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Alexandre Bureau

Professeur titulaire

Alexandre Bureau
Alexandre.Bureau@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Bioinformatique / données massives (big data)
Neurosciences et santé mentale
Reproduction, génétique, périnatalité et développement
Santé des populations et pratiques optimales en santé

Domaines et intérêts de recherche du (de la) professeur(e) :

Génétique humaine
  • Cartographie génétique
  • Interactions gènes et environnement
  • Génétique de traits complexes
  • Micropuces d'ADN et d'ARN
  • Génomique
Neurosciences, santé mentale et toxicomanies
  • Génétique des maladies neurologiques et psychiatriques
  • Schizophrénie
  • Troubles affectifs (de l'humeur)
Santé des populations
  • Prévention en santé
Statistiques et probabilités
  • Inférence paramétrique et non paramétrique
  • Statistique informatique

Projets de recherche

  • Centre de recherches mathématiques (CRM) - Université Laval - Fonds internes, Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2022-04-01 au 2028-03-31
  • Altered retinal response as a neurobiological component of the risk trajectory and of the developmental pathophysiology of major psychiatric disorders - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2022-04-01 au 2027-03-31
  • Exploring the role of rare genetic variations in the risk for schizophrenia and bipolar disorder in patients from multi-affected kindreds in the Quebec founder population - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-04-01 au 2025-03-31
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Identifying nutrition and lifestyle mediators of genetic susceptibility to obesity: towards a precision lifestyle medicine approach to obesity prevention - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2024-09-30
  • Transforming major brain disorder prevention by integrating genetic and socio-economic predispositions - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2020-03-31 au 2023-06-30
  • Déterminer la qualité de la polypharmacie chez les aînés : une approche basée sur l’intelligence artificielle - Conseil de recherches en sciences naturelles et génie Canada, Instituts de recherche en santé du Canada - Subvention de fonctionnement : Projets de recherche concertée sur la santé (avec le CRSNG), co-chercheur - 2020-04-01 au 2023-03-31
  • Centre de recherches mathématiques (CRM) - Université Laval - Fonds internes, Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2015-04-01 au 2022-03-31
  • Integrating genome structure information and statistical analysis of co-segregation of rare genetic variants with disease in families - Conseil de recherches en sciences naturelles et génie Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2017-04-01 au 2022-03-31

