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Nicolas Flamand

Professeur titulaire

Nicolas.Flamand@criucpq.ulaval.ca
Centre thématique de recherche en neurosciences
Groupe de recherche en santé respiratoire
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec
Centre de recherche en arthrite (ARThrite)
Centre de recherche de l'IUCPQ
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Contribution à la recherche

Axe de recherche de l'Université Laval :

L’humain dans son environnement

Thématiques de recherche de la Faculté de médecine :

Immunologie-infectiologie
Santé cardiovasculaire, respiratoire et métabolisme

Domaines et intérêts de recherche du (de la) professeur(e) :

Appareil locomoteur et arthrite
  • Affections cutanées
Santé circulatoire et respiratoire
  • Maladies inflammatoires du système respiratoire
  • Asthme
  • Fibrose kystique
  • Maladie pulmonaire obstructive chronique

Projets de recherche

  • Salaire d'un professeur - Fondation de l'Université Laval, Institut universitaire de cardiologie et de pneumologie de Québec, chercheur principal - 2009-07-01 au 2026-06-30
  • Cellular and molecular mechanisms involved in the biosynthesis and hydrolysis of the endocannabinoid 2-arachidonoyl-glycerol and its congeners - Conseil de recherches en sciences naturelles et génie Canada - Subventions à la découverte SD (individuelles et d'équipe), chercheur principal - 2021-04-01 au 2026-03-31
  • Caractérisation d’un nouvel endocannabinoïde ayant des effets bronchorelaxants - Fondation de l'Université Laval, chercheur principal - 2024-01-01 au 2025-12-31
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 3.2 - Instituts de recherche en santé du Canada - Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche, co-chercheur - 2019-11-01 au 2024-10-31
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.1 - Instituts de recherche en santé du Canada - Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche, co-chercheur - 2019-11-01 au 2024-10-31
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.2 - Instituts de recherche en santé du Canada - Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche, co-chercheur - 2019-11-01 au 2024-10-31
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3 - Instituts de recherche en santé du Canada - Subvention d'équipe : Initiative canadienne microbiome 2 : Équipes de recherche, co-chercheur - 2019-11-01 au 2024-10-31
  • Impact of dietary stearidonic acid-rich oil on rheumatoid arthritis - Instituts de recherche en santé du Canada - Subvention Projet, Université de Moncton, co-chercheur - 2019-10-01 au 2024-09-30
  • FMéd --- Canada Excellence Research Chair on the microbiome-endocannabinoidome connection in metabolic health - Instituts de recherche en santé du Canada, Université Laval - Fonds internes - Programme de chaires d'excellence en recherche du Canada, co-chercheur - 2017-06-01 au 2024-05-31
  • Cellular and molecular mechanisms involved in the regulation of the endocannabinoidome in the immune system in health and disease - Instituts de recherche en santé du Canada - Chaires de recherche sans organismes subventionnaires, chercheur principal - 2018-10-01 au 2024-05-31
  • Programme de soutien aux nouveaux chercheurs - Université Laval - Fonds internes - Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, chercheur principal - 2022-01-01 au 2023-12-31
  • Characterization of the novel metabolite 5-hydroxy-eicosatetraenoyl-glycerol in asthma - Fondation de l'Université Laval, chercheur principal - 2022-01-01 au 2023-12-31
  • COVID-19 trilogy: ARDS, inflammation and coagulopathy - Instituts de recherche en santé du Canada - Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19, co-chercheur - 2020-06-01 au 2021-05-31
  • Understanding the pathogenesis of COVID-19 - Instituts de recherche en santé du Canada, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC) - Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), co-chercheur - 2020-03-01 au 2021-02-28

