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Alexandre Bureau

Professeur titulaire

Alexandre Bureau
Alexandre.Bureau@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche CERVO
Centre de recherche en données massives
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Contribution à la recherche

Thématiques de recherche de la Faculté de médecine

  • Bioinformatique / données massives (big data)
  • Neurosciences et santé mentale
  • Reproduction, génétique, périnatalité et développement
  • Santé des populations et pratiques optimales en santé

Domaines de recherche

  • Statistique génétique
    • analyse génétique familiale
  • Méthodes biostatistiques
  • Analyse de données haute dimension
  • Méthodes statistiques pour les données à haut débit
    • séquence génomique

Projets de recherche en cours

  • Improving detection and interpretation of noncoding variants in familial genetic studies - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2024-04-01 au 2029-03-31
  • Centre de recherches mathématiques (CRM) - Université Laval - Fonds internes, Fonds de recherche du Québec - Nature et technologies - Regroupements stratégiques NT, Université de Montréal, co-chercheur - 2022-04-01 au 2028-03-31
  • Altered retinal response as a neurobiological component of the risk trajectory and of the developmental pathophysiology of major psychiatric disorders - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2022-04-01 au 2027-03-31
  • Integration of genomic and genealogical data to decipher the genetics of asthma - Instituts de recherche en santé du Canada - Subvention Projet, Université du Québec à Chicoutimi - UQAC , co-chercheur - 2022-04-01 au 2027-03-31
  • Integrating rare risk variants into the early detection and prevention of schizophrenia and bipolar disorder and major recurrent depression - Génome Québec - Programme d’intégration de la génomique, chercheur principal - 2024-10-01 au 2026-09-30
  • Programme STAGE (CANSSI Ontario) - Génome Québec, chercheur principal - 2025-03-21 au 2026-03-31
  • Identification des patrons alimentaires liés à l’incidence du cancer de la prostate - Fonds de recherche du Québec - Santé - Projet subsidiaire - Nouveaux Centres et Instituts de recherche - Subventions régulières (pour fins de gestion au VRRCI), co-chercheur - 2024-05-30 au 2025-05-31

Financements des 2 dernières années

  • Exploring the role of rare genetic variations in the risk for schizophrenia and bipolar disorder in patients from multi-affected kindreds in the Quebec founder population - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-04-01 au 2025-03-31
  • Identifying nutrition and lifestyle mediators of genetic susceptibility to obesity: towards a precision lifestyle medicine approach to obesity prevention - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2021-10-01 au 2024-09-30
  • Investigating the role of non-coding variations in epilepsy - Instituts de recherche en santé du Canada, Université du Québec à Chicoutimi - UQAC , co-chercheur - 2019-04-01 au 2024-03-31
  • Transforming major brain disorder prevention by integrating genetic and socio-economic predispositions - Secrétariat des programmes interorganismes à l’intention des établissements - Nouvelles frontières en recherche, chercheur principal - 2020-03-31 au 2023-06-30
  • Déterminer la qualité de la polypharmacie chez les aînés : une approche basée sur l’intelligence artificielle - Conseil de recherches en sciences naturelles et génie Canada, Instituts de recherche en santé du Canada - Subvention de fonctionnement : Projets de recherche concertée sur la santé (avec le CRSNG), co-chercheur - 2020-04-01 au 2023-03-31