Publications

  • Multivariate extension of penalized regression on summary statistics to construct polygenic risk scores for correlated traits, Meriem Bahda, Jasmin Ricard, Simon L. Girard, Michel Maziade, Maripier Isabelle, Alexandre Bureau, Human Genetics and Genomics Advances, 2023, 10.1016/j.xhgg.2023.100209
  • Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia, Loïc Mangnier, Charles Joly-Beauparlant, Arnaud Droit, Steve Bilodeau, Alexandre Bureau, Life Science Alliance, 2022, 10.26508/lsa.202101156
  • A multimodal attempt to follow-up linkage regions using RNA expression, SNPs and CpG methylation in schizophrenia and bipolar disorder kindreds, Yvon C. Chagnon, Michel Maziade, Thomas Paccalet, Jordie Croteau, Alain Fournier, Marc-André Roy, Alexandre Bureau, European Journal of Human Genetics, 2020, 10.1038/s41431-019-0526-y
  • Inferring disease risk genes from sequencing data in multiplex pedigrees through sharing of rare variants, Alexandre Bureau, Ferdouse Begum, Margaret A. Taub, Jacqueline B. Hetmanski, Margaret M. Parker, Hasan Albacha-Hejazi, Alan F. Scott, Jeffrey C. Murray, Mary L. Marazita, Joan E. Bailey-Wilson, Terri H. Beaty, Ingo Ruczinski, Genetic Epidemiology, 2019, 10.1002/gepi.22155
  • Polygenic risk scores distinguish patients from non-affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi-affected kindreds, Sébastien Boies, Chantal Mérette, Thomas Paccalet, Michel Maziade, Alexandre Bureau, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2018, 10.1002/ajmg.b.32614
  • Inferring Disease Risk Genes from Sequencing Data in Multiplex Pedigrees Through Sharing of Rare Variants, Alexandre Bureau, Ferdouse Begum, Margaret A. Taub, Jacqueline Hetmanski, Margaret M. Parker, Hasan Albacha-Hejazi, Alan F. Scott, Jeffrey C. Murray, Mary L. Marazita, Joan E. Bailey-Wilson, Terri H. Beaty, Ingo Ruczinski, 2018, 10.1101/285874
  • Estimating genetic effect sizes under joint disease-endophenotype models in presence of gene-environment interactions, Alexandre Bureau, Jordie Croteau, Christian Couture, Marie-Claude Vohl, Claude Bouchard, Louis Pérusse, Front. Genet., 2015, 10.3389/fgene.2015.00248
  • A genome-wide association study of suicidal behavior, Hanga Galfalvy, Fatemeh Haghighi, Colin Hodgkinson, David Goldman, Maria A. Oquendo, Ainsley Burke, Yung-yu Huang, Ina Giegling, Dan Rujescu, Alexandre Bureau, Gustavo Turecki, J. John Mann, Am. J. Med. Genet., 2015, 10.1002/ajmg.b.32330
  • A Genome-Wide Copy Number Variant Study of Suicidal Behavior, Jeffrey A. Gross, Alexandre Bureau, Jordie Croteau, Hanga Galfalvy, Maria A. Oquendo, Fatemeh Haghighi, Chantal Mérette, Ina Giegling, Colin Hodgkinson, David Goldman, Dan Rujescu, J. John Mann, Gustavo Turecki, PLoS ONE, 2015, 10.1371/journal.pone.0128369
  • Extension of the generalized disequilibrium test to polytomous phenotypes and two-locus models, Alexandre Bureau, Jordie Croteau, Yvon C. Chagnon, Marc-André Roy, Michel Maziade, Front. Genet., 2014, 10.3389/fgene.2014.00258
  • Inferring rare disease risk variants based on exact probabilities of sharing by multiple affected relatives., Bureau A, Younkin SG, Parker MM, Bailey-Wilson JE, Marazita ML, Murray JC, Mangold E, Albacha-Hejazi H, Beaty TH, Ruczinski I, 2014, 10.1093/bioinformatics/btu198
  • Plasma polychlorinated biphenyl and organochlorine pesticide concentrations in dementia: The Canadian Study of Health and Aging, Thierry Comlan Marc Medehouenou, Pierre Ayotte, Pierre-Hugues Carmichael, Edeltraut Kröger, René Verreault, Joan Lindsay, Éric Dewailly, Suzanne L. Tyas, Alexandre Bureau, Danielle Laurin, Environment International, 2014, 10.1016/j.envint.2014.04.016
  • Whole exome sequencing of distant relatives in multiplex families implicates rare variants in candidate genes for oral clefts., Bureau A, Parker MM, Ruczinski I, Taub MA, Marazita ML, Murray JC, Mangold E, Noethen MM, Ludwig KU, Hetmanski JB, Bailey-Wilson JE, Cropp CD, Li Q, Szymczak S, Albacha-Hejazi H, Alqosayer K, Field LL, Wu-Chou YH, Doheny KF, Ling H, Scott AF, Beaty TH, 2014, 10.1534/genetics.114.165225
  • Follow-up of a Major Psychosis Linkage Site in 13q13-q14 Reveals Significant Association in Both Case-Control and Family Samples, Alexandre Bureau, Yvon C. Chagnon, Jordie Croteau, Alain Fournier, Marc-André Roy, Thomas Paccalet, Chantal Mérette, Michel Maziade, Biological Psychiatry, 2013, 10.1016/j.biopsych.2013.03.004