Publications

  • Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin system, Laviolette, M., Chakir, J., Flamand, N., Davoine, F., Guilbert, M., Ferland, C., Journal of Leukocyte Biology, 2001
  • Androgen inactivation in human lung fibroblasts: Variations in levels of 17β-hydroxysteroid dehydrogenase type 2 and 5α-reductase activity compatible with androgen inactivation, Tremblay, Y., Flamand, N., Drolet, R., Blomquist, C.H., Provost, P.R., Journal of Clinical Endocrinology and Metabolism, 2002, 10.1210/jc.87.8.3883
  • Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma., , Frontiers in medicine, 2017, 10.3389/fmed.2017.00136
  • 5-Oxo-6,8,11,14-eicosatetraenoic acid induces important eosinophil transmigration through basement membrane components: Comparison of normal and asthmatic eosinophils, Laviolette, M., Lavigne, S., Flamand, N., Bossé, M., Ferland, C., Guilbert, M., American Journal of Respiratory Cell and Molecular Biology, 1999
  • Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists, Patrice D. Cani, Vincenzo Di Marzo, Willem M. de Vos, Nathalie M. Delzenne, Michel P. Hermans, Audrey Loumaye, Jean-Paul Thissen, Dominique Maiter, Rudy Pelicaen, Amandine Everard, Céline Druart, Nicolas Flamand, Cristoforo Silvestri, Fabio Arturo Iannotti, Rosa Maria Vitale, Clara Depommier, Cells, 2021, 10.3390/cells10010185
  • Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma, Marsolais, D., Bissonnette, T., Bossé, Y., Don, A.S., Blanchet, M.-R., Flamand, N., Bernatchez, T., Langlois, A., Lai, L.J.A., Tremblay, C., Lemay, A.-M., Gendron, D., Respiratory Research, 2015, 10.1186/s12931-015-0180-z
  • Toll-like receptor ligands induce polymorphonuclear leukocyte migration: Key roles for leukotriene B4 and platelet-activating factor, Borgeat, P., Flamand, N., Picard, S., Lévesque, T., Milot, V., Marleau, S., Lefebvre, J.S., FASEB Journal, 2010, 10.1096/fj.09-135624
  • Endocannabinoid hydrolysis inhibition unmasks that unsaturated fatty acids induce a robust biosynthesis of 2-arachidonoyl-glycerol and its congeners in human myeloid leukocytes., , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, 10.1096/fj.201902916r
  • Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling., , Journal of lipid research, 2019, 10.1194/jlr.ra119000424
  • Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S., Picard, S., Surette, M.E., Flamand, N., Molecular Pharmacology, 2002, 10.1124/mol.62.2.250
  • Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo., , PloS one, 2017, 10.1371/journal.pone.0169804
  • Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils., , PloS one, 2018, 10.1371/journal.pone.0202424
  • Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs., , Frontiers in pharmacology, 2016, 10.3389/fphar.2016.00317
  • CCL26/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11/eotaxin-1 and CCL24/eotaxin-2, Laviolette, M., Flamand, N., Rola-Pleszczynski, M., Langlois, A., Larose, M.-C., Provost, V., Journal of Leukocyte Biology, 2013, 10.1189/jlb.0212074
  • Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoylglycerol and arachidonoyl-ethanolamide, and their metabolites, Flamand, N., Lefebvre, J.S., Chouinard, F., Turcotte, C., Journal of Leukocyte Biology, 2015, 10.1189/jlb.3RU0115-021R
  • Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice., , mSystems, 2019, 10.1128/msystems.00407-19
  • Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis., , Nature communications, 2019, 10.1038/s41467-018-08051-7
  • Androgen formation and metabolism in the pulmonary epithelial cell line A549: Expression of 17β-hydroxysteroid dehydrogenase type 5 and 3α-hydroxysteroid dehydrogenase type 3, Tremblay, Y., Nadeau, D., Luu-The, V., Flamand, N., Huang, X.-F., Godin, C., Blomquist, C.H., Provost, P.R., Endocrinology, 2000, 10.1210/en.141.8.2786
  • Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models, Patrice D. Cani, Vincenzo Di Marzo, Nathalie M. Delzenne, Amandine Everard, Michel P. Hermans, Audrey Loumaye, Jean-Paul Thissen, Dominique Maiter, Rudy Pelicaen, Nicolas Flamand, Clara Depommier, Cells, 2021, 10.3390/cells10010071
  • Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity, Cristoforo Silvestri, Vincenzo Di Marzo, Angelo Tremblay, Vicky Drapeau, Yvon Chagnon, Nicolas Flamand, Francine Pérusse, Sébastien Lacroix, Claudia Manca, Biomedicines, 2021, 10.3390/biomedicines9091246
