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Conférence scientifique de M. Muhammad Saleh, Ph.D. - Universal MRS sequences for single- and multi-metabolite editing

Recherche, Département de réadaptation

Pour cette conférence, le Centre de recherche CERVO et le CINQ ont le plaisir d'accueillir M. Muhammad Saleh. M. Saleh est stagiaire post-doctoral au département de radiologie et de sciences radiologiques de John Hopkins University.

mercredi 15 janvier 2020

Centre de recherche CERVO, local F-1455 2601, chemin de la Canardière, Québec
11 h 00 - 12 h 00

Magnetic Resonance Spectroscopy (MRS) is a non-invasive methodology that allows the quantification of endogenous metabolites in the human body, including the inhibitory neurotransmitter GABA and redox compound glutathione (GSH) in the brain. However, due to their low concentration, measurement of GABA and GSH using conventional single-voxel MRS is difficult, and at 3T, spectral editing (MEGA-PRESS) is typically used. In this seminar, I will describe how GABA and GSH can be measured in the brain using spectral editing, including some of the limitations of the methodology. Most previously used edited MRS techniques focus on a single-voxel and are tailored for a specific metabolite (e.g., GABA, or GSH). I will then introduce a new method developed in our lab, HERMES, which allows multi-metabolite editing in one single MR examination.  Finally, I will discuss recent work we have been doing, developing universal sequences across vendors, and present some of our new results.