Publications

  • Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification., Parboosingh JS, McLeod DR, Scott JN, Chudley AE, Davey K, Wirrell E, Fujiwara TM, Glass HC, Bureau A, Flavelle S, Boycott KM, 2005, 10.1086/444400
  • Global gene expression profiling of the polyamine system in suicide completers, Gustavo Turecki, Chantal Mérette, Simon Noël, Jordie Croteau, Aurélie Labbe, Alexandre Bureau, Laura M. Fiori, Int. J. Neuropsychopharm., 2011, 10.1017/s1461145710001574
  • Using disease symptoms to improve detection of linkage under genetic heterogeneity., Mérette C, Croteau J, Labbe A, Bureau A, 2008, 10.1002/gepi.20320
  • Latent class model with familial dependence to address heterogeneity in complex diseases: adapting the approach to family-based association studies, Aurélie Labbe, Chantal Mérette, Arafat Tayeb, Jordie Croteau, Alexandre Bureau, Genet. Epidemiol., 2011, 10.1002/gepi.20566
  • Evidence for a novel glaucoma locus at chromosome 3p21-22, Alexandre Bureau, Terence P. Speed, Jamie Craig, David A. Mackey, Simon J. Foote, Paul N. Baird, Hum Genet, 2005, 10.1007/s00439-005-1296-x
  • An assessment of gene-by-environment interactions in developmental dyslexia-related phenotypes, C. Marino, M. Maziade, S. Beri, R. Giorda, M. R. Cellino, J. Croteau, E. Quadrelli, D. Simone, M. Battaglia, A. Bureau, S. Mascheretti, Genes, Brain and Behavior, 2012, 10.1111/gbb.12000
  • Applications of continuous time hidden Markov models to the study of misclassified disease outcomes, James P. Hughes, Stephen Shiboski, Alexandre Bureau, Statist. Med., 2003, 10.1002/sim.1270
  • Solving genetic heterogeneity in extended families by identifying sub-types of complex diseases, Chantal Mérette, Alexandre Bureau, Aurélie Labbe, Arafat Tayeb, Comput Stat, 2011, 10.1007/s00180-010-0224-2
  • UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women., Rousseau F, Bureau A, Bussières J, Giroux S, 2012, 10.1007/s00198-011-1662-6
  • A multimodal attempt to follow-up linkage regions using RNA expression, SNPs and CpG methylation in schizophrenia and bipolar disorder kindreds, Alexandre Bureau, Marc-André Roy, Alain Fournier, Jordie Croteau, Thomas Paccalet, Michel Maziade, Yvon C. Chagnon, European Journal of Human Genetics, 2020, 10.1038/s41431-019-0526-y
  • Estimating genetic effect sizes under joint disease-endophenotype models in presence of gene-environment interactions, Louis Pérusse, Claude Bouchard, Marie-Claude Vohl, Christian Couture, Jordie Croteau, Alexandre Bureau, Front. Genet., 2015, 10.3389/fgene.2015.00248
  • Application of microarray outlier detection methodology to psychiatric research-1, Gustavo Turecki, Alexandre Bureau, Carl Ernst, 2011, 10.6084/M9.FIGSHARE.41151
  • Considerations for the development of a reference method for sequencing of haploid DNA – an opinion paper on behalf of the IFCC Committee on Molecular Diagnostics. International Federation of Clinical Chemistry and Laboratory Medicine, Ian Young, Mario Pazzagli, Deborah Payne, Ron van Schaik, Cyril Mamotte, Alexandre Bureau, Michael Neumaier, Heinz Schimmel, David Gancberg, François Rousseau, Clinical Chemistry and Laboratory Medicine, 2009, 10.1515/cclm.2009.319
  • Inferring disease risk genes from sequencing data in multiplex pedigrees through sharing of rare variants, Ingo Ruczinski, Terri H. Beaty, Joan E. Bailey‐Wilson, Mary L. Marazita, Jeffrey C. Murray, Alan F. Scott, Hasan Albacha‐Hejazi, Margaret M. Parker, Jacqueline B. Hetmanski, Margaret A. Taub, Ferdouse Begum, Alexandre Bureau, Genetic Epidemiology, 2019, 10.1002/gepi.22155
  • Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia, Alexandre Bureau, Steve Bilodeau, Arnaud Droit, Charles Joly-Beauparlant, Loïc Mangnier, Life Science Alliance, 2022, 10.26508/lsa.202101156
  • Application of microarray outlier detection methodology to psychiatric research, Gustavo Turecki, Alexandre Bureau, Carl Ernst, BMC Psychiatry, 2008, 10.1186/1471-244x-8-29
  • Pedigree selection and tests of linkage in a Hutterite asthma pedigree., Morgan K, Goldstein DR, Fujiwara TM, Brewer CG, Crumley MJ, Roslin NM, Loredo-Osti JC, Bureau A, Greenwood CM, 2001
  • Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes., Maziade M, Mérette C, Bureau A, Roy MA, Chagnon YC, 2008, 10.1016/j.schres.2007.12.471
  • Multivariate extension of penalized regression on summary statistics to construct polygenic risk scores for correlated traits, Alexandre Bureau, Maripier Isabelle, Michel Maziade, Simon L. Girard, Jasmin Ricard, Meriem Bahda, Human Genetics and Genomics Advances, 2023, 10.1016/j.xhgg.2023.100209
  • Estimating Interaction Between Genetic and Environmental Risk Factors, L Adrienne Cupples, Jose M. Ordovas, Mamadou S. Diallo, Alexandre Bureau, Epidemiology, 2008, 10.1097/ede.0b013e31815c4d0e
  • Mapping complex traits using Random Forests, Paul Van Eerdewegh, Kathleen Falls, Brooke Hayward, Josée Dupuis, Alexandre Bureau, BMC Genet, 2003, 10.1186/1471-2156-4-s1-s64
  • Chromosome 13q13–q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype, Chantal Mérette, Alain Fournier, Alexandre Bureau, Marc-André Roy, Yvon C Chagnon, Michel Maziade, Eur J Hum Genet, 2009, 10.1038/ejhg.2008.268
  • Genome-wide Epigenetic Regulation by Early-Life Trauma, Gustavo Turecki, Michael J. Meaney, Moshe Szyf, Naguib Mechawar, Alexandre Bureau, Ian Mahar, Volodymyr Yerko, Luis Navaro, Gilles Maussion, Matt Suderman, Benoit Labonté, Arch Gen Psychiatry, 2012, 10.1001/archgenpsychiatry.2011.2287
  • Polygenic risk scores distinguish patients from non‐affected adult relatives and from normal controls in schizophrenia and bipolar disorder multi‐affected kindreds, Alexandre Bureau, Michel Maziade, Thomas Paccalet, Chantal Mérette, Sébastien Boies, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2018, 10.1002/ajmg.b.32614
  • Polychlorinated biphenyls and organochlorine pesticides in plasma of older Canadians, Danielle Laurin, Alexandre Bureau, Suzanne L. Tyas, Éric Dewailly, Joan Lindsay, René Verreault, Edeltraut Kröger, Pierre-Hugues Carmichael, Pierre Ayotte, Thierry Comlan Marc Medehouenou, Environmental Research, 2011, 10.1016/j.envres.2011.09.017
  • RetroFun‐RVS: A Retrospective Family‐Based Framework for Rare Variant Analysis Incorporating Functional Annotations, Alexandre Bureau, Michel Maziade, Simon Girard, Claudia Moreau, Jasmin Ricard, Ingo Ruczinski, Loïc Mangnier, Genetic Epidemiology, 2025, 10.1002/gepi.70001
  • Association of Polyaminergic Loci With Anxiety, Mood Disorders, and Attempted Suicide, Gustavo Turecki, Alexandre Bureau, Richard E. Tremblay, Jordie Croteau, Frank Vitaro, Valérie Jomphe, Brigitte Wanner, Laura M. Fiori, PLoS ONE, 2010, 10.1371/journal.pone.0015146
  • Inferring rare disease risk variants based on exact probabilities of sharing by multiple affected relatives., Ruczinski I, Beaty TH, Albacha-Hejazi H, Murray JC, Mangold E, Marazita ML, Bailey-Wilson JE, Parker MM, Younkin SG, Bureau A, 2014, 10.1093/bioinformatics/btu198
