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Steve Lacroix

Professeur titulaire

Steve Lacroix
Steve.Lacroix@fmed.ulaval.ca
Centre thématique de recherche en neurosciences
Centre de recherche du CHU de Québec - Université Laval
Centre de recherche en arthrite (ARThrite)
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Contribution à la recherche

Axe de recherche de l'Université Laval :

Santé et bien-être durables

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie
Médecine régénératrice et médecine moléculaire
Neurosciences et santé mentale

Domaines et intérêts de recherche du (de la) professeur(e) :

Neurosciences, santé mentale et toxicomanies
  • Hémiplégie et paraplégie
  • Maladies inflammatoires du système nerveux central
  • Maladies neuroimmunologiques
  • Traumatismes crânio-encéphaliques et de la moelle épinière
  • Sclérose en plaques
  • Neurotoxicité
  • Douleur
  • Neurogénèse et gliogénèse

Projets de recherche

  • Role of inflammation in recovery after spinal cord injury - Instituts de recherche en santé du Canada - Subvention Projet, University of Alberta, co-chercheur - 2021-04-01 au 2026-03-01
  • Fonds institutionnel d'exploitation des infrastructures pour l'Université Laval - Fondation Canadienne pour l'innovation (La) - Fonds d'exploitation des infrastructures (FEI), co-chercheur - 2002-04-01 au 2025-03-31
  • Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis - Instituts de recherche en santé du Canada - Subvention Projet, co-chercheur - 2020-04-01 au 2025-03-31
  • Elucidating the role of the IL-1 system in the pathogenesis of CNS autoimmunity - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2020-04-01 au 2025-03-31
  • Thérapie génique ciblée dans un modèle de sclérose en plaques - Fonds de recherche du Québec - Santé, co-chercheur - 2021-05-01 au 2024-04-30
  • The identification of the molecular mechanisms through which neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases - Fondation du CHU de Québec, chercheur principal - 2023-04-17 au 2024-03-31
  • Manipulating the neuroimmune response to promote spinal cord repair - Instituts de recherche en santé du Canada - Subvention Projet, chercheur principal - 2019-04-01 au 2024-03-31
  • Interleukin-1 alpha mediates secondary degeneration and neuropathic pain after spinal cord injury - Wings for Life Spinal Cord Research Foundation - Research Grant, chercheur principal - 2020-04-01 au 2023-03-31
  • Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis - La société d'arthrite, co-chercheur - 2020-01-01 au 2022-12-31
  • Turnbull-Tator Award in Spinal Cord Injury and Concussion Research - Brain Canada Foundation, chercheur principal - 2021-07-01 au 2022-06-30

