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Ayman El Ali

Professeur titulaire

Ayman El Ali
ayman.el-ali.1@ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Neurosciences et santé mentale

Domaines de recherche

  • Sciences vasculaires cérébrales (y compris l'accident vasculaire cérébral)
  • Neuro-inflammation
  • Neuroscience moléculaire
  • Neuroscience cellulaire
  • Biologie vasculaire et endothéliale
  • Neurodégénérescence

Projets de recherche en cours

  • Investigate the mechanisms regulating the fibrotic reaction mediated by perivascular cells in cerebrovascular disorders - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2023-04-01 au 2028-03-31
  • Elucidate the role of KLF4 in regulating mural cell contribution to tissue repair after stroke - Fondation des maladies du coeur et de l'AVC du Canada - Subventions de recherche, chercheur principal - 2023-07-01 au 2026-06-30
  • Canada Research Chair in molecular and cellular neurovascular interactions - Instituts de recherche en santé du Canada - Chaires de recherche du Canada - Fonctionnement, chercheur principal - 2020-07-01 au 2025-06-30

Financements des 2 dernières années

  • Mechanisms regulating contribution of pericytes to brain repair after stroke - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Role of canonical Wnt pathway in regulating the structural and functional integrity of the blood-brain barrier in the normal adult brain - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31