  • An assessment of gene-by-environment interactions in developmental dyslexia-related phenotypes, S. Mascheretti, A. Bureau, M. Battaglia, D. Simone, E. Quadrelli, J. Croteau, M. R. Cellino, R. Giorda, S. Beri, M. Maziade, C. Marino, Genes, Brain and Behavior, 2012, 10.1111/gbb.12000
  • An Assessment of Gene-by-Environment Interactions in Developmental Dyslexia-Related Phenotypes, Sara Mascheretti, Alexandre Bureau, Marco Battaglia, Daniela Simone, Ermanno Quadrelli, Jordie Croteau, Maria Rosaria Cellino, Roberto Giorda, Silvana Beri, Michel Maziade, Cecilia Marino, Genes, Brain and Behavior, 2012, 10.1111/j.1601-183x.2012.12000.x
  • Genome-wide Epigenetic Regulation by Early-Life Trauma, Benoit Labonté, Matt Suderman, Gilles Maussion, Luis Navaro, Volodymyr Yerko, Ian Mahar, Alexandre Bureau, Naguib Mechawar, Moshe Szyf, Michael J. Meaney, Gustavo Turecki, Arch Gen Psychiatry, 2012, 10.1001/archgenpsychiatry.2011.2287
  • Symptom dimensions as alternative phenotypes to address genetic heterogeneity in schizophrenia and bipolar disorder, Aurélie Labbe, Alexandre Bureau, Isabel Moreau, Marc-André Roy, Yvon Chagnon, Michel Maziade, Chantal Merette, Eur J Hum Genet, 2012, 10.1038/ejhg.2012.67
  • UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women., Giroux S, Bussières J, Bureau A, Rousseau F, 2012, 10.1007/s00198-011-1662-6
  • Detection of Phenotype Modifier Genes Using Two-Locus Linkage Analysis in Complex Disorders Such as Major Psychosis, Alexandre Bureau, Jordie Croteau, Chantal Mérette, Alain Fournier, Yvon C. Chagnon, Marc-André Roy, Michel Maziade, Hum Hered, 2012, 10.1159/000341392
  • Polychlorinated biphenyls and organochlorine pesticides in plasma of older Canadians, Thierry Comlan Marc Medehouenou, Pierre Ayotte, Pierre-Hugues Carmichael, Edeltraut Kröger, René Verreault, Joan Lindsay, Éric Dewailly, Suzanne L. Tyas, Alexandre Bureau, Danielle Laurin, Environmental Research, 2011, 10.1016/j.envres.2011.09.017
  • Latent class model with familial dependence to address heterogeneity in complex diseases: adapting the approach to family-based association studies, Alexandre Bureau, Jordie Croteau, Arafat Tayeb, Chantal Mérette, Aurélie Labbe, Genet. Epidemiol., 2011, 10.1002/gepi.20566
  • Solving genetic heterogeneity in extended families by identifying sub-types of complex diseases, Arafat Tayeb, Aurélie Labbe, Alexandre Bureau, Chantal Mérette, Comput Stat, 2011, 10.1007/s00180-010-0224-2
  • Global gene expression profiling of the polyamine system in suicide completers, Laura M. Fiori, Alexandre Bureau, Aurélie Labbe, Jordie Croteau, Simon Noël, Chantal Mérette, Gustavo Turecki, Int. J. Neuropsychopharm., 2011, 10.1017/s1461145710001574
  • Application of microarray outlier detection methodology to psychiatric research-1, Carl Ernst, Alexandre Bureau, Gustavo Turecki, 2011, 10.6084/M9.FIGSHARE.41151
  • Association of Polyaminergic Loci With Anxiety, Mood Disorders, and Attempted Suicide, Laura M. Fiori, Brigitte Wanner, Valérie Jomphe, Jordie Croteau, Frank Vitaro, Richard E. Tremblay, Alexandre Bureau, Gustavo Turecki, PLoS ONE, 2010, 10.1371/journal.pone.0015146
  • High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density, Sylvie Giroux, Latifa Elfassihi, Valérie Clément, Johanne Bussières, Alexandre Bureau, David E.C. Cole, François Rousseau, Bone, 2010, 10.1016/j.bone.2010.06.030
  • Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study., Brezo J, Bureau A, Mérette C, Jomphe V, Barker ED, Vitaro F, Hébert M, Carbonneau R, Tremblay RE, Turecki G, 2010, 10.1038/mp.2009.19
  • Profiling brain expression of the spermidine/spermine N 1 -acetyltransferase 1 (SAT1) gene in suicide, Timothy A. Klempan, Dan Rujescu, Chantal Mérette, Carla Himmelman, Adolfo Sequeira, Lilian Canetti, Laura M. Fiori, Barbara Schneider, Alexandre Bureau, Gustavo Turecki, Am. J. Med. Genet., 2009, 10.1002/ajmg.b.30920
  • Association With Replication Between Estrogen-Related Receptor Gamma ( ESRRG ) Polymorphisms and Bone Phenotypes in Women of European Ancestry, Latifa Elfassihi, Sylvie Giroux, Alexandre Bureau, Nathalie Laflamme, David EC Cole, François Rousseau, Journal of Bone and Mineral Research, 2009, 10.1359/jbmr.091014