  • Detection of Phenotype Modifier Genes Using Two-Locus Linkage Analysis in Complex Disorders Such as Major Psychosis, Michel Maziade, Marc-André Roy, Yvon C. Chagnon, Alain Fournier, Chantal Mérette, Jordie Croteau, Alexandre Bureau, Hum Hered, 2012, 10.1159/000341392
  • Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide., Turecki G, Lesage A, Seguin M, Bureau A, Renaud J, McGirr A, 2008, 10.1017/S0033291707001419
  • An S-Plus Implementation of Hidden Markov Models in Continuous Time, Stephen C. Shiboski, James P. Hughes, Alexandre Bureau, Journal of Computational and Graphical Statistics, 2000, 10.1080/10618600.2000.10474903
  • High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density, François Rousseau, David E.C. Cole, Alexandre Bureau, Johanne Bussières, Valérie Clément, Latifa Elfassihi, Sylvie Giroux, Bone, 2010, 10.1016/j.bone.2010.06.030
  • Statistics to prioritize rare variants in family‐based sequencing studies with disease subtypes, Jinko Graham, Alexandre Bureau, Angela Brooks‐Wilson, Fabiha Binte Farooq, Christina Nieuwoudt, Genetic Epidemiology, 2024, 10.1002/gepi.22579
  • A genome-wide association study of suicidal behavior, J. John Mann, Gustavo Turecki, Alexandre Bureau, Dan Rujescu, Ina Giegling, Yung-yu Huang, Ainsley Burke, Maria A. Oquendo, David Goldman, Colin Hodgkinson, Fatemeh Haghighi, Hanga Galfalvy, Am. J. Med. Genet., 2015, 10.1002/ajmg.b.32330
  • Identifying SNPs predictive of phenotype using random forests, Paul Van Eerdewegh, Tim P. Keith, Brooke Hayward, Kathryn L. Lunetta, Kathleen Falls, Jos�e Dupuis, Alexandre Bureau, Genet. Epidemiol., 2005, 10.1002/gepi.20041
  • Heterogeneity in the longitudinal courses of global functioning in children at familial risk of major psychiatric disorders: Association with trauma and familial characteristics, Michel Maziade, Marie‐Claude Boisvert, Énora Fortin‐Fabbro, Abdoulaye Dioni, Valérie Jomphe, Camille Lafrance, Jasmin Ricard, Nicolas Berthelot, Alexandre Bureau, Bipolar Disorders, 2024, 10.1111/bdi.13386
  • Replication of linkage with bipolar disorder on chromosome 16p in the eastern Quebec population, Michel Maziade, Yvon C. Chagnon, Valérie Jomphe, Denis Cliche, Claudia Émond, Alain Fournier, Alexandre Bureau, Marc-André Roy, Chantal Mérette, Am. J. Med. Genet., 2007, 10.1002/ajmg.b.30673
  • Association With Replication Between Estrogen-Related Receptor Gamma ( ESRRG ) Polymorphisms and Bone Phenotypes in Women of European Ancestry, François Rousseau, David EC Cole, Nathalie Laflamme, Alexandre Bureau, Sylvie Giroux, Latifa Elfassihi, Journal of Bone and Mineral Research, 2009, 10.1359/jbmr.091014
  • Inferring Disease Risk Genes from Sequencing Data in Multiplex Pedigrees Through Sharing of Rare Variants, Ingo Ruczinski, Terri H. Beaty, Joan E. Bailey-Wilson, Mary L. Marazita, Jeffrey C. Murray, Alan F. Scott, Hasan Albacha-Hejazi, Margaret M. Parker, Jacqueline Hetmanski, Margaret A. Taub, Ferdouse Begum, Alexandre Bureau, 2018, 10.1101/285874
  • Integration of Genetic Familial Dependence Structure in Latent Class Models, Chantal Merette, Alexandre Bureau, Aurelie Labbe, The International Journal of Biostatistics, 2009, 10.2202/1557-4679.1126
  • Symptom dimensions as alternative phenotypes to address genetic heterogeneity in schizophrenia and bipolar disorder, Chantal Merette, Michel Maziade, Yvon Chagnon, Marc-André Roy, Isabel Moreau, Alexandre Bureau, Aurélie Labbe, Eur J Hum Genet, 2012, 10.1038/ejhg.2012.67
