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Abid Oueslati

Professeur agrégé

Abid Oueslati
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Chorée de Huntington
  • Maladie d'Alzheimer
  • Maladie de Parkinson
  • Maladies neurodégénératives

Projets de recherche

  • Deciphering the physiological role of alpha-synuclein aggregation in the central nervous system - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2023-04-01 au 2028-03-31
  • Exploring the synergistic role of alpha-synuclein and tau in Alzheimer’s disease pathogenesis - Société Alzheimer du Canada - Proof of Concept Grants, chercheur principal - 2023-10-01 au 2026-09-30
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Investigation of the synergistic role of TMEM106B and alpha-synuclein in Parkinson’s disease pathogenesis - Parkinson Canada - Pilot Project Grant, chercheur principal - 2023-08-01 au 2024-07-31
  • Implication de l’alpha-synucléine dans la pathogenèse et les traitements de la maladie de Parkinson - Fonds de recherche du Québec - Santé - Chercheur-boursier Juniors 1 et 2, Seniors, chercheur principal - 2020-07-01 au 2024-06-30
  • Salaire d'un professeur - CHU de Québec – Université Laval – CHUL, chercheur principal - 2015-07-01 au 2024-06-30
  • Unveiling the role of alpha-synuclein clustering and Lewy body formation in Parkinson’s disease pathogenesis using an optogenetic-mediated protein aggregation system - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
  • Effects of post-translational modifications on intracellular alpha-synuclein oligomerization - Michael J. Fox Foundation for Parkinson's Research, Purdue University, co-chercheur - 2023-02-01 au 2024-01-31
  • Use of optogenetic-TDP43 to shed light on the dying-back hypothesis in ALS - Université Laval - Fonds internes - BDR - Contributions, co-chercheur - 2022-04-01 au 2023-03-31
  • Investigation of the synergistic role of PLK2 and alpha-synuclein in the regulation of neuronal homeostasis and functions. - Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2016-04-01 au 2022-03-31

Publications

  • Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson’s disease, Abid Oueslati, Walid Idi, Razan Sheta, Maxime Teixeira, STAR Protocols, 2023, 10.1016/j.xpro.2023.102738
  • Chronic high-frequency stimulation of the subthalamic nucleus and L-DOPA treatment in experimental parkinsonism: effects on motor behaviour and striatal glutamate transmission., , The European journal of neuroscience, 2006, 10.1111/j.1460-9568.2006.05047.x
  • High-frequency stimulation of the subthalamic nucleus potentiates L-DOPA-induced neurochemical changes in the striatum in a rat model of Parkinson's disease., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 10.1523/JNEUROSCI.2949-06.2007
  • Dysfunction of the cortico-basal ganglia-cortical loop in a rat model of early parkinsonism is reversed by metabotropic glutamate receptor 5 antagonism., , The European journal of neuroscience, 2005, 10.1111/j.1460-9568.2005.04498.x
  • Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade?, , Journal of Parkinson's disease, 2016, 10.3233/JPD-160779
  • Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 10.1523/JNEUROSCI.5922-09.2010
  • Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease., , The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, 10.1523/JNEUROSCI.3784-11.2012
  • Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains, Abid Oueslati, Omar M. A. El-Agnaf, Razan Sheta, Laura Martínez-Drudis, Morgan Bérard, Molecular Neurodegeneration, 2023, 10.1186/s13024-023-00683-8
  • Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation., , Experimental neurobiology, 2014, 10.5607/en.2014.23.4.324
  • Dissecting the Molecular Pathway Involved in PLK2 Kinase-mediated α-Synuclein-selective Autophagic Degradation., , The Journal of biological chemistry, 2017, 10.1074/jbc.M116.759373
  • Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease., , PloS one, 2015, 10.1371/journal.pone.0140880
  • Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo., , Proceedings of the National Academy of Sciences of the United States of America, 2013, 10.1073/pnas.1309991110
  • Different functional basal ganglia subcircuits associated with anti-akinetic and dyskinesiogenic effects of antiparkinsonian therapies., , Neurobiology of disease, 2009, 10.1016/j.nbd.2009.07.002
  • Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies., , Progress in brain research, 2010, 10.1016/s0079-6123(10)83007-9
  • Optogenetic-Mediated Spatiotemporal Control of α-Synuclein Aggregation Disrupts Nigrostriatal Transmission and Precipitates Neurodegeneration, , SSRN Electronic Journal, 2019, 10.2139/ssrn.3416893
  • Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo., , The Journal of biological chemistry, 2015, 10.1074/jbc.M114.610774
  • c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease., , Human molecular genetics, 2014, 10.1093/hmg/ddt674
  • Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons, Abid Oueslati, Walid Idi, Maxime Teixeira, Razan Sheta, STAR Protocols, 2023, 10.1016/j.xpro.2023.102486
  • The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity., , The Journal of biological chemistry, 2014, 10.1074/jbc.M114.553297
  • The many faces of α-synuclein: from structure and toxicity to therapeutic target., , Nature reviews. Neuroscience, 2013, 10.1038/nrn3406
  • Phosphorylation of synucleins by members of the Polo-like kinase family., , The Journal of biological chemistry, 2009, 10.1074/jbc.M109.081950
  • Human-to-mouse prion-like propagation of mutant huntingtin protein., , Acta neuropathologica, 2016, 10.1007/s00401-016-1582-9
  • Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease., , Proceedings of the National Academy of Sciences of the United States of America, 2016, 10.1073/pnas.1512876113

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Walid Idi - Doctorat - En cours
  • Raquel Rodríguez Aller - Doctorat - En cours
  • Laura Martínez Drudis - Doctorat - En cours
  • Dylan Musiol - Doctorat - En cours
  • Shanna Pigeyre - Maîtrise avec mémoire - En cours
  • Azzaddin Elasry - Doctorat - En cours
  • Maxime Teixeira - Doctorat - En cours
  • Morgan Bérard - Maîtrise avec mémoire - 2020/01
  • Rémi Pellegrinato - Maîtrise avec mémoire - 2022/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.