  • A New Strategy for Linkage Analysis under Epistasis Taking into Account Genetic Heterogeneity, Alexandre Bureau, Chantal Mérette, Jordie Croteau, Alain Fournier, Yvon C. Chagnon, Marc-André Roy, Michel Maziade, Hum Hered, 2009, 10.1159/000228921
  • Chromosome 13q13–q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype, Michel Maziade, Yvon C Chagnon, Marc-André Roy, Alexandre Bureau, Alain Fournier, Chantal Mérette, Eur J Hum Genet, 2009, 10.1038/ejhg.2008.268
  • Considerations for the development of a reference method for sequencing of haploid DNA – an opinion paper on behalf of the IFCC Committee on Molecular Diagnostics. International Federation of Clinical Chemistry and Laboratory Medicine, François Rousseau, David Gancberg, Heinz Schimmel, Michael Neumaier, Alexandre Bureau, Cyril Mamotte, Ron van Schaik, Deborah Payne, Mario Pazzagli, Ian Young, Clinical Chemistry and Laboratory Medicine, 2009, 10.1515/cclm.2009.319
  • Integration of Genetic Familial Dependence Structure in Latent Class Models, Aurelie Labbe, Alexandre Bureau, Chantal Merette, The International Journal of Biostatistics, 2009, 10.2202/1557-4679.1126
  • Using disease symptoms to improve detection of linkage under genetic heterogeneity., Bureau A, Labbe A, Croteau J, Mérette C, 2008, 10.1002/gepi.20320
  • Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes., Chagnon YC, Roy MA, Bureau A, Mérette C, Maziade M, 2008, 10.1016/j.schres.2007.12.471
  • Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide., McGirr A, Renaud J, Bureau A, Seguin M, Lesage A, Turecki G, 2008, 10.1017/S0033291707001419
  • Application of microarray outlier detection methodology to psychiatric research, Carl Ernst, Alexandre Bureau, Gustavo Turecki, BMC Psychiatry, 2008, 10.1186/1471-244x-8-29
  • Estimating Interaction Between Genetic and Environmental Risk Factors, Alexandre Bureau, Mamadou S. Diallo, Jose M. Ordovas, L Adrienne Cupples, Epidemiology, 2008, 10.1097/ede.0b013e31815c4d0e
  • Replication of linkage with bipolar disorder on chromosome 16p in the eastern Quebec population, Chantal Mérette, Marc-André Roy, Alexandre Bureau, Alain Fournier, Claudia Émond, Denis Cliche, Valérie Jomphe, Yvon C. Chagnon, Michel Maziade, Am. J. Med. Genet., 2007, 10.1002/ajmg.b.30673
  • Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification., Boycott KM, Flavelle S, Bureau A, Glass HC, Fujiwara TM, Wirrell E, Davey K, Chudley AE, Scott JN, McLeod DR, Parboosingh JS, 2005, 10.1086/444400
  • Evidence for a novel glaucoma locus at chromosome 3p21-22, Paul N. Baird, Simon J. Foote, David A. Mackey, Jamie Craig, Terence P. Speed, Alexandre Bureau, Hum Genet, 2005, 10.1007/s00439-005-1296-x
  • Identifying SNPs predictive of phenotype using random forests, Alexandre Bureau, Jos�e Dupuis, Kathleen Falls, Kathryn L. Lunetta, Brooke Hayward, Tim P. Keith, Paul Van Eerdewegh, Genet. Epidemiol., 2005, 10.1002/gepi.20041
  • Applications of continuous time hidden Markov models to the study of misclassified disease outcomes, Alexandre Bureau, Stephen Shiboski, James P. Hughes, Statist. Med., 2003, 10.1002/sim.1270
  • Mapping complex traits using Random Forests, Alexandre Bureau, Josée Dupuis, Brooke Hayward, Kathleen Falls, Paul Van Eerdewegh, BMC Genet, 2003, 10.1186/1471-2156-4-s1-s64
  • Pedigree selection and tests of linkage in a Hutterite asthma pedigree., Greenwood CM, Bureau A, Loredo-Osti JC, Roslin NM, Crumley MJ, Brewer CG, Fujiwara TM, Goldstein DR, Morgan K, 2001
  • An S-Plus Implementation of Hidden Markov Models in Continuous Time, Alexandre Bureau, James P. Hughes, Stephen C. Shiboski, Journal of Computational and Graphical Statistics, 2000, 10.1080/10618600.2000.10474903

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Abdoulaye Dioni - Doctorat - En cours
  • Samir Oubninte - Doctorat - En cours
  • Saeed Sabbah - Doctorat - En cours
  • Fousseni Sama - Maîtrise avec mémoire - En cours
  • Loïc Mangnier - Doctorat - En cours
  • N'Vyssan Samuella Bonou - Maîtrise avec mémoire - 2017/05
  • Rossana Peredo Nunez De Arco - Maîtrise avec mémoire - 2017/09
  • Sara Carazo Perez - Doctorat - 2018/05
  • Joseline Zafack Guetsop - Doctorat - 2019/09
  • Chaymae Yousfi - Maîtrise avec mémoire - 2020/09
  • Meriem Bahda - Maîtrise avec mémoire - 2022/01

Encadrement d'étudiant(e)s pour les programmes suivants :

*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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