, Natija Aldib, Anne-Sophie Paquette, Aymeric Ferreira, Sarah Lecordier, Maxime Bernard, Armen Saghatelyan, Ayman ElAli, 2021, 10.1101/2021.04.30.442194
- Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease, Romain Menet, Philippe Bourassa, Frédéric Calon, Ayman ElAli, Neurochemistry International, 2020, 10.1016/j.neuint.2020.104881
- Role of Microglia in Modulating Adult Neurogenesis in Health and Neurodegeneration., , International journal of molecular sciences, 2020, 10.3390/ijms21186875
- The implication of neurovascular unit signaling in controlling the subtle balance between injury and repair following ischemic stroke., , Neural regeneration research, 2016, 10.4103/1673-5374.184485
- Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice., , Oncotarget, 2016, 10.18632/oncotarget.7689
- The Role of Monocytes in Ischemic Stroke Pathobiology: New Avenues to Explore., , Frontiers in aging neuroscience, 2016, 10.3389/fnagi.2016.00029
- Erratum to: Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain., , Acta neuropathologica, 2015, 10.1007/s00401-015-1472-6
- Neurovascular Unit Dysfunction in Dementia: A Brief Summary., , Austin Alzheimer’s J Parkinsons Dis, 2014
- Innate immunity in the CNS: redefining the relationship between the CNS and Its environment., , Neuron, 2013, 10.1016/j.neuron.2013.04.005
- The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease., , Frontiers in physiology, 2013, 10.3389/fphys.2013.00045
- The abluminal endothelial membrane in neurovascular remodeling in health and disease., , Science signaling, 2012, 10.1126/scisignal.2002886
- Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation., , Stem cells (Dayton, Ohio), 2012, 10.1002/stem.1098
- Reelin depletion is an early phenomenon of Alzheimer's pathology., , Journal of Alzheimer's disease : JAD, 2012, 10.3233/jad-2012-112069
- Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain., , Acta neuropathologica, 2011, 10.1007/s00401-011-0914-z
- Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells., , Brain pathology (Zurich, Switzerland), 2011, 10.1111/j.1750-3639.2011.00517.x
- Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1, Sarah Lecordier, Romain Menet, Anne-Sophie Allain, Ayman ElAli, Journal of Cerebral Blood Flow & Metabolism, 2023, 10.1177/0271678X231183742
- Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy, Noëmie Jean LeBlanc, Romain Menet, Katherine Picard, Geneviève Parent, Marie-Ève Tremblay, Ayman ElAli, Molecular Neurobiology, 2019, 10.1007/s12035-019-1539-9
- Hyperlipidemia in Stroke Pathobiology and Therapy: Insights and Perspectives., , Frontiers in physiology, 2018, 10.3389/fphys.2018.00488
- High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice., , Oncotarget, 2016, 10.18632/oncotarget.12179
- Microglia in Alzheimer's disease: A multifaceted relationship., , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.07.021
- The dynamics of monocytes and microglia in Alzheimer's disease., , Alzheimer's research & therapy, 2015, 10.1186/s13195-015-0125-2
- The role of pericytes in neurovascular unit remodeling in brain disorders., , International journal of molecular sciences, 2014, 10.3390/ijms15046453
- Vascular endothelial growth factor promotes pericyte coverage of brain capillaries, improves cerebral blood flow during subsequent focal cerebral ischemia, and preserves the metabolic penumbra., , Stroke, 2013, 10.1161/strokeaha.111.000240
- Hyperlipidemia attenuates vascular endothelial growth factor-induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells., , Arteriosclerosis, thrombosis, and vascular biology, 2013, 10.1161/atvbaha.112.300749
- Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication., , Stroke, 2012, 10.1161/strokeaha.111.648923
- Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation., , Stroke, 2011, 10.1161/strokeaha.111.615559
- Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity., , Brain : a journal of neurology, 2011, 10.1093/brain/awq344
- Acute hepatocyte growth factor treatment induces long-term neuroprotection and stroke recovery via mechanisms involving neural precursor cell proliferation and differentiation., , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, 10.1038/jcbfm.2010.211
- Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain., , Science signaling, 2010, 10.1126/scisignal.2001213
- Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke, Ayman ElAli, Romain Menet, Maxime Bernard, Sarah Lecordier, Esther Trudel, Félix Distéfano-Gagné, Josée Seigneur, Anne-Sophie Allain, Daniel Manrique-Castano, Natija Aldib, Yacine Haili, Frederic Bretzner, David Gosselin, 2023, 10.21203/rs.3.rs-3189112/v1
- Endothelial caveolin at the crossroad of thrombo-inflammation coupling, Ayman ElAli, eBioMedicine, 2022, 10.1016/j.ebiom.2022.104329
- Wnt Pathway: An Emerging Player in Vascular and Traumatic Mediated Brain Injuries., , Frontiers in physiology, 2020, 10.3389/fphys.2020.565667
- Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer's disease., , Neuro-oncology, 2017, 10.1093/neuonc/nox058
- Vascular Endothelial Growth Factor Isoform-B Stimulates Neurovascular Repair After Ischemic Stroke by Promoting the Function of Pericytes via Vascular Endothelial Growth Factor Receptor-1., , Molecular neurobiology, 2017, 10.1007/s12035-017-0478-6
- Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions., , International journal of molecular sciences, 2017, 10.3390/ijms18030496
- Microglia Ontology and Signaling., , Frontiers in cell and developmental biology, 2016, 10.3389/fcell.2016.00072
- Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner., , Oncotarget, 2016, 10.18632/oncotarget.9652
- Tissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice., , Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, 10.1038/npp.2015.279
- Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation., , Acta neuropathologica communications, 2013, 10.1186/2051-5960-1-75
- A study on the effect of JNK inhibitor, SP600125, on the disruption of blood-brain barrier induced by methamphetamine., , Neurobiology of disease, 2012, 10.1016/j.nbd.2012.10.006
- Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions., , Neurobiology of disease, 2011, 10.1016/j.nbd.2011.12.026
- Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia., , Acta neuropathologica, 2011, 10.1007/s00401-011-0856-5
- ATP-binding cassette transporters and their roles in protecting the brain., , The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2011, 10.1177/1073858410391270
- Combination of tissue-plasminogen activator with erythropoietin induces blood-brain barrier permeability, extracellular matrix disaggregation, and DNA fragmentation after focal cerebral ischemia in mice., , Stroke, 2010, 10.1161/strokeaha.109.574418
- Role of Nogo-A in neuronal survival in the reperfused ischemic brain., , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, 10.1038/jcbfm.2009.268
- Differential motility of p190bcr-abl- and p210bcr-abl-expressing cells: respective roles of Vav and Bcr-Abl GEFs., , Oncogene, 2007, 10.1038/sj.onc.1210933
Contribution à l'enseignement aux cycles supérieurs
Étudiant(e)s dirigé(e)s*
Depuis 2009- Aliabbas Zia - Doctorat - En cours
- Maxime Bernard - Doctorat - En cours
- Margaux Rivière - Doctorat - En cours
- Angie Milena Bustos Rangel - Doctorat - En cours
- Lola Bertagnolio - Doctorat - En cours
- Romain Menet - Doctorat - En cours
- Natija Aldib - Doctorat - En cours
- Esther Trudel - Maîtrise avec mémoire - En cours
- Rayan Khaddaj Mallat - Post-doctorat - En cours
- Evaëlle Ferton - Doctorat - En cours
- Leila Nasrallah - Doctorat - En cours
- Revathy Guruswamy - Doctorat - En cours
- Yara El Moghrabi - Maîtrise avec mémoire - En cours
- Daniel Manrique Castano - Post-doctorat - En cours
- Noémie Jean-Leblanc - Maîtrise avec mémoire - 2018/09
- Sarah Claire Marie Lecordier - Doctorat - 2022/05
Encadrement d'étudiant(e)s pour les programmes suivants :
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Biologie cellulaire et moléculaire
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Médecine moléculaire
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Microbiologie-immunologie
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Neurobiologie — Neurosciences
Disponibilité d'encadrement d'étudiant(e)s
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