Publications

  • GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease, , Brain, Behavior, and Immunity, 2015, 10.1016/j.bbi.2015.01.010
  • Endogenous signals initiating inflammation in the injured nervous system, Lacroix, S., Pineau, I., 2009, 10.1002/glia.20763
  • In situ hybridization within the CNS tissue: Combining in situ hybridization with immunofluorescence, Lacroix, S., Bastien, D., Neuromethods, 2012, 10.1007/978-1-61779-897-9_3
  • Megakaryocytes compensate for Kit insufficiency in murine arthritis, Peter A. Nigrovic, Eric Boilard, Joseph E. Italiano, Michael F. Gurish, Jerry Ware, Yoichiro Iwakura, Steve Lacroix, Imene Melki, Mary M. Chen, Margaret H. Chang, Tatiana Jones, Paul A. Monach, Jonathan N. Thon, Loka R. Penke, Pierre Cunin, Journal of Clinical Investigation, 2017, 10.1172/JCI84598
  • Ly6C high monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice, Gosselin, J., Brown, J.P., Lacroix, S., Paré, A., Lacerte, P., Brunet, A., Egarnes, B., LeBel, M., European Journal of Immunology, 2018, 10.1002/eji.201747048
  • In Vivo Imaging of Glial and Immune Cell Responses in Central Nervous System Injury and Disease, Lacroix, S., Paré, A., Neuroinflammation: New Insights into Beneficial and Detrimental Functions, 2015, 10.1002/9781118732748.ch2
  • Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α and interleukin-1β Wallerian degeneration, David, S., Avilés-Trieueros, M., Lacroix, S., Perrin, F.E., 2005, 10.1093/brain/awh407
  • Mutant huntingtin is present in neuronal grafts in huntington disease patients, Freeman, T.B., Barker, R.A., Mantovani, D., Hauser, R.A., Skepper, J.N., Tolouei, R., St-Amour, I., Saint-Pierre, M., Vallières, N., Cisbani, G., Lacroix, S., Cicchetti, F., Annals of Neurology, 2014, 10.1002/ana.24174
  • Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury, Lacroix, S., Rivest, S., Vallières, N., Filali, M., Barrette, B., Pineau, I., Boivin, A., 2007, 10.1523/JNEUROSCI.3027-07.2007
  • IL-1β enables CNS access to CCR2 hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells, Steve Lacroix, Alyson Fournier, Manu Rangachari, Alexandre Prat, Marc-André Lécuyer, Prenitha Mercy Ignatius Arokia Doss, Camille Juzwik, Sébastien A. Lévesque, Benoit Mailhot, Alexandre Paré, Proceedings of the National Academy of Sciences, 2018, 10.1073/pnas.1714948115
  • T cells contribute to lysophosphatidylcholine-induced macrophage activation and demyelination in the CNS, David, S., Lacroix, S., Suh, Y.J., Ghasemlou, N., 2007, 10.1002/glia.20449
  • Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth, Tuszynski, M.H., Rose-John, S., Chang, L., Lacroix, S., 2002, 10.1002/cne.10407
  • Molecular approaches to spinal cord repair, Lacroix, S., David, S., 2003, 10.1146/annurev.neuro.26.043002.094946
  • Myeloid cell transmigration across the CNS vasculature triggers IL-1ß-driven neuroinflammation during autoimmune encephalomyelitis in mice, Lacroix, S., Keane, R.W., de Rivero Vaccari, J.P., Prat, A., Alvarez, J.I., Lécuyer, M.-A., Kébir, H., Bellver-Landete, V., Mailhot, B., Paré, A., Lévesque, S.A., Journal of Experimental Medicine, 2016, 10.1084/jem.20151437
  • Partial depletion of the proinflammatory monocyte population is neuroprotective in the myenteric plexus but not in the basal ganglia in a MPTP mouse model of Parkinson's disease, Soulet, D., Lacroix, S., Jobin, C., Aubé, B., Poirier, A.-A., Côté, M., Brain, Behavior, and Immunity, 2015, 10.1016/j.bbi.2015.01.009
  • IL-1α gene deletion protects oligodendrocytes after spinal cord injury through upregulation of the survival factor Tox3, Lacroix, S., Doyon, Y., Tremblay, M.-È., Takashima, A., Champagne, M., Vallières, N., Lessard, M., Landete, V.B., Bastien, D., Journal of Neuroscience, 2015, 10.1523/JNEUROSCI.0498-15.2015
  • The P2X7/P2X4 interaction shapes the purinergic response in murine macrophages, Jorge Arreola, Patricia Pérez-Cornejo, Steve Lacroix, Luis Vaca, Jonathan Pacheco, Sébastien A. Lévesque, Gabriela Pérez-Flores, Biochemical and Biophysical Research Communications, 2015, 10.1016/j.bbrc.2015.10.025
  • Bilateral Corticospinal Projections Arise from Each Motor Cortex in the Macaque Monkey: A Quantitative Study, Tuszynski, M.H., Roberts, J., Brant, A., Yang, H., McKay, H., Havton, L.A., Lacroix, S., 2004, 10.1002/cne.20051
  • Proinflammatory signal transduction pathways in the CNS during systemic immune response, Laflamme, N., Lacroix, S., Nadeau, S., Rivest, S., 2001, 10.1016/S1567-7443(01)80015-6