  • Whole exome sequencing of distant relatives in multiplex families implicates rare variants in candidate genes for oral clefts., Beaty TH, Scott AF, Ling H, Doheny KF, Wu-Chou YH, Field LL, Alqosayer K, Albacha-Hejazi H, Szymczak S, Li Q, Cropp CD, Bailey-Wilson JE, Hetmanski JB, Ludwig KU, Noethen MM, Mangold E, Murray JC, Marazita ML, Taub MA, Ruczinski I, Parker MM, Bureau A, 2014, 10.1534/genetics.114.165225
  • Extension of the generalized disequilibrium test to polytomous phenotypes and two-locus models, Michel Maziade, Marc-André Roy, Yvon C. Chagnon, Jordie Croteau, Alexandre Bureau, Front. Genet., 2014, 10.3389/fgene.2014.00258
  • Profiling brain expression of the spermidine/spermine N 1 -acetyltransferase 1 (SAT1) gene in suicide, Gustavo Turecki, Alexandre Bureau, Barbara Schneider, Lilian Canetti, Laura M. Fiori, Adolfo Sequeira, Carla Himmelman, Dan Rujescu, Chantal Mérette, Timothy A. Klempan, Am. J. Med. Genet., 2009, 10.1002/ajmg.b.30920
  • A Genome-Wide Copy Number Variant Study of Suicidal Behavior, Gustavo Turecki, J. John Mann, Dan Rujescu, David Goldman, Colin Hodgkinson, Ina Giegling, Chantal Mérette, Fatemeh Haghighi, Maria A. Oquendo, Hanga Galfalvy, Jordie Croteau, Alexandre Bureau, Jeffrey A. Gross, PLoS ONE, 2015, 10.1371/journal.pone.0128369
  • Follow-up of a Major Psychosis Linkage Site in 13q13-q14 Reveals Significant Association in Both Case-Control and Family Samples, Michel Maziade, Chantal Mérette, Thomas Paccalet, Marc-André Roy, Alain Fournier, Jordie Croteau, Yvon C. Chagnon, Alexandre Bureau, Biological Psychiatry, 2013, 10.1016/j.biopsych.2013.03.004
  • An Assessment of Gene-by-Environment Interactions in Developmental Dyslexia-Related Phenotypes, Cecilia Marino, Michel Maziade, Silvana Beri, Roberto Giorda, Jordie Croteau, Maria Rosaria Cellino, Ermanno Quadrelli, Marco Battaglia, Daniela Simone, Alexandre Bureau, Sara Mascheretti, Genes, Brain and Behavior, 2012, 10.1111/j.1601-183x.2012.12000.x
  • Plasma polychlorinated biphenyl and organochlorine pesticide concentrations in dementia: The Canadian Study of Health and Aging, Danielle Laurin, Alexandre Bureau, Suzanne L. Tyas, Éric Dewailly, Joan Lindsay, René Verreault, Edeltraut Kröger, Pierre-Hugues Carmichael, Pierre Ayotte, Thierry Comlan Marc Medehouenou, Environment International, 2014, 10.1016/j.envint.2014.04.016
  • Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study., Turecki G, Tremblay RE, Carbonneau R, Hébert M, Vitaro F, Barker ED, Jomphe V, Mérette C, Bureau A, Brezo J, 2010, 10.1038/mp.2009.19
  • A New Strategy for Linkage Analysis under Epistasis Taking into Account Genetic Heterogeneity, Michel Maziade, Marc-André Roy, Yvon C. Chagnon, Alain Fournier, Jordie Croteau, Chantal Mérette, Alexandre Bureau, Hum Hered, 2009, 10.1159/000228921

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2020/05
  • Saa Moussa Tenguiano - Maîtrise avec mémoire - En cours
  • Samir Oubninte - Doctorat - En cours
  • Abdoulaye Dioni - Doctorat - En cours
  • Ariane Tako Ange - Doctorat - En cours
  • Alexis Jobin - Maîtrise avec mémoire - En cours
  • Chaymae Yousfi - Maîtrise avec mémoire - 2020/09
  • Meriem Bahda - Maîtrise avec mémoire - 2022/01
  • Loïc Mangnier - Doctorat - 2022/09
  • Candide Ahouehome - Maîtrise avec mémoire - 2024/05
  • Fousseni Sama - Maîtrise avec mémoire - 2024/09

Encadrement d'étudiant(e)s

Direction de recherche dans les domaines suivants :

  • Épidémiologie
  • Biostatistique

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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