  • Leukotriene D4 and Interleukin-13 Cooperate to Increase the Release of Eotaxin-3 by Airway Epithelial Cells, Laviolette, M., Flamand, N., Chakir, J., Rola-Pleszczynski, M., Chouinard, F., Langlois, A., Provost, V., PLoS ONE, 2012, 10.1371/journal.pone.0043544
  • Reprogramming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines, Poubelle, P.E., Borgeat, P., Flamand, N., Rusu, D., Chakravarti, A., Laboratory Investigation, 2009, 10.1038/labinvest.2009.74
  • Effects of pyrrophenone, an inhibitor of group IVA phospholipase A 2, on eicosanoid and PAF biosynthesis in human neutrophils, Borgeat, P., Bourgoin, S.G., Pouliot, M., Lemieux, L., Picard, S., Flamand, N., British Journal of Pharmacology, 2006, 10.1038/sj.bjp.0706879
  • Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid, Lucia H. Faccioli, Robert C. Murphy, Nicolas Flamand, Carlos Guijas, Miguel A. Gijón, Rodrigo F. Scandiuzzi, Raphael L. Sanchez, Sarah A. Martin, Simona Zarini, Carlos A. Sorgi, Scientific Reports, 2017, 10.1038/s41598-017-11496-3
  • Hypersensitivity pneumonitis onset and severity is regulated by CD103 dendritic cell expression., , PloS one, 2017, 10.1371/journal.pone.0179678
  • RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis., , The Journal of allergy and clinical immunology, 2020, 10.1016/j.jaci.2020.03.004
  • The CB2 receptor and its role as a regulator of inflammation., , Cellular and molecular life sciences : CMLS, 2016, 10.1007/s00018-016-2300-4
  • Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: Involvement of the H 2 receptor and cAMP, Borgeat, P., Laviolette, M., Picard, S., Plante, H., Flamand, N., British Journal of Pharmacology, 2004, 10.1038/sj.bjp.0705654
  • Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma, Flamand, N., Laviolette, M., Provost, V., Joubert, P., Archambault, A.-S., Chakir, J., Larose, M.-C., Journal of Allergy and Clinical Immunology, 2015, 10.1016/j.jaci.2015.02.039
  • Plasma eicosanoid profiles determined by high-performance liquid chromatography coupled with tandem mass spectrometry in stimulated peripheral blood from healthy individuals and sickle cell anemia patients in treatment., , Analytical and bioanalytical chemistry, 2016, 10.1007/s00216-016-9445-8
  • Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii, Peters-Golden, M., Brock, T.G., Flamand, N., Chen, G.-H., Serezani, C.H., Peres, C.M., Lewis, C., Coleman, N., Chung, J., Hao, Y., Aronoff, D.M., Journal of Immunology, 2008
  • The intracellular localisation and phosphorylation profile of the human 5-lipoxygenase A13 isoform differs from that of its full length counterpart, Samant, R., Surette, M.E., Flamand, N., Boudreau, L.H., Allain, E.P., PLoS ONE, 2015, 10.1371/journal.pone.0132607
  • Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils, Borgeat, P., Picard, S., Surette, M.E., Lefebvre, J., Flamand, N., Journal of Biological Chemistry, 2006, 10.1074/jbc.M506513200
  • [Extracellular molecules controlling the contraction of airway smooth muscle and their potential contribution to bronchial hyperresponsiveness]., , Revue des maladies respiratoires, 2020, 10.1016/j.rmr.2020.03.009
  • Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism, Cani PD, Giulio G. Muccioli, Cristoforo Silvestri, serge luquet, Nicolas Flamand, Vincenzo Di Marzo, Nathalie M. Delzenne, Isabelle Leclercq, Rita Manco, Marialetizia Rastelli, Matthias Van Hul, Martin Roumain, Charlotte Lefort, Cells, 2020, 10.3390/cells9051247
  • Cellular analysis of the histamine H4 receptor in human myeloid cells., , Biochemical pharmacology, 2016, 10.1016/j.bcp.2016.01.007
  • Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol, Flamand, N., Laviolette, M., Provost, V., Martin, C., Ferland, C., Chouinard, F., Turcotte, C., Larose, M.-C., Journal of Allergy and Clinical Immunology, 2014, 10.1016/j.jaci.2013.12.1081
  • Leukotrienes: Mediators that have been typecast as villains, Brock, T.G., Serezani, C.H.C., Mancuso, P., Flamand, N., Cellular and Molecular Life Sciences, 2007, 10.1007/s00018-007-7228-2
  • Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways., , Journal of leukocyte biology, 2019, 10.1002/jlb.3a0919-049rrr
  • Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites, Flamand N, dummy-AUTHOR_name, Boilard É, Laviolette M, Tijani Y, Fares H, El Hassani A, Cheikh A, Amar Y, Martin C, Dubuc I, Doré É, Rakotoarivelo V, Zaid Y, Archambault A, 2020, 10.1101/2020.12.04.20242115
  • An in vitro study examining the duration between deep inspirations on the rate of renarrowing., , Respiratory physiology & neurobiology, 2017, 10.1016/j.resp.2017.04.013
  • A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma., , Frontiers in pharmacology, 2017, 10.3389/fphar.2017.00078
  • Lipopolysaccharide impacts murine CD103+ DC differentiation, altering the lung DC population balance., , European journal of immunology, 2019, 10.1002/eji.201847910
  • The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: Critical role of its hydrolysis and de novo leukotriene B4 biosynthesis, Flamand, N., Laviolette, M., Marsolais, D., Lalancette-Hébert, M., Ferland, C., Bouchard, L., Navarro, P., Lefebvre, J.S., Chouinard, F., Journal of Immunology, 2011, 10.4049/jimmunol.1002853
  • Crucial implication of protein kinase C (PKC)-δ, PKC-ζ, ERK-1/2, and p38 MAPK in migration of human asthmatic eosinophils, Laviolette, M., Rola-Pleszczynski, M., Ferland, C., Flamand, N., Chouinard, F., Langlois, A., Journal of Leukocyte Biology, 2009, 10.1189/jlb.0808492
  • LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells., , Prostaglandins, leukotrienes, and essential fatty acids, 2020, 10.1016/j.plefa.2020.102078
  • Phosphorylation by protein kinase A inhibits nuclear import of 5-lipoxygenase, Brock, T.G., Peters-Golden, M., Aronoff, D.M., Flamand, N., Jones, S.M., Luo, M., Journal of Biological Chemistry, 2005, 10.1074/jbc.M507045200
  • Methylation profiles of IL33 and CCL26 in bronchial epithelial cells are associated with asthma., , Epigenomics, 2018, 10.2217/epi-2018-0044
  • NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis, Peters-Golden, M., Flamand, N., Phare, S.M., Serezani, C.H., Coffey, M.J., Journal of Leukocyte Biology, 2007, 10.1189/jlb.0107019
  • Activation of TAK1 by chemotactic and growth factors, and its impact on human neutrophil signaling and functional responses, McDonald, P.P., Flamand, N., Dubois, C.M., Fortin, C.F., Simard, F.A., Ear, T., Sylvain-Prévost, S., Journal of Immunology, 2015, 10.4049/jimmunol.1402752
  • Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells, Roxane Pouliot, Julie Fradette, Pierre Julien, Nicolas Flamand, Sylvain L. Guérin, Cyril Martin, Sophie Morin, Geneviève Rioux, Mélissa Simard, Journal of Investigative Dermatology, 2021, 10.1016/j.jid.2021.02.755
  • Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism, Nicolas Flamand, Jyoti Sihag, Volatiana Rakotoarivelo, Cells, 2021, 10.3390/cells10061279
  • Differential regulation by leukotrienes and calcium of Fcγ receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages, Peters-Golden, M., Chen, G.-H., Toews, G.B., Wettlaufer, S., Flamand, N., Choe, M., Aronoff, D.M., Canetti, C., Journal of Leukocyte Biology, 2006, 10.1189/jlb.0705374
  • IL-16 activates plasminogen-plasmin system and promotes human eosinophil migration into extracellular matrix via CCR3-chemokine-mediated signaling and by modulating CD4 eosinophil expression, Laviolette, M., Chakir, J., Davoine, F., Flamand, N., Ferland, C., Journal of Immunology, 2004
  • Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions, Peters-Golden, M., Faccioli, L.H., Flamand, N., Serezani, C.H., Aronoff, D.M., Peres, C.M., Journal of Immunology, 2007
  • Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12., , Biochimica et biophysica acta. Molecular and cell biology of lipids, 2017, 10.1016/j.bbalip.2017.02.015
  • Suppressive effects of adenosine on the 5-lipoxygenase pathway in human polymorphonuclear leukocytes, Borgeat, P., Bourgoin, S., Krump, E., Surette, M.E., Austin, M., Picard, S., Plante, H., Flamand, N., Drug Development Research, 2001, 10.1002/ddr.1140
  • Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: Involvement of cPLA2α and reversal by lyso-PAF, Borgeat, P., Bourgoin, S.G., Lemieux, L., Picard, S., Lapointe, G., Lefebvre, J., Flamand, N., Journal of Leukocyte Biology, 2006, 10.1189/jlb.1005614
  • Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils, Nicolas Flamand, Vincenzo Di Marzo, ALESSIA LIGRESTI, ROSA MARIA VITALE, Louis-Philippe Boulet, Michel Laviolette, Roxane Pouliot, Cristoforo Silvestri, Mélissa Simard, Cyril Martin, Pier-Luc Plante, Magdalena Kostrzewa, Volatiana Rakotoarivelo, Élizabeth Dumais, Francesco Tinto, Anne-Sophie Archambault, Cells, 2021, 10.3390/cells10092322
  • Adenosine, a potent natural suppressor of arachidonic acid release and leukotriene biosynthesis in human neutrophils, Borgeat, P., Laviolette, M., Naccache, P., Gilbert, C., Vallée, M.-J., Krump, E., Plante, H., Surette, M.E., Austin, M., Picard, S., Boudreault, S., Flamand, N., American Journal of Respiratory and Critical Care Medicine, 2000
  • Pulmonary CD103 expression regulates airway inflammation in asthma, Blanchet, M.-R., McNagny, K.M., Marsolais, D., Flamand, N., Brassard, J., Lemay, A.-M., Langlois, A., Gold, M.J., Bernatchez, E., American Journal of Physiology - Lung Cellular and Molecular Physiology, 2015, 10.1152/ajplung.00319.2014
  • Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19., , The Journal of allergy and clinical immunology, 2021, 10.1016/j.jaci.2021.05.032
  • High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients., , FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, 10.1096/fj.202100540r
  • Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes, Surette, M.E., Flamand, N., Touaibia, M., Jean-François, J., LeBlanc, L.M., Maillet, J., Boudreau, L.H., PLoS ONE, 2012, 10.1371/journal.pone.0031833
  • 2-arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils releaseantimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV, Flamand, N., Grandvaux, N., Flamand, L., Provost, V., Bouchard, L., Poirier, S., Larose, M.-C., Guan, X., Turcotte, C., Chouinard, F., Journal of Leukocyte Biology, 2013, 10.1189/jlb.0412200
  • Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products, Surette, M.E., Flamand, N., Ouellette, R.J., Laflamme, M., Robichaud, P.P., Bertin, J., Boudreau, L.H., FASEB Journal, 2011, 10.1096/fj.10-173856
  • Arachidonic acid activates phospholipase D in human neutrophils; essential role of endogenous leukotriene B4 and inhibition by adenosine A 2A receptor engagement, Bourgoin, S.G., Borgeat, P., Naccache, P.H., Pelletier, J., Flamand, N., Grenier, S., Journal of Leukocyte Biology, 2003, 10.1189/jlb.0702371
  • The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors., , Journal of immunology (Baltimore, Md. : 1950), 2017, 10.4049/jimmunol.1601767
  • Metabolism of arachidonic acid to eicosanoids within the nucleus, Brock, T.G., Flamand, N., Luo, M., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2006, 10.1016/j.bbalip.2006.02.018
  • Phosphorylation of serine 271 on 5-Lipoxygenase and its role in nuclear export, Brock, G.T., Peters-Golden, M., Luo, M., Flamand, N., Journal of Biological Chemistry, 2009, 10.1074/jbc.M805593200
  • Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils, Pouliot, M., Borgeat, P., Cleland, L.G., Caughey, G.E., James, M.J., Laflamme, C., Dussault, A.-A., Bouchard, L., Picard, S., Biarc, J., Flamand, N., St-Onge, M., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 2007, 10.1016/j.bbalip.2007.06.002
  • 20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4 -mediated responses of human neutrophils and eosinophils., , Journal of leukocyte biology, 2019, 10.1002/jlb.ma0718-306r
  • Expression of membrane type-4 matrix metalloproteinase (metalloproteinase- 17) by human eosinophils, Laviolette, M., Tremblay, G.M., Chakir, J., Flamand, N., Ferland, C., Racine, C., Gauthier, M.-C., International Journal of Biochemistry and Cell Biology, 2003, 10.1016/S1357-2725(03)00136-5

Contribution à l'enseignement aux cycles supérieurs

Étudiant(e)s dirigé(e)s*

Depuis 2009
  • Jean-Philippe C Lavoie - Maîtrise avec mémoire - En cours
  • Oumaima Azeggouar wallen - Doctorat - En cours
  • Katherine Boulay - Maîtrise avec mémoire - 2011/01
  • Luc Boudreau - Doctorat - 2012/01
  • François Chouinard - Doctorat - 2012/01
  • Stéphanie Jean - Maîtrise avec mémoire - 2012/01
  • Marie-Chantal Larose - Maîtrise avec mémoire - 2015/01
  • Caroline Turcotte - Maîtrise avec mémoire - 2015/05
  • Anne-Sophie Archambault - Maîtrise avec mémoire - 2018/01
  • Samuel Poirier - Doctorat - 2019/05
  • Elizabeth Dumais - Maîtrise avec mémoire - 2023/09

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