  • The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations, Rivest, S., Feinstein, D., Lacroix, S., 1998
  • Expression profile of receptors for myelin-associated inhibitors of axonal regeneration in the intact and injured mouse central nervous system, Lacroix, S., Dubé, M., Vallières, N., Barrette, B., 2007, 10.1016/j.mcn.2006.12.004
  • Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain, Rivest, S., Lacroix, S., 1998
  • P2X 4 receptors influence inflammasome activation after spinal cord injury, Lacroix, S., Keane, R.W., De Koninck, Y., Dalton Dietrich, W., Pineau, I., Yurcisin, G., Bastien, D., de Rivero Vaccari, J.P., 2012, 10.1523/JNEUROSCI.4930-11.2012
  • Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: Implications for neuropathic pain, Lacroix, S., Keane, R.W., Vaccari, J.P.R., Iwakura, Y., Soulet, D., Rivest, S., Kerr, B.J., Zhang, J., Filali, M., Nadeau, S., 2011, 10.1523/JNEUROSCI.2840-11.2011
  • Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: Identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration, Lacroix, S., Vallières, N., Calvo, E., Barrette, B., 2010, 10.1016/j.bbi.2010.07.249
  • Requirement of myeloid cells for axon regeneration, Lacroix, S., Julien, J.-P., Gowing, G., Vallières, N., Lafortune, K., Filali, M., Hébert, M.-A., Barrette, B., 2008, 10.1523/JNEUROSCI.1447-08.2008
  • Involvement of the IL-1 system in experimental autoimmune encephalomyelitis and multiple sclerosis: Breaking the vicious cycle between IL-1β and GM-CSF, Steve Lacroix, Sébastien A. Lévesque, Benoit Mailhot, Alexandre Paré, Brain, Behavior, and Immunity, 2016, 10.1016/j.bbi.2016.07.146
  • C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type, Rivest, S., Vallières, L., Lacroix, S., 1996, 10.1016/S0165-5728(96)00114-2
  • Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases, Lacroix, S., Côté, D., Prat, A., Engelhardt, B., De Koninck, Y., Alvarez, J.I., Lécuyer, M.-A., Gorina, R., Kébir, H., Chamma, É., Paré, A., Lévesque, S.A., Aubé, B., Journal of Immunology, 2014, 10.4049/jimmunol.1400401
  • Platelets can enhance vascular permeability, Boilard, E., Lacroix, S., Nigrovic, P.A., Schumacher, H.R., Farndale, R.W., Paré, A., Cloutier, N., 2012, 10.1182/blood-2012-02-413047
  • The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis, Vallières, L., Lacroix, S., Keane, R.W., Chae, J.J., de Rivero Vaccari, J.P., Amiable, N., Dumas, A., PLoS Pathogens, 2014, 10.1371/journal.ppat.1004150
  • Influence of cytokines on neuroendocrine functions during immune response: Mechanisms and neuronal circuitry involved,INFLUENCE DES CYTOKINES SUR LES FONCTIONS NEUROENDOCRINIENNES DURANT LA REPONSE IMMUNITAIRE: MECANISMES IMPLIQUES ET VOIES NEURONALES EMPRUNTEES, Lacroix, S., Rivest, S., Annales d'Endocrinologie, 1995
  • Influence of lnterleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: An effect depending upon the route of administration, Rivest, S., Lacroix, S., Vallières, L., 1997, 10.1111/j.1460-9568.1997.tb01500.x
  • Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions, Fernandes, K.J.L., Grégoire, C.-A., Lévesque, S.A., Pineau, I., Breault-Dugas, C., Beaudoin, S., Vaugeois, A., Hamilton, L.K., Lacroix, S., 2014, 10.1371/journal.pone.0085916
  • Systemic injections of lipopolysaccharide accelerates myelin phagocytosis during wallerian degeneration in the injured mouse spinal cord, Lacroix, S., David, S., Berard, J.L., Vallières, N., 2006, 10.1002/glia.20266
  • Differential attenuation of β2 integrin-dependent and -independent neutrophil migration by Ly6G ligation., , Blood advances, 2019, 10.1182/bloodadvances.2018026732
  • Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells, Phillip G. Popovich, Ning Quan, Steve Lacroix, Xiaoyu Liu, Daniel P. Nemeth, Kristina A. Kigerl, Jodie C. Hall, Zhen Guan, David R. Sweet, Faith H. Brennan, Camila M. Freria, The Journal of Neuroscience, 2020, 10.1523/JNEUROSCI.0131-20.2020
  • Functional circuitry in the brain of immune-challenged rats: Partial involvement of prostaglandins, Rivest, S., Lacroix, S., 1997, 10.1002/(SICI)1096-9861(19971020)387:2<307::AID-CNE11>3.0.CO;2-R
  • Calretinin gene expression in the human thalamus, Parent, A., Beach, T.G., Lacroix, S., Cicchetti, F., 1998, 10.1016/S0169-328X(97)00314-8
  • Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease., , Neurobiology of disease, 2018, 10.1016/j.nbd.2018.11.002
  • Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology, Cicchetti, F., Barker, R.A., Francis, S.T., Gowland, P.A., Lacroix, S., Calon, F., Mason, S.L., St-Amour, I., Alata, W., Dury, R.J., Saint-Pierre, M., Kuan, W.-L., Lagacé, M., Cisbani, G., Sawiak, S.J., Drouin-Ouellet, J., Annals of Neurology, 2015, 10.1002/ana.24406
  • Betacellulin regulates schwann cell proliferation and myelin formation in the injured mouse peripheral nerve., , Glia, 2017, 10.1002/glia.23119
  • Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase a to promote inflammation, Boilard, E., Gelb, M.H., Semple, J.W., Thibault, L., Lacroix, S., Guderley, H., Nigrovic, P.A., Garraud, O., Cognasse, F., Hamzeh-Cognasse, H., Pouliot, M., Farndale, R.W., Lambeau, G., Marcoux, G., Laflamme, C., Lévesque, T., Naika, G.S., Rousseau, M., Paré, A., Bollinger, J., Martin, N., Soulet, D., Cloutier, N., Duchez, A.-C., Boudreau, L.H., Blood, 2014, 10.1182/blood-2014-05-573543
  • Cytokine pathways regulating glial and leukocyte function after spinal cord and peripheral nerve injury, Lacroix, S., Bastien, D., Experimental Neurology, 2014, 10.1016/j.expneurol.2014.04.006
  • Local assessment of myelin health in a multiple sclerosis mouse model using a 2D Fourier transform approach, Côté, D., De Koninck, Y., Lacroix, S., Bélisle, J., Chamma, É., Aubé, B., Laffray, S., Bélanger, E., Bégin, S., 2013, 10.1364/BOE.4.002003
  • A novel method for multiple labeling combining in situ hybridization with immunofluorescence, Lacroix, S., Vallières, N., Barrette, B., Pineau, I., 2006, 10.1369/jhc.6A7022.2006
  • Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain, Rivest, S., Lacroix, S., 1996, 10.1016/0891-0618(95)00106-9
  • The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury, Steve Lacroix, Ning Quan, Xiaoyu Liu, Nicolas Vallières, Martine Lessard, Dominic Belanger, Maxime Kusik, Benoit Mailhot, Adrian Castellanos-Molina, Floriane Bretheau, 2021, 10.21203/rs.3.rs-580331/v1
  • FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential., , Experimental cell research, 2018, 10.1016/j.yexcr.2018.04.017
  • Neurotrophic Factors and Gene Therapy in Spinal Cord Injury, Tuszynski, M.H., Lacroix, S., Neurorehabilitation and Neural Repair, 2000, 10.1177/154596830001400403
  • Automated Filtering of Intrinsic Movement Artifacts during Two-Photon Intravital Microscopy, Lacroix, S., Coste, J., Paré, A., Soulet, D., 2013, 10.1371/journal.pone.0053942
  • An essential role of interleukin-1β in mediating NF-κB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia, Rivest, S., Lacroix, S., Laflamme, N., 1999
  • NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection, Lu, P., Lacroix, S., Löw, K., Blesch, A., Brant, A., Jones, L.L., Grill, R., Tuszynski, M.H., 2003, 10.1016/S0014-4886(02)00055-9
  • How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli, Laflamme, N., Zhang, J., Nadeau, S., Vallières, L., Lacroix, S., Rivest, S., 2000
  • Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion, Lacroix, S., Bastien, D., Sun, L., Pineau, I., 2010, 10.1016/j.bbi.2009.11.007
  • Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved, Lacroix, S., Pineau, I., 2007, 10.1002/cne.21149
  • Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury., , Nature communications, 2019, 10.1038/s41467-019-08446-0
  • Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration., , Proceedings of the National Academy of Sciences of the United States of America, 2018, 10.1073/pnas.1720553115

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Adrian Castellanos Molina - Doctorat - En cours
  • Maxime Kusik - Doctorat - En cours
  • Felipe Da Gama Monteiro - Doctorat - En cours
  • Ana Boisvert - Doctorat - En cours
  • Camille Cassandre Illiano - Doctorat - En cours
  • Dominic Bélanger - Maîtrise avec mémoire - En cours
  • Juliette Ferry - Doctorat - En cours
  • Benoit Aubé - Maîtrise avec mémoire - 2013/09
  • Alexandre Paré - Maîtrise avec mémoire - 2015/05
  • Marie Rieux - Maîtrise avec mémoire - 2017/01
  • Benoit Mailhot - Maîtrise avec mémoire - 2017/01
  • Victor Bellver Landete - Doctorat - 2020/01
  • Floriane Bretheau - Doctorat - 2021/01

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*Les supervisions d’étudiant(e)s de 1er cycle en stage de recherche et de résident(e)s aux études médicales postdoctorales seront répertoriées ultérieurement.
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