Publications

  • Reelin depletion is an early phenomenon of Alzheimer's pathology., , Journal of Alzheimer's disease : JAD, 2012, 10.3233/jad-2012-112069
  • Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke, David Gosselin, Frederic Bretzner, Yacine Haili, Natija Aldib, Daniel Manrique-Castano, Anne-Sophie Allain, Josée Seigneur, Félix Distéfano-Gagné, Esther Trudel, Sarah Lecordier, Maxime Bernard, Romain Menet, Ayman ElAli, 2023, 10.21203/rs.3.rs-3189112/v1
  • Innate immunity in the CNS: redefining the relationship between the CNS and Its environment., , Neuron, 2013, 10.1016/j.neuron.2013.04.005
  • Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity., , Brain : a journal of neurology, 2011, 10.1093/brain/awq344
  • Vascular Endothelial Growth Factor Isoform-B Stimulates Neurovascular Repair After Ischemic Stroke by Promoting the Function of Pericytes via Vascular Endothelial Growth Factor Receptor-1., , Molecular neurobiology, 2017, 10.1007/s12035-017-0478-6
  • Dissecting glial scar formation by spatial point pattern and topological data analysis, Ayman ElAli, Dhananjay Bhaskar, Daniel Manrique-Castano, 2023, 10.1101/2023.10.04.560910
  • Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy, Ayman ElAli, Marie-Ève Tremblay, Geneviève Parent, Katherine Picard, Romain Menet, Noëmie Jean LeBlanc, Molecular Neurobiology, 2019, 10.1007/s12035-019-1539-9
  • Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation., , Stem cells (Dayton, Ohio), 2012, 10.1002/stem.1098
  • The Role of Monocytes in Ischemic Stroke Pathobiology: New Avenues to Explore., , Frontiers in aging neuroscience, 2016, 10.3389/fnagi.2016.00029
  • Tissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice., , Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, 10.1038/npp.2015.279
  • Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain., , Science signaling, 2010, 10.1126/scisignal.2001213
  • Neurovascular Unit Dysfunction in Dementia: A Brief Summary., , Austin Alzheimer’s J Parkinsons Dis, 2014
  • The implication of neurovascular unit signaling in controlling the subtle balance between injury and repair following ischemic stroke., , Neural regeneration research, 2016, 10.4103/1673-5374.184485
  • Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice., , Oncotarget, 2016, 10.18632/oncotarget.7689
  • Non-classical monocytes promote neurovascular repair in cerebral small vessel disease associated with microinfarctions via CX3CR1, Ayman ElAli, Anne-Sophie Allain, Romain Menet, Sarah Lecordier, Journal of Cerebral Blood Flow & Metabolism, 2023, 10.1177/0271678X231183742
  • Sub-acute systemic erythropoietin administration reduces ischemic brain injury in an age-dependent manner., , Oncotarget, 2016, 10.18632/oncotarget.9652
  • Microglia Ontology and Signaling., , Frontiers in cell and developmental biology, 2016, 10.3389/fcell.2016.00072
  • Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation., , Acta neuropathologica communications, 2013, 10.1186/2051-5960-1-75
  • Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer's disease., , Neuro-oncology, 2017, 10.1093/neuonc/nox058
  • Role of Nogo-A in neuronal survival in the reperfused ischemic brain., , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, 10.1038/jcbfm.2009.268
  • Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions., , Neurobiology of disease, 2011, 10.1016/j.nbd.2011.12.026
  • The role of pericytes in neurovascular unit remodeling in brain disorders., , International journal of molecular sciences, 2014, 10.3390/ijms15046453
  • Hyperlipidemia attenuates vascular endothelial growth factor-induced angiogenesis, impairs cerebral blood flow, and disturbs stroke recovery via decreased pericyte coverage of brain endothelial cells., , Arteriosclerosis, thrombosis, and vascular biology, 2013, 10.1161/atvbaha.112.300749
  • Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia., , Acta neuropathologica, 2011, 10.1007/s00401-011-0856-5
  • Unbiased quantification of the spatial distribution of murine cells using point pattern analysis, Ayman ElAli, Daniel Manrique-Castano, STAR Protocols, 2024, 10.1016/j.xpro.2024.102989
  • Hyperlipidemia in Stroke Pathobiology and Therapy: Insights and Perspectives., , Frontiers in physiology, 2018, 10.3389/fphys.2018.00488
  • Wnt Pathway: An Emerging Player in Vascular and Traumatic Mediated Brain Injuries., , Frontiers in physiology, 2020, 10.3389/fphys.2020.565667
  • The dynamics of monocytes and microglia in Alzheimer's disease., , Alzheimer's research & therapy, 2015, 10.1186/s13195-015-0125-2
  • Role of Microglia in Modulating Adult Neurogenesis in Health and Neurodegeneration., , International journal of molecular sciences, 2020, 10.3390/ijms21186875
  • Dissecting glial scar formation by spatial point pattern and topological data analysis (Article figures), Dhananjay Bhaskar, Daniel Manrique-Castano, Ayman ElAli, 2023, 10.6084/m9.figshare.23681433
  • Vascular endothelial growth factor promotes pericyte coverage of brain capillaries, improves cerebral blood flow during subsequent focal cerebral ischemia, and preserves the metabolic penumbra., , Stroke, 2013, 10.1161/strokeaha.111.000240
  • VEGF‐E Attenuates Injury After Ischemic Stroke by Promoting Reparative Revascularization, Ayman ElAli, Anne‐Sophie Allain, Maxime Bernard, Leila Nasrallah, Romain Menet, European Journal of Neuroscience, 2025, 10.1111/ejn.70114
  • Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease, Ayman ElAli, Frédéric Calon, Philippe Bourassa, Romain Menet, Neurochemistry International, 2020, 10.1016/j.neuint.2020.104881
  • VEGF-E attenuates injury after ischemic stroke by promoting reparative neovascularization, Ayman ElAli, Leila Nasrallah, Maxime Bernard, Romain Menet, 2024, 10.22541/au.173268063.39579959/v1
  • Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain., , Acta neuropathologica, 2011, 10.1007/s00401-011-0914-z
  • PDGF-D is de novo expressed after stroke and contributes to neurovascular protection by rescuing the function of pericytes, Ayman ElAli, Sarah Lecordier, Romain Menet, Maxime Bernard, 2023, 10.21203/rs.3.rs-3059240/v1
  • ATP-binding cassette transporters and their roles in protecting the brain., , The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2011, 10.1177/1073858410391270
  • Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation., , Stroke, 2011, 10.1161/strokeaha.111.615559
  • Early monocyte modulation by the non-erythropoietic peptide ARA 290 decelerates AD-like pathology progression, Ayman ElAli, Serge Rivest, Paul Prefontaine, Sarah Lecordier, Peter Thériault, Mohammed A. Al-Onaizi, Brain, Behavior, and Immunity, 2022, 10.1016/j.bbi.2021.07.016
  • Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions., , International journal of molecular sciences, 2017, 10.3390/ijms18030496
  • Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells., , Brain pathology (Zurich, Switzerland), 2011, 10.1111/j.1750-3639.2011.00517.x
  • The abluminal endothelial membrane in neurovascular remodeling in health and disease., , Science signaling, 2012, 10.1126/scisignal.2002886
  • Acute hepatocyte growth factor treatment induces long-term neuroprotection and stroke recovery via mechanisms involving neural precursor cell proliferation and differentiation., , Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, 10.1038/jcbfm.2010.211
  • SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection, Ayman ElAli, Armen Saghatelyan, Maxime Bernard, Sarah Lecordier, Aymeric Ferreira, Anne-Sophie Paquette, Natija Aldib, Rayan Khaddaj-Mallat, 2021, 10.1101/2021.04.30.442194
  • Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication., , Stroke, 2012, 10.1161/strokeaha.111.648923
  • The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease., , Frontiers in physiology, 2013, 10.3389/fphys.2013.00045
  • Differential motility of p190bcr-abl- and p210bcr-abl-expressing cells: respective roles of Vav and Bcr-Abl GEFs., , Oncogene, 2007, 10.1038/sj.onc.1210933
  • A study on the effect of JNK inhibitor, SP600125, on the disruption of blood-brain barrier induced by methamphetamine., , Neurobiology of disease, 2012, 10.1016/j.nbd.2012.10.006
  • Combination of tissue-plasminogen activator with erythropoietin induces blood-brain barrier permeability, extracellular matrix disaggregation, and DNA fragmentation after focal cerebral ischemia in mice., , Stroke, 2010, 10.1161/strokeaha.109.574418
  • High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice., , Oncotarget, 2016, 10.18632/oncotarget.12179
  • Endothelial caveolin at the crossroad of thrombo-inflammation coupling, Ayman ElAli, eBioMedicine, 2022, 10.1016/j.ebiom.2022.104329
  • Microglia in Alzheimer's disease: A multifaceted relationship., , Brain, behavior, and immunity, 2015, 10.1016/j.bbi.2015.07.021
  • Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions, Ayman ElAli, Sarah Lecordier, Romain Menet, Maxime Bernard, Cellular and Molecular Life Sciences, 2024, 10.1007/s00018-024-05244-w
  • Erratum to: Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain., , Acta neuropathologica, 2015, 10.1007/s00401-015-1472-6

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/05
  • Margaux Rivière - Doctorat - En cours
  • Natija Aldib - Doctorat - En cours
  • Rayan Khaddaj Mallat - Post-doctorat - En cours
  • Esther Trudel - Maîtrise avec mémoire - En cours
  • Leila Nasrallah - Doctorat - En cours
  • Romain Menet - Post-doctorat - En cours
  • Daniel Manrique Castano - Post-doctorat - En cours
  • Evaëlle Ferton - Doctorat - En cours
  • Sarah Claire Marie Lecordier - Doctorat - 2022/05
  • Yara El Moghrabi - Maîtrise avec mémoire - 2023/09
  • Lola Bertagnolio - Maîtrise avec mémoire - 2025/01

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Biologie cellulaire et moléculaire
  • Médecine moléculaire
  • Microbiologie-immunologie
  • Neurobiologie — Neurosciences

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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